Efficacy of ticagrelor and clopidogrel in treating unstable angina and their effects on serum inflammatory factors.

To evaluate the comparative efficacy of Ticagrelor and Clopidogrel in treating patients with coronary heart disease and unstable angina, as well as their effects on serum inflammatory factors, thereby providing a solid foundation for future clinical diagnosis and treatment. The frequency of angina attacks in the Ticagrelor group was lower than in the Clopidogrel group (P<0.05).

Atomically Dispersed Co/Mo Sites Anchored on Mesoporous Carbon Hollow Spheres for Highly Selective Oxygen Reduction to Hydrogen Peroxide in Acidic Media.

Two-electron oxygen reduction reaction (2e ORR) in acidic media is a promising route for the decentralized and on-site hydrogen peroxide (HO) generation. Nevertheless, strong interaction between active sites and OOH intermediates usually induces the O─O bond cleavage to convert 2e pathway into the sluggish 4e ORR. Therefore, it is highly necessary to optimize the electronic structure of 2e ORR electrocatalysts for the regulation of adsorption energy.

Simultaneous Verification of Genuine Multipartite Nonlocality and Full Network Nonlocality.

Genuine multipartite nonlocality and nonlocality arising in networks composed of several independent sources have been investigated separately. While some genuinely entangled states cannot be verified by violating a single Bell-type inequality, a quantum network consisting of different sources enables the certification of the nonclassicality of all sources. In this Letter, we propose the first method to verify both types of nonlocality simultaneously in a single experiment.

Lung Adenocarcinoma With Initially Co-Occurring EGFR and BRAF Double Mutation: A Case Report and Literature Review.

Vrafmurine sarcoma viral oncogene homolog B (BRAF) mutations, including both V600E and non-V600E variants, are infrequent in non-small cell lung cancer (NSCLC), representing approximately 2% of lung adenocarcinomas. Activated BRAF mutations are regarded as an underappreciated oncogenic driver in NSCLC, typically occurring in a mutually exclusive manner with epidermal growth factor receptor (EGFR) mutations, as well as ALK and ROS1 rearrangements. In recent years, advancements in multiple-gene panel testing have demonstrated that EGFR mutations and BRAF mutations can coexist.

Isolation and Functional Characterization of the MADS-Box Gene in Rubber Dandelion ( Rodin).

Rubber dandelion ( Rodin, TKS), also referred to as Russian dandelion, is one of the most promising natural rubber (NR)-producing plants that produce high-quality NR comparable to that from the Pará rubber tree (, Hb), currently the only commercial source. It needs further breeding to improve the agricultural traits. However, little has been known about the genetic mechanisms underlying the regulation of floral induction and flower development in TKS, an important trait that remains to be improved for commercial production.

Co-decoding dynamics in volatiles and sensory profiles of Zhaiji millet vinegar during aging by integrating multiple flavor characterization techniques and chemometrics.

Zhaiji millet vinegar (ZJMV) is a signature acidic condiment. To investigate the effect of aging on the flavor of ZJMV, here gas chromatography-mass spectrometry (GC-MS), gas chromatography-ion mobility spectrometry (GC-IMS), electronic nose, electronic tongue, and quantitative descriptive analysis were used to characterize the flavor profiles of ZJMV for five aging years (2 to 10 years). GS-MS and GC-IMS identified 84 and 44 volatile organic compounds (VOCs), with the most abundant alcohols and esters (p < 0.

High-Throughput Proteoform Imaging for Revealing Spatial-Resolved Changes in Brain Tissues Associated with Alzheimer's Disease.

Spatially resolved characterization of proteoforms has substantial potential to significantly advance the understanding of physiological and disease mechanisms. However, challenges remain regarding throughput and coverage. A robust method is developed for high-throughput proteoform imaging (HTPi) by combining matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI MSI) and region-specific top-down proteomic analysis.

Mobility Control of Mechanical Bonds to Modulate Energy Dissipation in Mechanically Interlocked Networks.

Mechanically interlocked networks (MINs) with dense mechanical bonds can amplify the dynamic behaviors of the mechanical bonds to exhibit decent mechanical properties. Energy dissipation resulting from mechanical bond motion is essential for improving toughness, yet effective strategies to optimize this process remain underexplored. Here, by designing mechanical bond models with controllable mobility, we establish a fortification strategy for the two key factors governing energy dissipation, host-guest recognition and sliding friction, thereby enabling mechanical property enhancement of mechanically interlocked materials.

