Trojan Horse Bioheterojunction Empowers Adhesive Hydrogel with Robust Antibacterial Activity and Sensing Capacity for Infected Cutaneous Regeneration.

Strategic integration of adhesive hydrogels with phototherapy-based antibacterial properties has been extensively leveraged in infected tissue repair. Nevertheless, the interference of bacterial heat shock proteins and antioxidant defense systems attenuates the bactericidal potency of phototherapy. To address this imposing predicament, a Trojan horse bioheterojunction (Th-bioHJ) incorporating liquid metal and copper sulfide is devised to confer an adhesive hydrogel with multimodal and comprehensive antibacterial properties for remedying infectious wounds.

Identification and Functional Analysis of Ras-Related Associated with Diabetes Gene () in -Resistant Individuals of Japanese Flounder ().

Ras-related associated with diabetes (RRAD) is a member of the Ras GTPase superfamily that plays a role in several cellular functions, such as cell proliferation and differentiation. In particular, the superfamily acts as an NF-κB signaling pathway inhibitor and calcium regulator to participate in the immune response pathway. A recent transcriptome study revealed that was expressed in the spleen of disease-resistant Japanese flounder () individuals compared with disease-susceptible individuals, and the results were also verified by qPCR.

Exploring Naturally Tailored Bacterial Outer Membrane Vesicles for Selective Bacteriostatic Implant Coatings.

In treating infectious diseases, achieving selective bacterial inhibition is crucial for preserving the microecological equilibrium. The current approaches predominantly rely on synthetic materials tailored to specific bacteria, considering their cell walls or oxygen requirements. Herein, inspired by intricate bacterial communication, a natural implant is proposed coating utilizing bacterial outer membrane vesicles (OMVs), essential components in bacterial signaling, integrated onto diverse implant surfaces through a universal poly (tannic acid) bridging layer.

Application of personalized templates in minimally invasive management of coronal dens invaginatus: a report of two cases.

Background: Treating the coronal dens invaginatus (CDI) with pulp infection commonly involves the removal of invagination, which increases the risk of perforation and fracture, and compromises the tooth structure. Minimally invasive endodontic management of CDI is highly recommended. This report describes two cases of type II CDI with the application of personalized templates.

Identification and Functional Analysis of Z-Linked E3 Ubiquitin Ligase .

The high proportion of males in hinders their industrial development. The genetic ZW individual can become a pseudomale by sex reversal. And the pseudomale can produce Z-sperm (with epigenetic information to cause sex reversal) while W-sperm is absent, which leads to an even higher male proportion in offspring.

Stress in the Yellow Sea of China: Suppressed Antioxidant Capacity and Induced Inflammatory Response of the Japanese Flounder ().

As the largest green macroalgal bloom in the Yellow Sea of China, the overgrowth and degradation of (. ) have a harmful effect on marine organisms and the aquaculture industry. However, the regulation mechanism of stress on the antioxidant capacity and inflammatory response of marine fish is still not completely understood.

Pudilan Keyanning mouthwash inhibits dextran-dependent aggregation and biofilm organization of Streptococcus mutans.

Aims: This research aimed to investigate the inhibitory effects of Pudilan mouthwash (PDL) on Streptococcus mutans (S. mutans) biofilms and identify its chemical components.

Methods And Results: The impacts of 100% concentrated PDL on S.

Mechanical behavior and reloading reinforcement characteristics of fractured coal under low confining pressure.

To study the basic mechanical behavior and the reloading reinforcement characteristics of fractured coal, conventional triaxial loading tests with different fissure angle were first carried out. On this basis, conventional triaxial loading and unloading tests were conducted to investigate the reloading reinforcement characteristics of fractured coal. The results reveal that when the fissure angle was small, the stress-strain curve exhibited the multi-peak phenomena.

Implementation of mind mapping with problem-based learning in prosthodontics course for Chinese dental students.

Background: The traditional Chinese dentistry classroom teaching model focuses on the instruction of knowledge details, but less on the frameworks and learners' motivation. Here, we introduced a combination of mind mapping and PBL instruction (MBL)into the prosthodontics course for Chinese dental students. This study aimed to evaluate the effectiveness and efficiency of MBL in prosthodontics and make observations from the students' perspectives, based on their response with the learning process.

Engineered Bio-Heterojunction with Infection-Primed H S Liberation for Boosted Angiogenesis and Infectious Cutaneous Regeneration.

Photodynamic therapy (PDT) acts as a powerful weapon against infectious diseases for its enormous antimicrobial activity that quickly elicits storms of reactive oxygen species (ROS). Nevertheless, redundant ROS during treatment inevitably bring detriments in revascularization. To address this dilemma, an innovative P-N bio-heterojunction (bio-HJ) material consisting of p-type copper sulfide (p-CuS), n-type bismuth sulfide (n-Bi S ), and lactate oxidase (LOx) for effective treatment of recalcitrant infectious wounds by promoting angiogenesis is devised.

An engineered dual-functional peptide with high affinity to demineralized dentin enhanced remineralization efficacy and .

Dental caries continues to be a major global public health problem. Remineralization of demineralized dentin is regarded as one of the hotspots in the current study in the treatment of dental caries. However, traditional remineralization agents, which usually lack the ability to bind to demineralized dentin collagen, are easily removed by the fluids in the oral cavity, thus decreasing the remineralization efficacy.

Spermine-starch nanoparticles with antisense suppress cariogenicity.

