Publications by authors named "Yang-Di Wang"
Article Synopsis
- The study investigates the gut-brain axis dysfunction as a factor in Crohn's disease (CD) and aims to create a brain MRI-based radiomics model to analyze neural changes in CD patients.
- Using data from 230 CD patients and 46 healthy controls, researchers developed and validated a model that shows high accuracy in distinguishing CD patients from healthy individuals based on MRI features.
- The findings suggest significant correlations between specific blood metabolites and microbiota in CD patients, indicating that dysbiosis may influence brain blood flow and contribute to the disease's pathology.
Objectives: We aimed to develop MRI-based radiomic models (RMs) to improve the diagnostic accuracy of radiologists in characterizing intestinal fibrosis in patients with Crohn's disease (CD).
Methods: This retrospective study included patients with refractory CD who underwent MR before surgery from November 2013 to September 2021. Resected bowel segments were histologically classified as none-mild or moderate-severe fibrosis.
Objectives: Differences in clinical adverse outcomes (CAO) based on different intestinal stricturing definitions in Crohn's disease (CD) are poorly documented. This study aims to compare CAO between radiological strictures (RS) and endoscopic strictures (ES) in ileal CD and explore the significance of upstream dilatation in RS.
Methods: This retrospective double-center study included 199 patients (derivation cohort, n = 157; validation cohort, n = 42) with bowel strictures who simultaneously underwent endoscopic and radiologic examinations.
Article Synopsis
- More than half of patients with Crohn's disease need surgery, but many face a risk of surgical recurrence called postoperative anastomotic recurrence (PAR).
- This study aimed to create and validate a radiomics signature based on preoperative computed tomography enterography (CTE) to predict early PAR in patients with Crohn's disease.
- The findings showed that both intestinal and mesenteric radiomic signatures were significant independent risk factors for PAR, and a new radiomics-based nomogram was more effective in predicting outcomes compared to traditional clinical models.
Inflammatory bowel disease cross-sectional imaging: What's new?
United European Gastroenterol J
December 2022
Cross-sectional imaging-ultrasonography, computed tomography enterography, and magnetic resonance enterography-is a routine and indispensable tool for patients with Crohn's disease (CD) that helps to detect or monitor disease characteristics before, during, and after CD treatment. New emerging radiological technologies may have further clinical applications in the management of CD. In this review article, we focus on the latest developments in cross-sectional imaging in CD research, including its role in intra- and extra-luminal lesion detection, intestinal inflammation and fibrosis grading, therapeutic response assessment and outcome prediction, postoperative recurrence detection and prediction, and the gut-brain axis.
View Article and Find Full Text PDFChronic fluid over-hydration is common in dialysis patients. It is associated with mortality and cardiovascular events. Optimal methods for adjusting fluid volume status and ideal dry weight remain uncertain.
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