BATF participates in airway inflammation of neutrophilic asthma via regulating Th17 cells activation.

Neutrophilic asthma (NA) is a common subtype of non-eosinophilic asthma, characterized by the infiltration of neutrophils. Basic leucine zipper transcription factor ATF-like (BATF) is the nuclear transcription factor that initiates lymphocyte differentiation. The mechanism by which BATF affects T cell differentiation leading to neutrophil accumulation in NA lung tissue remains unclear.

Correlation Between the Quality of Life of Stroke Caregivers and the Readiness of Patients and Caregivers for Hospital Discharge.

Objective: This study aimed to evaluate the quality of life of stroke caregivers and analyze its association with the discharge readiness of both caregivers and patients.

Methods: A total of 302 stroke patients and their primary caregivers were recruited from the neurology departments of three hospitals affiliated with Chengdu Medical College using a convenience sampling method. Sociodemographic data, the WHO Quality of Life Scale (WHOQOL-BREF), the Caregiver Preparedness Scale (CPS), and the Readiness for Hospital Discharge Scale (RHDS) were used.

The Adhesion GPCR ADGRL2 engages Ga13 to Enable Epidermal Differentiation.

Homeostasis relies on signaling networks controlled by cell membrane receptors. Although G-protein-coupled receptors (GPCRs) are the largest family of transmembrane receptors, their specific roles in the epidermis are not fully understood. Dual CRISPR-Flow and single cell Perturb-seq knockout screens of all epidermal GPCRs were thus performed, uncovering an essential requirement for adhesion GPCR ADGRL2 (latrophilin 2) in epidermal differentiation.

Molecular basis of β-arrestin coupling to the metabotropic glutamate receptor mGlu3.

β-Arrestins (βarrs) mediate the desensitization and internalization of activated G-protein-coupled receptors (GPCRs). The molecular mechanism by which dimeric family C GPCR members recruit arrestins remains elusive. Here we report two structures of metabotropic glutamate receptor subtype 3 (mGlu3) coupled to βarr1, with stoichiometries of 2:1 and 2:2.

Atmospheric chemistry of the coastal area is influenced by the convergence between the inland and marine air: Insight into carbonyl compounds.

Marine biological activity has long been recognized to impact the atmospheric chemistry of coastal areas. In this work, we monitored the seasonal variation of carbonyl compounds in the coastal city of Qingdao, located in the north of China's coastline and the south of Jiaodong Peninsula, with the vast hinterland in the west. The mean total concentration of the 15 carbonyls varied significantly between seasons, with the highest observed in autumn (10.

A specific model of resting-state functional brain network in MRI-negative temporal lobe epilepsy.

Purpose: Without any visible indicator on structure magnetic resonance imaging (MRI), the diagnosis of MRI-negative temporal lobe epilepsy (NTLE) gets harder. By considering healthy control (HC), a specific functional connectivity (FC) model was constructed in a network topology to improve FC computation to a high-level.

Methods: MRI data of 20 NTLE patients and 60 HC were pre-processed.

Ocular surface side effects of botulinum toxin type A injections in the treatment of lateral canthal wrinkles (Crow's Feet).

Purpose: This study investigates the impact of Botulinum Toxin Type A (BoNT-A) injections for lateral canthal wrinkles on the ocular surface.

Methods: A total of 30 patients (30 eyes) who received BoNT-A injections were followed over a three-month period. Evaluations included tear meniscus height (TMH), strip meniscometry test, fluorescein tear film break-up time (FTBUT), corneal staining score, meibomian gland orifice and meibum quality score.

Wholly-WOOD: Wholly Leveraging Diversified-quality Labels for Weakly-supervised Oriented Object Detection.

Accurately estimating the orientation of visual objects with compact rotated bounding boxes (RBoxes) has become a prominent demand, which challenges existing object detection paradigms that only use horizontal bounding boxes (HBoxes). To equip the detectors with orientation awareness, supervised regression/classification modules have been introduced at the high cost of rotation annotation. Meanwhile, some existing datasets with oriented objects are already annotated with horizontal boxes or even single points.

STAR: A First-Ever Dataset and A Large-Scale Benchmark for Scene Graph Generation in Large-Size Satellite Imagery.

