Erythrocyte Alloimmunization and Autoimmunization in the Pediatric Population: A Multicenter, Cross-Sectional Study in Central China.

Background: Erythrocyte alloantibodies and autoantibodies complicate transfusion. However, the prevalence of erythrocyte alloimmunization and autoimmunization has not been estimated in the Chinese pediatric population. Therefore, we investigated the prevalence of erythrocyte alloimmunization and autoimmunization in the Chinese pediatric population with the aim of developing a reasonable transfusion management policy in children from China.

A case of recurrent proximal femoral fracture after open reduction and internal fixation with bilateral locking plates for a Rorabeck type II periprosthetic fracture.

Introduction And Importance: Periprosthetic distal femur fractures (PDFFs) are rare complications that may occur during or after total knee arthroplasty (TKA). The incidence of PDFFs is increasing. Plate internal fixation has demonstrated positive results.

Plasma Ionomic Profile and Interaction Patterns in Coronary Artery Disease Patients.

Humans are exposed to various chemical elements that have been associated with the development and progression of diseases such as coronary artery disease (CAD). Unlike previous research, we employed a multi-element approach to investigate CAD patients and those with comorbid conditions such as diabetes (CAD-DM2), high blood pressure (CAD-HBP), or high blood lipids (CAD-HBL). Plasma concentrations of 21 elements, including lithium (Li), boron (B), aluminum (Al), calcium (Ca), titanium (Ti), vanadium (V), chromium (Cr), manganese (Mn), iron (Fe), cobalt (Co), nickel (Ni), copper (Cu), zinc (Zn), arsenic (As), selenium (Se), strontium (Sr), cadmium (Cd), tin (Sn), stibium (Sb), barium (Ba), and lead (Pb), were measured in CAD patients (n = 201) and healthy subjects (n = 110) using inductively coupled plasma-mass spectrometry (ICP-MS).

Exerkine β-aminoisobutyric acid protects against atrial structural remodeling and atrial fibrillation in obesity via activating AMPK signaling and improving insulin sensitivity.

Moderate exercise decreases the risk for atrial fibrillation (AF), an effect which is probably mediated via exercise-stimulated release of exerkines. β-Aminoisobutyric acid (BAIBA), a novel exerkine, has been reported to provide protective benefits against many cardiovascular diseases, yet its role in AF remains elusive. Herein, using a mouse model of obesity-related AF through high-fat diet (HFD) feeding, we found that 12-week drinking administration of BAIBA (170 mg/kg/day) decreased AF susceptibility in obese mice.

[Metabolic mechanism and intervention strategy of atrial fibrillation in the elderly].

Atrial fibrillation (AF) is a cardiovascular epidemic that occurs primarily in the elderly with primary cardiovascular diseases, leading to severe consequences such as stroke and heart failure. The heart is an energy-consuming organ, which requires a high degree of metabolic flexibility to ensure a quick switch of metabolic substrates to meet its energy needs in response to physiological and pathological stimulation. Metabolism is closely related to the occurrence of AF, and AF patients manifest metabolic inflexibility, such as insulin resistance and the metabolic shift from aerobic metabolism to anaerobic glycolysis.

Preparing Data for Artificial Intelligence in Pathology with Clinical-Grade Performance.

The pathology is decisive for disease diagnosis but relies heavily on experienced pathologists. In recent years, there has been growing interest in the use of artificial intelligence in pathology (AIP) to enhance diagnostic accuracy and efficiency. However, the impressive performance of deep learning-based AIP in laboratory settings often proves challenging to replicate in clinical practice.

The role of the miR-4306/PAK6 axis in degenerative nucleus pulposus cells in human intervertebral disc degeneration.

Intervertebral disc degeneration (IDD), characterized by degenerative changes that occur in intervertebral discs due to aging or structural injury, is thought to be the most common cause of lower back pain. Recent studies have shown that microRNAs (miRNAs) have a critical role in the etiopathogenesis of IDD. In the current study, we aimed to determine the role of miRNAs in mediating the underlying mechanisms associated with IDD.

Synthesis of rare-earth metal complexes with a morpholine-functionalized β-diketiminato ligand and their catalytic activities towards C-O and C-N bond formation.

