US-Guided Thermal Ablation for Secondary Hyperparathyroidism: A Prospective Multicenter Study.

Background Interest in microwave ablation (MWA) and radiofrequency ablation (RFA) use for treating secondary hyperparathyroidism (SHPT) is rising; however, ablation outcomes in patients with SHPT are not well characterized. Purpose To assess the response of parathyroid hormone (PTH), calcium, phosphorus, and alkaline phosphatase (ALP) levels to US-guided parathyroid MWA and RFA and the safety of these treatments in participants with SHPT. Materials and Methods This prospective multicenter cohort study, conducted from September 2017 to March 2022, included participants with SHPT.

Kidney Gastrin/CCKBR Attenuates Type 2 Diabetes Mellitus by Inhibiting SGLT2-Mediated Glucose Reabsorption through Erk/NF-κB Signaling Pathway.

Background: Both sodium-glucose cotransporters (SGLTs) and Na+/H+ exchangers (NHEs) rely on a favorable Na-electrochemical gradient. Gastrin, through the cholecystokinin B receptor (CCKBR), can induce natriuresis and diuresis by inhibiting renal NHEs activity. The present study aims to unveil the role of renal CCKBR in diabetes through SGLT2-mediated glucose reabsorption.

Interaction between sex and one-hour post-load glucose on metabolic syndrome and its components among Chinese people at high risk of diabetes.

Background: Recently, International Diabetes Federation position statement has adopted one-hour post-load glucose (1hPG) ≥ 8.6 mmol/L for diagnosing intermediate hyperglycemia. We aimed to assess the association of 1hPG ≥ 8.

Chiral Symmetry Breaking in Nanocrystal Superlattices Enabled by Shear and Nanowires.

The self-assembly of colloidal nanocrystals typically leads to the formation of highly symmetric superlattices, while chiral symmetry breaking within these structures remains rare. Here, we present a universal approach for achieving chiral symmetry breaking within self-assembled nanocrystal superlattices through the incorporation of nanowires and shear force. The networked film, composed of highly flexible nanowires that are only a few nanometers in diameter and bound by weak van der Waals interactions, can be manipulated to stretch and rotate, resulting in a controlled chiral pattern with a specified handedness.

Effectiveness of strategies for implementing guideline-concordant care in low back pain: a systematic review and meta-analysis of randomised controlled trials.

Background: International low back pain guidelines recommend providing education/advice to patients, discouraging routine imaging use, and encouraging judicious prescribing of analgesics. However, practice variation occurs and the effectiveness of implementation strategies to promote guideline-concordant care is unclear. This review aims to comprehensively evaluate the effectiveness of implementation strategies to promote guideline-concordant care for low back pain.

Research on geological hazard characteristics and susceptibility of the Duku Highway based on SBAS-InSAR and improved spatiotemporal clustering.

The high-altitude Duku Highway is characterized by complex terrain changes and frequent geological hazards, which severely impact the lives of local residents and the sustainable development of the regional economy. The lack of understanding of terrain deformation, coupled with scarce foundational observation data, makes it challenging to apply mainstream susceptibility assessment methods such as slope modeling and causality analysis. Consequently, this study utilizes Sentinel-1 A data and employs the SBAS-InSAR technique to extract and analyze the deformation characteristics of 184 hazard areas along the Duku Highway over nearly three years.

When Push Comes to Shove: Unravelling the Developmental and Longitudinal Dynamic Relationship between Bullying and Empathy in Chinese School Children.

While bullying has significant long-term impacts on mental health, the developmental relationship between empathy and bullying behaviors remains unclear. Specifically, it is uncertain whether bullying perpetration and victimization predict changes in empathy over time or if empathy influences these behaviors. This study addresses this gap by examining the longitudinal dynamic relationship between empathy, bullying perpetration, and victimization.

Improving spectral linewidth performance of InP quantum dots by promoting size-focused growth and decreasing exciton-phonon coupling.

