Publications by authors named "Yang-Hyun Cho"
Introduction And Objectives: There are 2 options to achieve revascularization in ischemic cardiomyopathy: percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG). While the benefits of PCI for ischemic cardiomyopathy are unclear, achieving complete revascularization with PCI could improve outcomes comparable to CABG.
Methods: A total of 1496 patients with left ventricular ejection fraction (LVEF) <50% and multivessel disease who underwent either PCI or CABG were selected from a single-center cohort registry.
Background: Vascular complications are common and can be fatal even after successful decannulation in patients with peripherally cannulated veno-arterial extracorporeal membrane oxygenation (VA-ECMO). Therefore, we aimed to accurately determine the incidence of arterial complications assessed by Duplex ultrasound following peripheral VA-ECMO decannulation. In addition, we investigated the predictors of severe complications requiring intervention.
View Article and Find Full Text PDFBackground: Sarcopenia is an aging-related condition characterized by loss of skeletal muscle mass and is an indicator of subclinical atherosclerosis. The relationship between reduced muscle mass and long-term clinical outcomes in patients with advanced coronary artery disease who have undergone coronary artery bypass grafting (CABG) is not fully understood. This study is sought to evaluate the prognostic implications of sarcopenia screening in patients undergoing CABG.
View Article and Find Full Text PDFObjective: This study aimed to assess the effect of the lesion sets for surgical ablation of atrial fibrillation on long-term outcomes and identify the optimal lesion set.
Methods: Between 2005 and 2017, 1825 patients underwent surgical ablation concomitant to mitral valve surgery in the participating institutions. Of these, 529 underwent left atrial ablation, whereas the remainder had biatrial ablation.
Article Synopsis
- The study examined how isolating the left atrial appendage (LAA) affects clinical outcomes in patients with atrial fibrillation (AF) who had surgical ablation along with mitral valve (MV) surgery.
- Among 875 patients analyzed, those who had LAA isolated experienced a significantly lower risk of long-term stroke compared to those who preserved it, but there were no notable differences in mortality or AF recurrence.
- The findings suggest that while LAA isolation reduces long-term stroke risk, it does not lead to increased survival rates for these patients.
Article Synopsis
- - This study investigates the relationship between visceral adiposity (fat stored in the abdominal cavity) and long-term mortality in patients who underwent coronary artery bypass grafting (CABG), revealing that lower levels of visceral fat are linked to a higher risk of death.
- - A total of 2810 CABG patients were analyzed, classifying them into three groups based on their visceral fat area index (VFAI), with findings indicating that patients in the low VFAI group (least visceral fat) had a higher incidence of long-term mortality compared to those in the higher VFAI groups.
- - The results suggest that having low visceral fat does not necessarily protect critically ill patients, contradicting the obesity paradox; thus, managing
Article Synopsis
- - The study analyzed risk factors for abdominal aortic aneurysm (AAA) development in adults over 50 with diabetes, highlighting that despite diabetes being linked to a lower AAA risk, some patients still develop it.
- - It followed over 1.9 million participants from 2009 to 2019 and found factors like age, male gender, smoking, and certain health issues (e.g., hypertension) increased AAA risk, while longer diabetes duration and specific oral medications decreased risk.
- - Notably, the research indicated that heavy alcohol consumption and obesity were linked to lower AAA risk, whereas insulin use marginally increased risk, showcasing a complex relationship between diabetes management and AAA development.
Article Synopsis
- This study explored how early diagnosis (ED) of Loeys-Dietz syndrome (LDS) impacts surgical outcomes in patients undergoing aortic surgery.
- The research involved a review of 38 LDS patients, comparing those diagnosed before surgery (ED group) to those diagnosed afterward (DD group).
- Results showed that the ED group had fewer emergency surgeries, shorter hospital stays, and a lower reoperation rate, highlighting the benefits of early diagnosis for better patient outcomes.
