Publications by authors named "Yang Xinghui"

This case report presents a novel treatment approach for refractory purulent meningitis in a 1-month-old infant caused by penicillin-sensitive group B Streptococcus. Despite initial treatment with intravenous antibiotics, including penicillin and vancomycin, the infant experienced persistent symptoms and bilateral subdural effusions. Conventional therapies failed to resolve these issues, leading to the use of a new technique: subarachnoid puncture via the anterior fontanelle combined with intrathecal vancomycin administration.

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Article Synopsis
  • * An 8-year-old boy with macrolide-resistant pneumonia developed thrombosis in critical areas, including the pulmonary artery and larger veins, leading to abdominal pain and dangerous thrombi sizes.
  • * After standard anti-infection and anticoagulation treatments failed to alleviate his symptoms and manage the risk of thrombus detachment, the patient underwent specialized procedures that successfully improved his condition and prevented recurrence, underscoring the importance of early thrombosis recognition in pediatric cases.
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T-2 toxin, a fungal secondary metabolite produced by toxigenic species, poses a significant threat to grain food and feed due to its potential to cause intestinal inflammation in livestock and poultry. Macrophages play a crucial role as integral components of the body's immune system during intestinal inflammation. This study aimed to elucidate the mechanism behind the inflammatory response triggered by T-2 toxin in macrophages.

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Background: Takayasu arteritis (TA) is a chronic granulomatous vasculitis with unknown pathophysiology. TA with severe aortic obstruction has a poor prognosis. However, the efficacy of biologics and appropriate timing of surgical intervention remain controversial.

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Macrophage activation syndrome (MAS) and widespread brain lesions are rare and severe complications of childhood-onset systemic lupus erythematosus (SLE). We report an 11-year-old girl who presented with recurrent rashes for half a year and fever for 2 weeks. Clinical and laboratory features at admission pointed to the diagnosis of SLE and SLE-associated MAS.

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Rationale: Osteonecrosis (ON) is a devastating illness that leads to bone ischemia and potential joint destruction. Systemic lupus erythematosus (SLE) is a chronic, autoimmune disease, with multi-system involvement which is closely associated with occurrence of ON. Multifocal ON, with an estimated morbidity of 3% in SLE patients, is extremely rare in juvenile subjects.

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In July-December 2018, an outbreak of polio-like acute flaccid myelitis (AFM) occurred in Zhejiang province, China. Enterovirus (EV)-D68 infection has been reported to be associated with AFM. This study aimed to investigate the clinical presentation, laboratory findings, and outcomes of AFM patients.

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Background: Phalangeal microgeodic syndrome is an uncommon benign self-limiting condition that often occurs during cold weather. The etiology and the pathogenesis of the disease remain unclear.

Objective: To report a series of children with phalangeal microgeodic syndrome.

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  • * Inhibitors of DNMTs aim to reverse gene silencing of tumor suppressor genes, but existing options have faced challenges due to side effects.
  • * A new approach using RNA-cleaving DNAzymes specifically targeting DNMT1 has shown promise by successfully reducing DNMT1 levels, reactivating the p16 gene, and slowing down bladder cancer cell growth.
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Background: Pancreatoblastoma is a rare primary pancreatic neoplasm of children. The tumour may arise from any portion of the pancreas, but no tumour originating from ectopic pancreatic tissue has been reported in the English medical literature.

Objective: We report the radiological findings of pancreatoblastoma in four children, including one tumour originating from the mesentery, to our knowledge, reported for the first time.

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Endodermal sinus tumour usually arises in a gonad; extragonadal endodermal sinus tumours are rare. We report a 3-year-old boy with an endodermal sinus tumour arising in the greater omentum, which may be the second reported case in the English literature. He presented with a solid mass in the upper abdomen and a markedly raised serum alpha-fetoprotein (AFP) level.

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Fluorescence enhancement of anhydrotetracycline hydrochloride and iso-tetracycline has been described. The fluorescence intensities of anhydrotetracycline hydrochloride and iso-tetracycline with cetyltrimethylammonium bromide (CTMAB) enhanced by micellar solution have been examined. It is found that fluorescence enhancement of anhydrotetracycline hydrochloride and iso-tetracycline depends on the concentration of CTMAB and pH of the solution.

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