InP-based quantum dots (QDs) are widely adopted as a superior alternative to CdSe-based QDs in various fields owing to their high quantum yield, environmental friendliness, and excellent stability. However, improving its color purity remains a challenging task. In this work, we employ a multistage heating strategy to optimize the nucleation and shell growth processes of amino-phosphine-based InP/ZnSe/ZnS QDs for reducing emission linewidths.

Insights into the chirality-dependent recognition of Danshensu Bingpian Zhi stereoisomers with PPAR.

Peroxisome proliferator-activated receptor γ (PPAR), a nuclear receptor involved in metabolic processes, inflammation, and energy balance, represents a promising therapeutic target for cardiovascular diseases. Danshensu Bingpian Zhi (DBZ), a chiral compound derived from traditional Chinese medicine, exhibits potential as a PPAR agonist. Using an ensemble-based docking approach, molecular dynamics (MD) simulations, and the molecular mechanics generalized born surface area (MM/GBSA) methods, we explored the binding modes and energetics of DBZ stereoisomers with the PPAR ligand-binding domain (LBD).

Advancing Cancer Immunotherapy through Engineering New PD-L1 Degraders: A Comprehensive Study from Small Molecules to PD-L1-Specific Peptide-Drug Conjugates.

Despite the considerable achievements of antibodies targeting PD-1/PD-L1 in cancer immunotherapy, limitations in antitumor immune response and pharmacokinetics hinder their clinical adoption. Small molecules toward PD-L1 degradation signifies an innovative avenue to modulate PD-1/PD-L1 axis. Herein, we unveil a comprehensive engineering involving the development of new PD-L1 degraders based on the berberine (BBR) and palmatine (PMT) bioactive frameworks and explore their translational potential for cancer immunotherapy using a peptide-drug conjugate strategy.

Acidic "Water-in-Salt" Electrolyte Enables a High-Energy Symmetric Supercapacitor Based on Titanium Carbide MXene.

Titanium carbide MXene, TiCT, exhibits ultrahigh capacitance in acidic electrolytes at negative potentials yet poor stability at positive potentials, resulting in low-energy densities for TiCT-based symmetric supercapacitors. Utilizing "water-in-salt" electrolytes has successfully expanded the stable operation potential window of MXenes. However, this advancement comes at the cost of sacrificing their high capacitance in acidic electrolytes.

Assessing and predicting type 2 diabetes risk with triglyceride glucose-body mass index in the Chinese nondiabetic population-Data from long-term follow-up of Da Qing IGT and Diabetes Study.

Aims: We intended to characterize the superiority of triglyceride glucose-body mass index (TyG-BMI) in predicting type 2 diabetes mellitus (T2DM) compared with triglyceride glucose (TyG) and homeostatic model assessment for insulin resistance (HOMA-IR).

Methods: A total of 699 nondiabetic participants in the Da Qing IGT and Diabetes Study were involved in the present analysis and classified according to the median of baseline TyG-BMI, namely the G1 (low TyG-BMI) and G2 (high TyG-BMI) groups. Information on developing diabetes was assessed from 1986 to 2020.

Water-soluble AIE photosensitizer in short-wave infrared region for albumin-enhanced and self-reporting phototheranostics.

Organic photosensitizers (PSs) play important roles in phototheranostics, and contribute to the fast development of precision medicine. However, water-soluble and highly emissive organic PSs, especially those emitting in the short-wave infrared region (SWIR), are still challenging. Also, it's difficult to prepare self-reporting PSs for visualizing the treatment via stimulated emission depletion (STED) nanoscopy.

Anisotropic Superprotonic Conduction in a Layered Single-Component Hydrogen-Bonded Organic Framework with Multiple In-Plane Open Channels.

Hydrogen-bonded organic frameworks (HOFs) are promising proton conductive materials because of their inherent and abundant hydrogen-bonding sites. However, most superprotonic-conductive HOFs are constructed from multiple components to enable favorable framework architectures and structural integrity. In this contribution, layered HOF-TPB-A with a single component is synthesized and exfoliated.