Unusual tridentate β-diketiminato rare-earth metal chlorides LRECl(μ-Cl)Li(THF) (RE = Y (1a), Yb (1b), and Lu (1c); L = MeC(NDipp)CHC(Me)N(CH)NCHO; Dipp = 2,6-PrCH) and the corresponding dialkyl complexes LRE(CHSiMe) (RE = Y (2a), Yb (2b), and Lu (2c)) were prepared by reaction of a morpholine-functionalized β-diketiminato proligand HL with anhydrous RECl and rare-earth metal trialkyl complexes RE(CHSiMe)(THF), respectively. In 1 and 2, the morpholine moiety displayed a stable chair conformation and the resulting ligand coordinated to the rare-earth metal ion in a [NNN]-tridentate chelating fashion. Further studies demonstrated that these dialkyl complexes showed high activity towards the catalytic formation of C-O and C-N bonds in the alcoholysis of isothiocyanates and aminolysis of epoxides.

Rare-Earth-Metal-Complex-Catalyzed Hydroalkoxylation and Tandem Hydroalkoxylation/Cyclohydroamination of Isocyanates: Synthesis of Carbamates and Oxazolidinones.

Novel N,N,N-tridentate β-diketiminato rare-earth-metal dialkyl complexes RE(CHSiMe) [RE = Y (), Gd (), Yb (), Lu (); = MeC(NDipp)CHC(Me)N(CH)NCH, where Dipp = 2,6-PrCH] have been conveniently synthesized by one step from reactions of the rare-earth-metal trialkyl complexes RE(CHSiMe)(THF) (THF = tetrahydrofuran) with a pyrrolidine-functionalized β-diketiminate H, and their catalytic behaviors toward hydroalkoxylation and tandem hydroalkoxylation/cyclohydroamination of isocyanates have been described. These rare-earth-metal catalysts exhibited high efficiency in the hydroalkoxylation of isocyanates, providing a variety of -alkyl and -aryl carbamate derivatives under mild reaction conditions with a rather low catalyst loading (0.04 mol %).

[Effect of acupuncture for regulating spleen and stomach on aspirin resistance in patients with type 2 diabetes mellitus: a randomized controlled trial].

Objective: To observe the effect of acupuncture for regulating spleen and stomach on aspirin resistance in patients with type 2 diabetes mellitus (T2DM) and explore the effect mechanism.

Methods: A total of 68 T2DM patients complicated with aspirin resistance were randomized into an observation group and a control group, 34 cases in each one. On the base of the conventional treatment for diabetes, aspirin enteric-coated tablets were prescribed for oral administration, 100 mg each time, once daily in the control group.

Serum TBA and GCA Levels Across Pregnancy and the Gestational Age-Specific Reference Intervals for Pregnant Chinese.

Background: Reference intervals of clinical laboratory indexes are the basis of interpretation of test results. While intrahepatic cholestasis of pregnancy (ICP) could severely threaten maternal and fetal health, reference intervals of the biomarkers serum total bile acids (TBA) and glycocholic acid (GCA) are unsatisfactory. The purpose of this study was to derive gestational age-specific reference intervals for serum TBA and GCA in a Chinese population to promote early diagnosis of ICP.

Sub-wavelength grating assisted mode order converter on the SOI substrate.

We have designed three mode order converters using the sub-wavelength grating on the silicon-on-insulator substrate. The proposed mode order converters can separately realize the mode order conversion from the fundamental transverse electric mode to the first-order transverse electric mode (TE-to-TE), the second-order transverse electric mode (TE-to-TE) and the third-order transverse electric mode (TE-to-TE) with compact device sizes and good performances. The simulation results show that the mode order conversion efficiencies of TE-to-TE, TE-to-TE and TE-to-TE are larger than 94.

Reference Intervals for Serum Creatinine with Jaffe's Method in Healthy Chinese Geriatric Population.

Background: Reliable reference intervals (RIs) for the serum creatinine (SCr), assayed by Jaffe's method and categorized in small intervals, are still lacking in elderly population. The study aims to establish RIs for SCr with Jaffe's method in healthy geriatric population of China.

Methods: Eight hundred twenty cases from six representative geographical regions in China (including 369 male cases and 374 female cases) of apparently healthy Chinese elderly aged 60 - 90 years were recruited.

[Clinical trials of acupuncture treatment of post-stroke shoulder pain].

Objective: To observe the clinical therapeutic effect of "Tiaoshen Zhitong" (mental regulating and pain relieving) needling and its influence on serological indicators in the treatment of post-stroke shoulder pain, so as to provide new therapeutic thoughts and approach for post-stroke shoulder pain.

Methods: A total of 80 inpatients with post-stroke shoulder pain were randomly divided into a control group (routine needling, 39 cases) and an observation group ("Tiaoshen Zhitong" needling, 41 cases) according to the random number table. Patients of the two groups accepted basic medication treatment including anticoagulants, hypotensive drugs, hypoglycermic drugs, lipid-lowering drugs, etc.

Association of hepatitis B infection with high-risk complications in total joint arthroplasty.

