Stereotactic neurosurgery as a symptomatic treatment for autism spectrum disorders: A systematic review.

Stereotactic neurosurgery has been employed in autism spectrum disorders (ASD). However, its safety and effectiveness remain unclear owing to limited sample size and other methodological limitations. We aimed to systematically investigate the safety and efficacy of stereotactic neurosurgery for ASD.

Bone marrow-derived mesenchymal stem cell-conditioned medium ameliorates diabetic foot ulcers in rats.

Objectives: This study aimed to explore the effects of bone marrow-derived Mesenchymal Stem Cell-Conditioned Medium (MSC-CM) treating diabetic foot ulcers in rats.

Methods: Models of T2DM rats were induced by a high-fat diet and intraperitoneal injection of STZ in SD rats. Models of Diabetic Foot Ulcers (DFUs) were made by operation on hind limbs in diabetic rats.

ATP5O Hypo-crotonylation Caused by HDAC2 Hyper-Phosphorylation Is a Primary Detrimental Factor for Downregulated Phospholipid Metabolism under Chronic Stress.

Chronic stress (CS)-induced abnormal metabolism and other subsequent aspects of abnormality are threatening human health. Little is known regarding whether and how protein post-translational-modifications (PTMs) correlate with abnormal metabolism under CS. The aim of this study was to address this issue and also identify novel key protein PTM.

Deep brain stimulation for chorea-acanthocytosis: a systematic review.

Deep brain stimulation (DBS) is a reversible treatment for chorea-acanthocytosis (ChAc). Its safety and efficacy remain elusive due to the low prevalence of ChAc. We aimed to investigate the safety and efficacy of DBS for ChAc by systematically reviewing literature through PubMed and EMBASE.

Three-dimensional digital measurement of the facet joint in normal individual and lumbar intervertebral disc herniation patients aged 13 - 18 years.

Background: Lumbar facet joint is an important element of spinal "three-joint complex". Whether there is a relationship between strange structure of facet joint and adolescent lumbar disc herniation (ALDH) is nonetheless controversial, and the current research is mainly centered on adults.

Objective: To find out the normal lumbar facet joints between 13 and 18 years old to provide anatomical basis for early diagnosis and therapy of lumbar disc herniation.

Role of thoracic radiotherapy in extensive stage small cell lung cancer: a systemic review and meta-analysis.

Background: The role of thoracic consolidation radiotherapy in patients with extensive stage small cell lung cancer (ES-SCLC) remains controversial. This study aimed to evaluate the efficacy of thoracic radiotherapy (TRT) in these patients.

Methods: A systematic literature search was performed in PubMed, Embase, and the Cochrane library to identify qualified clinical studies.

Hepatoid adenocarcinoma of the lung: An analysis of the Surveillance, Epidemiology, and End Results (SEER) database.

Hepatoid adenocarcinoma of the lung (HAL) is a rare malignant tumor that is defined as a primary alpha-fetoprotein (AFP)-producing lung carcinoma. We aimed to identify prognostic factors associated with the survival of patients with HAL using data from the Surveillance, Epidemiology, and End Results (SEER) database. We collected data from patients diagnosed with HAL, adenocarcinoma (ADC), and squamous cell carcinoma (SCC) of the lung between 1975 and 2016 from the SEER database.

Early Research on COVID-19: A Bibliometric Analysis.

In December 2019, an outbreak of pneumonia, which was named COVID-2019, emerged as a global health crisis. Scientists worldwide are engaged in attempts to elucidate the transmission and pathogenic mechanisms of the causative coronavirus. COVID-19 was declared a pandemic by the World Health Organization in March 2020, making it critical to track and review the state of research on COVID-19 to provide guidance for further investigations.

Comparative transcriptome and co-expression analysis reveal key genes involved in leaf margin serration in .

Objective: In this study, we aimed to identify the genes involved in leaf margin serration in (Family: Lamiaceae) is widely grown in Asian countries. Perilla leaf is the medicinal part stipulated in the . There are mainly two types of perilla leaves: one with serrated leaf margin which is the phenotype described in the pharmacopoeia and the other with smooth leaf margin.

Light-Induced Thermal Decomposition of Alkoxyamines upon Infrared CO Laser: Toward Spatially Controlled Polymerization of Methacrylates in Laser Write Experiments.

Systems combining photopolymerization and thermal polymerization have already been reported in the literature. Upon near-infrared (NIR) light exposure, this principle of polymerization is called photoinduced thermal polymerization or photothermal polymerization. Thanks to an NIR dye used as the light-to-heat convertor (called hereafter a heater), an alkoxyamine (e.

3D Printing of Polydiacetylene Photocomposite Materials: Two Wavelengths for Two Orthogonal Chemistries.

Polydiacetylene (PDA) materials are appealing and gaining increasing research interest due to their outstanding chromatic transition and fluorescence enhancement effects upon exposure to various environmental stimuli. However, despite the photomask method, there are very few reports about the spatial controllable photopolymerization and subsequent 3D printing of PDA until now. Herein, for the first time, we reported the preparation of PDA photocomposite materials based on polyacrylate through the strategy of dual-wavelength polymerization and orthogonal chemistry.

Micelles prepared from poly(N-isopropylacrylamide-co-tetraphenylethene acrylate)-b-poly[oligo(ethylene glycol) methacrylate] double hydrophilic block copolymer as hydrophilic drug carrier.

