Synopsis of recent research by authors named "Yang-An Wen"
- Yang-An Wen's research primarily focuses on the molecular mechanisms underlying colon cancer tumorigenesis, particularly the roles of specific proteins such as PHLPP, protein tyrosine phosphatase receptor type F (PTPRF), and mitochondrial function in cancer cell metabolism and signaling pathways.
- Significant findings include the identification of PHLPP downregulation as a driver of chemoresistance and tumor initiation via eIF2α phosphorylation and the involvement of adipocytes in promoting colon cancer tumor growth through metabolic modulation.
- Wen's work also explores the impact of mitochondrial retrograde signaling on Wnt signaling pathways and demonstrates the potential of targeting these pathways for therapeutic interventions in colorectal cancer.
