Ultrafast Charged MnO Nanosheets/Carbon Fiber with Mechanical and Postcharging Antibacterial Activity.

Postcharging antibacterials have shown good application prospects in combating bacterial infections through electrical interaction. Herein, manganese oxide nanosheets in situ grown on carbon fibers (CM) are designed to perform the integration of mechanical intervention and postcharging therapy for efficient bacterial killing. This electrode disrupts bacterial membranes via sharp-edged microstructures.

Interaction between the liver transcriptome and gut microbiota in mice during Toxoplasma gondii infection as identified by integrated transcriptomic and microbiome analysis.

Background: Toxoplasma gondii is a single-cell parasite capable of infecting both humans and a variety of animal species. Although T. gondii infection is known to adversely affect the liver and gut microbiota, the precise interplay between the gut microbiome and the liver transcriptome in infected mice remains largely unknown.

Flexible Patterned Fuel Cell Patches Stimulate Nerve and Myocardium Restoration.

The distribution of electrical potentials and current in exogenous electrostimulation has significant impacts on its effectiveness in promoting tissue repair. However, there is still a lack of a flexible, implantable power source capable of generating customizable patterned electric fields for in situ electrostimulation(electrical stimulation). Herein, this study reports a fuel cell patch (FCP) that can provide in situ electrostimulation and a hypoxic microenvironment to promote tissue repair synergistically.

The sentinels of coronary artery disease: heterogeneous monocytes.

Monocytes are heterogeneous immune cells that play a crucial role in the inflammatory response during atherosclerosis, influencing the progression and outcome of the disease. In the pathogenesis of atherosclerotic diseases, such as coronary artery disease (CAD), monocytes not only serve as the initial sensors of endogenous and exogenous pathogenic factors, but also function as intermediators that bridge the circulatory system and localized lesions. In the bloodstream, heterogeneous monocytes, acting as sentinels, are rapidly recruited to atherosclerotic lesions, where they exhibit a heightened capacity to respond to various pathological stimuli upon detecting signals from damaged vascular endothelial cells.

Innovative Insights into Fatigue Damage Evolution of Shield Tunnel Segments by Introducing Stable Damage Limit and Memory Effect.

In this study, an experimental equipment is designed to simulate the mechanical boundary conditions of shield tunnels and test samples that exhibit varying degrees of initial damage fabricated through low-energy impact experiments. The fatigue damage characteristics of the initially damaged segments are examined under multistage cyclic loading. A comprehensive analysis of dynamic strain, mean strain, and strain amplitude time-history curves is conducted to derive damage evolution curves based on the degradation of elastic modulus.

Becoming a Researcher: An Empirical Study on the Factors Influencing Chinese PhD Students' Research Career Intentions.

Increasing the attractiveness of research careers for PhD students has been a key objective of science, technology, and innovation policies worldwide. This study draws on an expanded career construction theory framework to examine the effects of proactive personality, employability social capital, and career adaptability on PhD students' research career intentions as well as the moderating role of gender in this structural model. We collected data from 795 Chinese PhD students at 10 universities via an online questionnaire survey.

Assessment of platelet-to-white blood cell ratio on short-term mortality events in patients hospitalized with acute decompensated heart failure: evidence from a cohort study from Jiangxi, China.

Objective: Platelet-to-white blood cell ratio (PWR) as a comprehensive indicator of inflammatory response has been widely used to assess the prognosis of various diseases. However, the relationship between PWR and adverse outcomes in patients with acute decompensated heart failure (ADHF) remains unclear. This study aimed to evaluate the association between PWR and all-cause mortality within 30 days of hospitalization in ADHF patients from Jiangxi, China.

Caloric restriction prevents inheritance of polycystic ovary syndrome through oocyte-mediated DNA methylation reprogramming.

Polycystic ovary syndrome (PCOS) is a prevalent metabolic and reproductive endocrine disorder with strong heritability. However, the independent role of oocytes in mediating this heritability remains unclear. Utilizing in vitro fertilization-embryo transfer and surrogacy, we demonstrated that oocytes from androgen-exposed mice (F1) transmitted PCOS-like traits to F2 and F3 generations.

Cancer-secreted exosomal miR-1246 promotes colorectal cancer liver metastasis by activating hepatic stellate cells.

Colorectal cancer liver metastases (CRLM) are the primary cause of mortality in colorectal cancer (CRC) patients, highlighting the importance of understanding the underlying mechanisms. The tumor microenvironment (TME) and its interaction with tumor cells play a crucial role in CRLM progression. Notably, the stability and peak levels of tumor-derived exosomal miRNAs facilitate intercellular communication in the TME.

