Publications by authors named "Yang Yao"

Article Synopsis
  • * These proteins undergo various posttranslational modifications that can change their roles in cancer-related processes and promote tumor progression.
  • * The review focuses on the molecular characteristics and functions of DDX5/DDX17, their involvement in cancer, and their potential as targets for cancer treatment.*
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Cathodic corrosion represents an enigmatic electrochemical process in which metallic electrodes corrode under sufficiently reducing potentials. Although discovered by Fritz Haber in the 19th century, only recently has progress been made in beginning to understand the atomistic mechanisms of corroding bulk electrodes. The creation of nanoparticles as the end-product of the corrosion process suggests an additional length scale of complexity.

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  • Two water-extractable polysaccharide fractions from chickpea seeds, named CWP and CWP-0.2, were isolated and characterized, showing different chemical compositions and structures.
  • CWP contains mannose (Man) and glucose (Glc) in a 44.6:55.4 ratio, while CWP-0.2 consists of rhamnose (Rha), arabinose (Ara), Man, Glc, and galactose (Gal) in a different ratio.
  • Both polysaccharides displayed antioxidant and immunoregulatory properties, but CWP-0.2 showed significantly greater bioactivity in stimulating immune responses.
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The design of engineered living materials (ELMs) is an emerging field developed from synthetic biology and materials science principles. ELMs are multi-scale bulk materials that combine the properties of self-healing and organism adaptability with the designed physicochemical or mechanical properties for functional applications in various fields, including therapy, electronics, and architecture. Among the many ELM design and manufacturing methods, three-dimensional (3D) bioprinting stands out for its precise control over the structure of the fabricated constructs and the spatial distribution of cells.

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Poor vascularization was demonstrated as a factor inhibiting bone regeneration in patients receiving radiotherapy. Various copper-containing materials have been reported to increase angiogenesis, therefore might improve bone formation. In this study, a Ti6Al4V-1.

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Purpose: To present our experience with retractorless surgery for resection of petroclival meningiomas (PCMs) via the subtemporal approach with routine operative instruments.

Methods: Clinical data of patients with PCMs who received surgical treatments via subtemporal approach were retrospectively analyzed. Patient demographics, duration of operation, extent of resection, postoperative brain injury rate, postoperative complication, and surgical outcome were reviewed.

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Liquid biopsy has advantages over traditional biopsy, which cannot determine tumor dynamics. As a noninvasive and precise test, liquid biopsy detects biomarkers that carry information on tumor progression and has undergone tremendous development in recent years. Exosome detection is one of the methods of liquid biopsy.

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New drugs or active leads with high efficiency and low toxicity are needed in the treatment of lung cancer. Natural products are an important source of anti-tumor drugs. At present, there are many molecular-targeted anti-tumor drugs derived from natural products or their derivatives for tumor treatment or in clinical trials.

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Ocular alkali burn (OAB) is a sight-threatening disease with refractory ocular inflammation causing various blinding complications. Th17 lymphocytes account for the pathogeneses of the autoimmune disease and chronic inflammation, but their role in prolonged anterior intraocular inflammation after OAB is still unknown. A rat OAB model was established for this purpose.

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Purpose: To analyze the clinical characteristics of trauma-dominant orbital cellulitis (OC) and evaluate the risk factors associated with evisceration.

Methods: This retrospective study included inpatients diagnosed with orbital cellulitis at the Zhongshan Ophthalmic Center between January 2010 and December 2020. The demographic features, etiology, clinical characteristics, microbiological isolates, and risk factors associated with evisceration were analyzed.

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Coronavirus disease 2019 (COVID-19), which is known to be caused by the virus severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is characterized by pneumonia, cytokine storms, and lymphopenia. Patients with malignant tumors may be particularly vulnerable to SARS-CoV-2 infection and possibly more susceptible to severe complications due to immunosuppression. Recent studies have found that CD209 (DC-SIGN) might be a potential binding receptor for SARS-CoV-2 in addition to the well-known receptor ACE2.

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Rosmarinic acid (RA) is a natural polyphenol with various biological activities, such as anti-oxidative, anti-fibrotic, and hepatoprotective properties. The objective of this study was to investigate the protective effect of RA against acetaminophen (APAP)-induced hepatotoxicity (AILI) and explore the underlying mechanisms. Kunming mice were treated with RA (20, 40, or 80 mg/kg, i.