Dental caries of permanent teeth is a common public health concern and has the second-highest incidence among global diseases. The exopolysaccharides (EPS) synthesized by () are the principal virulence factor for cariogenic etiology. We previously discovered that an endogenous antisense RNA (AS) could significantly inhibit EPS synthesis in and reduce its cariogenicity.

Research on Temporal Patterns of Water-Rock Interaction in the Coal Mine Underground Reservoir Based on the Dynamic Simulation Test.

The temporal pattern of water-rock interaction is significant in predicting the ion concentration of the effluent in coal mine underground reservoirs. This study used the roof-caved rock samples and main incoming water (mine water and fissure water) of the Daliuta coal underground reservoir as the research object and designed four groups of dynamic simulation experiments of the water-rock interaction. Based on the main ion concentrations in the water sample at different reaction times, Q-type hierarchical cluster analysis (HCA) was used to classify the stages of water-rock interaction.

Effect of fissure angle on energy evolution and failure characteristics of fractured rock under uniaxial cyclic loading.

To study the influence of fissure angle on the rock damage process and energy evolution characteristics, uniaxial cyclic loading and unloading tests were conducted on fractured rock specimens with different prefabricated fissure angles. The stress-strain curves, mechanical properties, and failure characteristics were analyzed. Subsequently, the energy evolution characteristics and failure mechanisms were investigated.

A Chinese herb preparation, honokiol, inhibits Streptococcus mutans biofilm formation.

Objective: This study aimed to investigate the antibiofilm and anticariogenic effects of honokiol, a traditional Chinese medicine, on the cariogenic bacterium Streptococcus mutans (S. mutans).

Design: The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of honokiol on S.

Single-cell-resolution transcriptome map revealed novel genes involved in testicular germ cell progression and somatic cells specification in Chinese tongue sole with sex reversal.

Female-to-male sex reversals (pseudomales) are common in lower vertebrates and have been found in natural populations, which is a concern under rapid changes in environmental conditions. Pseudomales can exhibit altered spermatogenesis. However, the regulatory mechanisms underlying pseudomale spermatogenesis remain unclear.

High-quality Japanese flounder genome aids in identifying stress-related genes using gene coexpression network.

The Japanese flounder is one of the most economically important marine flatfish. However, due to the increased frequency of extreme weather events and high-density industrial farming, an increasing number of environmental stresses have become severe threats to the healthy development of the Japanese flounder culture industry. Herein, we produced a high-quality chromosome-scale Japanese flounder genome using PacBio Circular Consensus Sequencing technologies.

RNase III coding genes modulate the cross-kingdom biofilm of and .

constantly coexists with in plaque biofilms of early childhood caries (ECC). The progression of ECC can be influenced by the interactions between and through exopolysaccharides (EPS). Our previous studies have shown that , the gene encoding ribonuclease III (RNase III), is implicated in the cariogenicity of by regulating EPS metabolism.

Identification and Expression Pattern of Gene in Gonad of the Chinese Tongue Sole ().

As an RA-metabolizing enzyme, has a substantial impact on RA-signaling pathways. The gene from the Chinese tongue sole was cloned and identified in this investigation. The ORF was 1536 bp in length and encoded a 512 amino acid protein.

Enterococcus faecalis rnc gene modulates its susceptibility to disinfection agents: a novel approach against biofilm.

Background: Enterococcus faecalis (E. faecalis) plays an important role in the failure of root canal treatment and refractory periapical periodontitis. As an important virulence factor of E.

Effects of long-term sex steroid hormones (estradiol and testosterone)-supplemented feeds on the growth performance of Chinese tongue sole (Cynoglossus semilaevis).

The phenomenon of sexual size dimorphism (SSD), existing in mammals, birds, reptiles, spiders, amphibians, insects, and fishes, is generally related to feeding efficiency, energy allocation, sex steroids, and somatotropic and reproductive endocrine axes. Recently, positive and negative regulations of sex steroids have been reported on SSD in various species. Chinese tongue soles (Cynoglossus semilaevis) at 4 months were fed with 17β-estradiol (E2) and testosterone (T) supplemented feeds for 8 months to assess the effect of sex steroids on growth traits in different sexes.

A Dentin Biomimetic Remineralization Material with an Ability to Stabilize Collagen.

The integrity of collagen matrix structure is a prerequisite for effectively inducing biomimetic remineralization. Repeated low pH stimulation activates matrix metalloproteinases (MMPs) in dental caries. Activated MMPs cause the breakdown of collagen fibrils.

Dual-functional adhesive containing amorphous calcium phosphate nanoparticles and dimethylaminohexadecyl methacrylate promoted enamel remineralization in a biofilm-challenged environment.

Objective: The cariogenic biofilm on enamel, restoration, and bonding interface is closely related to dental caries and composite restoration failure. Enamel remineralization at adhesive interface is conducive to protecting bonding interface and inhibiting secondary caries. This study intended to assess the remineralization efficiency of adhesive with dimethylaminohexadecyl methacrylate (DMAHDM) and nanoparticles of amorphous calcium phosphate (NACP) on initial caries lesion of biofilm-coated enamel.

Science Popularization Education regarding Oral Health-General Health for Nonmedical Undergraduates Applying a SPOC Teaching Model.

Objective: To see how effective a blended teaching model based on a small private online course (SPOC) is in a science popularization education course on oral health-general health (OHGH).

Methods: The SPOC blended teaching model was created using an elective classroom course "Oral Prophylaxis and Hygiene" in conjunction with an online learning course called "Preventive Dentistry" from the China University massive open online course (MOOC) for the science popularization education on OHGH. Students' evaluations and teaching efficacy of this science popularization education course were tested using pre- and postcourse questionnaires.