Article Synopsis
- The study tested a new hemostatic agent, ActiClot (ATC), comparing its effectiveness and safety against the commercial product FLOSEAL using animal models (rat and porcine).
- ATC significantly decreased bleeding time in the rat liver model compared to gauze, showing a 70% reduction, and performed similarly to FLOSEAL in both models without major differences in effectiveness.
- The safety tests indicated ATC is biocompatible and does not cause inflammation, suggesting it could be a viable option for controlling bleeding in surgical and emergency situations.
Article Synopsis
- Neuron-specific enolase (NSE) is a biomarker that has been used to predict neurologic outcomes after cardiac arrest, and this study specifically evaluates its effectiveness in patients undergoing extracorporeal cardiopulmonary resuscitation (ECPR).
- The study included 47 adult ECPR patients, revealing that 46.8% experienced poor neurologic outcomes and 25.5% had abnormal brain CT findings.
- NSE levels measured 72 hours after ECPR were found to be the most predictive of poor outcomes and 30-day mortality, with cutoff values indicating significant predictive power.
Objective: To analyze and compare the outcomes of mitral valve surgery for atrial functional mitral regurgitation (AFMR) and for degenerative mitral regurgitation (DMR).
Methods: Patients with AFMR or DMR who underwent mitral valve repair/replacement at 2 institutions between January 2012 and December 2022 were included. Patients <18 years of age and patients undergoing concomitant cardiac surgery (except for the maze procedure or tricuspid annuloplasty) were excluded.
Article Synopsis
- This study analyzed a large dataset from the Korean National Health Insurance Service to explore the relationship between diabetes mellitus (DM), impaired fasting glucose (IFG), and abdominal aortic aneurysm (AAA) over a ten-year period.
- Participants aged 50 and older showed a lower incidence of AAA among those with IFG or DM compared to those with normal blood sugar, with a stronger risk reduction observed for those with longer diabetes duration.
- The findings suggest that both IFG and untreated DM are independently associated with a reduced risk of developing AAA, contradicting some previous assumptions about the relationship between these conditions.
Background And Objectives: The number of sensitized heart failure patients on waiting lists for heart transplantation (HTx) is increasing. Using the Korean Organ Transplantation Registry (KOTRY), a nationwide multicenter database, we investigated the prevalence and clinical impact of calculated panel-reactive antibody (cPRA) in patients undergoing HTx.
Methods: We retrospectively reviewed 813 patients who underwent HTx between 2014 and 2021.
Aims: This study evaluated how well serial pulse pressure (PP) and PP adjusted by the vasoactive inotropic score (VIS) predicted venoarterial extracorporeal membrane oxygenation (VA-ECMO) weaning success and clinical outcomes in acute myocardial infarction complicated by cardiogenic shock (AMI-CS) patients.
Methods And Results: A total of 213 patients with AMI-CS who received VA-ECMO between January 2010 and August 2021 were enrolled in the institutional ECMO registry. Serial PP and VIS were measured immediately, 12, 24, and 48 h after VA-ECMO insertion.
Background: Limited data are available on the relationship of disseminated intravascular coagulation (DIC) with mortality in patients receiving extracorporeal membrane oxygenation (ECMO). Thus, we investigated the association of DIC score and antithrombin (AT) III with clinical outcomes in patients undergoing ECMO.
Methods: We analyzed 703 patients who underwent ECMO between January 2014 and May 2022 at Samsung Medical Center.
Background: We aimed to analyze the impact of concomitant Maze procedure on the clinical and rhythm outcomes, and echocardiographic parameters in tricuspid repair for patients with severe tricuspid regurgitation (TR) and persistent atrial fibrillation (AF).
Methods: Patients who had severe TR and persistent AF and underwent tricuspid valve (TV) repair were included in the study. Both primary TR and secondary TR were included in the current study.
