Electroacupuncture attenuates ferroptosis by promoting Nrf2 nuclear translocation and activating Nrf2/SLC7A11/GPX4 pathway in ischemic stroke.

Objective: Electroacupuncture has been shown to play a neuroprotective role following ischemic stroke, but the underlying mechanism remains poorly understood. Ferroptosis has been shown to play a key role in the injury process. In the present study, we wanted to explore whether electroacupuncture could inhibit ferroptosis by promoting nuclear factor erythroid-2-related factor 2 (Nrf2) nuclear translocation.

Numerical investigation of plasmon sensitivity and surface-enhanced Raman scattering enhancement of individual TiN nanosphere multimers.

Titanium nitride (TiN) nanoparticles have recently been considered as potential candidate plasmonic materials; such materials support localized surface plasmon resonances (LSPRs) and show excellent thermal stability with a high melting point. The electromagnetic (EM) field coupling and gap distance between components of individual TiN nanosphere multimers are critical parameters affecting their plasmonic sensitivity and surface-enhanced Raman scattering (SERS) performance, both of which are numerically investigated by the finite element method. It is demonstrated that the fractional shifts of both the dipolar LSPR wavelength [Formula: see text] and the refractive index sensitivity factor S follow the universal 'plasmon ruler' behavior, which is explained well in terms of EM field distribution.

Protective effect of microRNA-224 on acute lower extremity ischemia through activation of the mTOR signaling pathway via CHOP in mice.

Acute lower extremity ischemia (ALEXI) is known worldwide as an urgent condition, occurring when there is an abrupt interruption in blood flow into an extremity. This study aims to investigate whether microRNA-224 (miR-224) affects the ALEXI mice and the underlying mechanism. The miR-224 expression and C/EBP homologous protein (CHOP), mammalian target of rapamycin (mTOR), translation initiation factor 4E-binding protein 1 (4E-BP1), and phosphoprotein 70 ribosomal protein S6 kinase (p70S6K) messenger RNA (mRNA), as well as protein expressions, were determined.

Effects of orthodontic load on the periodontium of autogenously transplanted teeth in beagle dogs.

Objective: To observe the periodontal healing of autogenously transplanted teeth loaded orthodontically after autotransplantation in Beagle dogs.

Methods: Forty-eight teeth were autogenously transplanted, 24 of which were loaded postoperatively with orthodontic force at different time points and for different durations. Periodontal healing was evaluated by probing pocket depth (PPD), the expression of relevant proteins, and histomorphometric analyses.

Autophagy appears during the development of the mouse lower first molar.

Odontogenesis consists of a series of consecutive tooth morphogenesis stages, in which apoptosis is involved to eliminate the unnecessary cells. Autophagy, a lysosome or endosome-mediated self-degradation process, is indicated to participate in embryogenesis and tissue morphogenesis associated with apoptosis. This study hypothesized that autophagy may be involved and associated with apoptosis in odontogenesis.

[Histological study about the effect of orthodontic loading time and duration on the periodontal repair in autologous tooth transplantation].

Objective: The study established an animal model of autologous tooth transplantation in dogs and aimed to explore the effects of orthodontic loading time and duration on the periodontal repair in autologous tooth transplantation.

Methods: 12 Beagle dogs were selected and grouped randomly in this research. Four first premolar teeth in every dog were carried on autologous transplant operation.

[Effect of asymmetry elastic on the maturation of bone collagen and mineralization in condyle of adult SD rat].

Purpose: The aim of this investigation was to study the osteogenesis activation following asymmetric inter-maxillary elastic on the subchondral bone of adult SD rats.

Methods: Twenty SD ten-week old rats were used in this study (eight rats loading 0.39 N elastic force, another eight rats loading 1.

Factors influencing subjective orthodontic treatment need and culture-related differences among Chinese natives and foreign inhabitants.

Aim: The aim of this survey was to compare Chinese natives and foreign inhabitants in Chengdu, China, with respect to: (1) attitudes towards dental appearance, (2) subjective orthodontic treatment need, and (3) the main factors influencing orthodontic treatment need.

Methodology: A total of 522 subjects, including 227 foreign inhabitants and 295 Chinese natives in Chengdu participated in the survey. A simple random sampling method was adopted and a face-to-face interview was conducted at some public sites using a questionnaire.

[The technique characteristic and clinical application of HX straight-wire appliance].

HX straight-wire appliance (HX-SWA) is designed and adjusted by doctors of Orthodontic Department, West China College of Stomatology, Sichuan University. It is a set of appliance that is constructed according to normal occlusion features of the Chinese people, including the prescription of tip, torque, in/out, counter-tip, counter-rotation and overcorrection in brackets and buccal tubes. Some ingredients of the appliance are different from that of the most popular Roth straight-wire appliance in the world wide.

[Angle's class II malocclusion: a report of seven cases in one family].

A family with Angle's Class ii malocclusion was identified in West China Stomatological Hospital of Sichuan University. The proband was a 22-year-old woman with Angle's Class II Division 2 malocclusion with congenitally missing teeth. A total of 15 members of the 3 generations in the family were investigated.

Proteomic analysis of early-response to mechanical stress in neonatal rat mandibular condylar chondrocytes.

