Publications by authors named "Yang-Fan Cheng"
Article Synopsis
- The study investigates how peripheral inflammation affects Huntington's disease (HD) by comparing inflammatory markers in HD patients and healthy controls.
- Key findings include lower lymphocyte counts and higher neutrophil-to-lymphocyte ratios in HD patients, indicating a distinct inflammatory profile associated with the disease.
- Elevated inflammatory markers are linked to faster disease progression and higher risks of disability and mortality in individuals with HD.
Background And Aim: Huntington's disease (HD) is an autosomal dominant inherited neurodegenerative disorder caused by CAG repeats expansion. Cognitive decline contributes to the loss of daily activity in manifest HD. We aimed to examine the cognition status in a Chinese HD cohort and explore factors influencing the diverse cognitive domains.
View Article and Find Full Text PDFBackground: The etiology of amyotrophic lateral sclerosis (ALS) remains largely unknown. This study aimed to summarize the relationship between ALS and its genetic and non-genetic risk factors.
Method: A search of relevant literature from PubMed, Embase, and Cochrane Database from inception to December 2022 was performed.
Background: Amyotrophic lateral sclerosis (ALS) is a progressive, fatal neurodegenerative disorder (NDS) with unclear pathophysiology and few therapeutic options. Mutations in and are the most common in Asian and Caucasian patients with ALS, respectively. Aberrant (microRNAs) miRNAs found in patients with gene-mutated ALS may be involved in the pathogenesis of gene-specific ALS and sporadic ALS (SALS).
View Article and Find Full Text PDFBackground And Purpose: Recent genetic progress has shown many causative/risk genes linked to Parkinson's disease (PD), mainly in patients of European ancestry. The study aimed to investigate the PD-related genes and determine the mutational spectrum of early-onset PD in ethnic Chinese.
Methods: In this study, whole-exome sequencing and/or gene dosage analysis were performed in 704 early-onset PD (EOPD) patients (onset age ≤45 years) and 1866 controls.
Background: The survival time of amyotrophic lateral sclerosis (ALS) is greatly variable and protective or risk effects of the potential survival predictors are controversial. Thus, we aim to undertake a comprehensive meta-analysis of studies investigating non-genetic prognostic and survival factors in patients with ALS.
Methods: A search of relevant literature from PubMed, Embase, Cochrane library and other citations from 1 January 1966 to 1 December 020 was conducted.
Article Synopsis
- * The research identified 155 patients with rare pathogenic variants linked to ALS, with specific genes showing a higher mutation frequency and certain variants associated with increased disease risk and poor prognosis.
- * Findings indicate that understanding ALS genetics in diverse populations, like those in China, can inform genetic testing strategies and enhance the evaluation of disease outcomes.
In order to investigate the explosion process of calcium carbide (CaC) dust in the acetylene (CH) atmosphere, the explosion characteristics of CH gas and CH/CaC dust gas-solid two-phase mixture were studied using a 20-L spherical vessel, and the chemical composition of solid residues after explosion were also analyzed. Experimental results showed that the P values of CH gas explosion rose first and then remained stable with the increasing stoichiometric ratio values (φ) of CH/air, while the (dP/dt) values tended to increase at early stage and then decrease, the inflection point of (dP/dt) values was φ = 1.78.
View Article and Find Full Text PDF[Predictive Value of Obesity Indicators for Metabolic Syndrome in Adults of Han and Yi Nationalities in Sichuan].
Sichuan Da Xue Xue Bao Yi Xue Ban
January 2019
Objective: To compare the predictive value of different measures of obesity for metabolic syndrome (MetS) in adult Yi and Han nationality population.
Methods: A total of 3 492 urban and rural residents in Chengdu and Liangshan Yi Autonomous Prefecture participated in this study. Demographic and laboratory data were collected.
[Clinical Characteristics of Patients with Type 2 Diabetes Mellitus and Obstructive Sleep Apnea Syndrome].
Sichuan Da Xue Xue Bao Yi Xue Ban
May 2017
Objectives: To compare the clinical characteristics and prevalence of chronic complications in type 2 diabetes mellitus (T2DM) patients with various degrees of obstructive sleep apnea syndrome (OSAS).
Methods: A total of 170 patients with T2DM and OSAS were enrolled in this study. These participants were divided into three groups with low, medium and high apnea-hypopnea index (AHI), respectively.