Publications by authors named "Yanghong Zhang"

Article Synopsis
  • The process starts with a three-component reaction involving 2-aminopyridine, 2-azidobenzaldehydes, and isocyanides, leading to azide intermediates without needing to separate them.
  • Initial tests show that the resulting compounds can effectively inhibit glioma cells, highlighting potential uses in both synthesis and medicinal chemistry.
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Dwarfing interstocks play an essential role in determining the performance of fruit trees. SH40, Jizhen 1, and Jizhen 2 are widely used dwarfing interstocks in Hebei Province, China. This study examined the influence of these three dwarfing interstocks on vegetative growth, fruit quality and yield, and leaf and fruit macro- (N, P, K, Ca, and Mg) and micro- (Fe, Zn, Cu, Mn, and B) element contents for 'Tianhong 2'.

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A new one-pot preparation of 4-tetrazolyl-3,4-dihydroquinazolines has been reported. The Ugi-azide reactions of 2-azidobenzaldehydes, amines, trimethylsilyl azide, and isocyanides produced azide intermediates without separation, which were treated with isocyanides to give 4-tetrazolyl-3,4-dihydroquinazoline derivatives through a sequential Palladium-catalyzed azide-isocyanide cross-coupling/cyclization reaction in moderate to good yields. The biological evaluation demonstrated that compound inhibited breast cancer cells well and displayed broad applications for synthesis and medicinal chemistry.

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Progress toward intelligent human-robotic interactions requires monitoring sensors that are mechanically flexible, facile to implement, and able to harness recognition capability under harsh environments. Conventional sensing methods have been divided for human-side collection or robot-side feedback and are not designed with these criteria in mind. However, the iontronic polymer is an example of a general method that operates properly on both human skin (commonly known as skin electronics or iontronics) and the machine/robotic surface.

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Background: Lignin is a complex aromatic heteropolymer comprising 15-30% dry weight of the lignocellulose. The complex structural characteristic of lignin renders it difficult for value-added utilization. Exploring efficient lignin-degrading microorganisms and investigating their lignin-degradation mechanisms would be beneficial for promoting lignin valorization.

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Background: Pretreatment is a critical step required for efficient conversion of woody biomass into biofuels and platform chemicals. Fungal pretreatment is regarded as one of the most promising technology for woody biomass conversion but remains challenging for industrial application. The exploration of potential fungus strain with high efficient delignification and less processing time for woody biomass pretreatment will be valuable for development of biorefinery industry.

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A large number of cancer stem cells (CSCs) have been isolated and identified; however, none has been cultured in an unlimited manner in vitro without losing tumorigenicity and multipotency. In this study, we successfully clonogenically cultured a newly identified CD34+ liver CSC (LCSC) on feeder cells up to 22 passages (to date) without losing CSC property. Cloned CD34+ LCSC formed a round packed morphology and it could also be cryopreserved and recultured.

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CD34(+) stem cells play an important role during liver development and regeneration. Thus, we hypothesized that some human liver carcinomas (HLCs) might be derived from transformed CD34(+) stem cells. Here, we determined that a population of CD34(+) cells isolated from PLC/PRF/5 hepatoma cells (PLC) appears to function as liver cancer stem cells (LCSCs) by forming HLCs in immunodeficient mice with as few as 100 cells.

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Objective: To describe the short-term outcomes of a non-pharmacological conservative approach to patients with LSS.

Methods: This is a prospective consecutive case series with short-term follow-up of 21 consecutive patients who were diagnosed with LSS. Patients recruited from the outpatients of orthopaedic department and rehabilitation department in the Peking University People's Hospital from March 2010 to March 2011.

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Article Synopsis
  • The study analyzed grassland desertification dynamics in Naqu, northern Tibet, over the last 20 years using vegetation cover and soil-adjusted vegetation index data from NOAA/AVHRR.
  • It found that 43.1% of total land area is degraded grassland, with a decrease in degradation in the first ten years but an increase in the last ten years, showing an overall declining trend.
  • The western part of Naqu experienced more degradation, and among various climatic factors, potential evapotranspiration had the most significant impact on grassland degradation.
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