The objectives of this study were to investigate the early response to mechanical stress in neonatal rat mandibular chondrocytes by proteomic analysis. To evaluate its molecular mechanism, chondrocytes were isolated and cultured in vitro, then loaded mechanical stress by four-point bending system on different patterns. Morphological observation, flow cytometric analysis, and MTT assays indicated that 4,000 microstrain loading for 60 min was an appropriate mechanical stimulus for the following proteome analysis, which produced a transient but obvious inhibitory effect on the cell cycle.

[The skeletal regulating mechanisms and concepts in growth and development of cranial-facial bones and orthodontic treatment].

There are three kinds of mechanisms regulating the growth and development of skeletal tissue: Bone growth, bone modeling and bone remodeling. However, in the current orthodontics literature, there continues to be substantial confusion regarding the usage of the term "bone remodeling". This article reviews the historical causes for this semantics problem and explains the difference between bone modeling and remodeling, as well as the detailed skeletal regulating mechanisms in the growth and development of cranial-facial bones and orthodontic treatment.

[Effect of asymmetry traction on the expression of type II collagen in adult rat condyle].

Objective: The aim of this investigation was to study the expression of collagen type II in the cartilage of mandibular condyle following asymmetric inter-maxillary traction.

Methods: Two hundred and twenty SD rats were used in this study (one hundred and four rats loading 0.39 N elastic force, another one hundred and four rats loading 1.

[Displacement of impacted mandibular canine: a case report].

The long distance displacement of canine is a rare phenomenon in orthodontic clinic. Its related clinical epidemiology, etiology, diagnosis and treatment methods are briefly summarized, and a case of mandibular canine displaced in chin is reported.

[Effects of orthodontic tooth movements on insulin-like growth factors expression in periodontal tissues].

Objective: To elucidate the regulatory bio-mechanism of estrogen and local stress on the bone remodeling activities in vivo.

Methods: A Wistar rat experimental model was established to apply orthodontic activation during different stages of estrous cycle. In situ hybridization was used to detect the variation of the insulin-like growth factors (IGF) mRNA expression in the periodontal tissues.

[A bio-mechanism study of differential orthodontic tooth moving speed during the estrous cycle].

Objective: The purpose of this article was to investigate the changes of the estrogen and insulin-like growth factors (IGF) level induced by orthodontic tooth movements in order to elucidate the bio-mechanism of orthodontic treatments during the estrous cycle.

Methods: A Wistar rat experimental model was established to apply orthodontic activation during different stages of estrous. The serum and periodontal tissue estradiol level were determined by radioimmunoassay and immunohistochemistry.

[Improvement on the making process of double splints before orthognathic surgery of skeletal Class III].

The conventional methods on making double splints in presurgery of skeletal Class III were complicated. To find an easy method for the improvement of the production of splints and simplify the making process, 17 severe skeletal Class III patients accepted bimaxillary surgery after making double splints were used. According to visual treatment objective (VTO) forecasting on the lateral cephalometric radiograph of ending presurgical orthodontics and analyzing study models, the surgical methods were designed, the mobile osteotomy bone volume was estimated and the maxillary abnormity was classified.

[PAR index of adolescents with congenital missing teeth pre- and post-orthodontic treatment].

Objective: To assess the outcome of orthodontic treatment for adolescents with congenital missing teeth using the PAR (Peer Assessment Ration) index.

Methods: The PAR index was adopted to evaluate and compare the teeth arrangement, molar occlusion, overjet, overbite and centerline condition of 20 adolescents with congenital missing teeth before and after orthodontic treatments.

Results: The initial PAR scores and weighted PAR total scores decreased significantly after Orthodontic treatments (P < 0.

[Effects of orthodontic tooth movements on serum and local estrogen expression].

Purpose: To investigate the changes of the serum and local estrogen level during orthodontic tooth movements and attempt to elucidate the bio-mechanism of orthodontic treatment.

Methods: A Wistar rat experimental model was established to apply orthodontic activation during different stages of estrous cycle. One hundred and twenty female rats were randomly divided into sham-operated group, activation group and control group.

[Influence of orthodontic force on osteoprotegerin and osteoprotegerin ligand mRNA expression in the inflammatory periodontal tissues].

Objective: To explore certain principle of how osteoprotegerin (OPG) and osteoprotegerin ligand (OPGL) take part in the periodontal tissues remodeling under the combined influence of inflammation and orthodontic force.

Methods: The positive signals of OPG and OPGL mRNA were measured with in situ hybridzation after orthodontic tooth movement in the experimental periodontitis groups and control ones.

Results: The OPG and OPGL mRNA expression intensity in the experimental group showed difference from control.

[Early effects of the cyclic uniaxial compressive stress on Actin and Vimentin of the rat condylar chondrocytes].

Objective: To investigate the early effects of the cyclic uniaxial compressive stress on Actin and Vimentin of the rat condylar chondrocyte.

Methods: The third-passage chondrocyte were harvested from the mandibular condyles of 2-day-old rats, and a cellular compressive stress device was used to apply stress on cells at 4 000 microstrain for 15, 30, 60, 120, 240 min. The early effects of the cyclic uniaxial compressive stress on Actin and Vimentin of the rat mandibular condylar chondrocytes were examined by laser scanning confocal microscope (LSCM), immunofluorescence technique and Western blot.