Antifungal activity of essential oils and their potential synergistic effect with amphotericin B.

Candida albicans is a common opportunistic pathogen, causing infections ranging from superficial to bloodstream infections. The limited antifungal options and rising drug resistance challenge clinical treatment. We screened 98 essential oils and identified 48 with antifungal activity against Candida albicans at 1% concentration, determining their minimum inhibitory concentrations (MIC).

Antimicrobial and Antibiofilm Effects of Bithionol against .

() is a multidrug-resistant nontuberculous mycobacterium (NTM) that is responsible for a wide spectrum of infections in humans. The lack of effective bactericidal drugs and the formation of biofilm make its clinical treatment very difficult. The FDA-approved drug library containing 3048 marketed and pharmacopeial drugs or compounds was screened at 20 μM against type strain 19977 in 7H9 medium, and 62 hits with potential antimicrobial activity against were identified.

Psoralea corylifolia L. and its active component isobavachalcone demonstrate antibacterial activity against Mycobacterium abscessus.

Ethnopharmacological Relevance: Psoralea corylifolia L. (Fabaceae) is a traditional medicinal herb used to treat various diseases, including kidney disease, asthma, psoriasis and vitiligo.

Aim Of The Study: To explore the antibacterial activity of Psoralea corylifolia L.

Identification of essential oils with strong activity against stationary phase .

Purpose: To identify essential oils (EOs) active against non-growing stationary phase and multidrug-resistant strains.

Methods: The activity of EOs against both stationary and log phase was evaluated by colony forming unit (CFU) assay and minimum inhibitory concentration (MIC) testing.

Results: We assessed the activity of 80 EOs against stationary phase and found 12 EOs (Cinnamon, Satureja montana, Palmarosa, Lemon eucalyptus, Honey myrtle, Combava, Health shield, Mandarin, Thyme, Rosewood, Valerian Root and Basil) at 0.

Genomic revisitation and reclassification of the genus .

Unlabelled: Members of , although typically opportunistic, can cause severe infections in immunocompromised hosts. Recent advances in genome sequencing provide an opportunity for more precise study of this genus. In this study, we first identified and characterized a novel species named sp.

Stenotrophomonas maltophilia: An Urgent Threat with Increasing Antibiotic Resistance.

Stenotrophomonas maltophilia is a Gram-negative opportunistic pathogen that can cause many infections, such as chronic pulmonary infections in patients with cystic fibrosis and infections in immunocompromised patients with hematology-oncology diseases. Because of its remarkable and increasing antimicrobial resistance, the treatment of S. maltophilia infections is quite challenging.

Whole-genome sequencing provides insights into a novel species: associated with urinary tract infections.

is a clinically significant opportunistic pathogen that is involved in urinary tract infections. Due to the resolution limitations of identification, distinguishing from closely related species is challenging by commercial biochemical test systems. Here, we first reported a novel species, , which had been misidentified as .

Controllable Flowing of a Dielectric Fluid Droplet under the Action of Corona Discharge.

Polymer microfluidic technology is widely used in chemistry, biology, medicine, nanoparticles synthesis, and other fields. In this article, we introduce a novel method for the controllable flowing of dielectric fluid droplets. Under the action of corona discharge, the dielectric fluid droplet can be controllably driven to one or more conductive plate electrodes that are connected to the negative electrode on the substrate.

Research progress in laboratory detection of SARS-CoV-2.

Background: Nucleic acid testing is a reliable method for diagnosing viral infection in clinical samples. However, when the number of cases is huge and there are individual differences in the virus itself, the probability of false-negative results increases. With the advancement in research on the new coronavirus, new detection technologies that use serum-specific antibodies as detection targets have been developed.

Research progress of circular RNA in digestive tract tumors: a narrative review.

Circular RNA (circRNA) is a newly discovered non-coding RNA with a closed loop structure. The 3' end and the 5' end of circRNA are covalently bonded and not easily degraded by nucleases. Besides, circRNA can exist in eukaryotes widely and conservatively, and it is stably expressed in human liver, brain, lung and other organs.