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Background: At present, bronchoscopic intervention has become an important treatment approach for central airway obstruction (CAO). Choosing an appropriate access channel for different patients during this operation has become a research focus.

Methods: Data of bronchoscopic interventions in 201 patients with CAO in which one of endotracheal intubation, laryngeal mask, or rigid bronchoscope were used as the only access channel were retrospectively reviewed.

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Objective: Anlotinib, a novel multitarget kinase inhibitor of VEGFR, FGFR, PDGFR and c-Kit, has proven to be effective and safe for refractory soft tissue sarcoma patients, but has not been examined in recurrent or metastatic primary malignant bone tumors in a clinical trial setting.

Methods: This is a multicenter single-arm trial. Patients with pathologically proven recurrent or metastatic primary malignant bone tumors were eligible.

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Adjusting land use is a practical way to protect the ecosystem, but protecting water resources by optimizing land use is indirect and complex. The vegetation, soil, and rock affected by land use are important components of forming the water cycle and obtaining clean water sources. The focus of this study is to discuss how to optimize the demands and spatial patterns of different land use types to strengthen ecological and water resources protection more effectively.

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Background: Soft tissue sarcomas (STSs) are rare tumors and occur at any site in the body. Our goal was to identify a putative molecular mechanism for N6-methyladenosine (m6A) lncRNA alteration and to develop predictive biomarkers for sarcoma.

Methods: The lncRNA levels were obtained from TCGA datasets.

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Objective: Preterm birth is the leading cause of morbidity and mortality involving over 10% of infants. Tools for timely diagnosis of preterm birth are lacking and the underlying physiological mechanisms are unclear. The aim of the present study is to improve early assessment of pregnancy progression by combining and optimizing a large number of electrohysterography (EHG) features with a dedicated machine learning framework.

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Article Synopsis
  • * The study identified four dsRNase genes and found they are highly expressed in the midgut and older larvae, suggesting their involvement in RNAi efficiency.
  • * An effective delivery method for RNAi was developed using dsRNA encapsulated in liposomes, which reduced the degradation of dsRNA in both the midgut and hemolymph, indicating a promising strategy for improved RNAi applications.
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  • * A new spectral fractal dimension index (SFDI) was developed to enhance prediction accuracy by analyzing specific wavelengths in the hyperspectral range of 420 to 950 nm, revealing a strong correlation with SPAD values.
  • * Machine learning methods, particularly support vector regression combined with SFDI, proved most effective, achieving high performance metrics which suggest potential for improved monitoring of plant health in agricultural settings.
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Understanding the chemical environment and interparticle dynamics of nanoparticle electrocatalysts under operating conditions offers valuable insights into tuning their activity and selectivity. This is particularly important to the design of Cu nanocatalysts for CO electroreduction due to their dynamic nature under bias. Here, we have developed electrochemical resonant soft X-ray scattering (EC-RSoXS) to probe the chemical identity of active sites during the dynamic structural transformation of Cu nanoparticle (NP) ensembles through 1 μm thick electrolyte.

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NiFe alloys are among the most promising electrocatalysts for oxygen evolution reaction (OER). However, a comprehensive study is yet to be done to reveal the surface structure-performance relationship of NiFe alloys. In particular, the role of the ultrathin surface oxide layer, which is unavoidable for pure NiFe alloys, is always neglected.

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This study aimed to compare the short-term clinical efficacy between prior and traditional approach of Henle trunk in laparoscopic right hemicolectomy (LRH) for right colon cancer. A total of 161 patients underwent LRH for right colon cancer between June 2018 and December 2020 by the same group of physicians. The prior approach of Henle trunk (priority group) was used in 82 patients and traditional approach in 79 (traditional group).

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A label-free electrochemical impedimetric biosensor was constructed based on gold carbon dots (GCDs) modified screen-printed carbon electrode for the detection of genetic modified (GM) soybean. The structure and property of GCDs were investigated. The GCDs can directly bind to single-stranded DNA probes through Au-thiol interaction and boost electric conductivity for the DNA sensor construction.

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Research on the biological role of exosomes is rapidly developing, and recent evidence suggests that exosomal effects involve ferroptosis. Exosomes derived from different tissues inhibit ferroptosis, which increases tumour cell chemoresistance. Therefore, exosome-mediated regulation of ferroptosis may be leveraged to design anticancer drugs.

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