Immunomodulatory and anti-ovarian cancer effects of novel astragalus polysaccharide micelles loaded with podophyllotoxin.

Ovarian cancer, a highly lethal form of gynecological cancer globally, has witnessed notable advancements in its treatment through the integration of nanotechnology and immunotherapy. Here, we designed a novel astragalus polysaccharide vector (PDA), encapsulating podophyllotoxin (PPT), and modifying methotrexate (DSPE-PEG-MTX) on its surface for targeting ovarian cancer cells with high folate receptor expression. We prepared novel MTX-modified PPT-loaded astragalus polysaccharide micelles (MTX-PPT-micelles) by dialysis method and evaluated their characterization, stability, safety and targeting ability.

Succinonitrile Electrolyte Additive for Stabilizing Aqueous Zinc Metal Batteries.

The utilization of water electrolytes in zinc-ion batteries offers the advantages of enhanced safety, reduced cost, and improved environmental friendliness, rendering them an optimal choice for replacing lithium-ion batteries. Nevertheless, the conventional zinc sulfate electrolyte fails to meet stringent requirements. Therefore, developing electrolytes is crucial for addressing the low cycle life of zinc ions and suppressing the growth of zinc dendrites.

CircIRAK3 Promotes Neutrophil Extracellular Trap Formation by Improving the Stability of ELANE mRNA in Sepsis.

Excessive formation of neutrophil extracellular traps (NETs) has been shown to exacerbate inflammatory injury and organ damage in patients with sepsis. Circular RNAs (circRNAs) abnormally expressed in immune cells of sepsis patients, and play an important role in the pathogenesis of dysregulated immune responses. However, the functions of circRNAs in NET formation during sepsis remain unknown.

Organic electro-scattering antenna: Wireless and multisite probing of electrical potentials with high spatial resolution.

Monitoring electrical potentials with high recording site density and micrometer spatial resolution in liquid is critical in biosensing. Organic electronic materials have driven remarkable advances in the field because of their unique material properties, yet limitations in spatial resolution and recording density remain. Here, we introduce organic electro-scattering antennas (OCEANs) for wireless, light-based probing of electrical signals with micrometer spatial resolution, potentially from thousands of sites.

Genomic, transcriptomic, and metabolomic analyses reveal convergent evolution of oxime biosynthesis in Darwin's orchid.

Angraecum sesquipedale, also known as Darwin's orchid, possesses an exceptionally long nectar spur. Charles Darwin predicted the orchid to be pollinated by a hawkmoth with a correspondingly long proboscis, later identified as Xanthopan praedicta. In this plant-pollinator interaction, the A.

Malignant transformation of nephrogenic adenoma of the bladder: case report and literature review.

Background: Nephrogenic adenoma (NA) is a rare benign tumor that can develop at any site of the urinary system, with the bladder being the most common, followed by the urethra, ureters, renal pelvises, etc. Currently, it is unclear what the pathogenesis of NA is. This study discussed a rare case of malignant transformation from NA to mesonephric adenocarcinoma of the bladder.

Improving soil carbon sequestration stability in farmland through co-application of rice straw and its biochar.

Introduction: Susbtantial agricultural wastes are produced globally which need urgent management policies. To explore the effective utilization of agricultural waste in enhancing soil quality and carbon sequestration capacity, straw and its biochar can be applied as soil ameliorants.

Methods: This study was designed to investigate the impact of different return-to-field methods of rice straw on the transformation between different carbon components in the soil of i fields.

An antioxidant nanozyme for targeted cardiac fibrosis therapy post myocardial infarction.

The excessive release of reactive oxygen species (ROS) after myocardial infarction (MI) disrupts the natural healing process, leading to cardiac fibrosis and compromising patient prognosis. However, the clinical application of many antioxidant drugs for MI treatment is hindered by their poor antioxidant efficacy and inability to specifically target the heart. Here we developed a tannic acid-modified MnO nanozyme (named MnO@TA), which can achieve cardiac targeting to inhibit post-MI fibrosis and enhance cardiac function.

Monitoring the safety of the adjuvanted human papillomavirus vaccine, HPV-16/18-AS04: Protocol for a cohort study using electronic health records in Yinzhou, China.

This protocol was developed to conduct population-wide surveillance of the bivalent HPV-16/18-AS04-adjuvanted human papillomavirus (HPV) vaccine in terms of uptake and safety outcomes including potential immune-mediated diseases (pIMDs) and pregnancy-related outcomes in China. The study will use electronic health records from 2010 to 2020 from the Yinzhou Regional Health Information Platform and include a population-based cohort of female permanent residents aged 9-45 years. Baseline and follow-up periods will be defined according to the 2017 introduction of HPV-16/18-AS04 in China.

Physicochemical properties and structure of rice dough and protein based on TGase combined with sodium metabisulfite modification.

To improve the toughness of the rice dough, protein transglutaminase (TGase) combined with sodium metabisulfite (SMB) modification was used. The influences of modification on rice dough and protein were investigated, and their physicochemical and structural characteristics were analyzed. Mechanical analysis results indicated that the tanδ and texture characteristics of the modified rice dough were close to those of the wheat dough.

Recent progress using novel tetraphenylethylene-based macrocyclic hosts in water.

Macrocyclic structures are popular in supramolecular chemistry and have enjoyed considerable success as platforms for elaboration to container compounds and new materials. Host/guest studies in organic media have relied heavily on structures derived from crown ethers, calixarenes, cucurbiturils, resorcinarenes and pillararenes over the past decades. More recently, their water-soluble versions have been developed for potential applications in biology.

Soy Protein and Safflower-Seed Oil Attenuate Inflammation and Immune Dysfunction in Rats with Hyperuricemia.

