Modulation of TNFR 1-Triggered Inflammation and Apoptosis Signals by Jacaranone in Cancer Cells.

Jacaranone derived from , a traditional Chinese medicine used for centuries, has been documented to exhibit anti-inflammatory and antiproliferative properties in various tumor cell lines. However, the mechanism of action and relationship between inflammation and apoptosis induced by jacaranone remain inadequately elucidated. In this study, the targets of jacaranone and cancer were identified from various databases, while potential targets and pathways were predicted through the analysis of the protein-protein interactions (PPI) network and pathway enrichment.

Keratin 16 spatially inhibits type I interferon responses in stressed skin.

The stress-induced keratin intermediate filament gene/protein (K16) is spatially restricted to the suprabasal compartment of the epidermis and extensively used as a biomarker for psoriasis, hidradenitis suppurativa, atopic dermatitis and other inflammatory disorders. However, its role in these conditions remains poorly defined. Here we show that K16 negatively regulates type-I interferon (IFN) signaling and innate immune responses.

Efficacy and safety of chimeric antigen receptor T cells targeting BCMA and GPRC5D in relapsed or refractory multiple myeloma.

Background: Clinical studies have demonstrated the high efficacy of using chimeric antigen receptor (CAR)-T cells targeting B-cell maturation antigen (BCMA) and orphan G protein-coupled receptor, class C group 5 member D (GPRC5D) to treat relapsed or refractory multiple myeloma (RRMM). In this study, we compared the efficacy and safety of BCMA CAR-T-cell therapy (BCMA CAR-T) and GPRC5D CAR T-cell therapy (GPRC5D CAR-T) in patients with RRMM.

Methods: We retrieved and included eligible clinical trials of BCMA or GPRC5D CAR-T for RRMM patients.

A Wireless Health Monitoring System Accomplishing Bimodal Decoupling Based on an "IS"-Shaped Multifunctional Conductive Hydrogel.

Flexible wearable sensors with bimodal functionality offer substantial value for human health monitoring, as relying on a single indicator is insufficient for capturing comprehensive physiological information. However, bimodal sensors face multiple challenges in practical applications, including mutual interference between various modalities, and integration of excellent mechanical properties, interfacial adhesion, environmental adaptability and biocompatibility. Herein, the multifunctional hydrogel, synthesized through radical grafting and supramolecular self-crosslinking reactions, exhibits excellent thermal sensitivity (TCR = -1.

Preparation of Inorganic-Organic Hybrid Flocculant Silicon Dioxide-Chitosan-Dimethyl Diallyl Ammonium Chloride for the Treatment of Papermaking Wastewater.

In order to solve the shortcomings of a single flocculant, the inorganic-organic hybrid flocculant SiO-CTS-DMDACC was successfully prepared by grafting copolymerization of chitosan (CTS), dimethyl diallyl ammonium chloride (DMDACC), and silicon dioxide (SiO). The performance of SiO-CTS-DMDACC in treating papermaking wastewater was investigated, and the mechanism of the flocculation process was analyzed. The results showed that the crystallinity of chitosan was reduced due to the introduction of DMDACC and SiO.

Heparin rebound in patients undergoing off-pump coronary artery bypass grafting surgery: a single-center retrospective study.

Background: Heparin, an anticoagulant used in cardiac surgery, can result in heparin rebound (HR), where it returns postoperatively despite being neutralized with protamine. This study was designed to investigate the prevalence of HR in patients undergoing off-pump coronary artery bypass grafting (OPCAB) and evaluate the impact of HR on their short-term outcomes.

Methods: HR was defined by a 10% increase in activated coagulation time (ACT) following two hours of heparin neutralization with protamine, bleeding over 200 mL/h, and abnormal laboratory coagulation examination results.

Integrated HPLC, pharmacodynamics, and immunoprofiling to explore active components and mechanism of Zhi Bai Heye Fang on glycolipid metabolic disorders in mice.

Zhi Bai Heye Fang (AR-PCC-NF) exerts a positive effect on glycolipid metabolic disorders in the clinical setting; however, its efficacy components and mechanisms of action remain unclear. Glycolipid metabolic disorders in mice were used to evaluate the therapeutic effects of AR-PCC-NF and its individual components, and the chemical components of AR-PCC-NF were detected by HPLC. An insulin-resistant cell model was then treated with 12 biological components in vitro, and seven candidate active components were administered to mice with glycolipid metabolic disorders to investigate the efficacy and mechanism of AR-PCC-NF.

Risk analysis of cardiovascular toxicity in patients with lymphoma treated with CD19 CAR T cells.

