Effects ofdirect current on Klebsiella spp. viability and corresponding resistance gene expression in simulative bio-electrochemical reactors.

The fate of antibiotic-resistant bacteria (ARB) and associated antibiotic-resistant gene (ARG) expression under electrolytic stimulation in bio-electrochemical reactors (BERs) was unknown. In this study, sulfadiazine resistant bacteria (Klebsiella spp.), which were isolated from a BER, were subjected to constant direct current (DC) stimulation in a simulated BER.

Posterior reversible encephalopathy syndrome after postpartum hemorrhage and uterine artery embolization: A case report.

Rationale: Posterior reversible encephalopathy syndrome (PRES) is characterized by clinical and radiological features, including headache, disturbed consciousness, seizures, and cortical blindness associated with findings indicating posterior leukoencephalopathy on imaging studies. Ours is the first case of PRES developing after postpartum hemorrhage and uterine artery embolization.

Patient Concerns: An 18-year-old patient had postpartum hemorrhage after a normal delivery.

Comparative analysis of molecular activity in dermal mesenchymal stem cells from different passages.

Mesenchymal stem cells (MSCs) are used for tissue regeneration in several pathological conditions, including autoimmune diseases. However, the optimal sources and culture requirements for these cells are still under investigation. Here, we compared mRNA expression in dermal MSCs (DMSCs) at passage (P) 3 and P5 to provide a reference for future studies related to DMSCs expansion.

Long-term presence of angiotensin II type 1 receptor autoantibody reduces aldosterone production by triggering Ca overload in H295R cells.

Preeclamptic women are reported to have inadequate plasma volume expansion coupled with a suppressed secretion of aldosterone; however, the specific mechanism of preeclampsia remains unclear. We demonstrated that the presence of long-term angiotensin II type 1 receptor autoantibody (AT1-AA) reduces aldosterone production by triggering a Ca overload in H295R cells. AT1-AA was discovered in preeclamptic women and reported to activate ATR, and consequently elevate intracellular Ca.

Clinicopathological and prognostic significance of PKM2 protein expression in cirrhotic hepatocellular carcinoma and non-cirrhotic hepatocellular carcinoma.

Pyruvate kinase M2 (PKM2), a key protein in glucose and lipid metabolism, has been reported to be related to carcinogenesis in various malignancies. However, its roles in hepatocellular carcinoma with cirrhotic liver (CL) and hepatocellular carcinoma with non-cirrhoticliver (NCL) haves not been investigated. In our study western bloting, qRT-PCR and immunohistochemistry were performed to evaluate the clinical significance of PKM2 protein expression in CL and NCL.

GP73 regulates Hepatic Steatosis by enhancing SCAP-SREBPs interaction.

Elevated Golgi phosphoprotein 2 (GP73, also known as GOLPH2 or GOLM1) expression in serum and liver, which can be induced by viral infection and cytokine treatments, is intimately connected with liver disease, including acute hepatitis, cirrhosis and hepatocellular carcinoma (HCC). However, its pathogenic roles in hepatic diseases have never been clarified in detail. Here, we showed that the upregulated GP73 is indispensable for SREBPs activation and lipogenesis.

Association between increased small airway obstruction and asbestos exposure in patients with asbestosis.

Background: Asbestos exposure may cause asbestos-related lung diseases including asbestosis, pleural abnormalities and malignancies. The role of asbestos exposure in the development of small airway obstruction remains controversial. Anatomic and physiologic small airway abnormalities may develop as part of the pathophysiologic process of asbestosis.

Taming stochastic bifurcations in fractional-order systems via noise and delayed feedback.

The dynamics in fractional-order systems have been widely studied during the past decade due to the potential applications in new materials and anomalous diffusions, but the investigations have been so far restricted to a fractional-order system without time delay(s). In this paper, we report the first study of random responses of fractional-order system coupled with noise and delayed feedback. Stochastic averaging method has been utilized to determine the stationary probability density functions (PDFs) by means of the principle of minimum mean-square error, based on which stochastic bifurcations could be identified through recognizing the shape of the PDFs.

Autapse-induced multiple stochastic resonances in a modular neuronal network.

This study investigates the nontrivial effects of autapse on stochastic resonance in a modular neuronal network subjected to bounded noise. The resonance effect of autapse is detected by imposing a self-feedback loop with autaptic strength and autaptic time delay to each constituent neuron. Numerical simulations have demonstrated that bounded noise with the proper level of amplitude can induce stochastic resonance; moreover, the noise induced resonance dynamics can be significantly shaped by the autapse.

Association Between the Asp312Asn, Lys751Gln, and Arg156Arg Polymorphisms in and the Risk of Prostate Cancer.

Prostate cancer is the most common solid cancer and genetic factors play important roles in its pathogenesis. is one of the 8 core genes involved in the nucleotide excision repair pathway. The relationship between Asp312Asn, Lys751Gln, and Arg156Arg polymorphisms in and prostate cancer risk is a controversial topic.

Degradation of sulfamethoxazole in bioelectrochemical system with power supplied by constructed wetland-coupled microbial fuel cells.

The removal rate and degradation pathway of Sulfamethoxazole (SMX) in bioelectrochemical system (BES) and the elimination dynamics of SMX in a BES driven by stacked constructed wetland-coupled microbial fuel cells (CW-MFCs) were investigated. The results found that SMX (30mgL) was rapidly degraded in the BES, and the SMX removal kinetics was simulated well by a first-order kinetic model (R>0.93).

Association between F508 deletion in CFTR and chronic pancreatitis risk.

Background: The cystic fibrosis transmembrane conductance regulator (CFTR) has been reported to influence individual susceptibility to chronic pancreatitis (CP), but the results of previous studies are controversial.

