High BRCA1 gene expression increases the risk of early distant metastasis in ER breast cancers.

Although the function of the BRCA1 gene has been extensively studied, the relationship between BRCA1 gene expression and tumor aggressiveness remains controversial in sporadic breast cancers. Because the BRCA1 protein is known to regulate estrogen signaling, we selected microarray data of ER breast cancers from the GEO public repository to resolve previous conflicting findings. The BRCA1 gene expression level in highly proliferative luminal B tumors was shown to be higher than that in luminal A tumors.

Autodetect extracranial and intracranial artery stenosis by machine learning using ultrasound.

Background: and Purpose: This study proposed a machine learning method for identifying ≥50% stenosis of the extracranial and intracranial arteries.

Patients And Methods: A total of 8211 patients with both carotid ultrasound and cerebral angiography were enrolled. Support vector machine (SVM) was employed as the machine learning classifier.

An exploratory study using an openEHR 2-level modeling approach to represent common data elements.

Background And Objective: In order to facilitate clinical research across multiple institutions, data harmonization is a critical requirement. Common data elements (CDEs) collect data uniformly, allowing data interoperability between research studies. However, structural limitations have hindered the application of CDEs.