Background: An increasing number of patients with hepatitis B virus (HBV) infection are undergoing total joint arthroplasty (TJA) surgery in China. Less attention is provided to the special populations and the purpose of this study is to assess the effect of HBV infection on the prognosis TJAs.

Methods: We retrospectively reviewed patients who underwent elective primary hip and knee arthroplasties in Shanghai Huashan Hospital from 2013 to 2016.

Switchable multifunctional terahertz metasurfaces employing vanadium dioxide.

In this paper, we design a type of switchable metasurfaces by employing vanadium dioxide (VO), which possess tunable and diversified functionalities in the terahertz (THz) frequencies. The properly designed homogeneous metasurface can be dynamically tuned from a broadband absorber to a reflecting surface due to the insulator-to-metal transition of VO. When VO is in its insulating state, the metasurface can efficiently absorb the normally incident THz wave in the frequency range of 0.

Nonradiating anapole states in nanophotonics: from fundamentals to applications.

Nonradiating sources are nontrivial charge-current distributions that do not generate fields outside the source domain. The pursuit of their possible existence has fascinated several generations of physicists and triggered developments in various branches of science ranging from medical imaging to dark matter. Recently, one of the most fundamental types of nonradiating sources, named anapole states, has been realized in nanophotonics regime and soon spurred considerable research efforts and widespread interest.

On-Chip Detection of Optical Spin-Orbit Interactions in Plasmonic Nanocircuits.

On-chip manipulating and controlling the temporal and spatial evolution of light are of crucial importance for information processing in future planar integrated nanophotonics. The spin and orbital angular momentum of light, which can be treated independently in classical macroscopic geometrical optics, appear to be coupled on subwavelength scales. We use spin-orbit interactions in a plasmonic achiral nanocoupler to unidirectionally excite surface plasmon polariton modes propagating in seamlessly integrated plasmonic slot waveguides.

Active control of anapole states by structuring the phase-change alloy GeSbTe.

High-index dielectric nanoparticles supporting a distinct series of Mie resonances have enabled a new class of optical antennas with unprecedented functionalities. The great wealth of multipolar responses has not only brought in new physical insight but also spurred practical applications. However, how to make such a colorful resonance palette actively tunable is still elusive.

Laser Writing of Bright Colors on Near-Percolation Plasmonic Reflector Arrays.

Coloration by surface nanostructuring has attracted a great deal of attention by the virtue of making use of environment-friendly recyclable materials and generating nonbleaching colors. Recently, it was found possible to delegate the task of color printing to laser postprocessing that modifies carefully designed and fabricated nanostructures. Here we take the next crucial step in the development of structural color printing by dispensing with preformed nanostructures and using instead near-percolation metal films atop dielectric-metal sandwiches, that is, near-percolation plasmonic reflector arrays.

Changes of serum homocysteine levels during pregnancy and the establishment of reference intervals in pregnant Chinese women.

Backgroud: Reference intervals (RIs) of clinical laboratory indexes are important basis for interpretation of corresponding test results. While elevated homocysteine (HCY) level is a risk factor of some severe gestational diseases, HCY RIs for pregnant women have not been reported so far. The current use of HCY RIs established for general population in pregnant women may challenge clinicians' judgment.

Event-triggered distributed receding horizon control for tracking and formation of homogeneous multi-agent systems.

This paper proposes an event-triggered distributed receding horizon control (DRHC) approach for the formation and tracking problems of homogeneous multi-agent systems. For each agent, an event-triggering condition, based on assumed predictive information of the neighbours, is derived from stability analysis. Considering the uncertain deviation between the assumed and true predictive information, we design a time-varying compatibility constraint for the individual optimization problem.

The predictive value of preoperative neutrophil-lymphocyte ratio (NLR) on the recurrence of the local pigmented villonodular synovitis of the knee joint.

Background: To explore and evaluate the predictive value of preoperative Neutrophil-lymphocyte ratio (NLR) on the recurrence of pigmented villonodular synovitis (PVNS) of the knee joint treated by arthroscopic surgery combining local radiotherapy.

Methods: Sixty pathological-proven PVNS cases of the knee joint in our department from April 2006 to March 2017 were included. All of them are treated by arthroscopic synovectomy combined with adjuvant radiotherapy.

Ultra-compact branchless plasmonic interferometers.

Miniaturization of functional optical devices and circuits is a key prerequisite for a myriad of applications ranging from biosensing to quantum information processing. This development has considerably been spurred by rapid developments within plasmonics exploiting its unprecedented ability to squeeze light into subwavelength scale. In this study, we investigate on-chip plasmonic systems allowing for synchronous excitation of multiple inputs and examine the interference between two adjacent excited channels.