S100A4 suppresses cancer stem cell proliferation via interaction with the IKK/NF-κB signaling pathway.

Background: Bladder cancer often recurs due to incomplete elimination of the cancer stem cells (CSCs). Therefore, new strategies targeting bladder CSCs are needed and the aim of this study was to investigate the effect of S100A4 on the proliferation capacity of MB49 bladder cancer stem cells (MCSCs).

Methods: MCSCs were established and validated.

[Occupational, educational and residential factors are associated with the outcomes of in vitro fertilization-embryo transfer].

Objective: To investigate the associations of occupational, educational and residential factors with the outcomes of in vitro fertilization -embryo transfer (IVF-ET).

Methods: A retrospective analysis was conducted among 3998 patients undergoing the first treatment with IVF-ET and 3064 perinatal infants in our center between January, 2010 and June, 2014. The relation of the patients' occupation, educational background, and residence registry with IVF-ET outcomes was analyzed.

The outcome of different post-thawed culture period in frozen-thawed embryo transfer cycle.

Purpose: To study the influence of post-thawed culture (2-4 h and 20-24 h) on the outcome of frozen-thawed embryo transfer (FET) cycle.

Methods: In this retrospective study, a total of 1,353 patients were undergoing the FET treatment at the reproductive medical center between June 2010 and July 2012. 3,398 frozen-thawed embryos were divided in two study groups, depending on their post-thawed culture period: short culture (2-4 h) group and long culture (20-24 h) group.