Publications by authors named "Yang-Yang Tang"
Article Synopsis
- Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disorder linked to immune system dysfunction, particularly involving Th1 cells and associated factors.
- The review focuses on the expression and involvement of the Th1 cell family in SLE, analyzing data from patients and animal studies.
- Key findings include the role of T-bet-related age-associated B cells and the potential of low-dose IL-2 treatment in understanding and possibly targeting lupus pathogenesis.
Neuropeptide Y, a potential marker for lupus, promotes lupus development.
Int Immunopharmacol
January 2024
Article Synopsis
- This study investigates the connection between neuropeptide Y (NPY) levels, genetic mutations, and the development of systemic lupus erythematosus (SLE), aiming to clarify NPY's role in SLE pathogenesis.
- Analyzing serum samples from over 460 SLE patients and healthy controls, the researchers found elevated serum NPY levels in SLE patients and identified significant genetic differences related to NPY SNPs among them.
- Results from lupus mice treated with an NPY-Y1 receptor antagonist showed reduced organ damage and autoantibody production, indicating that NPY might serve as a potential biomarker and contribute to SLE progression.
Article Synopsis
- Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder linked to increased levels of endothelin-1 (ET-1), which may contribute to vascular damage.
- A study involving 314 SLE patients, 252 non-SLE patients, and 500 healthy controls found that SLE patients had higher ET-1 levels, which correlated with clinical features and other cytokines.
- Specific ET-1 gene polymorphisms were associated with SLE risk and various manifestations like alopecia, pericarditis, and the presence of anti-SSB antibodies, suggesting that ET-1 could be a disease marker for SLE.
Objective: Systemic lupus erythematosus is a complex autoimmune disorder, and evidence supports the significance of genetic polymorphisms in SLE genetic susceptibility. The aim of this study was to assess the effects of BTN3A1 (butyrophilin 3A1), SHP2 (Src homology-2 containing protein tyrosine phosphatase), CD274 (programmed cell death 1 ligand 1), and STAT3 (signal transducer-activator of transcription 3) gene interactions on SLE risk.
Materials And Methods: Two hundred and ninety patients diagnosed with SLE and 370 healthy controls were recruited.
Objective: Evidence supports the important role of STAT3 in SLE; however, association between STAT3 gene polymorphisms and SLE risk needs discussion.
Methods: Three hundred SLE patients and 380 healthy controls from Chinese Han population were included. DNA is extracted from peripheral blood mononuclear cells and the clinical characteristics of patients are collected.
Objectives: To investigate whether machine learning, which is widely used in disease prediction and diagnosis based on demographic data and serological markers, can predict herpes occurrence in patients with systemic lupus erythematosus (SLE).
Methods: A total of 286 SLE patients were included in this study, including 200 SLE patients without herpes and 86 SLE patients with herpes. SLE patients were randomly divided into a training group and a test group, and 18 demographic characteristics and serological indicators were compared between the two groups.
Hypoxia-inducible factor-1α (HIF-1α) is a primary metabolic sensor, and is expressed in different immune cells, such as macrophage, dendritic cell, neutrophil, T cell, and non-immune cells, for instance, synovial fibroblast, and islet β cell. HIF-1α signaling regulates cellular metabolism, triggering the release of inflammatory cytokines and inflammatory cells proliferation. It is known that microenvironment hypoxia, vascular proliferation, and impaired immunological balance are present in autoimmune diseases.
View Article and Find Full Text PDFThere are some defects in constructed wetland, including the uneven distribution of flow, easily blocked, lack of oxygen supply systems and the unsatisfactory phosphorus adsorption capacity of the substrates, etc. The research mainly studied the function and contribution of the pool of hydrolysis acidification, the natural reoxygenation/sinking device and strengthen slot for reducing nitrogen and phosphorus. The results showed the removal efficiency of COD and SS in hydrolysis-acidification pool accounted for 38.
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