Development and validation of a nomogram to predict overall survival in patients with External auditory canal cancer.

Aim: We aimed to examine the influence of various prognostic factors on the outcome of external auditory canal (EAC) cancer and create a graphical prediction tool, marking a first in this field, premised on these determinants.

Methods: We retrospectively analysed 173 patients with EAC cancer, making this the largest patient cohort in the literature. Survival analysis was performed using the Kaplan-Meier method, and the log-rank test was used to assess the differences between established prognostic variables.

Study on the physiological mechanism and transcriptional regulatory network of early fruit development in Gleditsia sinensis Lam. (Fabaceae).

Background: Gleditsia sinensis Lam. (Fabaceae) is a medicinal legume characterized by its spines and pods, which are rich in saponins, polysaccharides, and various specialized metabolites with potential medicinal and industrial applications. The low fruit set rate in artificially cultivated economic forests significantly impedes its development and utilization.

Real-time cell barrier monitoring by spatial transepithelial electrical resistance measurement on a microelectrode array integrated Transwell.

Transepithelial electrical resistance (TEER) measurement is a label free, rapid and real-time technique, which is commonly used to evaluate the integrity of cell barriers. TEER characterization is important for applications, such as tissue (brain, intestines, lungs) barrier modeling, drug screening, and cell growth monitoring. Traditional TEER methods usually only show the average impedance of the whole cell layer, and lack accuracy and the characterization of internal spatial differences within cell layer regions.

The Effect of Ultrasonic Vibration on the 3D Printing Fabrication and Grinding Performance of Structured CBN Grinding Wheel.

The abrasives of traditional grinding wheels are usually randomly arranged on the substrate, reducing the number of effective abrasive grains involved in the machining during the grinding process. However, there are some problems such as uneven distribution of chip storage space, high grinding temperature, and easy surface burn. In trying to address this issue, an ultrasonic vibration 3D printing method is introduced to fabricate the structured CBN (Cubic Boron Nitride) grinding wheel.

Lack of consensus among stroke experts on the optimal blood pressure target of acute ischemic stroke: evidence from a national survey.

Introduction: There remains a lack of consensus among physicians regarding the blood pressure management strategy for acute ischemic stroke patients, this study sought to determine current practice patterns and extension of consensus among stroke physicians after publications of several randomized controlled trials (RCTs).

Methods: An online survey of stroke clinicians registered to OCIN (Oriental Conference of Interventional Neurovascology) platform and ENCHANTED2/MT trial (Enhanced Control of Hypertension and Thrombectomy Stroke Study) collaborators was conducted to investigate the blood pressure management strategy after mechanical thrombectomy. The survey was sent out in March 2024, extracted within 1 month, and then analyzed comprehensively using descriptive statistics.

ProteoNet: A CNN-based framework for analyzing proteomics MS-RGB images.

Proteomics is crucial in clinical research, yet the clinical application of proteomic data remains challenging. Transforming proteomic mass spectrometry (MS) data into red, green, and blue color (MS-RGB) image formats and applying deep learning (DL) techniques has shown great potential to enhance analysis efficiency. However, current DL models often fail to extract subtle, crucial features from MS-RGB data.

Full-space trifunctional metasurface with independent control of amplitude and phase for circularly polarized waves.

Flexible and diverse manipulation of electromagnetic (EM) waves in half space (reflection or transmission) has facilitated strong aspiration toward full-space wave control. However, it remains challenging to achieve independent amplitude and phase control, which seriously hinder the real-world applications. Herein, an innovative strategy of trifunctional metasurface is proposed to independently and simultaneously manipulate the amplitude and phase of circular polarized waves in full space.

Dynamic graph attention network based on multi-scale frequency domain features for motion imagery decoding in hemiplegic patients.

Brain-computer interfaces (BCIs) establish a direct communication pathway between the brain and external devices and have been widely applied in upper limb rehabilitation for hemiplegic patients. However, significant individual variability in motor imagery electroencephalogram (MI-EEG) signals leads to poor generalization performance of MI-based BCI decoding methods to new patients. This paper proposes a Multi-scale Frequency domain Feature-based Dynamic graph Attention Network (MFF-DANet) for upper limb MI decoding in hemiplegic patients.

Carnitine supplementation in progressive supranuclear palsy.

Mitochondrial dysfunction has been implicated in the pathogenesis of several neurodegenerative disorders, including progressive supranuclear palsy (PSP). PSP is a Parkinsonian syndrome characterized by a rapidly progressive state that manifests itself as tremors, bradykinesia, and supranuclear gaze palsy. Carnitine plays an essential role in mitochondrial function by transporting fatty acids across the mitochondrial membrane to be used in energy production.

Kupffer cells, the limelight in the liver regeneration.

Kupffer cells are pivotal in initiating hepatocyte proliferation and establishing connections between different cell types during liver regeneration following partial hepatectomy. As resident macrophages within the liver, Kupffer cells collaborate with hepatocytes and non-parenchymal cells to release various inflammatory mediators that promote hepatocyte proliferation through induction signals like STAT3 phosphorylation. Additionally, the regeneration and replenishment of Kupffer cells themselves are integral components of liver regeneration.

Association between brachial-ankle pulse wave velocity, obesity-related indices, and the 10-year incident risk score of atherosclerotic cardiovascular disease: The rural Chinese cohort study.

Background And Aims: Although existing evidence suggests that arterial stiffness and obesity impact cardiovascular health, limited studies have been conducted to explore the association between brachial-ankle pulse wave velocity (baPWV), obesity-related indices, and the risk of atherosclerotic cardiovascular disease (ASCVD).