Deep-Blue OLEDs with BT. 2020 Blue Gamut, External Quantum Efficiency Approaching 40.

The hyperfluorescence (HF) technology holds great promise for the development of high-quality organic light-emitting diodes (OLEDs) for their excellent color purity, high efficiency, and low-efficiency roll-off. Sensitizer plays a crucial role in the performance of HF devices. However, designing sensitizers with simultaneous high photoluminescence quantum yield (PLQY), rapid radiative decay (k), and fast reverse intersystem crossing rate (k) poses a great challenge, particularly for the thermally activated delayed fluorescence (TADF) sensitizers targeting deep-blue HF device.

High-power-efficiency and ultra-long-lifetime white OLEDs empowered by robust blue multi-resonance TADF emitters.

White organic light-emitting diodes (WOLEDs) show very promising as next-generation light-sources, but achieving high power efficiency (PE) and long operational lifetime remains challenging because of the lack of stable blue emitters that can harvest all triplet (T) excitons for light emission. Herein, we propose integrating stable azure multi-resonance thermally activated delayed fluorescent (MR-TADF) emitters into tri-color hybrid WOLEDs to tackle these issues. By meticulously selecting MR-TADF emitters and precisely tuning the exciton recombination zone, the optimized tri-color devices based on BCzBN-3B achieve color-stable white light emission with maximum external quantum efficiency (EQE) and maximum PE (PE) of 34.

Dynamic event-triggered synchronization control for neutral-type SMJ neural networks with additive delays under synchronized attacks.

This paper studies the double event-triggered synchronization (ETS) of neutral-type semi-Markovian jump (SMJ) neural networks under synchronous attacks. Firstly, synchronous attacks are modeled by an independent semi-Markovian jump process. Secondly, the double dynamic event-triggered mechanisms (DDETMs) introduced offer the advantage of conserving communication resources and alleviating the computational burden.

Multi-omics analysis reveals key regulatory defense pathways in Ruppia sinensis in response to water salinity fluctuations.

Seagrasses maintain cellular water balance by regulating ion concentrations and accumulating organic osmolytes, enabling them to survive in the fluctuating salinity of intertidal environments. However, the molecular mechanisms underlying seagrass responses to salinity changes remain relatively understudied. To address this, we conducted a multi-omics analysis of Ruppia sinensis under low, moderate, and high salinity conditions to uncover the mechanisms behind its adaptation to salinity fluctuations.

Fast response and stable dyed cellulose nanofibrous films for shrimp spoilage detection.

In this study, the electrospun cellulose acetate (CA) nanofibrous films were hydrolyzed and then dyed with a synthetic dye of 1-hydroxy-4-[4-(ethylsulfurate sulfonyl)-phenylazo]-naphthalene (HESPN). The physicochemical properties of the dyed films were similar to the unmodified films. Due to the covalent bonds formed between dye and cellulose molecules, the dyed films showed high stability with almost no dye leakage in acidic solutions and minimal leakage (0.

A rare deleterious missense mutation in the gene in Chinese women with polycystic ovary syndrome.

Background: Polycystic ovary syndrome (PCOS) is an endocrine disorders and characterized by polycystic ovary morphology and oligomenorrhea, affecting fertility and health condition of female around the world. The causative factors of PCOS are complex, and genetic structure remains a long-standing medical challenge in genetics. Previous genome-wide association study (GWAS) showed that Wing-less-related integration site (Wnt) signaling is the most affected pathway among PCOS-related risk genes, and genetic mutations in the Wnt/β-catenin signaling may lead to abnormal development of PCOS.

Analyzing the impact of glycemic metabolic status on cardiovascular mortality and all-cause mortality related to the estimated glucose disposal rate: a nationwide cohort study.

Objective: The Estimated Glucose Disposal Rate (eGDR) serves as a surrogate marker for insulin resistance, with numerous studies highlighting its significant prognostic value. This paper aims to analyze the impact of eGDR on cardiovascular and all-cause mortality across different glycemic metabolic statuses, including normal fasting glucose (NFG), prediabetes, and diabetes.

Methods: This study included 46,016 American adults who underwent health examinations as part of the National Health and Nutrition Examination Survey from 1999 to 2018.

Liquid Metal-Based Conductive Nerve Guidance Conduit Combined With Electrical Stimulation Boosts Peripheral Nerve Repair.