Aims: We performed a study to demonstrate the relationship between CFTR and CP.

Methods: We searched PubMed, Scopus, and Embase for studies of patients with CP.

High serum creatinine is associated with reduction of vision impaired in patients with NMOSD.

Serum creatinine (SCR) has been found to be neuroprotective in neurodegenerative disease. However, whether SCR is a protective factor for vision impaired in neuromyelitis optica spectrum disorder (NMOSD) is unclear. This study to determine the relationship between SCR level and vision impaired in NMOSD patients through multivariate-adjusted linear regression analyses.

Serum Golgi protein 73 is a prognostic biomarker of liver transplantation patients.

Background: The death after liver transplantation (LT) was most commonly caused by HCC recurrence. Golgi protein 73 (GP73), a type II Golgi membrane protein, has been proved to be a better serum marker for HCC.

Objective: This study aims to clarify the relationship between serum GP73 levels and tumor recurrence as well as survival of HCC patients after LT.

Bifid Mandibular Canals Incidence and Anatomical Variations in the Population of Shanghai Area by Cone Beam Computed Tomography.

Objective: The aim of this study was to analyze the rate, location, and characteristics of bifid mandibular canals (BMCs) in the population of the Shanghai area using cone beam computed tomography to avoid complications during surgical procedures.

Methods: Two hundred eighty patients were recruited for this study, and the presence and morphology of BMCs were evaluated.

Results: The occurrence rate of BMCs in the Shanghai area was relatively high compared with that in other populations, reaching 31.

PARP-1 serves as a novel molecular marker for hepatocellular carcinoma in a Southern Chinese Zhuang population.

PARP-1 (poly(ADP-ribose) polymerase-1) plays an important role in tumorigenesis. Since its effects on different populations are varied, this study investigated the impact of PARP-1 on primary hepatocellular carcinoma in a Southern Chinese Zhuang population. We assessed the global PARP-1 messenger RNA expression in patients with hepatocellular carcinoma using The Cancer Genome Atlas dataset.

Acupuncture for the treatment of obesity in adults: a systematic review and meta-analysis.

Objective: Meta-analysis was used to assess the clinical efficacy of acupuncture treatment for simple obesity and to provide evidence-based medical data for treating obesity with acupuncture.

Methods: A comprehensive search of studies on MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials and Chinese databases (Wan Fang,CNKI and VIP) from 1 January 1915 through 30 November 2015 (MEDLINE search updated through 31 December 2015) was performed. We included only randomised controlled trials (RCTs) that used acupuncture and sham acupuncture to treat simple obesity.

Similarity in gene-regulatory networks suggests that cancer cells share characteristics of embryonic neural cells.

Cancer cells are immature cells resulting from cellular reprogramming by gene misregulation, and redifferentiation is expected to reduce malignancy. It is unclear, however, whether cancer cells can undergo terminal differentiation. Here, we show that inhibition of the epigenetic modification enzyme enhancer of zeste homolog 2 (EZH2), histone deacetylases 1 and 3 (HDAC1 and -3), lysine demethylase 1A (LSD1), or DNA methyltransferase 1 (DNMT1), which all promote cancer development and progression, leads to postmitotic neuron-like differentiation with loss of malignant features in distinct solid cancer cell lines.

[Translation and Development of the Chinese-Version Patient Privacy Scale].

Background: The unauthorized releasing of confidential patient information is a serious problem worldwide. Nurses, the healthcare professionals who are in most frequent contact with patients, have access to a significant amount of confidential patient information and play a key role in protecting patient privacy. However, currently, there is no proper tool to measure the level to which clinical nurses protect the privacy of their patients in China.

Partial coupling delay induced multiple spatiotemporal orders in a modular neuronal network.

The influence of partial coupling delay on the spatiotemporal spiking dynamics is explored in a modular neuronal network. The modular neuronal network is composed of two subnetworks which present the small-world property and scale-free property, respectively. Numerical results show that spatiotemporal order that the modular network is most coherent in time and nearly synchronized in space can emerge intermittently when the coupling delays among neurons are appropriately tuned.

Association between the ERCC2 Asp312Asn polymorphism and risk of cancer.

Cancer is the leading cause of death in economically developed countries and the second leading cause of death in developing countries. The relationship between genetic polymorphisms and the risk of cancers has been widely researched. Excision repair cross-complementing group 2 (ERCC2) gene plays important roles in the nucleotide excision repair pathway.

Targeted delivery and pH-responsive release of doxorubicin to cancer cells using calcium carbonate/hyaluronate/glutamate mesoporous hollow spheres.

Currently, the efficacies of the existing anticancer drugs used in chemotherapy are still unsatisfactory. Therefore, drug delivery system has received considerable research interest. In the present study, calcium carbonate/hyaluronate/glutamate mesoporous hollow spheres are prepared through a facile method.

Enhanced nitrogen removal by membrane-aerated nitritation-anammox in a bioelectrochemical system.

A bioelectrochemical system (BES) containing membrane-aerated nitritation-anammox in its cathode has been developed for enhancing nitrogen removal. Long-term performance and microbial community structure were investigated. The BES using loop operation and external voltage achieved the highest total nitrogen removal efficiency of 94.

Glycopatterns of Urinary Protein as New Potential Diagnosis Indicators for Diabetic Nephropathy.

Diabetic nephropathy is a major cause of chronic kidney disease and end-stage kidney disease. However, so little is known about alterations of the glycopatterns in urine with the development of diabetic nephropathy. Presently, we interrogated glycopatterns in urine specimens using a lectin microarray.