Synopsis of recent research by authors named "Yangjie Xiong"
- Yangjie Xiong's recent research primarily focuses on the structural biology of G-protein-coupled receptors (GPCRs) and their roles in various signaling pathways, particularly in relation to WNT signaling and immune system interactions.
- A significant finding includes the identification of oleic acid as an endogenous ligand for GPR3 and the cryo-EM structures that detail the activation mechanisms of adhesion GPCRs like CD97 and ADGRL3, revealing crucial insights into their G-protein coupling selectivity.
- Additionally, the research extends into cancer biology, identifying PKMYT1 as a therapeutic target in pancreatic ductal adenocarcinoma through genome-wide CRISPR screens and exploring the effects of SETD2 inactivation on cancer cell sensitivity to immune checkpoint blockade therapies.