Scene graph generation (SGG) in satellite imagery (SAI) benefits promoting understanding of geospatial scenarios from perception to cognition. In SAI, objects exhibit great variations in scales and aspect ratios, and there exist rich relationships between objects (even between spatially disjoint objects), which makes it attractive to holistically conduct SGG in large-size very-high-resolution (VHR) SAI. However, there lack such SGG datasets.

Transcatheter annuloplasty with the K-Clip system for tricuspid regurgitation: one-year results from the TriStar study.

Background: Despite the fact that morbidity and mortality rates significantly increase with tricuspid regurgitation (TR) severity, limited treatment options are available for treating severe TR.

Aims: The single-arm, multicentre, prospective Confirmatory Clinical Study of Treating Tricuspid Regurgitation With K-Clip TM Transcatheter Annuloplasty System (TriStar) evaluated the 1-year outcomes of the novel transcatheter K-Clip annuloplasty system in treating secondary TR.

Methods: Between May 2022 and October 2022, patients with ≥severe secondary TR despite optimal medical therapy at 11 centres in China were deemed candidates for transcatheter tricuspid repair by the local Heart Team and a multidisciplinary screening committee.

CD36 knockdown attenuates pressure overload-induced cardiac injury by preventing lipotoxicity and improving myocardial energy metabolism.

The heart predominantly derives its energy from fatty acid (FA) oxidation. However, the uncoupling of lipid uptake and FA oxidation can result in abnormal cardiac lipid accumulation and lipotoxicity, particularly in the context of heart failure. CD36 is a critical mediator of FA uptake in cardiac tissue.

CTCF is selectively required for maintaining chromatin accessibility and gene expression in human erythropoiesis.

Background: CTCF is considered as the most essential transcription factor regulating chromatin architecture and gene expression. However, genome-wide impact of CTCF on erythropoiesis has not been extensively investigated.

Results: Using a state-of-the-art human erythroid progenitor cell model (HUDEP-2 and HEL cell lines), we systematically investigate the effects of acute CTCF loss by an auxin-inducible degron system on transcriptional programs, chromatin accessibility, CTCF genome occupancy, and genome architecture.

Exosomes carrying adipose mesenchymal stem cells function alleviate scleroderma skin fibrosis by inhibiting the TGF-β1/Smad3 axis.

Systemic sclerosis (SSc) is a connective tissue disease characterized by progressive fibrosis of the skin and visceral organs, to date, skin fibrosis remains a clinical therapeutic challenge. Adipose-derived mesenchymal stem cells (AMSCs) have been considered extremely promising for the treatment of SSc, and the biological effects of MSCs are partly attributed to the secretion of exosomes (exos). Our aim was to determine whether exosomes derived from AMSCs have parental biological effects to AMSCs in the therapy of SSc skin fibrosis.

A Nomogram for Predicting the Transition From Recurrent Acute Pancreatitis to Chronic Pancreatitis.

Objectives: Acute pancreatitis, recurrent acute pancreatitis, and chronic pancreatitis are recognized as a continuum of pancreatic diseases. Recurrence increases the risk of progression to chronic pancreatitis. The aim of this study was to search for clinical features that may promote the progression of chronic pancreatitis in patients with recurrent acute pancreatitis.

The International Work Addiction Scale (IWAS): A screening tool for clinical and organizational applications validated in 85 cultures from six continents.

Background And Aims: Despite the last decade's significant development in the scientific study of work addiction/workaholism, this area of research is still facing a fundamental challenge, namely the need for a valid and reliable measurement tool that shows cross-cultural invariance and, as such, allows for worldwide studies on this phenomenon.

Methods: An initial 16-item questionnaire, developed within an addiction framework, was administered alongside job stress, job satisfaction, and self-esteem measures in a total sample of 31,352 employees from six continents and 85 cultures (63.5% females, mean age of 39.

Triethyl methyl ammonium ionic liquid as an effective electrolyte additive for high-performance zinc-iodine batteries.

An ionic liquid (IL)-based electrolyte using a quaternary ammonium IL (triethyl methyl ammonium chloride (NCl)) as an additive is proposed to effectively inhibit the growth of zinc (Zn) dendrites and the shuttling effect of I ions, which significantly improves the cycle life of Zn-iodine (I) batteries (ZIBs).