High-entropy doping in NASICON cathodes: Activating the V/V redox couple and inducing a reversible single solid-solution phase reaction for advanced sodium ion batteries.

NaV(PO) (NVP) with typical NASICON structure is highly regarded as one of the most appealing cathodes for sodium-ion batteries (SIBs) for their excellent structural stability; however, the poor electronic conductivity and irreversible phase transition at high voltage (∼4 V) for the material result in poor rate capabilities and significant capacity degradation during electrochemical reactions. Herein, the high-entropy doping strategy of introducing six types of metal ions into the V-sites in NaV(PO) is used to design a high-performance cathode of NaV(Mn, Ca, Mg, Al, Zr)Nb(PO) (HE-NVP) for SIBs. After the high-entropy doping, a reversible V/V redox pair is activated at high voltage of ∼4 V, which significantly contributes to the enhancement of energy density and operating voltage.

Comparing between virtual reality based pre-clinical implantation training and traditional learning methods.

Objective: As dental implanting becomes an increasing demand among patients with tooth loss, an efficient and effective training for students is to be necessary. In this case, we anticipate the possible application of virtual reality (VR) technology to pre-clinical implantation training (PCIT) in order to improve the students' learning efficiency and effectiveness.

Methods: The study divided 20 subjects into two groups on average-VR based PCIT (experimental group) and traditional PCIT (control group) with the completion of the background survey (BS) before PCITs, to guarantee no apparent backgroud variation including learning of oral implantology and VR technology, learning habits, interests and hobbies, .

Late Gadolinium-Enhanced Cardiac Magnetic Resonance for Predicting Left Ventricular Reverse Remodeling in Dilated Cardiomyopathy A Comprehensive Review and Meta-Analysis.

Background: There is currently a lack of evidence regarding the significance of late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) in predicting left ventricular (LV) reverse remodeling (RR) in pooled data. This study aimed to evaluate the predictive value of the presence and extent of LGE for LVRR in patients with dilated cardiomyopathy (DCM).

Methods: Systematic searches were conducted in PubMed, Embase, Cochrane Library, and ClinicalTrials.

Body mass index, regional adipose deposition, and clinical outcomes in non-ischemic dilated cardiomyopathy: a prospective cohort study.

Aim: To assess the relationship between body mass index (BMI), subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), epicardial adipose tissue (EAT), pericardial adipose tissue (PAT) and clinical outcomes in dilated cardiomyopathy (DCM) patients.

Methods: Non-ischemic DCM patients were prospectively enrolled. Regional adipose tissue, cardiac function, and myocardial tissue characteristics were measured by cardiac magnetic resonance (CMR).

Assessment of macrobenthos in evaluating the restoration effects of artificial mangrove planting on tidal flats in Zhejiang, China.

Artificially planted mangroves are widely used for tidal flat restoration, but their effectiveness in restoring these ecosystems remains unclear. Macrobenthos, as key indicators of tidal flat ecosystem health, can reflect changes in environmental conditions and quality resulting from the introduction of artificial mangroves. This study aimed to investigate the ecological restoration effects of artificially planted mangroves in northern China by surveying macrobenthic communities across four regions in June 2023.

Increased epicardial adipose tissue is associated with left ventricular reverse remodeling in dilated cardiomyopathy.

Background: Epicardial adipose tissue (EAT) has been suggested to play paradoxical roles in patients with heart failure. The role of EAT in dilated cardiomyopathy (DCM) patients remains unclear. We aimed to assess the associations between the dynamic changes EAT and left ventricular reverse remodeling (LVRR) in DCM patients based on baseline and follow-up CMR.

A taxonomic note on the order : description of 12 novel families and emended description of 21 families.

The order , belonging to class , is globally distributed in various ecosystems. Currently, this order comprised 12 families that show vast phenotypic, ecological and genotypic variation. The classification of at the family level is currently mainly based on 16S rRNA gene sequencing analysis and the presence of shared phenotypic characteristics, resulting in noticeable anomalies.

Dramatic Enhancement Enabled by Introducing TiN into Bread-like Porous Si-Carbon Anodes for High-Performance and Safe Lithium Storage.

Doping modifications and surface coatings are effective methods to slow volume dilatation and boost the conductivity in silicon (Si) anodes for lithium-ion batteries (LIBs). Herein, using low-cost ferrosilicon from industrial production as the energy storage material, a bread-like nitrogen-doped carbon shell-coated porous Si embedded with the titanium nitride (TiN) nanoparticle composite (PSi/TiN@NC) was synthesized by simple ball milling, etching, and self-assembly growth processes. Remarkably, the porous Si structure formed by etching the FeSi phase in ferrosilicon alloys can provide buffer space for significant volume expansion during lithiation.

