The NcRNA/Wnt axis in lung cancer: oncogenic mechanisms, remarkable indicators and therapeutic targets.

Early diagnosis of lung cancer (LC) is challenging, treatment options are limited, and treatment resistance leads to poor prognosis and management in most patients. The Wnt/β-catenin signaling pathway plays a vital role in the occurrence, progression, and therapeutic response of LC. Recent studies indicate that non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) function as epigenetic regulators that can promote or inhibit Wnt/β-catenin signaling by interacting with Wnt proteins, receptors, signaling transducers, and transcriptional effectors, thereby affecting LC cell proliferation, metastasis, invasion, and treatment resistance.

Clinical Significance of RBM15 in Gastric Cancer: A Multi-Database Validation.

Background: Gastric Cancer (GC) represents a highly prevalent and aggressive form of malignancy. Recent scholarly endeavors have implicated the RNA binding motif protein 15 (RBM15) gene in the onset and progression of cancer. The present study was designed to delve into the expression profile of RBM15 in GC, assess its prognostic significance, and explore its potential as a viable therapeutic target.

Advancing nonadiabatic molecular dynamics simulations in solids with E(3) equivariant deep neural hamiltonians.

Non-adiabatic molecular dynamics (NAMD) simulations have become an indispensable tool for investigating excited-state dynamics in solids. In this work, we propose a general framework, NAMD (Neural-Network Non-Adiabatic Molecular Dynamics), which employs an E(3)-equivariant deep neural Hamiltonian to boost the accuracy and efficiency of NAMD simulations. Distinct from conventional machine learning methods that predict key quantities in NAMD, NAMD computes these quantities directly with a deep neural Hamiltonian, ensuring excellent accuracy, efficiency, and consistency.

Chitosan films incorporated with cinnamon essential oil Pickering emulsions stabilized by methyl tetrahydrophthalic anhydride esterified corn starch for pork preservation.

Chitosan films containing cinnamon essential oil Pickering emulsions (CEO-PEs) stabilized by methyl tetrahydrophthalic anhydride esterified corn starch (MeCS) were prepared and characterized. The incorporation of CEO-PEs was confirmed by Fourier transform infrared spectroscopy and scanning electron microscopy. The cinnamon essential oil content affected the color of film significantly (p < 0.

Design and implementation of an independent-drive bionic dragonfly robot.

Bionic flapping wing robots achieve flight by imitating animal flapping wings, which are safe, flexible, and efficient. Their practicality and human-machine symbiosis in narrow and complex environments are better than traditional fixed-wing or multirotor drones, indicating broader application potential. By systematic and biomimetic methods, a bionic dragonfly robot with four independent drive flapping wings, called DFly-I, was designed.

The Role of SUMO1 Modification of SOX9 in Cartilage Development Stimulated by Zinc Ions in Mice.

Zinc ions play a pivotal role in facilitating the development of cartilage in mice. Nevertheless, the precise underlying mechanism remains elusive. Our investigation was centered on elucidating the impact of zinc deficiency on cartilage maturation by modulating SUMO1 and UBC9 at both the protein and mRNA levels.

Assisted Solubilization Strategy in Spiro-OMeTAD for Thermally and Mechanically Stable Perovskite Solar Cells.

The ions migration and de-doping reactions caused by conventional doping seriously jeopardizes the thermal stability of perovskite solar cells (PVSCs) based on spiro-OMeTAD as hole transport layer (HTL), which poses a significant challenge for subsequent commercialization. To address these issues, a novel assisted solubilization strategy has been firstly developed using deep eutectic solvent (DES) synthesized from N-(cyanomethyl)acetamide (NCMA) and lithium bis(trifluoromethanesulfonyl)imide (LiTFSI). NCMA can form multiple strong interaction modes with LiTFSI through N-H⋅⋅⋅O hydrogen bonding and Li-O/Li-N coordination, which effectively inhibits Li ions migration at high temperature and increases solubility of LiTFSI in chlorobenzene without acetonitrile and 4-tert-butylpyridine (tBP), fundamentally solving de-doping reaction.

In vitro activity of ceftolozane/tazobactam against Pseudomonas aeruginosa and Enterobacterales isolates collected from two general hospitals in Singapore.

