Publications by authors named "Yang Yuntao"

Sulfur mustard (HD) alkylates biomolecules such as proteins, generating specific biomarkers. This study employs steric hindrance, electronic effects, and solvent effects through an occupancy-removal strategy to synthesize regioisomers [N1-HETE]-His and [N3-HETE]-His, overcoming isomer separation challenges in conventional methods. Density functional theory (DFT) calculations revealed hexafluoroisopropanol (HFIP)'s critical role in directing HD's regioselective alkylation: HFIP modulates steric and electronic environments to preferentially target N1 or N3 sites of histidine imidazole rings, with predictions validated experimentally.

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The aim of this study was to investigate the energy evolution characteristics and an ontological model of the deformation of coal under different water contents. Uniaxial compression tests were conducted for coal with different water contents, and the analyses were based on the energy principle and the principle of minimum energy dissipation. The results showed that the physical properties of the coal specimens were different under different water contents, the peak strain was positively correlated with water content, and the compressive strength and elastic modulus were negatively correlated with water content.

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Stretchable microwave absorbers (SMAs) are vital for flexible electronics. Traditional SMAs display unstable tensile properties resulting from inconsistencies between the constrained conductive layer and the flexible dielectric layer. This study introduces an organohydrogel-based stretchable microwave absorber (OSMA) that incorporates an organohydrogel within an island-bridge structure.

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Article Synopsis
  • Alternative splicing is a cellular process in eukaryotes that produces multiple protein isoforms from a single gene, influencing protein functions and interactions.
  • The ASpdb database was developed to enhance understanding of alternative splicing by providing structures and models for over 10,000 human protein isoforms, including both canonical and alternative forms.
  • ASpdb offers detailed information on splicing events, 3D structures, sequence variations, and comparative analysis tools, making it a key resource for research in structural biology and disease mechanisms.
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The rapidly aging population is consuming more alcohol, leading to increased alcohol-associated acute pancreatitis (AAP) with high mortality. However, the mechanisms remain undefined, and currently there are no effective therapies available. This study aims to elucidate aging- and alcohol-associated spatial transcriptomic signature by establishing an aging AAP mouse model and applying Visium spatial transcriptomics for understanding of the mechanisms in the context of the pancreatic tissue.

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Simple and efficient sample pretreatment methods are important for analysis and detection of chemical warfare agents (CWAs) in environmental and biological samples. Despite many commercial materials or reagents that have been already applied in sample preparation, such as SPE columns, few materials with specificity have been utilized for purification or enrichment. In this study, ionic magnetic mesoporous nanomaterials such as poly(4-VB)@M-MSNs (magnetic mesoporous silicon nanoparticles modified by 4-vinyl benzene sulfonic acid) and Co@M-MSNs (magnetic mesoporous silicon nanoparticles modified by cobalt ions) with high absorptivity for ethanol amines (EAs, nitrogen mustard degradation products) and cyanide were successfully synthesized.

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  • Dermal fibrosis, a key characteristic of systemic sclerosis (SSc), currently lacks effective treatment, partly due to an incomplete understanding of white adipose tissue's role in skin fibrosis.
  • Researchers found that SIX1, a gene associated with fibrosis, is elevated in SSc skin samples and correlates with other adipose-related genes.
  • Deleting the SIX1 gene in both general and adipocyte-specific models reduced fibrosis-related gene expression and prevented fat cell shrinkage, suggesting that targeting SIX1 could be a promising therapeutic approach for SSc-related skin fibrosis.
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Purpose: To evaluate the postoperative outcomes of the all-inside technique in arthroscopic anterior cruciate ligament reconstruction (ACLR).

Methods: Patients who underwent ACLR using the all-inside technique between 2018 and 2021 were retrospectively assessed. All patients were followed up for at least 2 years.

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The clinical experience of 's needling technique for post-stroke depression is introduced. Professor proposes that the main pathogenesis of this condition lies in the "imbalance of body and spirit," with its onset closely related to the heart, liver, spleen, and kidney. In clinical practice, based on the principle of "treating both the body and spirit", "three acupoints for treating the spirit" including Dazhui (GV 14), Fengchi (GB 20), and Baihui (GV 20) are selected, combined with back- points such as Xinshu (BL 15), Ganshu (BL 18), Pishu (BL 20), and Shenshu (BL 23).

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Objective: In this paper, a single-hand-operated hepatic pedicle clamp was introduced, and its application value in laparoscopic liver tumor resection was preliminarily discussed.

Methods: The clinical data of 67 patients who underwent laparoscopic liver tumor resection at the First Affiliated Hospital of Wannan Medical College from March 2019 to October 2023 were retrospectively analyzed. The Pringle maneuver was performed with a hepatic pedicle clamp during the operation.