Self-assembled micelles obtained from a double hydrophilic block copolymer (DHBC) based on poly(N-isopropylacrylamide) (PNIPAAm) are a facile and green strategy compared to the conventional solvent exchange method. However, hydrophobic drug encapsulation in micelles from PNIPAAm-based DHBC has relatively low drug loading (DL) and encapsulation efficiency (EE). Intermolecular and intramolecular hydrogen bondings of PNIPAAm chains are formed to exclude hydrophobic drugs.

Estimating the prevalence of Echinococcus in domestic dogs in highly endemic for echinococcosis.

Background: Cystic echinococcosis (CE) and alveolar echinococcosis (AE) are highly endemic in Xiji County of Ningxia Hui Autonomous Region (NHAR) in China where the control campaign based on dog de-worming with praziquantel has been undertaken over preceding decades. This study is to determine the current prevalence of Echinococcus granulosus and E. multilocularis in domestic dogs and monitor the echinococcosis transmission dynamics.

Advanced Architectures and Relatives of Air Electrodes in Zn-Air Batteries.

Zn-air batteries are becoming the promising power sources for portable and wearable electronic devices and hybrid/electric vehicles because of their high specific energy density and the low cost for next-generation green and sustainable energy technologies. An air electrode integrated with an oxygen electrocatalyst is the most important component and inevitably determines the performance and cost of a Zn-air battery. This article presents exciting advances and challenges related to air electrodes and their relatives.

[Research progress on antidepressant effects of Sini San based on three progressive levels of "single herb, herb-pair, and complicated Chinese herbal formula"].

Depression is a kind of mental illness accompanied by complex etiology and pathogenesis in clinic. With the quickening pace of circadian rhythm and increase of life pressure in modern society, the incidence of depression is increasing year by year. Nowadays, some typical antidepressant Western medicines, such as selective serotonin re-uptake inhibitors (SSRI) and tricyclic antidepressants (TCA), have been used as the main therapeutic drugs in clinic.

Gamma Knife Surgery for Recurrent Trigeminal Neuralgia in Cases with Previous Microvascular Decompression.

Background: Microvascular decompression (MVD) and Gamma Knife surgery (GKS) are the primary treatments for trigeminal neuralgia (TN). However, many patients require further surgical treatment after initial surgery for recurrent TN. The aim of this study was to evaluate efficacy and safety of GKS for recurrent TN cases with prior MVD.

TAGLN2 is a candidate prognostic biomarker promoting tumorigenesis in human gliomas.

Background: Transgelin-2 (TAGLN2) is a member of the calponin family of actin-bundling proteins that is involved in the regulation of cell morphology, motility, and cell transformation. Here, the clinical significance and potential function of TAGLN2 in malignant gliomas were investigated.

Methods: Molecular and clinical data was obtained from The Cancer Genome Atlas (TCGA) database.

[Research progress of Baizhu Shaoyao powder in treating ulcerative colitis].

Ulcerative colitis is a chronic, nonspecific and complex intestinal disease. The current clinical treatment guideline of this disease recommends a variety of options with oral western medicines, such as aminosalicylic acids, glucocorticosteroids, and immunosuppressors. However, due to their unstable therapeutic effects, high toxicities, and strong drug dependence, they are not suitable for long-term administration.

Using 'WeChat' online social networking in a real-world needs analysis of family members of youths at clinical high risk of psychosis.

Objective: The argument surrounding the safety and effectiveness of interventions for the population of individuals at a clinical high risk of developing psychosis has been ongoing for the past 30 years. However, few studies have assessed the needs of this special young population, who are struggling with the recent onset of psychotic symptoms.

Method: The sample consisted of 171 family members of 108 clinical high-risk individuals included from the ShangHai at Risk for Psychosis research programme.

Hollow Nitrogen-Doped Carbon Spheres with FeO Nanoparticles Encapsulated as a Highly Active Oxygen-Reduction Catalyst.

The development of nonprecious electrocatalyst with low cost and high efficiency for the oxygen reduction reaction (ORR) is a main challenge for electrochemical energy technology. In this work, a hierarchical hollow core-shell structured N-doped carbon spheres (N-HSCS), in which FeO nanoparticles are encapsulated (FeO/N-HCSC) has been successfully prepared. The FeO/N-HCSC electrocatalyst exhibits a remarkable catalytic performance toward ORR.

Gamma knife radiosurgery for brainstem cavernous malformations.

Objective: The goal of this retrospective study was to evaluate the efficacy and safety of gamma knife radiosurgery (GKS) for the treatment of brainstem cavernous malformations (CMs).

Methods: Between January of 2009 and December of 2014, 43 patients (20 males and 23 females) with brainstem CMs were treated at the West China Hospital, Sichuan University, Gamma Knife Center. The mean age of these patients was 41.

[Formation Mechanism of the Disinfection By-product 1, 1-Dichloroacetone in Drinking Water].

A novel method using methyl tertiary butyl ether (MTBE) as extractant and 1,2-dibromopropane as internal standard for the determination of the disinfection by-producs 1,1-dichloroacetone (DCAce) by gas chromatography mass spectrometry (GC-MS) was described. The formation process of DCAce and its influencing factors were discussed with L-leucine as the precursor during the chloramination process. The results indicated that the DCAce production increased with the increase of chloramine dosage when the chloramine addition was in the range of 5-30 mg · L(-1).