The combination of nerve guide conduits (NGCs) and electrical stimulation (ES) is an effective treatment for peripheral nerve injury (PNI). Flexible conductive materials with mechanical properties similar to those of biological tissues have been shown to have better long-term biointegration and functionality than rigid conductive materials. In this study, liquid metal (LM)-based conductive polycaprolactone/gelatin/polypyrrole/LM (PCL/Gel/PPy/LM, PGPL) NGC was combined with exogenous ES to repair PNI.

A mesityl-functionalized double-boron-nitrogen-oxygen-embedded multi-resonance framework achieves anti-quenching narrowband deep-blue electroluminescence with EQE over 30% and CIE of 0.046.

Developing highly efficient deep-blue multi-resonance thermal activated delayed fluorescence (MR-TADF) materials for ultra-high-definition organic light-emitting diodes (OLEDs) displays that meet the stringent BT.2020 standard remains a significant challenge. In this study, we present a strategy to achieve high-performance deep-blue MR-TADF emitters by integrating a large π-conjugated double-boron-embedded MR skeleton with strategically positioned peripheral steric hindrance groups.

Expansion counteraction effect assisted vanadate with rich oxygen vacancies as a high cycling stability cathode for aqueous zinc-ion batteries.

In this study, a novel tunnel structure vanadate NaVO (NaVO) cathode for aqueous zinc ion batteries (AZIBs) is facilely fabricated by thermal decomposition of polyoxovanadate containing NH ions. The NaVO cathode is characterized by abundant oxygen vacancies and nanometer dimensions. These attributes can offer extra reaction sites and suppress structural collapse during circulation.

Arsenic mobility and microbial community composition in the sediments of coastal wetlands driven by tidal action.

Arsenic (As) pollution in coastal wetlands has been receiving growing attention. However, the exact mechanism of As mobility driven by tidal action is still not completely understood. The results reveal that lower total As concentrations in solution were observed in the flood-ebb treatment (FE), with the highest concentration being 7.

A Tribo/Piezoelectric Nanogenerator Based on Bio-MOFs for Energy Harvesting and Antibacterial Wearable Device.

New types of metal-organic framework (MOF) materials have great potential in solving the current global dilemma on energy, environment, and medical care. Herein, based on two kinds of biomolecule-MOFs (Bio-MOFs) with favorable biocompatibility and degradation-reconstruction characteristics, we have established a self-powered muti-functional device to achieve an efficient and broad-spectrum environmental energy collection and biomedical applications. Combining Zn(II) and carnosine-based Zn-Car_MOF possessing a high piezoelectric response (d = 11.

Research on spatial prediction technology for mitigating tunnel inrush disasters under complex geological conditions in China's Hengduan Mountain Range.

The proportion of railway high-altitude buried tunnels in complex and dangerous mountainous areas in southwest China is exceptionally high. With the characteristics of suddenness, intermittency, instantaneousness, and destruction, inrushinrushing and collapse is one of the main risks in the tunnel construction process. Therefore, in the design and construction process of tunnels in Hengduan Mountain area, it is very important to identify the mechanism of sudden s inrushing and collapse risks, predict the spatial location and scale of possible inrushing and collapse, and formulate corresponding tunnel design and construction response measures.

Research of carrying mechanism between β-lactoglobulin and linoleic acid: Effects on protein structure and oxidative stability of linoleic acid.

Spectroscopic techniques and molecular docking were employed to explore the binding mechanism and structural characteristics of β-lactoglobulin (β-lg) with linoleic acid. The research revealed that the interaction between β-lg and linoleic acid was primarily governed by static quenching. The attachment of linoleic acid to β-lg happened naturally via hydrophobic forces.

Multifunctional electrospinning periosteum: Development status and prospect.

In the repair of large bone defects, loss of the periosteum can result in diminished osteoinductive activity, nonunion, and incomplete regeneration of the bone structure, ultimately compromising the efficiency of bone regeneration. Therefore, the research and development of tissue-engineered periosteum which can replace the periosteum function has become the focus of current research. The functionalized electrospinning periosteum is expected to mimic the natural periosteum and enhance bone repair processes more effectively.

The systemic inflammation response index as a significant predictor of short-term adverse outcomes in acute decompensated heart failure patients: a cohort study from Southern China.

Objective: The deterioration of acute decompensated heart failure (ADHF) is associated with abnormal activation of inflammatory pathways. This study aims to evaluate the impact and predictive value of a novel inflammatory marker, the systemic inflammation response index (SIRI), on short-term adverse outcomes in ADHF patients.

Methods: This retrospective cohort study included 1,448 ADHF patients from Jiangxi Provincial People's Hospital between 2019-2022.