GraphTGI: an attention-based graph embedding model for predicting TF-target gene interactions.

Motivation: Interaction between transcription factor (TF) and its target genes establishes the knowledge foundation for biological researches in transcriptional regulation, the number of which is, however, still limited by biological techniques. Existing computational methods relevant to the prediction of TF-target interactions are mostly proposed for predicting binding sites, rather than directly predicting the interactions. To this end, we propose here a graph attention-based autoencoder model to predict TF-target gene interactions using the information of the known TF-target gene interaction network combined with two sequential and chemical gene characters, considering that the unobserved interactions between transcription factors and target genes can be predicted by learning the pattern of the known ones.

Heterogeneous graph embedding model for predicting interactions between TF and target gene.

Motivation: Identifying the target genes of transcription factors (TFs) is of great significance for biomedical researches. However, using biological experiments to identify TF-target gene interactions is still time consuming, expensive and limited to small scale. Existing computational methods for predicting underlying genes for TF to target is mainly proposed for their binding sites rather than the direct interaction.

A high-efficiency L-band coaxial three-period relativistic Cherenkov oscillator.

Miniaturization is one of the important research directions of low frequency high power microwave sources. This paper presents a three-period coaxial slow-wave structure L-band high-power microwave source. Because the coaxial Quasi-TEM mode has no cut-off frequency, the radial size of the device can be reduced.

Experiments of a 100 kV-level pulse generator based on metal-oxide varistor.

This paper introduces the development and experiments of a 100 kV-level pulse generator based on a metal-oxide varistor (MOV). MOV has a high energy handling capacity and nonlinear voltage-current (V-I) characteristics, which makes it useful for high voltage pulse shaping. Circuit simulations based on the measured voltage-current characteristics of MOV verified the shaping concept and showed that a circuit containing a two-section pulse forming network (PFN) will result in better defined square pulse than a simple L-C discharging circuit.

A gigawatt level repetitive rate adjustable magnetic pulse compressor.

In this paper, a gigawatt level repetitive rate adjustable magnetic pulse compressor is investigated both numerically and experimentally. The device has advantages of high power level, high repetitive rate achievability, and long lifetime reliability. Importantly, dominate parameters including the saturation time, the peak voltage, and even the compression ratio can be potentially adjusted continuously and reliably, which significantly expands the applicable area of the device and generators based on it.

An improved rolled strip pulse forming line.

The rolled strip pulse forming line (RSPFL) has advantages of compactness, portability, and long pulse achievability which could well meet the requirements of industrial application of the pulse power technology. In this paper, an improved RSPFL with an additional insulator between the grounded conductors is investigated numerically and experimentally. Results demonstrate that the jitter on the flat-top of the output voltage waveform is reduced to 3.

Effects of the transparent cathode on the performance of a relativistic magnetron with axial radiation.

Experimental investigation of the transparent cathode used in a relativistic magnetron with axial radiation is reported in this paper. The transparent cathode is composed of six separate stalks with the diameter of 6 mm. Under the working condition of 549 kV and ∼0.

An all solid-state, rolled strip pulse forming line with low impedance and compact structure.

An all solid-state and compact pulsed strip pulse forming line (PFL) is investigated both theoretically and experimentally. The electromagnetic field distribution and the pulse formation in the strip PFL are analyzed numerically. Based on the theoretical analysis and numerical results, a rolled strip PFL with output voltage of 20 kV, pulse duration of 230 ns, and characteristic impedance of 0.