Fragment Correlation Mass Spectrometry Enables Direct Characterization of Disulfide Bond Cleavage Pathways of Therapeutic Peptides.

Therapeutic peptides that are connected by disulfide bonds are often difficult to analyze by traditional tandem mass spectrometry without chemical modification. Using fragment correlation mass spectrometry, we analyzed 56 pairs of fragment ions generated from an equimolar (10 μM) mixture of three cyclic peptides, achieving sequence coverage of 86%, 100%, and 75% for octreotide, desmopressin, and the structural analogue of desmopressin, respectively. In all detected fragment ion pairs, only 20% of the fragment ions are terminal ions, with most of the measured ions only detected by fragment correlation mass spectrometry.

The signatures and crosstalk of gut microbiome, mycobiome, and metabolites in decompensated cirrhotic patients.

Background: Numerous studies have confirmed that gut microbiota plays a crucial role in the progression of cirrhosis. However, the contribution of gut fungi in cirrhosis is often overlooked due to the relatively low abundance.

Methods: We employed 16S ribosomal RNA sequencing, internal transcribed spacer sequencing, and untargeted metabolomics techniques to investigate the composition and interaction of gut bacteria, fungi, and metabolites in cirrhotic patients.

Angelica sinensis polysaccharide facilitates chondrogenic differentiation of adipose-derived stem cells via MDK-PI3K/AKT signaling cascade.

Object: Adipose-derived mesenchymal stem cells (ADSCs) have received significant attention in the field of cartilage tissue repair. Angelica sinensis polysaccharide (ASP) can enhance both the proliferation and differentiation of mesenchymal stem cells. Therefore, we intend to explore the effect of ASP on chondrogenic differentiation of ADSCs in vitro, and elucidate the underlying mechanisms.

Fragment correlation mass spectrometry: Determining the structures of biopolymers in a complex mixture without isolating individual components.

Fragment correlation mass spectrometry correlates ion pairs generated from the same fragmentation pathway, achieved by covariance mapping of tandem mass spectra generated with an unmodified linear ion trap without preseparation. We enable the identification of different precursors at different charge states in a complex mixture from a large isolation window, empowering an analytical approach for data-independent acquisition. The method resolves and matches isobaric fragments, internal ions, and disulfide bond fragments.

Hydrogen Sulfide Promotes Platelet Autophagy via PDGFR-α/PI3K/Akt Signaling in Cirrhotic Thrombocytopenia.

Background And Aims: The role of platelet autophagy in cirrhotic thrombocytopenia (CTP) remains unclear. This study aimed to investigate the impact of platelet autophagy in CTP and elucidate the regulatory mechanism of hydrogen sulfide (HS) on platelet autophagy.

Methods: Platelets from 56 cirrhotic patients and 56 healthy individuals were isolated for analyses.

Sudden Cardiac Death Risk Stratification in Heart Failure With Preserved Ejection Fraction.

Heart failure with preserved ejection fraction (HFpEF) poses a significant clinical challenge, with sudden cardiac death (SCD) emerging as one of the leading causes of mortality. Despite advancements in cardiovascular medicine, predicting and preventing SCD in HFpEF remains complex due to multifactorial pathophysiological mechanisms and patient heterogeneity. Unlike heart failure with reduced ejection fraction, where impaired contractility and ventricular remodeling predominate, HFpEF pathophysiology involves heavy burden of comorbidities such as hypertension, obesity, and diabetes.

Construction of a stable fluorescent sensor based on CsPbBr/CdS core/shell quantum dots for selective and sensitive detection of tetracycline in ethanol.

The weakly bound organic ligand shells around perovskite quantum dots (QDs) are easily decomposed and cannot provide sufficient stability in polar solvents, which greatly obstructs their applications in sensing. Herein, a fluorescent sensor based on CsPbBr/CdS core/shell QDs was developed for the detection of tetracycline (TC) in the polar solvent-ethanol. Pristine CsPbBr QDs were treated with cadmium diethyldithiocarbamate (Cd(DDTC)) to form a shell on the surface at 110 °C, while extra oleylammonium bromide (OAmBr) was added to inhibit the phase transformation of CsPbBr into a CsPbBr impurity phase during high-temperature processing.

