Therapeutic efficacy of orthokeratology lenses with different back optic zone diameters in myopia control: A systematic review and meta-analysis.

Objective: This study evaluates the efficacy of orthokeratology lenses with different back optic zone diameters (BOZD) in controlling myopia progression among adolescents.

Methods: Following PRISMA 2020 guidelines, a systematic search was performed across multiple databases, including PubMed, Web of Science, EMBASE, Cochrane Library, EBSCO, Scopus, Ovid, CBM, CNKI, VIP, and Wanfang. Inclusion criteria encompassed randomized controlled trials (RCTs) and controlled studies comparing the effectiveness of orthokeratology lenses with various BOZD designs for myopia control in adolescents.

Blueberry leaves as a promising sustainable source of polyphenols: Chemical composition, functional activities and future application perspectives.

Blueberry leaves are a byproduct of blueberry cultivation, often overlooked despite their potential value. As global consumption of blueberries continues to rise, the area under cultivation expands, leading to an increased production of blueberry leaves. Blueberry leaves are a rich source of polyphenols, and in recent years, extensive research has been conducted on the composition and biological functions of these compounds.

Testes-specific protease 50 heightens stem-like properties and improves mitochondrial function in colorectal cancer.

Aims: The progression of colorectal cancer (CRC) is driven by a small subset of cancer stem-like cells (CSCs), and mitochondrial function is essential for maintaining their stemness. TSP50, a novel identified oncogene, has been found to promote cell proliferation in multiple cancer types. In this study, we detected the regulatory role of TSP50 in regulating CSC-like properties and mitochondrial mass in CRC.

Characterization of glucans from diverse sources and their influence on fat and carbohydrate absorption, digestion in vitro, and glucose tolerance in vivo.

Glucan, a recognized prebiotic primarily derived from fungi, bacteria, and plants, possesses significant nutritional value and biological activity. It serves as a thickener and emulsifier stabilizer, enhancing the texture and sensory properties of food. This study aimed to compare the inhibitory effects of glucans from yeast, oats, and bacteria on energy intake by characterizing their physicochemical properties and evaluating their impact on fat and glucose adsorption, starch and fat digestion in vitro, and glucose tolerance in vivo.

Ferroptosis, necroptosis, and pyroptosis in calcium oxalate crystal-induced kidney injury.

Kidney stones represent a highly prevalent urological disorder worldwide, with high incidence and recurrence rates. Calcium oxalate (CaOx) crystal-induced kidney injury serves as the foundational mechanism for the formation and progression of CaOx stones. Regulated cell death (RCD) such as ferroptosis, necroptosis, and pyroptosis are essential in the pathophysiological process of kidney injury.

Glutamine binds HSC70 to transduce signals inhibiting IFN-β-mediated immunogenic cell death.

Glutamine plays a role in cell signaling that regulates gene expression and impacts tumorigenesis. However, it is still unclear how glutamine transduces signals in cells. Here, we show that glutamine binds to heat shock cognate protein 70 (HSC70) to stimulate the deubiquitinase otubain domain containing protein (OTUD4) independently of known glutamine metabolic or signaling pathways, resulting in lactate dehydrogenase A (LDHA) stabilization via the microautophagy-lysosome pathway, increased lactate production and decreased expression of interferon (IFN)-β and its targets, hallmarks of immunogenic cell death (ICD).

Synergistic effect of the Phytic acid-halamine as a novel durability, antibacterial and flame retardant system for cotton fibers.

Phytic acid's high-efficiency flame retardant and N-halamine antibacterial were synergistically applied to cotton fibers for durable antibacterial and flame retardancy. Antimicrobial flame retardant structures were characterized by H Nuclear Magnetic Resonance Spectra (NMR) and Fourier Transform Infrared Spectrometer (FT-IR). FT-IR, X-ray Photoelectron Spectroscopy (XPS), Scanning Electron Microscope (SEM), Thermogravimetric (TG), Vertical Flammability Test (VFT), and Limiting Oxygen Index (LOI) were utilized to test and characterize the prepared cotton fibers.

Application of iron-modified biochar in the fields of adsorption and degradation of antibiotics.

Antibiotics, as emerging contaminants, have led to persistent global pollution issues, prompting long-standing attention on methods for their effective removal. Among various methods, iron-modified biochar stood out for its ability to adsorb and degrade antibiotics in the environment because biochar can provide a porous structure and oxygen-rich functional groups for efficient antibiotic adsorption, while the Fe/Fe redox cycle in the iron modification biochar enhanced electronic transmission and further increased degradation. This review systematically summarized preparation methods of different iron-modified biochar, the adsorption capacities, mechanisms, and influencing factors of pollutants.

