iPSC-derived exosomes as amphotericin B carriers: a promising approach to combat cryptococcal meningitis.

Background: Cryptococcal meningitis (CM) is a significant global health issue, particularly affecting individuals with HIV. Amphotericin B (AmB) serves as the cornerstone treatment for CM; however, its clinical application is restricted due to limited penetration of the blood-brain barrier and associated nephrotoxicity.

Objective: This study investigates the use of exosomes derived from induced pluripotent stem cells (iPSC-Exos) as carriers for AmB in treating CM, aiming to enhance therapeutic efficacy and safety and reduce AmB toxicity.

Therapeutic potential of mesenchymal stem cells for fungal infections: mechanisms, applications, and challenges.

As a particularly serious condition in immunocompromised patients, fungal infections (FIs) have increasingly become a public health problem worldwide. Mesenchymal stem cells (MSCs), characterized by multilineage differentiation potential and immunomodulatory properties, are considered an emerging strategy for the treatment of FIs. In this study, the therapeutic potential of MSCs for FIs was reviewed, including their roles played by secreting antimicrobial peptides, regulating immune responses, and promoting tissue repair.

[Impacts of treatments of testicular tumor on the sexual and reproductive functions of the patients].

Testicular tumor is a malignance that usually occurs in young men. Its treatment mainly relies on surgical resection with postoperative radio- and/or chemotherapy, which can achieve a high survival rate of the patients. The main complications of the tumor and its treatment include a low testosterone level, ED, and infertility, which seriously influence the patients' quality of life.