Metal Doping Enabling Defective CoMo-Layered Double Hydroxide Nanosheets as Highly Efficient Photosensitizers for NIR-II Photodynamic Cancer Therapy.

Photodynamic therapy (PDT) is attracting widespread attention as a promising strategy for tumor treatment. However, the efficacy of PDT is severely limited by the insufficient tissue penetration depth of the light source and low reactive oxygen species (ROS) generation efficiency. Herein, the metal doping strategy is reported to construct a series of defect-rich M-doped amorphous CoMo-layered double hydroxide (a-M-CoMo-LDH, M = Mn, Cu, Al, Ni, Mg, Zn) photosensitizers (PSs) for NIR-II PDT.

Thickness-dependent surface reconstructions in non-van der Waals two-dimensional materials.

Bismuth oxychalcogenides (BiOX, X = S, Se, Te), a family of non-van der Waals (non-vdW) two-dimensional (2D) semiconductors, are attracting significant attention due to their outstanding semiconducting properties and huge potential in various applications of electronic and optoelectronic devices. Surface imperfections (, surface vacancies) and surface reconstructions are more likely to appear and may cause intriguing physical properties and novel phenomena in the non-vdW 2D materials than the vdW cases. Here, we explore the impacts of surface vacancies and surface reconstructions on the properties of the surfaces and 2D structures of BiOX by using the first-principles method.

Design and synthesis of piperine-based photoaffinity probes for revealing potential targets of piperine in neurological disease.

Piperine (PIP) has attracted extensive attention due to its diverse biological activities. In this study, we developed two photoaffinity probes PIP-1 and PIP-2, which are biologically safe and retain PIP's bioactivity, to investigate its protein targets . Using labeling and cell imaging, we were able to effectively detect and visualize the drug targets of PIP with our probes.

Adenocarcinoma of the rete testis: clinicopathological study of 18 cases with emphasis on MET amplification and a review of the literature.

Background: Knowledge regarding adenocarcinoma of the rete testis (ACRT) is extremely limited due to its scarcity.

Methods And Results: This study enrolled 18 patients with ACRT from multiple institutions. Clinicopathological and immunohistochemical features were investigated, together with a comprehensive review of 95 previously reported cases.

Comparing 1-L and 2-L Polyethylene Glycol with Ascorbic Acid for Small Bowel Capsule Endoscopy: A Randomized Controlled Trial.

Background/aims: Small bowel capsule endoscopy (SBCE) has become the standard for initial evaluation in the diagnosis of small bowel lesions. Although optimal visualization of the mucosa is important, patients experience difficulty in consuming a large volume of bowel preparation agents. This study aimed to compare the efficacy and safety of 1-L polyethylene glycol (PEG) with ascorbic acid (AA) and 2-L PEG with AA.

[Comprehensive Assessment of the Health Risk of Cadmium Exposure from Soil-wheat System in Wheat Fields in Northern China].

Accurately assessing the health risks of cadmium （Cd） exposure in the soil-wheat system is of great importance for the formulation of regional health risk prevention measures. Based on regional large-scale survey and Monte Carlo simulation methods, a case study on the health risk of Cd exposure in a soil-wheat system in a wheat production area of North China Plain was conducted by constructing a comprehensive health risk assessment （CHRA） model. The results showed that 73% of the soil samples in the study area exceeded the screening value of Cd for farmland soil （GB 15618-2018） and 57.

[Land Use Change and Ecosystem Service Value Measurement in the Peak Cluster Depression Basin in Southwest Guangxi Under Simulated Multiple Scenarios].

Simulating the changes in ecosystem service value induced by land use changes in the peak cluster depression basin of southwestern Guangxi under multiple scenarios is of great importance for ensuring ecological security in the basin and enhancing regional ecosystem service value capabilities. Based on the CA-Logistic-Markov model, the land use of the study area was simulated under natural development, food security, and ecological protection scenarios in 2030. The ecosystem service value was calculated under each scenario using the equivalent factor correction model, and the spatiotemporal dynamic characteristics of the ecosystem service value in the peak cluster depression basin of southwestern Guangxi were quantitatively analyzed.

Clinical evaluation of SonicFill bulk resin technique in the restoration of proximal deep caries of primary molars: a two-year randomized controlled trial.

Background/purpose: Traditional restorative composites require time-consuming incremental layering techniques which poses challenges in pediatric dentistry. SonicFill bulk resin allows for thicker layers to be placed efficiently, reducing treatment time and enhancing filling quality. This prospective, parallel, randomized, controlled clinical study aimed to compare the operative time and outcomes between SonicFill bulk resin and conventional restorative composite for deep proximal restorations in primary molars.

Novel candidate plasma proteins for the pathogenesis and treatment of atopic dermatitis revealed by proteome-wide association study.

Atopic dermatitis (AD) is an immune-related skin disease with a genetic background. Numerous loci have been identified associated with AD to better comprehend its complicated genetic mechanisms by genome‑wide association studies (GWASs). However, current studies reveal the underlying mechanisms of these loci in the pathogenesis of AD inadequately.

Thermal-responsive activation of engineered bacteria to trigger antitumor immunity post microwave ablation therapy.

Incomplete tumor removal after microwave ablation (MWA), a widely used hyperthermia-based therapy, can result in tumor recurrence. Herein, attenuated Salmonella typhimurium VNP20009 is engineered to release interleukin-15&interleukin-15-receptor-alpha (IL-15&IL-15Rα) in response to mildly elevated temperature. Such 15&15R@VNP colonizes in tumors upon intravenous injection, and the expression of IL-15&IL-15Rα is triggered by MWA.