Dual single nucleotide polymorphisms typing of apolipoprotein E gene based on double restriction endonuclease with lambda exonuclease and triple helix molecular switch assistance.

Single nucleotide polymorphisms (SNPs) are critical determinants of disease susceptibility, pathogenesis, and drug response, underscoring the need for their accurate monitoring in clinical practice. In this study, we propose a novel apolipoprotein E (APOE) genotyping method for the rapid and precise identification of six genotypes (ε2/ε2, ε3/ε3, ε4/ε4, ε2/ε3, ε2/ε4, and ε3/ε4). The method utilizes restriction endonucleases AflIII and HaeII to selectively cleave the rs429358 and rs7412 sites, thereby generating distinct double-stranded DNA fragments.

Integration analysis of miRNA-mRNA uncovers the mechanisms of ochratoxin A-induced hepatotoxicity.

Ochratoxin A (OTA), the most toxic member of the ochratoxin family, is frequently detected in contaminated food and beverages, posing substantial health risks to both humans and animals, particularly due to its hepatotoxic effects. Although OTA is known to cause liver damage, the precise molecular mechanisms driving its toxicity remain poorly understood. In this study, we explored the hepatotoxic effects of OTA using LO2 cells and zebrafish models, combining miRNA and mRNA analyses to uncover the underlying mechanisms.

Ellagic acid ameliorates atherosclerosis by inhibiting PCSK9 through the modulation of FoxO3 and HNF1α.

Introduction: Proprotein convertase subtilisin/kexin type 9 (PCSK9) hinders the clearance of low-density lipoprotein cholesterol (LDL-C) by promoting the degradation of the low-density lipoprotein receptor (LDLR), leading to the accumulation of LDL-C and thus becoming an important cause of atherosclerosis. Ellagic acid, a naturally occurring polyphenol widely present in fruits, vegetables, and nuts, has attracted significant attention due to its potential role in the prevention and treatment of cardiovascular diseases. However, the molecular mechanisms by which ellagic acid alleviates atherosclerosis by inhibiting PCSK9 are not fully understood.

Simultaneous Verification of Genuine Multipartite Nonlocality and Full Network Nonlocality.

Genuine multipartite nonlocality and nonlocality arising in networks composed of several independent sources have been investigated separately. While some genuinely entangled states cannot be verified by violating a single Bell-type inequality, a quantum network consisting of different sources enables the certification of the nonclassicality of all sources. In this Letter, we propose the first method to verify both types of nonlocality simultaneously in a single experiment.

First Determination of the Spin-Parity of Ξ_{c}(3055)^{+,0} Baryons.

The Ξ_{b}^{0(-)}→Ξ_{c}(3055)^{+(0)}(→D^{+(0)}Λ)π^{-} decay chains are observed, and the spin-parity of Ξ_{c}(3055)^{+(0)} baryons is determined for the first time. The measurement is performed using proton-proton collision data at a center-of-mass energy of sqrt[s]=13  TeV, corresponding to an integrated luminosity of 5.4  fb^{-1}, recorded by the LHCb experiment between 2016 and 2018.

Synthesis of Polycyclic Heteroarenes via Rh(III)-Catalyzed Twofold C-H Activation of 3-Aryl-2-benzo[][1,4]oxazines and Annulation with α-Diazo-β-ketoesters.

An efficient Rh(III)-catalyzed annulation between 3-aryl-2-benzo[][1,4]oxazines and α-diazo-β-ketoesters was developed, affording a series of polycyclic heteroarenes in moderate to excellent yields with good functional group compatibility. The procedure featured high efficiency, redox neutrality, twofold -C-H activation, and dual [4 + 2] annulation. Moreover, several important intermediates and products have been isolated as powerful evidence for the proposed reaction mechanism.

A multimodal defect-rich nanoreactor triggers sono-piezoelectric tandem catalysis and iron metabolism disruption for implant infections.

Tracking and eradicating drug-resistant bacteria are critical for combating implant-associated infections, yet effective antibacterial therapies remain elusive. Herein, we propose an oxygen vacancy-rich (BiFe)(BaTi)O nanoreactor as a piezoelectric sonosensitizer by spatiotemporal ultrasound-driven sono- and chemodynamic tandem catalysis to amplify antibacterial efficacy. The piezoelectric charge carriers under a built-in electric field synchronize the reaction of O and HO, efficiently generating HO.

Multiple B-site doping suppresses ion migration in halide perovskites.