Longitudinal Dynamic Relationships Between Videogame Use and Symptoms of Gaming Disorder and Depression Among Chinese Children and Adolescents.

Although previous studies have shown a close relationship between gaming disorder and depressive symptoms, few have measured normal videogame use, symptoms of gaming disorder, and depressive symptoms concurrently. The longitudinal dynamics between these variables remain unclear. This study used two demographic cohorts to examine the longitudinal relationship between gaming and depressive symptoms: children (n = 1513, 46.

Mechanisms of traditional Chinese medicine overcoming of radiotherapy resistance in breast cancer.

Breast cancer stands as the most prevalent malignancy among women, with radiotherapy serving as a primary treatment modality. Despite radiotherapy, a subset of breast cancer patients experiences local recurrence, attributed to the intrinsic resistance of tumors to radiation. Therefore, there is a compelling need to explore novel approaches that can enhance cytotoxic effects through alternative mechanisms.

Twin Strep-Tag Modified CPT1A Mitochondrial Membrane Chromatography in Screening Lipid Metabolism Regulators.

Mitochondrial Membrane Chromatography (MMC) is a bioaffinity chromatography technique developed to study the interaction between target proteins embedded in the mitochondrial membrane and their ligand compounds. However, the MMC stationary phases (MMSP) prepared by chemical immobilization are prone to nonspecific binding in candidate agent screening inevitably. To address these challenges, Twin Strep-Tag/Strep Tactin was employed to establish a specific affinity system in the present study.

Facile synthesis of Cu-based catalysts from CuSi and their catalysis properties study.

Supported copper species are well-known for their remarkable catalytic properties across numerous reactions. However, the current preparation methods pose challenges for large-scale production. In this study, we present a cost-effective method for the facile preparation of a series of copper-silicon composites using CuSi@Si particles as precursors.

Diatom Cribellum-Inspired Hierarchical Metamaterials: Unifying Perfect Absorption Toward Subwavelength Color Printing.

Diatom exoskeletons, known as frustules, exhibit a unique multilayer structure that has attracted considerable attention across interdisciplinary research fields as a source of biomorphic inspiration. These frustules possess a hierarchical porous structure, ranging from millimeter-scale foramen pores to nanometer-scale cribellum pores. In this study, this natural template for nanopattern design is leveraged to showcase metamaterials that integrates perfect absorption and subwavelength color printing.

Comparing the efficacy of traditional Chinese exercises and general aerobic exercises in university students with sleep disorders: A systematic review and meta-analysis.

Background: The objective of this study was to compare the impact of traditional Chinese exercise (TCEs) and general aerobic exercise (GAEs) on the sleep quality of university students and to determine which exercise is more effective in improving sleep quality in this specific population.

Methods: We utilized Review Manager 5.3 to analyze data from 21 randomized controlled trials (RCTs), which included a total of 1252 participants.

[Analysis of clinical treatment of acute respiratory distress syndrome assisted by artificial intelligence].

Objective: To evaluate the clinical practice of intensive care unit (ICU) physicians at Hebei General Hospital in identifying patients meeting the diagnostic criteria for acute respiratory distress syndrome (ARDS) and the current status of invasive mechanical ventilation management and adjunctive therapy in these patients, and to analyze the incidence and clinical outcomes of ARDS.

Methods: A retrospective cohort study was conducted. The patients who were hospitalized in the ICU of Hebei General Hospital from April 10, 2017 to June 30, 2022 and met the Berlin definition diagnostic criteria for ARDS were enrolled as study subjects.

Photocatalytic CO reduction with iron porphyrin catalysts and anthraquinone dyes.

Herein we studied visible-light-driven CO reduction using a series of tetra-phenylporphyrin iron catalysts and inexpensive anthraquinone dyes. Varying the functional groups on the phenyl moieties of the catalysts significantly enhances the photocatalytic activity, achieving an optimal turnover number (TON) of 10 476 and a selectivity of 100% in the noble-metal-free systems. The highest activity found in a bromo-substituted catalyst is attributed to favorable electron transfer from the photosensitizer to the iron porphyrin.