Publications by authors named "Yang-Lin Zhu"
Article Synopsis
- Chronic rejection (CR) is a major challenge for allograft survival, and oxymatrine (OMT), a compound from traditional Chinese medicine, shows promise for treating this condition.
- In experiments with B6 mice, OMT was found to reduce pathological damage in heart transplants, inhibit harmful T cell activities, and enhance regulatory T cell differentiation, leading to improved graft survival.
- OMT appears to work by blocking specific signaling pathways (like mTOR and TGF-β-Smad 2/3), which helps decrease immune responses and fibrosis in the transplanted tissues, indicating potential for future therapeutic approaches.
Background: The purpose of this study was to investigate the specific effects of signal transducer and activator of transcription 4 (STAT4)-induced long intergenic nonprotein coding RNA 1278 (LINC01278) on the growth of non-small cell lung cancer (NSCLC) cells involved in the microRNA (miR)-877-5p/activated transcription factor 4 (ATF4) axis.
Methods: NSCLC tumor tissue and adjacent normal tissue were collected. Human normal lung epithelial cell BEAS-2B and human NSCLC cell lines (H1299, H1975, A549, H2228) were collected.
Background: The disruption of intestinal barrier functions and the dysregulation of mucosal immune responses, mediated by aberrant purinergic metabolism, are involved in the pathogenesis of inflammatory bowel diseases (IBD). A novel mesenchymal-like endometrial regenerative cells (ERCs) has demonstrated a significant therapeutic effect on colitis. As a phenotypic marker of ERCs, CD73 has been largely neglected for its immunosuppressive function in regulating purinergic metabolism.
View Article and Find Full Text PDFBackground: IL-37 is a recently identified cytokine with potent immunosuppressive functions. The research fronts of IL-37 are worth investigating, and there is no bibliometric analysis in this field. The purpose of this study is to construct the intellectual base and predict research hotspots of IL-37 research both quantitatively and qualitatively according to bibliometric analysis.
View Article and Find Full Text PDFBackground: Immunotherapy has been considered as a promising cancer treatment for hepatocellular carcinoma (HCC). However, due to the particular immune environment of the liver, identifying patients who could benefit from immunotherapy is critical in clinical practice.
Methods: The pyroptosis gene expression database of 54 candidates from The Cancer Genome Atlas (TCGA) were collected to discover the critical prognostic-related pyroptosis genes.
Article Synopsis
- This study reviews the global collaboration in research on mesenchymal stem cells (MSCs) related to liver diseases using bibliometrics to assess trends and knowledge structures from 2001-2021.
- A total of 3,404 publications were analyzed, showing an increase in MSC research, primarily from institutions in China and the USA, with Li L being the most prolific author.
- Key emerging topics identified include liver scaffolds, MSC therapy, and keywords like "machine perfusion" and "microRNAs," providing insights for future research directions.
Background: The prognostic value of m6A-related genes in hepatocellular carcinoma (HCC) and its correlation with the immune microenvironment still requires further investigation.
Methods: Consensus clustering by m6A related genes was used to classify 374 patients with HCC from The Cancer Genome Atlas (TCGA) database. Then we performed the least absolute shrinkage and selection operator (LASSO) to construct the m6A related genes model.
Article Synopsis
- Chronic allograft vasculopathy (CAV) is a significant issue in transplant survival, with various complicated mechanisms hindering effective treatments.
- The study investigates the combined effects of melatonin (MT) and mesenchymal stromal cells (MSCs) on mitigating CAV in a mouse model of aorta transplantation.
- Results indicate that the MT and MSC combination significantly reduces CAV-related pathological changes and alters immune cell infiltration, promoting a healthier immune response by increasing regulatory T cells (Tregs) while inhibiting other T cell populations.
The promise of high-density and low-energy-consumption devices motivates the search for layered structures that stabilize chiral spin textures such as topologically protected skyrmions. At the same time, recently discovered long-range intrinsic magnetic orders in the two-dimensional van der Waals materials provide a new platform for the discovery of novel physics and effects. Here we demonstrate the Dzyaloshinskii-Moriya interaction and Néel-type skyrmions are induced at the WTe/FeGeTe interface.
View Article and Find Full Text PDFBackground: Chemotherapy is the standard treatment for non-small cell lung cancer (NSCLC). However, chemoresistance frequently occurs, making the treatment of NSCLC more difficult.
Method: We combined clinical and experimental studies to establish the role of microRNA (miR)-34c in NSCLC metastasis and chemoresistance.