Publications by authors named "Yang-Ying Ou"
Article Synopsis
- Cytomegalovirus (CMV) pneumonia still has high mortality rates (30%-50%) in immunosuppressed patients despite effective antiviral treatments like ganciclovir (GCV), prompting research into alternative therapies like the anti-malarial drug artesunate (ART).
- In vitro experiments with human embryonic lung fibroblasts (HELF) showed that ART effectively reduces infection rates when applied after HCMV inoculation, while GCV did not have significant effects in certain treatment groups.
- ART not only demonstrated strong antiviral activity but also inhibited the proliferation of HCMV-infected cells, highlighting its potential as a dual-action treatment against CMV pneumonia.
