Molecular interactions of icariin and icariside II with human serum albumin: a spectroscopic and molecular docking analysis.

Icariin and icariside II are flavonoids derived from Epimedium Herba, which exhibit significant pharmacological potential across various diseases. However, limited research exists regarding their interaction with human serum albumin (HSA). Therefore, this study was conducted to investigate the binding characteristics of icariin and icariside II with HSA through ultraviolet-visible, fluorescence, and synchronous fluorescence spectroscopy, as well as molecular docking analysis.

Microfluidic magnetic droplet-based chemiluminescence enzyme immunoassay for multiplex sepsis biomarker screening.

Sepsis is a systemic inflammatory response syndrome caused by infection, requiring the joint detection of multiplex biomarkers for specific diagnosis. Here, we present a chemiluminescence enzyme immunoassay based on microfluidic magnetic droplets for multiplex sepsis biomarker screening. The droplet-based chemiluminescence enzyme immunoassay (CLIA) technology utilizes multicolor-encoded microspheres to distinguish biomarkers and mesoporous silica-loaded enzymes for signal amplification and catalytic fluorescent substrates.

Unraveling the Roles of UBE3A in Neurodevelopment and Neurodegeneration.

The ubiquitin-protein ligase E3A (UBE3A, aka E6-AP), an E3 ligase belonging to the HECT family, plays crucial roles in the stability of various proteins through the proteasomal degradation system. Abnormal UBE3A activity is essential for the initiation and progression of several cancers. A gain of function and an overdosage of maternal UBE3A is associated with an increased risk of autism spectrum disorders.

The contribution of coding variants to the heritability of multiple cancer types using UK Biobank whole-exome sequencing data.

Genome-wide association studies have been highly successful at identifying common variants associated with cancer; however, they do not explain all the inherited risks of cancer. Family-based studies, targeted sequencing, and, more recently, exome-wide association studies have identified rare coding variants in some genes associated with cancer risk, but the overall contribution of these variants to the heritability of cancer is less clear. Here, we describe a method to estimate the genome-wide contribution of rare coding variants to heritability that fits models to the burden effect sizes using an empirical Bayesian approach.

LncRNA-DANCR Promotes ESCC Progression and Function as ceRNA to Regulate DDIT3 Expression by Sponging microRNA-3193.

Long non-coding RNAs (lncRNAs) have emerged as crucial regulators of cancer development and progression. Among them, Differentiation Antagonizing Non-Protein Coding RNA (DANCR) has been implicated in various malignancies, including esophageal squamous cell carcinoma (ESCC). This study explores the clinical characteristics, prognostic implications, functional roles, and molecular mechanisms of DANCR in ESCC.

Attitudes and Perceptions of eHealth Among Female Patients with Urinary Incontinence and Healthcare Providers: A Systematic Review and Thematic Synthesis.

Aim: The objective of this systematic review was to synthesize qualitative evidence to explore the promoters and barriers to implementing eHealth interventions from the perspective of female patients with urinary incontinence and healthcare providers.

Background: Guiding patients to pelvic floor muscle training through eHealth can effectively improve urinary incontinence symptoms, and understanding the attitudes and perceptions of patients and healthcare providers is critical to the successful application of eHealth. However, systematic reviews that combine both views are lacking.

Wearable transdermal drug delivery system controlled by wirelessly powered acoustic waves.

Transdermal drug administration offers an alternative route for drug delivery through the skin, and surface acoustic wave (SAW) technology has recently emerged as a promising approach to enhance this process. However, conventional cable-connected SAW control units face several challenges, including inconvenience, poor wearability, limited miniaturization and integration, and restricted reusability. This study introduces a wireless-powered transport strategy for the transdermal delivery of large drug molecules using a thin-film-based SAW platform.

Age and sex differences in the prevalence of specific comorbidities among pediatric acute lymphoblastic leukemia and lymphoblastic lymphoma patients at diagnosis.

Limited knowledge exists on the prevalence of comorbidity among pediatric patients diagnosed with acute lymphoblastic leukemia (ALL) or lymphoblastic lymphoma (LL). To determine the prevalence of comorbidities present within 3 months before diagnosis among pediatric ALL/LL patients, and to examine if the prevalence varies by age, biological sex at birth, and race/ethnicity. We analyzed data on patients diagnosed with ALL/LL at ≤21 years of age from 1/1/2005 to 6/30/2020 (n=5,455), using electronic health records data from the TriNetX Research Network Database.