A plant-based diet is considered a promising approach for managing hyperuricemia (HUA). This study examined the effects of soy protein and plant-based oils on HUA-induced inflammation and immune dysfunction. Male Wistar rats, induced with HUA using oxonic acid and uric acid (UA), were fed casein or soy protein with palm or safflower oil (2 × 2 factorial design) for 8 weeks.

Research Progress and Outlook of Molecular Dynamics Simulation on Carbon Dioxide Applied for Methane Exploitation from Hydrates.

Research progress of carbon dioxide applied for methane exploitation from hydrates is summarized, with a focus on advances in molecular dynamics simulations and their application in understanding the mechanism of carbon dioxide replacement for hydrate exploitation. The potential of carbon dioxide in enhancing energy recovery efficiency and promoting carbon capture and storage is emphasized. An overview is provided of the advancements made in utilizing carbon dioxide for methane hydrate exploitation, highlighting its significance.

Insight into the Amelioration Effect of Nitric Acid-Modified Biochar on Saline Soil Physicochemical Properties and Plant Growth.

Soil salinization is a major factor threatening global food security. Soil improvement strategies are therefore of great importance in mitigating the adverse effect of salt stress. Our study aimed to evaluate the effect of biochar (BC) and nitric acid-modified biochar (HBC) (1%, 2%, and 3%; m/m) on the properties of salinized soils and the morphological and physiological characteristics of pakchoi.

Influence of Elevated Potassium Fertilization on Structural and Functional Properties of Sweet Potato Root Tuber Starch.

Nine sweet potato varieties with different flesh colors were cultivated under uniform environmental conditions with potassium (K) fertilizer treatments at levels of 0, 22.5, and 45 kg/ha. The structural and functional properties of the starches were subsequently analyzed.

Oncoplastic Breast-Conserving Surgery for Upper Inner Quadrant Breast Cancer Using Pedicled Pectoralis Major Myofascial Flap.

Background: Oncoplastic breast-conserving surgery (OBCS) has emerged as a pivotal approach in the management of breast cancer, ensuring both oncological safety and aesthetic outcomes. However, challenges persist, particularly in upper inner quadrant (UIQ) tumors, where achieving satisfactory cosmetic results while preserving oncological integrity remains intricate.

Methods: 15 patients with UIQ breast cancer received OBCS using a pedicled pectoralis major myofascial flap (PMMF).

Multiple recognition-powered abiotic bimetallic oxide nanozyme-based colorimetric platform for the selective detection of allergen β-lactoglobulin.

β-lactoglobulin (β-lg) is the major allergen in dairy products, and poses a significant threat to special people including infants and young children. Therefore, a convenient, cost-efficient, and aptamer-free colorimetric sensing platform is developed for β-lg assay based on a germanium/zinc bimetallic oxide nanozyme (GeO/ZnO). The CTAB-assisted intercalation growth of ZnO nanoparticles between GeO layers endows GeO/ZnO with enhanced peroxidase-mimicking activity and β-lg affinity.

RPA and Rad27 limit templated and inverted insertions at DNA breaks.

Formation of templated insertions at DNA double-strand breaks (DSBs) is very common in cancer cells. The mechanisms and enzymes regulating these events are largely unknown. Here, we investigated templated insertions in yeast at DSBs using amplicon sequencing across a repaired locus.

Design of trot gait parameters planning system for parallel quadruped robot based on virtual model controller and fuzzy neural network.

The capability to achieve fast motion in varying road conditions is a crucial research aspect in the dynamic control of quadruped robot. In this study, a gait parameters planning system for quadruped robot based on virtual model controller (VMC) and fuzzy neural network controller (FNNC) is proposed. According to the expert knowledge, the FNNC is designed to help optimize the parameters in the central pattern generator and virtual model controller (CPG-VMC).

Cyclopiazonic acid suppresses the function of Leydig cells in prepubertal male rats by disrupting mitofusin 1-mediated mitochondrial function.

This research investigated the impact of cyclopiazonic acid (CPA), a mycotoxin, on the function of progenitor Leydig cells (PLCs) in prepubertal male rats, focusing on its potential disruption of mitochondrial integrity through mitofusin 1 (MFN1) modulation. In vivo, Sprague Dawley rats received CPA (0.2, 1, 5 mg/kg/day) via gavage from postnatal days 21-28 to evaluate PLC function and mitochondrial morphology using serum hormone levels, histology, qPCR, and Western blot analyses.

Kerr-lens mode-locked GHz-repetition-rate Yb:CYA laser with 11-W average power.

We demonstrate on a high-power 1-GHz Kerr-lens mode-locked (KLM) ytterbium (Yb):CYA laser delivering 149-fs pulses with an average power of 11.1 W. The corresponding single-pulse energy and peak power are 10.

Urethra-preserving and dorsal capsule fenestration with robot-assisted simple prostatectomy for severe LUTS in small prostate: a case report.

Background: Small prostates (volume <30 ml) induce bladder outlet obstruction with pathophysiological changes distinct from those associated with large prostates. Treatment options often include transurethral incision of the prostate (TUIP) or transurethral resection of the prostate (TURP). Existing treatments have issues with high recurrence and complication rates.

Exploring the mechanism of Paotianxiong polysaccharide in the treatment of chronic kidney disease combining metabolomics and microbiomics technologies.

A close relationship between the pathogenesis of chronic kidney disease (CKD) and abnormalities in the gut-kidney axis. Paotianxiong polysaccharides (PTXP) that have demonstrated therapeutic effects on CKD. However, the specific mechanism by which PTXP ameliorates CKD through the gut-kidney axis remains to be explored.