Background: Anti-CD19 chimeric antigen receptor (CAR) T cell therapy is a common, yet highly efficient, cellular immunotherapy for lymphoma. However, many recent studies have reported on its cardiovascular (CV) toxicity. This study analyzes the cardiotoxicity of CD19 CAR T cell therapy in the treatment of lymphoma for providing a more valuable reference for clinicians.

A molecular toxicological study to explore potential health risks associated with ultrafine particle exposure in cold and humid indoor environments.

Environmental pollutants including ultrafine particulate matter (UFPs) and adverse meteorological conditions pose significant public health impacts, particularly affecting respiratory health. This study aims to elucidate the synergistic effects of cold-humid conditions and UFPs exposure on respiratory health, utilizing Carbon Black Nanoparticles (CB-NPs) as surrogates for UFPs. Through comprehensive lung function tests, histopathological examinations, and biomarker analyses, this research focuses on the modulation of oxidative stress signaling pathways and NF-κB activation.

Genetic identification of acetyl-CoA synthetases involved in acetate activation in .

Unlabelled: Acetate/acetyl-CoA interconversion is an interesting metabolic node, primarily catalyzed by a set of various enzymes in prokaryotes. is a promising haloarchaeaon, capable of utilizing acetate as a sole carbon source for biosynthesis of high value-added products. Here, we have reported the key enzymes that catalyzed acetate activation in .

Optical and Electrical Dual-Mode Detection of a Carcinogenic Substance Based on Synergy of Liquid Crystals and Ionic Liquids.

Visual, sensitive, and selective detection of carcinogenic substances is highly desired in portable health protection and practical medicine production. However, achieving this goal presents significant challenges with the traditional single-mode sensors reported so far, as they have limited sensing mechanisms and provide only a single output signal. Here, we report an effective optical and electrical dual-mode sensor for the visual, sensitive, and selective detection of -nitrosodiethylamine (NDEA), a typical volatile carcinogenic substance, leveraging the synergy of ionic liquid-doped liquid crystals (IL-LC).

A study on cognitive trajectory changes and predictive factors in middle-aged and older adults individuals with dual sensory impairment based on the health social determinants model.

Aim: This study aims to explore the cognitive trajectory changes in middle-aged and older adults individuals with dual sensory impairment (simultaneous visual and hearing impairment) and to identify the predictors of different trajectory changes.

Methods: Based on the longitudinal data from the China Health and Retirement Longitudinal Study (CHARLS) from 2013 to 2020, data from 2,369 middle-aged and older adults individuals with dual sensory impairment were selected. A latent variable growth mixture model was constructed to analyze the cognitive function development trajectories in this population and to identify their predictive factors.

Identification of lesion location and discrimination between benign and malignant findings in thyroid ultrasound imaging.

Thyroid nodules are a common thyroid disorder, and ultrasound imaging, as the primary diagnostic tool, is susceptible to variations based on the physician's experience, leading to misdiagnosis. This paper constructs an end-to-end thyroid nodule detection framework based on YOLOv8, enabling automatic detection and classification of nodules by extracting grayscale and elastic features from ultrasound images. First, an attention-weighted DCN is introduced to enhance superficial feature extraction and capture local information.

Chronic myelogenous leukemia coexpressing V-e16a2, V-e13a2, e13a2, and e14a2 fusion transcripts: a case report and review of the literature.

The coexistence of three or more transcripts in one patient with chronic myeloid leukemia (CML) is rarely reported. Thus, the disease progression and drug response are still unknown. This case report aimed to explore the drug response of CML with variant transcripts and to enrich the clinical treatment of rare types of CML.

Identification and validation of up-regulated TNFAIP6 in osteoarthritis with type 2 diabetes mellitus.

Lines of evidence have indicated that type 2 diabetes mellitus (T2DM) is an independent risk factor for osteoarthritis (OA) progression. However, the study focused on the relationship between T2DM and OA at the transcriptional level remains empty. We downloaded OA- and T2DM-related bulk RNA-sequencing and single-cell RNA sequencing data from the Gene Expression Omnibus (GEO) dataset.

Conductive polyacrylamide/pullulan/ammonium sulfate hydrogels with high toughness, low-hysteresis and tissue-like modulus as flexible strain sensors.

Conductive hydrogels have great potential for applications in flexible wearable sensors due to the combination of biocompatibility, mechanical flexibility and electrical conductivity. However, constructing conductive hydrogels with high toughness, low hysteresis and skin-like modulus simultaneously remains challenging. In the present study, we prepared a tough and conductive polyacrylamide/pullulan/ammonium sulfate hydrogel with a semi-interpenetrating network.