Architecting of All-Cellulose-Based Wicking Fabric for a Large-Scale, Low-Cost, and Highly Efficient Solar Desalination Evaporator.

Interfacial solar vapor generation (ISVG) technology has been considered a promising and sustainable strategy for seawater desalination and wastewater treatment. However, its practical application is greatly limited due to severe salt accumulation and poor long-term evaporation stability. Herein, an all-cellulose-based wicking fabric (CB@CA/CF) is fabricated via a breath figure template (BFT) method for high-performance and stable desalination.

Multimodal discovery of bavachinin A: A natural FLT3 agonist for treating thrombocytopenia.

Background: Radiation-induced thrombocytopenia (RIT) poses a serious risk to patients with cancer undergoing radiotherapy and leads to hemorrhage and mortality. Unfortunately, effective treatment options for RIT are currently limited.

Purpose: This study aimed to discover active compound from Fructus Psoraleae, a traditional Chinese medicine recognized for its hemostatic properties, and to elucidate its mechanism of action in the treatment of RIT.

Efficient electrolytic hydrogen evolution from cobalt porphyrin covalently functionalized with chain-like phosphazene on double-walled carbon nanotubes.

The development of efficient electrocatalysts for the hydrogen evolution reaction (HER) is crucial for advancing electrochemical water splitting technology. Herein, we report a novel hybrid electrocatalyst, CoTHPP-PDCP@DWCNTs, synthesized through a covalent functionalization of cobalt-porphyrin (CoTHPP) with chain-like polydichlorophosphazenes (PDCP) and subsequent incorporation onto double-walled carbon nanotubes (DWCNTs). The successful synthesis was confirmed by various spectroscopic techniques, which collectively revealed strong electronic interactions between components, improved charge transfer, and enhanced electrochemical stability.

A novel compound, SYHA1813, inhibits malignant meningioma growth directly by boosting p53 pathway activation and impairing DNA repair.

Introduction: Meningioma is a common tumor of the central nervous system but effective therapies for malignant meningiomas are still lacking. Therefore, the development of novel therapeutic reagents is urgently needed. SYHA1813 is a novel compound and our previous study demonstrated its potent anti-tumor activity on glioblastoma through the inhibition of macrophages and human umbilical vein endothelial cells (HUVECs).

Morphological characteristics and phylogenetic analyses reveal five new species of Hymenochaetales (Agaricomycetes, Basidiomycota) from southwestern China.

Wood-inhabiting fungi can decompose wood materials and play a crucial role in the natural world by maintaining the equilibrium of the Earth's ecosystems. In the present study, five new wood-inhabiting fungal species belonging to the order Hymenochaetales, , , , and , collected from southern China, are proposed based on a combination of morphological features and molecular evidence. is characterized by a coriaceous, tuberculate hymenial surface, a monomitic hyphal system with simple-septate generative hyphae, and ellipsoid to narrow ellipsoid basidiospores (4.

Bifunctional transition-metal catalysts for energy-saving hydrogen generation from nitrogenous wastewater.

Wastewater from industrial chemical synthesis, agricultural activities, and domestic sewage usually contains high levels of nitrogenous compounds, endangering environmental health and human well-being. Nitrogenous wastewater electrolysis (NWE), despite its ecological merits, is inherently hampered by sluggish kinetics. To improve process efficiency, lower costs, and avoid cross-contamination between the anode and cathode, a range of bifunctional transition-metal catalysts capable of efficient operation at both electrodes have recently been developed.

Genetics, primary care records and lifestyle factors for short-term dynamic risk prediction of colorectal cancer: prospective study of asymptomatic and symptomatic UK Biobank participants.

Objectives: To quantify the contributions of polygenic scores, primary care records (presenting symptoms, medical history and common blood tests) and lifestyle factors, for short-term risk prediction of colorectal cancer (CRC) in general and symptomatic individuals.

Methods And Analysis: This prospective cohort study used data from the UK Biobank with follow-up until 2018. It included 160 507 participants with linked primary care records and a subcohort of 42 782 participants with recent CRC-related symptoms.