The emerging resistance to cephalosporins and carbapenems in gram-negative pathogens poses significant health challenges and increased treatment failures. The development and evaluation of novel therapeutic options are needed urgently. This study aimed to assess the in vitro activity of ceftolozane/tazobactam (C/T), a new cephalosporin and β-lactamase inhibitor combination, against isolates of Pseudomonas aeruginosa, Escherichia coli, and Klebsiella pneumoniae from different infection sources in two general hospitals in Singapore.

Profiling microRNA expression differentiates monozygotic twins in peripherical blood by droplet digital PCR.

It is challenging to distinguish monozygotic (MZ) twins using traditional autosomal STR genotyping due to their nearly identical genomes. As an important kind of small non-coding RNAs, microRNAs (miRNAs) are essential regulators of gene expression and considered as excellent biomarkers due to their resistance to degradation. Moreover, droplet digital PCR (ddPCR) has emerged as a powerful technique for detecting gene mutations and pathogenic microorganisms, owing to its sensitivity and reliability.

Taxonomic notes on the genus Yoshida, 2007 (Araneae, Theridiidae) from China, with two new species.

Four species are reported from Hubei Province, China, including two new species: R. Zhong, J. Liu & Hu, (♂) and R.

Diffuse large B-cell lymphoma cell-derived exosomal NSUN2 stabilizes PDL1 to promote tumor immune escape and M2 macrophage polarization in a YBX1-dependent manner.

Background: Diffuse large B-cell lymphoma (DLBCL) is a prevalent and aggressive form of non-Hodgkin's lymphoma with a complex etiology. NOP2/Sun domain 2 (NSUN2) is an RNA methyltransferase that has been linked to the regulation of gene expression in various cancers. However, the function of NSUN2 in DLBCL, specifically its contribution to exosome-driven tumor progression, remains to be thoroughly elucidated.

Platelet membrane biomimetic nanomedicine induces dual glutathione consumption for enhancing cancer radioimmunotherapy.

Radiotherapy (RT) is one of the most common treatments for cancer. However, intracellular glutathione (GSH) plays a key role in protecting cancer from radiation damage. Herein, we have developed a platelet membrane biomimetic nanomedicine (PMD) that induces double GSH consumption to enhance tumor radioimmunotherapy.

Oral microbiota as a biomarker for predicting the risk of malignancy in indeterminate pulmonary nodules: a prospective multicenter study.

Background: Determining the benign or malignant status of indeterminate pulmonary nodules (IPN) with intermediate malignancy risk is a significant clinical challenge. Oral microbiota-lung cancer (LC) interactions have qualified oral microbiota as a promising non-invasive predictive biomarker in IPN.

Materials And Methods: Prospectively collected saliva, throat swabs, and tongue coating samples from 1040 IPN patients and 70 healthy controls across three hospitals.

A Biomimetic Pose Estimation and Target Perception Strategy for Transmission Line Maintenance UAVs.

High-voltage overhead power lines serve as the carrier of power transmission and are crucial to the stable operation of the power system. Therefore, it is particularly important to detect and remove foreign objects attached to transmission lines, as soon as possible. In this context, the widespread promotion and application of smart robots in the power industry can help address the increasingly complex challenges faced by the industry and ensure the efficient, economical, and safe operation of the power grid system.

Does deformation of immobilization devices impact treatment accuracy in thoracic cancer radiotherapy?

Background: Immobilization devices are essential for maintaining accurate and repeatable patient positioning in radiotherapy. This study aimed to evaluate the setup errors and dosimetric deviation induced by the deformation of immobilization devices in thoracic cancer radiotherapy using CT-linac.

Materials And Methods: A retrospective analysis was conducted on 40 thoracic cancer patients who underwent radiotherapy, using vacuum cushion (VC) and thermoplastic mask (TM) for immobilization.

Neural mechanisms of fairness decision-making: An EEG comparative study on opportunity equity and outcome equity.

Social equity consists of opportunity equity and outcome equity, where outcome equity refers to the equitable distribution of resource, while opportunity equity refers to equivalent sets of opportunities to obtain a satisfactory outcome, ensuring equality in expected payoffs rather than the actual payoffs. Previous studies showed the existence of inequity aversion for opportunity inequality and identified some differences between opportunity equity and outcome equity in the behavior pattern of evaluation and reaction processes. However, the commonalities and distinctions in brain activity during the fairness decision-making of opportunity equity and outcome equity remain unclear.