Identification of patients with unstable angina based on coronary CT angiography: the application of pericoronary adipose tissue radiomics.

Objective: To explore whether radiomics analysis of pericoronary adipose tissue (PCAT) captured by coronary computed tomography angiography (CCTA) could discriminate unstable angina (UA) from stable angina (SA).

Methods: In this single-center retrospective case-control study, coronary CT images and clinical data from 240 angina patients were collected and analyzed. Patients with unstable angina ( = 120) were well-matched with those having stable angina ( = 120).

Depression in middle-aged and older adults with hearing loss: the use and construction of a nomogram tool.

Objective: This study aims to explore the influencing factors of depressive symptoms in middle-aged and older adult patients with hearing loss and to construct a nomogram risk prediction model.

Methods: A total of 2,729 middle-aged and older adult patients with hearing loss from the community were selected as the study subjects. Single-factor and multifactorial stepwise logistic regression analyses were used to screen influencing factors.

Controllable reconstruction of lignified biomass with molecular scissors to form carbon frameworks for highly stable Li metal batteries.

Lithium metal batteries (LMBs) promise high-energy-density storage but face safety issues due to dendrite-induced lithium deposition, irreversible electrolyte consumption, and large volume changes, which hinder their practical applications. To address these issues, tuning lithium deposition by structuring a host for the lithium metal anode has been recognized as an efficient method. Herein, we report a supercritical water molecular scissor-controlled strategy to form a carbon framework derived from biomass wood.

Radiation-induced aerobic oxidation solvent-derived peroxyl radicals.

Oxidation is a fundamental transformation in synthesis. Developing facile and effective aerobic oxidation processes under ambient conditions is always in high demand. Benefiting from its high energy and good penetrability, ionizing radiation can readily produce various reactive species to trigger chemical reactions, offering another option for synthesis.

Low cross talk, low silicon optical switch based on highly balanced couplers and folded phase shifters.

The cross talk and power consumption of the 2 × 2 optical switch is a key metric in the design of large-scale photonic integrated circuits (PICs). We build a theoretical model of a 2 × 2 Mach-Zehnder interferometer (MZI) optical switch, taking into account both imbalances in the arm loss and the coupler splitting ratio. The splitting ratio imbalance requirement for a given switch cross talk is summarized, which provides a guideline for the switch design.

Genomic analysis, culturing optimization, and characterization of bacteriophage OSYSP, previously studied as effective pathogen control on fresh produce.

Advances in bacteriophage genome sequencing and regulatory approvals of some bacteriophages in various applications have renewed interest in these antibacterial viruses as a potential solution to persistent food safety challenges. Here, we analyzed in depth the genome of the previously studied bacteriophage OSYSP (phage OSYSP), revealed its application-related characteristics, and optimized its enumeration techniques for facilitating industrial implementation. We previously sequenced phage OSYSP genome completely by combining results from Illumina Miseq and Ion Torrent sequencing platforms and completing the remaining sequence gaps using PCR.

Long non-coding RNA fine-tunes bone homeostasis and repair by orchestrating cellular crosstalk and β-catenin-OPG/Jagged1 pathway.

The IncRNA was initially believed to be dispensable for physiology due to the lack of observable phenotypes in knockout (KO) mice. However, our study challenges this conclusion. We found that both KO and conditional KO mice in the osteoblast lineage exhibit significant osteoporosis.

Molecular Customization of Anode-Electrolyte Interfaces for Enhanced Stability and Reversibility in Aqueous Zinc-Carbon Capacitors.

Aqueous zinc-carbon capacitors display application potential in green power and high-end equipment owing to their high security, large power and sustainability. The water-rich zinc anode-electrolyte interface (AEI) and disordered zinc-ion diffusion are the culprits triggering corrosion reactions and dendrite growth, threatening the sustainability of aqueous zinc-carbon capacitors. Herein, a polyfunctional biomolecular, vitamin B6, is introduced into the traditional aqueous electrolyte for customizing the functional AEI and fine-regulating the interfacial coordination environment of zinc ions.

Self-Assembled Metal Complexes in Biomedical Research.

Cisplatin is widely used in clinical cancer treatment; however, its application is often hindered by severe side effects, particularly inherent or acquired resistance of target cells. To address these challenges, an effective strategy is to modify the metal core of the complex and introduce alternative coordination modes or valence states, leading to the development of a series of metal complexes, such as platinum (IV) prodrugs and cyclometalated complexes. Recent advances in nanotechnology have facilitated the development of multifunctional nanomaterials that can selectively deliver drugs to tumor cells, thereby overcoming the pharmacological limitations of metal-based drugs.