Methods And Results: The study participants were among those who completed the baPWV measurement at the second follow-up examination (during 2018-2020) of the Rural Chinese Cohort Study. Logistic regression models were employed to calculate odds ratios (ORs) and 95 % confidence intervals (CIs) of the 10-year incident risk score of ASCVD associated with baPWV and obesity-related indices.

FBLN1 regulates ferroptosis in acute respiratory distress syndrome by reducing free ferrous iron by inhibiting the TGF-β/Smad pathway.

Background: Acute respiratory distress syndrome (ARDS) / acute lung injury (ALI) is a serious medical disease characterized by pulmonary dysfunction and inflammation. This study aims to determine the main molecular modules linked to ARDS and investigate the role of Fibulin-1 (FBLN1) in regulating ferroptosis in ARDS.

Methods: Weighted Gene Co-expression Network Analysis (WGCNA) was employed on the GSE263867 dataset to find key modules associated with ALI.

The Presence and Pathogenic Roles of M(IL-33 + IL-2) Macrophages in Allergic Airway Inflammation.

Background: Macrophages, one of the most abundant immune cells in the lung, have drawn great attention in allergic asthma. Currently, most studies emphasize alternative activated (M2) polarization bias. However, macrophage function in allergic asthma is still controversial.

Identification of accident-prone segments using APIU: A case study on highway safety analysis in China.

Objective: This study proposes the accident point interval unit (APIU) method combined with the characteristics of road traffic accidents. The aim is to automatically identify accident aggregation areas, providing basis for highway design and traffic management.

Methods: Historical accident data from a secondary highway in Guizhou Province and an expressway in Guangdong Province over 3 to 4 years were analyzed using APIU to identify accident-prone segments.

Deep Learning-Assisted Design of Novel Donor-Acceptor Combinations for Organic Photovoltaic Materials with Enhanced Efficiency.

Designing donor (D) and acceptor (A) structures and discovering promising D-A combinations can effectively improve organic photovoltaic (OPV) device performance. However, to obtain excellent power conversion efficiency (PCE), the trial-and-error structural design in the infinite chemical space is time-consuming and costly. Herein, a deep learning (DL)-assisted design framework for OPV materials is proposed.

Hollow Mo/MoS Nanoreactors with Tunable Built-in Electric Fields for Sustainable Hydrogen Production.

Constructing built-in electric field (BIEF) in heterojunction catalyst is an effective way to optimize adsorption/desorption of reaction intermediates, while its precise tailor to achieve efficient bifunctional electrocatalysis remains great challenge. Herein, the hollow Mo/MoS nanoreactors with tunable BIEFs are elaborately prepared to simultaneously promote hydrogen evolution reaction (HER) and urea oxidation reaction (UOR) for sustainable hydrogen production. The BIEF induced by sulfur vacancies can be modulated from 0.

Influence of atomic coordination on the activity of lattice oxygen and catalytic oxidation of toluene over regular CuO crystalline.

VOCs oxidation over transition metal catalyst is commonly understood via the Mars-van Krevelen mechanism involving the crucial role of lattice oxygen (O) activity, however, how it is influenced by atomic coordination is still unclear. Herein, we use model catalysts of CuO-cub, CuO-oct and CuO-dod with crystal planes of (100), (111) and (110), respectively, to investigate the O activity and catalytic oxidation of toluene. The activity of CuO-oct is found to be the highest, followed by CuO-cub and CuO-dod.

Job satisfaction among hospital nurses: An updated literature review.

Background: Nurses' job satisfaction has long been a global concern because of the critical significance it holds on nurse turnover and the quality and safety of patient care.

Objectives: To perform an updated literature review of the newly emerging studies on job satisfaction among hospital nurses.

Design: Literature review.

Atomically Dispersed Mn-Doped Ru@RuO Core/Shell Nanostructure with High Acidic Water Oxidation Performance Arising from Multiple Synergies.

The high overpotential and unsatisfactory stability of RuO-based catalysts seriously hinder their application in acidic oxygen evolution reaction (OER). Herein, a Ru@RuO core/shell catalyst doped with atomically dispersed Mn species, denoted as Ru@Mn-RuO, is reported, which is prepared by a facile one-pot method. Detailed structural characterizations confirm that Mn is homogeneously and atomically distributed in RuO shell, which causes lattice contraction of RuO.

Analysis of the key component puff-by-puff transport in special segments and aerosol for electrical heated tobacco product.

Understanding the puff-by-puff delivery mechanisms of key components of heated tobacco products is critical to developing product designs. This study investigates the puff-by-puff release patterns of key components in Natural Smoke Cigarettes (NSCs), which are designed to deliver nicotine without combustion by reducing oxygen content, utilizing a 30-s puff interval, a 2-s puff duration, and a 55 mL puff volume to simulate realistic smoking conditions. By establishing models to analyze the variation of nicotine, glycerol, 1,2-propylene glycol (PG), and water in different functional sections of the cigarette under controlled smoking conditions.

Elevated lipid accumulation product trajectory patterns are associated with increasing incident risk of type 2 diabetes mellitus in China.

Purpose: Our study aimed to identify the trajectory patterns of lipid accumulation product (LAP) and investigate their association with the incident risk of type 2 diabetes mellitus (T2DM) in China.

Methods: This study included 37,316 eligible participants, with data collected between1998 and 2021. The LAP trajectory patterns were identified through latent mixture modeling.