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  • The rapid growth of biomedical literature requires automated methods to understand relationships between concepts, leading to the LitCoin NLP challenge aimed at developing and benchmarking these techniques.
  • The study employed ensemble learning with specialized models like BioBERT and PubMedBERT for named entity recognition (NER), while also finetuning a large model for improved relation extraction tasks.
  • The developed NLP system achieved first place in NER and second in relation extraction, demonstrating that specialized models significantly outperform general models like ChatGPT in biomedical contexts, supporting future research initiatives.
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  • A uniaxial compression test on sandstone at different angles was used to study how energy changes during deformation and damage.
  • The study found that as the angle increases, peak strain increases while compressive strength and elasticity decrease, influencing energy absorption and dissipation.
  • Overall, higher inclination angles correlated with reduced absorbed strain and increased energy dissipation, providing insights into geological disasters related to fissures in rock formations.
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  • Alternative splicing in eukaryotes modifies pre-mRNA to produce different protein isoforms from a single gene, but there's limited data on how this affects protein structures.
  • Using AlphaFold 2, researchers analyzed the structural impacts of alternative splicing on about 3,000 human genes, discovering significant changes in protein structures, particularly in coils and beta-sheets.
  • The study highlighted important findings, including connections between alternative splicing and protein features in Septin-9, as well as potential missense mutations in Tau that may relate to Alzheimer's disease.
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SMARCB1 loss has long been observed in many solid tumors. However, there is a need to elucidate targetable pathways driving growth and metastasis in SMARCB1-deficient tumors. Here, we demonstrate that SMARCB1 deficiency, defined as genomic SMARCB1 copy number loss associated with reduced mRNA, drives disease progression in patients with bladder cancer by engaging STAT3.

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With the increasing complexity of the electromagnetic environment, there is a growing demand for the manipulation of electromagnetic waves, leading to the rapid development in configurable microwave absorbers. All-dielectric absorbers offer broadband and high-intensity absorption effects in microwave absorption and shielding. However, they face a significant challenge: their performance is not adjustable once the design is completed.

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The present aims to investigate the mechanical characteristics and energy evolution in rock masses containing weak structural planes under conventional triaxial loading conditions. Using a fluid-solid coupling test system of coal rock, numerous conventional triaxial compression tests were performed on rock masses at various dip angles of the structural plane. The obtained empirical outcomes revealed that the deviatoric stress-strain curve of the weak structural plane rock mass with an inclination angle greater than 20° rises step-by-step.

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Carbamate nerve agents (CMNAs) are a type of lethal cholinesterase inhibitor with one or more quaternary amine centres and aromatic rings. CMNAs have been recently added to the Annex on Chemicals of the Chemical Weapons Convention (CWC) and Schedules of Controlled Chemicals of China. In this study, a rapid, sensitive and selective method was developed for the fluorescence detection of ambenonium chloride (AC) through host-guest and electrostatic dual interactions between AC and cyclodextrin/11-mercaptoundecanoic acid (CD/MUA) dually functionalized gold nanoclusters (AuNCs).

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Flavonoids are a kind of secondary metabolite which widely exist in plants. They contain a lot of active hydroxyls, which can react with toxic chemicals to produce potential exposure biomarkers. In this article, the model plant (L.

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  • The study aimed to evaluate the impact of local infiltration anesthesia (LIA) combined with femoral nerve block (FNB) on early postoperative pain and rehabilitation after ACL reconstruction in 73 patients, divided into two groups.
  • Group A received LIA at the hamstring donor site, while Group B received saline; pain levels, opioid use, and knee function scores were assessed pre- and post-surgery.
  • Results showed that LIA reduced early postoperative pain and opioid consumption, but there were no significant differences in pain intensity or functional outcomes between the groups at later assessments.
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As vegetation is part of our lives, plants are good candidates as indicators of toxic chemicals. Numerous components in plants may react with toxic chemicals to produce exposure biomarkers. Plant biomarkers formed by the modification of endogenous plant components by chemical warfare agents have not been reported.

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An accurate description of the mechanical properties and deformation characteristics of a structural plane of a rock mass with a large chamber or slope under the ultimate stress with periodic stress disturbances is of great significance to ensure the stability and safety of underground rock engineering. By theoretically analysing the strength effect of a structural plane of a rock mass under dynamic disturbance, a criterion for the occurrence of shear damage on a structural plane of a compressed rock mass under dynamic disturbance is proposed. The results of the cyclic disturbance kinetic test show that there is a disturbance threshold for the shear failure of the structural plane under different disturbance stresses.

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  • The study investigates how varying confining pressures and inclination angles affect the energy characteristics and damage mechanisms of coal-rock combinations.
  • It examines the relationship between brittleness indexes, inclination angles, and confining pressures, revealing how these factors influence plastic yielding, energy dissipation, and crack behavior before peak damage occurs.
  • The research concludes that damage in composite specimens primarily results from oblique shear and tensile factors, with energy distribution following a negative exponential function relative to inclination angle, significantly influenced by confining pressure changes.
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Purpose: To evaluate the extent of tunnel widening after anterior cruciate ligament reconstruction (ACLR) using the all-inside technique and to establish its correlation with patient-reported clinical outcomes and femoral graft bending angle (GBA).

Methods: Tunnel widening was evaluated using computed tomography (CT)-based three-dimensional (3D) models, and the femoral GBA was directly measured on CT images using the Picture Archiving and Communication System (PACS) software. Clinical follow-up was routine procedure, and patient-reported clinical outcomes mainly included International Knee Documentation Committee (IKDC), Lysholm, and Knee Injury and Osteoarthritis Outcome Scores (KOOS) scores, and subjective knee stability assessment.

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  • * The authors propose a new method that uses a two-layer evidence-based lexical pattern approach to identify potentially missing relations in GO, by analyzing existing relationships to automatically suggest missing ones.
  • * Their approach was applied to a recent release of GO, uncovering 866 potentially missing relations, of which experts validated 821 as truly missing and 45 as erroneous, demonstrating the effectiveness of this quality assurance method.
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