Efficacy and safety of minocycline in retinitis pigmentosa: a prospective, open-label, single-arm trial.

Retinitis pigmentosa (RP) is characterized by progressive photoreceptor cells death accelerated by the proliferation and activation of microglia pathologically. No consensus exists on the treatment. Minocycline is recognized as a microglia inhibitor with great anti-inflammatory and neuro-protective functions.

Colchicine to prevent cardiovascular death after an acute myocardial infarction.

Background: Clinical and experimental evidence have demonstrated the protective benefits of colchicine in acute myocardial infarction (AMI) through its potential anti-inflammatory effect. However, investigations on the Asian population are limited.

Methods: This retrospective longitudinal cohort study used electronic medical records from a tertiary medical center in Taiwan.

Large Band Splitting in g-Wave Altermagnet CrSb.

Altermagnetism (AM), a newly discovered magnetic state, ingeniously integrates the properties of ferromagnetism and antiferromagnetism, representing a significant breakthrough in the field of magnetic materials. Despite experimental verification of some typical AM materials, such as MnTe and MnTe_{2}, the pursuit of AM materials that feature larger spin splitting and higher transition temperature is still essential. Here, our research focuses on CrSb, which possesses Néel temperature of up to 700 K and giant spin splitting near the Fermi level (E_{F}).

Pectin/caffeic acid nanoparticles in a poloxamer thermosensitive gel for the treatment of ulcerative colitis by inhibiting cGAS-STING pathway.

Ulcerative colitis is a recurring condition that causes inflammation and sores in the digestive system. Current clinical treatments for ulcerative colitis have limitations due to side effects and poor patient compliance. This study investigates the therapeutic potential of a novel drug delivery system, CA-Gel, which comprises caffeic acid (CA) stabilized by pectin nanoparticles within a poloxamer thermosensitive gel for rectal administration.

Effect of exogenous IBA on root morphology and endogenous hormone Metabolic pathways in castor seedlings under Pb/Zn stress.

Ricinus communis, a plant of significant industrial value for its oil, is renowned for its robust root system and vigorous growth, qualities that render it an exemplary candidate for the ecological remediation of soils contaminated with heavy metals. The impact of heavy metal stress on root development is characterized by inhibition, a phenomenon whose underlying mechanisms are not fully elucidated. To shed light on this, a study was conducted wherein varying concentrations of the exogenous auxin, IBA, were applied to the roots of Ricinus communis to scrutinize its influence on the endogenous indole-3-acetic acid (IAA) metabolism in seedlings and to delineate the molecular underpinnings of its effects on root morphology.

Ramifloraolides A - D, four highly oxygenated picrotoxane-type sesquiterpenoids from the stems of Baccaurea ramiflora and their antithrombotic activity.

A phytochemical investigation of the ethanol extract from air-dried stems of Baccaurea ramiflora led to the isolation of four highly oxygenated picrotoxane-type sesquiterpenoids, ramifloraolides A - D (1-4). Their structures were elucidated by comprehensive spectroscopic data (HRESIMS, IR, 1D, and 2D NMR), and their absolute configuration of them were unambiguously determined by single-crystal X-ray diffraction. Structurally, all compounds possess a unique [4.

A chiral porous organic cage-modified restricted-access material achieves online analysis of serum samples containing enantiomers and positional isomers.

Restricted-access materials (RAMs) allow biological samples to directly enter the chromatographic column for analysis owing to the steric exclusion function ability for biomolecules and extraction function for small-molecule analytes, which promoting the development of rapid, efficient, and automated in vivo drug analysis. Few reports on chiral RAMs that have been used to analyze enantiomers and positional isomers in serum by direct injection in currently. In this study, a chiral porous organic cage material RCC3 was innovatively introduced into the inner surface of silica gel and modified the outer surface with polyethylene glycol to prepare a novel type of chiral RAM-RCC3, and reported the use of chiral RAM-RCC3 as a stationary phase for the separation of chiral compounds and positional isomers in blank serum using high-performance liquid chromatography.

Polypeptide-Folded Artificial Ferroprotein Promotes Ferroptosis in Multiple Tumor Cells.

Although the current nanozymes, such as FeO nanoparticles, exhibit biocatalytic activities, they dramatically differ from natural enzymes, lacking a degradable organic framework and an intrinsically flexible structure. Single-chain folding of a synthetic polypeptide by metal coordination can mimic metalloproteins more similarly. A triblock PEG-polypeptide copolymer, poly(ethylene glycol)--poly(but-3-yn-1-yl glutamate)--poly(-butyl glutamate) [EG(Glu-yne)(Glu-tBu)], was synthesized by NCA polymerization.

Comparison of Different Diagnostic Criteria of 68Ga-Pentixafor PET/CT for the Classification of Primary Aldosteronism.

Context: 68Ga-Pentixafor positron emission tomography/computed tomography (PET/CT) is an emerging method for the classification diagnosis primary aldosteronism (PA). However, the diagnosis criteria are still controversial.

Objective: To compare the accuracy of different criteria of 68Ga-Pentixafor PET/CT in the classification diagnosis of PA.

Determination of QLNC-3A6 in canine plasma by UHPLC-MS/MS and its application in pharmacokinetic studies.

Multi-targeted tyrosine kinase inhibitor QLNC-3A6 Di-maleate, a structurally novel small molecule compound, has therapeutic efficacy for the treatment of canine cutaneous mast cell tumor (CMCT) caused by mutations in the c-Kit gene. Since pharmacokinetic (PK) information plays an important role in the development and application of new drugs, etc., a rapid, highly sensitive and selective UHPLC-MS/MS analytical method was developed and validated for the first time in this study for the quantitative detection of QLNC-3A6 in canine plasma.