Article Synopsis
- Valve-in-valve transcatheter aortic valve replacement (AVR) is being considered as a safer alternative to redo surgical AVR due to its higher risks, particularly when dealing with failed prostheses.
- A study involving 324 patients from 2010 to 2021 found an overall operative mortality rate of 4.6%, which dropped to 2.5% when excluding those with endocarditis.
- Key risk factors for operative mortality identified were the presence of endocarditis, longer cardiopulmonary bypass time, and lower left ventricular ejection fraction (LVEF), indicating that patients without endocarditis and acceptable LVEF have good outcomes with redo AVR.
A 70-year-old man with dilated cardiomyopathy underwent left ventricular assist device (LVAD) implantation, using a HeartWare ventricular assist device, as a bridge to candidacy. After 26 months, computed tomography (CT) angiography indicated stenosis in the LVAD outflow graft; however, the patient was asymptomatic, prompting a decision to manage his condition with close monitoring. Ten months later, the patient presented with dizziness and low-flow alerts.
View Article and Find Full Text PDFBackground: Both stroke and right heart failure (RHF) are common and serious complications after left ventricular assist device (LVAD) implantation. The objective of this study was to evaluate relation between stroke and RHF early after LVAD implantation.
Methods: This is a retrospective observational cohort study.
Article Synopsis
- The study aimed to analyze long-term outcomes of atrial fibrillation surgery in patients with atrial fibrillation and mitral valve disease by comparing those who had atrial fibrillation surgery during mitral valve surgery versus those who did not.
- A total of 2,680 patients were included from 2005 to 2017, out of which 1,442 were analyzed after matching, assessing outcomes like all-cause mortality and major complications.
- Results showed that patients who had atrial fibrillation surgery experienced better overall and cardiac mortality-free survival rates, as well as lower occurrences of major adverse events compared to those without the surgery, although they had a higher need for permanent pacemakers.
Background: Pericardial effusion (PE) is a serious condition in cancer patients, primarily arising from malignant dissemination. Pericardial window formation is a surgical intervention for refractory PE. However, the long-term outcomes and factors associated with postoperative survival remain unclear.
View Article and Find Full Text PDFThe HeartWare Ventricular Assist Device (HVAD) was widely used for mechanical circulatory support in patients with end-stage heart failure. However, there have been reports of a critical issue with HVAD pumps failing to restart, or experiencing delays in restarting, after being stopped. This case report describes 2 instances of HVAD failure-to-restart during heart transplantation surgery and routine outpatient care.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to investigate the potential link between metabolic syndrome (MetS) and the risk of developing abdominal aortic aneurysm (AAA) in a large group of individuals aged 50 and over.
- Using data from over 4 million participants, researchers found that those with MetS had a significantly higher risk of developing AAA compared to those without it, especially if they had multiple components of MetS.
- Among MetS components, elevated waist circumference, blood pressure, triglycerides, and low HDL-C were associated with increased AAA risk; notably, elevated glucose was linked to a reduced risk, indicating a complex relationship between MetS and AAA.
Background: There is not sufficient evidence of the superiority of hybrid procedures over total arch replacement (TAR) for the aortic arch aneurysm of an elderly patients. This retrospective study aimed to compare total arch replacement and hybrid procedures for treatment of aortic arch aneurysms in patients aged ≥75.
Methods: This study was a multicenter retrospective investigation of peri-operative outcomes of patients undergoing aortic arch aneurysm repair using either TAR or hybrid procedures between January 2012 and May 2021.
Background: Only some studies have directly compared and analyzed the roles of activated partial thromboplastin time (aPTT) and activated clotting time (ACT) in coagulation monitoring during argatroban administration.
Objectives: This study aims to assess the correlation of argatroban dose with ACT and aPTT values and to identify the optimal coagulation test for argatroban dose adjustment.
Methods: We evaluated 55 patients on extracorporeal membrane oxygenation (ECMO) who received argatroban for more than 72 hours.