Hollow VO microspheres anchored on graphene as advanced cathodes for aqueous zinc-ion batteries.

Vanadium dioxide-based materials have been proved to be promising cathodes for aqueous zinc ion batteries (AZIBs) due to their cost-effectiveness and high theoretical specific capacity; nevertheless, the low electronic conductivity and poor cycle stability restrict their application. Herein, hollow VO microspheres anchored on graphene oxide (H-VO@GO) are synthesized via a facile simple hydrothermal reaction as high-performance cathodes for AZIBs. The hollow micromorphology of the material provides a large specific surface area and effectively alleviates the volume changes during cycling, while the anchoring of VO on graphene oxide greatly improves the electronic conductivity and inhibits the agglomeration and pulverization of the material.

Optimizing Interplanar Spacing, Oxygen Vacancies and Micromorphology via Lithium-Ion Pre-Insertion into Ammonium Vanadate Nanosheets for Advanced Cathodes in Aqueous Zinc-Ion Batteries.

Ammonium vanadates, featuring an N─H···O hydrogen bond network structure between NH and V─O layers, have become popular cathode materials for aqueous zinc-ion batteries (AZIBs). Their appeal lies in their multi-electron transfer, high specific capacity, and facile synthesis. However, a major drawback arises as Zn ions tend to form bonds with electronegative oxygen atoms between V─O layers during cycling, leading to irreversible structural collapse.

The impact of type 2 diabetes mellitus on the clinical profile, myocardial fibrosis, and prognosis in non-ischemic dilated cardiomyopathy: a prospective cohort study.

Background: The impact of the coexistence of type 2 diabetes mellitus (T2DM) in patients with non-ischemic dilated cardiomyopathy (DCM) on clinical profiles, myocardial fibrosis, and outcomes remain incompletely understood.

Method: A total of 1152 patients diagnosed with non-ischemic DCM were prospectively enrolled from June 2012 to October 2021 and categorized into T2DM and non-T2DM groups. Clinical characteristics, cardiac function, and myocardial fibrosis evaluated by CMR were compared between the two groups.

Prognostic value of mid-term cardiovascular magnetic resonance follow-up in patients with non-ischemic dilated cardiomyopathy: a prospective cohort study.

Background: The prognostic value of follow-up cardiovascular magnetic resonance (CMR) in dilated cardiomyopathy (DCM) patients is unclear. We aimed to investigate the prognostic value of cardiac function, structure, and tissue characteristics at mid-term CMR follow-up.

Methods: The study population was a prospectively enrolled cohort of DCM patients who underwent guideline-directed medical therapy with baseline and follow-up CMR, which included measurement of biventricular volume and ejection fraction, late gadolinium enhancement, native T1, native T2, and extracellular volume.

Liver T1 Mapping Derived From Cardiac Magnetic Resonance Imaging: A Potential Prognostic Marker in Idiopathic Dilated Cardiomyopathy.

Background: Hepatic alterations are common aftereffects of heart failure (HF) and ventricular dysfunction. The prognostic value of liver injury markers derived from cardiac MRI studies in nonischemic dilated cardiomyopathy (DCM) patients is unclear.

Purpose: Evaluate the prognostic performance of liver injury markers derived from cardiac MRI studies in DCM patients.

Visual analysis of commognitive conflict in collaborative problem solving in classrooms.

In today's knowledge-intensive and digital society, collaborative problem-solving (CPS) is considered a critical skill for students to develop. Moreover, international education research has embraced a new paradigm of communication-focused inquiry, and the commognitive theory helps enhance the understanding of CPS work. This paper aims to enhance the CPS skills by identifying, diagnosing, and visualizing commognitive conflicts during the CPS process, thereby fostering a learning-oriented innovative approach and even giving the script of technology-assisted feedback practices.

Dual immobilization of porous Si by graphene supported anatase TiO/carbon for high-performance and safe lithium storage.

Smart surface coatings have been proven to be an effective strategy to significantly enhance the electronic conductivity and cycling stability of silicon-based anode materials. However, the single/conventional coatings face critical challenges, including low initial Coulomb efficiency (ICE), poor cyclability, and kinetics failure, etc. Hence, we proposed a dual immobilization strategy to synthesize graphene supported anatase TiO/carbon-coated porous silicon composite (denoted as PSi@TiO@C/Graphene) using industrial-grade ferrosilicon as lithium storage raw materials through the simple etching, combined with sol-gel and hydrothermal coating processes.