Reaction-Diffusion and Crystallization Kinetics Modulation of Two-Step Deposited Tin-Based Perovskite Film via Reducing Atmosphere.

The two-step deposition method effectively mitigates the efficiency decline observed in tin-based perovskite solar cells (TPVSCs) with increasing cell area, stemming from film in-homogeneity. However, the high solubility of SnI in the conventionally used solvent isopropyl alcohol, coupled with the absence of effective modulation of reaction-diffusion process, results in inadequate film coverage and conversion. In this study, we introduce formic acid as the second-step solvent and introduce dithiothreitol (DTT) to regulate reaction-diffusion/crystallization kinetics meticulously.

Diagnostic potential of salivary microbiota in persistent pulmonary nodules: identifying biomarkers and functional pathways using 16S rRNA sequencing and machine learning.

Background: The aim of this study was to explore the microbial variations and biomarkers in the oral environment of patients with persistent pulmonary nodules (pPNs) and to reveal the potential biological functions of the salivary microbiota in pPNs.

Materials And Methods: This study included a total of 483 participants (141 healthy controls and 342 patients with pPNs) from June 2022 and January 2024. Saliva samples were subjected to sequencing of the V3-V4 region of the 16S rRNA gene to assess microbial diversity and differential abundance.

Single-cell RNA sequencing reveals immune microenvironment niche transitions during the invasive and metastatic processes of ground-glass nodules and part-solid nodules in lung adenocarcinoma.

Background: Radiographically, ground-glass nodules (GGN) and part-solid nodules (PSN) in lung adenocarcinoma (LUAD) have significant heterogeneity in their clinical manifestations, biological characteristics, and prognosis. This study aimed to explore the heterogeneity of LUAD in different radiological phenotypes and associated factors influencing tumor evolution.

Methods: We performed single-cell RNA sequencing (scRNA-seq) on tumor tissues from eight and seven cases of GGN- and PSN-LUAD, respectively, at different disease stages, including minimally invasive adenocarcinoma (MIA), invasive adenocarcinoma (IAC), and metastatic lung cancer (MLC).

Afpdb: an efficient structure manipulation package for AI protein design.

Motivation: The advent of AlphaFold and other protein Artificial Intelligence (AI) models has transformed protein design, necessitating efficient handling of large-scale data and complex workflows. Using existing programming packages that predate recent AI advancements often leads to inefficiencies in human coding and slow code execution. To address this gap, we developed the Afpdb package.

Wheat bran oil ameliorates high-fat diet-induced obesity in rats with alterations in gut microbiota and liver metabolite profile.

Background: Obesity is one of the public health issues that seriously threatens human health. This study aimed to investigate the effects of wheat bran oil (WBO) on body weight and fat/lipid accumulation in high-fat diet (HFD)-induced obese rats and further explore the possible mechanisms by microbiome and metabolome analyses.

Methods: Fifty Sprague-Dawley (SD) rats were fed either a normal chow diet (B group, n = 10) or HFD (n = 40) for 14 weeks to establish an obesity model.

Physics-based prediction of moisture-capture properties of hydrogels.

Moisture-capturing materials can enable potentially game-changing energy-water technologies such as atmospheric water production, heat storage, and passive cooling. Hydrogel composites recently emerged as outstanding moisture-capturing materials due to their low cost, high affinity for humidity, and design versatility. Despite extensive efforts to experimentally explore the large design space of hydrogels for high-performance moisture capture, there is a critical knowledge gap on our understanding behind the moisture-capture properties of these materials.

Influence of High-Altitude Residential History on Optimal HbA1c Cutoff for Detecting Abnormal Glucose Metabolism.

Zengmei, Sun, Suyuan Wang, Hua He, Chenghui Zhang, Mingxia Li, Yan Ye, Huiqin Zhang, Xuanyu Yao, Shuyao Sun, Yuanze Du, Yang Zhong, and Yunhong Wu. Influence of high-altitude residential history on optimal HbA1c cutoff for detecting abnormal glucose metabolism. 26:45-54, 2025.