Channels and Transporters in Ischemic Brain Edema.

Brain edema is one of the most devastating consequences of acute ischemic stroke, but an effective and preventive therapy targeting the formation of ischemic brain edema has not yet to be validated. Ischemic brain edema is primarily caused by damage to the blood-brain-barrier, leading to the leakage of ions and water into the brain tissue. Ion channels and transporters play a crucial role in ischemic brain edema.

A phase I dose escalation study of the HIF-2 alpha inhibitor DFF332 in patients with advanced clear cell renal cell carcinoma.

Background: Mutations or silencing of the von Hippel Lindau (VHL) tumor suppressor gene accumulates hypoxia-inducible factors (HIFs). HIF-2α is implicated in the oncogenesis of ~50% of patients with clear cell renal cell carcinoma (ccRCC) but, has been considered "undruggable". DFF332, an orally administered novel allosteric inhibitor of HIF-2α showed dose-dependent antitumor efficacy in preclinical models of ccRCC.

Discovery of a novel AhR-CYP1A1 axis activator for mitigating inflammatory diseases using an functional imaging assay.

The aryl hydrocarbon receptor (AhR) plays a crucial role in regulating many physiological processes. Activating the AhR-CYP1A1 axis has emerged as a novel therapeutic strategy against various inflammatory diseases. Here, a practical cell-based fluorometric assay was constructed to screen AhR-CYP1A1 axis modulators, functional sensing of CYP1A1 activities in live cells.

Canopy structural heterogeneity drives α and β species-genetic diversity correlations in a Chinese subtropical forest.

Patterns and drivers of species-genetic diversity correlations (SGDCs) have been broadly examined across taxa and ecosystems and greatly deepen our understanding of how biodiversity is maintained. However, few studies have examined the role of canopy structural heterogeneity, which is a defining feature of forests, in shaping SGDCs. Here, we determine what factors contribute to α- and β-species-genetic diversity correlations (i.

YEATS2 promotes malignant phenotypes of esophageal squamous cell carcinoma via H3K27ac activated-IL6ST.

Introduction: Histone acetylation modifications can regulate gene transcription and play crucial roles in multiple tumorigeneses processes. YEATS domain proteins are one important type of acetylation readers. We have found significant mutations and copy number amplifications of YEATS domain containing 2 (YEATS2) gene in esophageal squamous cell carcinoma (ESCC) through whole genome sequencing (WGS).

Deep learning framework for interpretable quality control of echocardiography video.

Background: Echocardiography (echo) has become an indispensable tool in modern cardiology, offering real-time imaging that helps clinicians evaluate heart function and identify abnormalities. Despite these advantages, the acquisition of high-quality echo is time-consuming, labor-intensive, and highly subjective.

Purpose: The objective of this study is to introduce a comprehensive system for the automated quality control (QC) of echo videos.

Investigation on the reactive transport characteristic of uranium-bearing sandstone during the in-situ leaching mining uranium.

The multi-phase flow in dynamic pore-fracture is crucial to the safety and efficient uranium mining using the in-situ leaching method. In this study, the pore-fracture evolution and multi-phase flow morphology was investigated using the online low-field nuclear magnetic resonance (NMR) system, and the relationship of pore structure, permeability transformation and chemical reaction was analyzed. The results show that the adsorption pore (0.

Evaluation of the Long-Term Corneal Biomechanics Following SMILE With Different Residual Stromal Bed Thickness in Rabbits.

Purpose: The long-term safety of small-incision lenticule extraction (SMILE) surgery for correcting high myopia with a residual stromal bed thickness (RST) less than 50% of the central corneal thickness (CCT) was investigated from a biomechanical perspective.

Methods: Twelve rabbits were enrolled in this study, in which the right eye underwent SMILE surgery (the corneal cap thickness was one third of the preoperative CCT, approximately 120 µm), and the left eye served as the control. The rabbits were evenly divided into two groups, with the RST of 50% and 30% of the preoperative CCT in each group, respectively.

Demand analysis of public sports service for older adults using Kano model.

Aim: China is one of the countries with a relatively high degree of population aging in the world. Compared with other countries, China has the largest number of older adults and the fastest aging speed. In the increasingly serious situation of population aging, it has become the common desire of the whole society to actively develop sports for older adults and improve the health and quality of life of older adults.