Publications by authors named "Yang-wen Ou"
Article Synopsis
- Emulsified isoflurane was developed to address the limitations of traditional inhalation anesthetics, specifically their slower onset and higher drug usage, and this study aims to evaluate its efficacy and safety compared to propofol for anesthesia induction in adults.
- In a randomized phase III clinical trial involving 416 patients, both emulsified isoflurane and propofol were administered at different dosages, with success measured via sedation scores and the avoidance of additional sedatives.
- Results indicated that emulsified isoflurane achieved successful anesthesia induction in 100% of patients, demonstrating it is non-inferior to propofol, and it also showed safety through the monitoring of adverse events and vital signs.
PERK Signaling Controls Myoblast Differentiation by Regulating MicroRNA Networks.
Front Cell Dev Biol
May 2021
The unfolded protein response (UPR) plays important roles in various cells that have a high demand for protein folding, which are involved in the process of cell differentiation and development. Here, we separately knocked down the three sensors of the UPR in myoblasts and found that PERK knockdown led to a marked transformation in myoblasts from a fusiform to a rounded morphology, which suggests that PERK is required for early myoblast differentiation. Interestingly, knocking down PERK induced reprogramming of C2C12 myoblasts into stem-like cells by altering the miRNA networks associated with differentiation and stemness maintenance, and the PERK-ATF4 signaling pathway transactivated muscle differentiation-associated miRNAs in the early stage of myoblast differentiation.
View Article and Find Full Text PDFObjective: To study the chemical constituents of Pileostegia viburnoides var. glabrescens.
Methods: The compounds were isolated and purified by various techniques.