Publications by authors named "Yangbin Liang"
Article Synopsis
- The differences in phospholipids between bacterial and mammalian cell membranes offer new ways to design antimicrobial drugs, but distinguishing between similar phospholipids (PG and PS) is challenging.
- A new class of antimicrobial peptides (RAPs) has been developed that can specifically identify bacterial phosphatidylglycerol (PG) due to their unique helical structure.
- One particular RAP, L-MMBen, not only effectively targets PG but also shows low toxicity in living organisms and proves to be effective in treating infections in mice models.
Since the development of bacterial resistance, the decreasing effectiveness of antibiotics is becoming one of the most critical problems worldwide. Novel antibacterial agents are urgently needed to prevent humanity from falling back into the "post-antibiotic era". As an important part of the innate immune system, antimicrobial peptides (AMPs) are one of the most promising antibacterial agents showing broad-spectrum activity against bacteria and low propensity for drug resistance.
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