Publications by authors named "Yang X"
Article Synopsis
- Researchers developed a method for site-selective C-H trifluoromethylation using arylthianthrenium salts and generated CuCF from Ruppert-Prakash reagent under visible light.
- The reaction was notably sped up with a small amount of -BINAP, completing in just 15 minutes under mild conditions.
- This approach demonstrated high efficiency, broad substrate compatibility, and excellent regioselectivity, which could enhance the discovery of fluorinated medicinal compounds.
Objective: Treating and managing rifampicin resistant tuberculosis (RR-TB) patients in Yunnan, China, are major challenges. This study aims to evaluate the risk of poor treatment outcomes in RR-TB patients, allowing clinical doctors to proactively target patients who would benefit from enhanced patient management.
Methods: Four RR-TB care facilities in different regions of Yunnan province as the data collection points were selected.
Effects of activities participation on frailty of older adults in China.
Front Public Health
December 2024
Objective: Frailty represents a significant health challenge among older adults, necessitating effective interventions to enhance their overall wellbeing. This study aims to investigate the impact of various types of activity participation on frailty in older adults and to elucidate their intrinsic associations, thereby providing a basis for targeted interventions.
Methods: This study constructed a classification of activities based on the framework proposed by the WHO regarding functional ability in healthy aging, innovatively dividing activities into five categories: physical activity, social activity, economic activity, information activity and sleep activity.
Article Synopsis
- The superficial circumflex iliac artery perforator (SCIP) flap is commonly used in covering wounds, but occasionally faces failure due to venous congestion.
- A new approach called the modified "chemical leech" technique incorporates a venous catheter to better manage blood drainage from congested areas, which has shown improved outcomes.
- This method facilitates more effective draining of congested blood at both venule and capillary levels, ultimately enhancing the healing of the flap as microcirculation is restored.
2D materials such as transition metal dichalcogenides (TMDCs) are a new class of atomic-layer materials possessing optical and electric properties that significantly depend on the number of layers. Electronic transitions can be manipulated in artificial resonant electromagnetic (EM) fields using metasurfaces and other designed nanostructures. Here, we demonstrate prominently resonant enhancement in the photoluminescence (PL) of atomic monolayer, WS, doped with a small quantity of Mo.
View Article and Find Full Text PDFObjective: To evaluate correlations between ultrasonographic pupillary assessment (UPA) and automated UPA in neurocritical patients.
Methods: This was a prospective, observational study of 20 adult patients admitted to the intensive care unit with neurological pathology. Between UPA and automated UPA, 40 pupillary measurements were made.
Introduction: Working memory (WM) is suggested to play a pivotal role in relearning and neural restoration during stroke rehabilitation. Using EEG, this study investigated the oscillatory mechanisms of WM in subacute stroke.
Methods: This study included 48 first subacute stroke patients (26 good-recovery, 22 poor-recovery, based on prognosis after a 4-week period) and 24 matched health controls.
Article Synopsis
- Telomere length (TL) is an important indicator of cellular aging, with shorter lengths associated with age-related diseases, and a new measurement method called DNAmTL has been developed to assess TL using DNA methylation.
- In a study of 2532 participants from a national survey, it was found that each kilobase increase in DNAmTL reduced the risk of cardiovascular disease (CVD) by 53%, and longer DNAmTL was linked to a 36% lower risk of all-cause mortality and a 35% decrease in CVD mortality.
- DNAmTL showed a stronger correlation with age and better predictive performance for CVD risk and mortality compared to traditional qPCR-based TL measurements, suggesting it
Article Synopsis
- Rheumatoid arthritis (RA) is an autoimmune disease influenced by genetics and the environment, and this study investigated the controversial link between alcohol consumption and RA risk.
- By analyzing data from the National Health and Nutrition Examination Survey and conducting Mendelian randomization, researchers assessed how alcohol, particularly spirits, might causally affect RA.
- Results showed a significant positive relationship between alcohol consumption and RA risk across various demographics, with the findings confirming that higher alcohol intake could potentially increase the risk of developing RA.
PACS2/CPT1A/DHODH signaling promotes cardiomyocyte ferroptosis in diabetic cardiomyopathy.
Cardiovasc Diabetol
December 2024
Objectives: The pathophysiology of diabetic cardiomyopathy (DCM) is a phenomenon of great interest, but its clinical problems have not yet been effectively addressed. Recently, the mechanism of ferroptosis in the pathophysiology of various diseases, including DCM, has attracted widespread attention. Here, we explored the role of PACS2 in ferroptosis in DCM through its downregulation of PACS2 expression.
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- The study investigates the effectiveness of the triglyceride-glucose (TyG) index and other insulin resistance markers in diagnosing non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM).
- A total of 268 T2DM patients were analyzed, comparing those with NAFLD to those without, and various blood indicators and insulin resistance indices were assessed using Receiver Operating Characteristic (ROC) analysis.
- Results indicated that four TyG-related parameters showed strong predictive performance for identifying NAFLD, with TyG-BMI being particularly effective, especially in males, showcasing a high sensitivity and predictive value.
Efficacy of reactive soft tissue for alveolar ridge preservation: a prospective cohort study.
Clin Oral Investig
December 2024
Article Synopsis
Wide-bandgap perovskite solar cells (WBG-PSCs) are critical for developing perovskite/silicon tandem solar cells. The defect-rich surface of WBG-PSCs will lead to severe interfacial carrier loss and phase segregation, deteriorating the device's performance. Herein, we develop a surface reconstruction method by removing the defect-rich crystal surface by nano-polishing and then passivating the newly exposed high-crystallinity surface.
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- Cutaneous T-cell lymphoma (CTCL) is a type of skin cancer that affects T cells and can spread throughout the body, making current treatments like chemotherapy less effective and often accompanied by severe side effects.
- Research has identified cyclin dependent kinase 9 (CDK9) as a key factor in CTCL growth, with specific malignant T-cell characteristics revealed through single-cell RNA sequencing.
- Targeting CDK9 with specialized treatments like PROTACs not only significantly reduces CTCL cell growth but also, when combined with all-trans retinoic acid (ATRA), shows promise for more effective and complete treatment options.
Aims: The interaction between pancreatic islets and skeletal muscle plays a pivotal role in the development of insulin resistance. The present study aimed to elucidate the impact of non-hormonal molecules from islets on the insulin sensitivity of skeletal muscle cells.
Materials And Methods: We developed a mouse model of obesity through a high-fat diet, assessing glucose tolerance and conducting miRNA sequencing on skeletal muscle samples.
Article Synopsis
- Developing the sericulture industry is a promising way to utilize cadmium-contaminated soils, but managing silkworm excrement (SE) presents challenges.
- This study examined the impact of SE biochar (with and without cadmium) on paddy soil chemistry, mulberry leaf quality, and cadmium accumulation in mulberry plants.
- Results showed that both types of biochar improved soil pH and cation exchange capacity, boosted mulberry growth, and helped reduce cadmium levels in the plants, suggesting that using SE biochar is a viable method to remediate cadmium-polluted soils.