Publications by authors named "Yang Yu-Jiang"
JAK2-STAT5 signaling is insensitive to porcine growth hormone (pGH) in hepatocytes of neonatal pig.
Anim Cells Syst (Seoul)
April 2020
Article Synopsis
- Porcine growth hormone (pGH) plays a crucial role in the growth of pigs, but neonatal pigs are found to be insensitive to its effects, and the reasons for this are not completely understood.
- This study investigates the intracellular signaling pathways in neonatal pig hepatocytes, focusing on the JAK2-STAT signaling pathway, which was found to be inactive in response to pGH.
- The research suggests that negative regulatory molecules may be influencing this lack of signaling, explaining why growth in neonatal pigs does not depend on growth hormone, unlike in older pigs.
Article Synopsis
- Traditional views hold that the growth hormone and its receptor primarily function at the plasma membrane, but new research shows they can also enter cell nuclei to perform crucial physiological roles.
- Recent studies revealed the nuclear localization of porcine growth hormone (pGH) and its receptor (GHR) in pig liver cells, suggesting they hold potential functions beyond the plasma membrane.
- The proposed mechanisms for pGH/GHR nuclear transport include two pathways: one through endocytosis to the endoplasmic reticulum, and another that allows direct entry to the nucleus via endosomes associated with the nuclear membrane.