Lead halide perovskites hold great promise for photovoltaics and optoelectronics, yet ion migration continues to challenge their long-term stability. Here, combining first-principles calculations and machine learning molecular dynamics, we unravel the interplay between perovskite octahedral lattice dynamics and energy barrier associated with ion migration. Our results show that B-site substitution, particularly with alkaline-earth and lanthanide elements, notably strengthens lattice interactions, restrains octahedral oscillation, and increases iodine-migration barriers, outperforming the commonly used A-site and X-site substitutions and interstitial doping.

Flippable multitask diffractive neural networks based on double-sided metasurfaces.

Diffractive neural networks (DNNs) have garnered significant attention in recent years as a physical computing framework, combining high computational speed, parallelism, and low-power consumption. However, the non-reconfigurability of cascaded diffraction layers limits the ability of DNNs to perform multitasking, and methods such as replacing diffraction layers or light sources, while theoretically feasible, are difficult to implement in practice. This Letter introduces a flippable diffractive neural network (F-DNN) in which the diffraction layer is an integrated structure processed on both sides of the substrate.

Synthesis and Characterization of Ultralight Syndiotactic Polystyrene Aerogels Prepared by Freeze-Drying.

We have developed a strategy to synthesize high-quality ultralight (<10 mg/cm) syndiotactic polystyrene (sPS) aerogels. The ultralight sPS aerogels with the same shape as gels were prepared via direct freeze-drying of -xylene-based sPS gels without cumbersome solvent exchange steps. Due to the high melting point of -xylene (13 °C), it can be solidified during the freeze-drying process, and no solvent exchanges were required to suppress the collapse during the formation of sPS aerogels, unlike in typical sPS aerogel preparation.

Value of ultrasound in predicting the outcome of conservative treatment of testicular appendage torsion in children.

Background: The treatment modalities for testicular appendage torsion in children are classified as conservative or surgical, and the choice is controversial.

Objectives: This study aimed to identify ultrasound-based indicators influencing the outcome of conservative treatment in children with testicular appendage torsion to divide the boundaries between conservative and surgical management.

Methods: A retrospective analysis was conducted on testicular appendage torsion data of children from November 2022 and November 2023 in the Children's Hospital of Zhejiang University School of Medicine to compare the conservatively successful and conservatively unsuccessful groups' clinical and ultrasound characteristics.

Exosomes derived from baicalin‑pretreated mesenchymal stem cells mitigate atherosclerosis by regulating the SIRT1/NF‑κB signaling pathway.

Atherosclerosis (AS) is a disease with high global incidence and mortality rates. Currently, the treatment of AS in clinical practice carries a high risk of adverse effects and toxic side effects. The pretreatment of mesenchymal stem cells (MSCs) with drugs may enhance the bioactivity of MSC‑derived exosomes (MSC‑exos), which could be a promising candidate for inhibiting the progression of AS.

Clinical combined PET/CT radiomics model prediction of benefit from platinum-based chemotherapy and chemoradiotherapy in patients with small cell lung cancer.

Objective: To develop and validate a clinical combined radiomics model for predicting the treatment response and long-term survival prognosis of small cell lung cancer (SCLC) patients receiving platinum-based chemotherapy, as well as survival outcomes following chemoradiotherapy.

Methods: A total of 98 SCLC patients treated with platinum-based first-line chemotherapy were included in this study. Five prediction models for assessing the short-term efficacy of platinum-based first-line chemotherapy were developed using a logistic regression algorithm.

KAT7 contributes to ponatinib-induced hypertension by promoting endothelial senescence and inflammatory responses through activating NF-κB signaling pathway.

Background And Purpose: Ponatinib, a tyrosine kinase inhibitor (TKI) leads to hypertension; however, the mechanisms remain elusive. We aimed to investigate whether lysine acetyltransferase 7 (KAT7), a key regulator of cellular senescence that is closely associated with cardiovascular diseases, involves in ponatinib-induced hypertension.

Methods And Results: After administering ponatinib to Sprague-Dawley (SD) rats for 8 days, we measured blood pressure, vasodilation, and endothelial function using tail-cuff plethysmography, isometric myography, and the Total NO Assay kit, respectively.

A meta-analysis of the effects of strength training on physical fitness in dancers.

Background: Physical fitness is fundamental for successfully carrying out daily tasks and activities associated with dance. This meta-analysis aimed to evaluate the impact of strength training on various aspects of physical fitness in dancers.

Methods: A comprehensive search of Web of Science Core Collection, PubMed, SPORTDiscus, SCOPUS, Cochrane library, CINAHL, and Embase was conducted until 10 December 2024, supplemented by hand-searches via Google Scholar and reference lists of included studies.

Inhibition of Cyclin D1 by Novel Biguanide Derivative YB-004 Increases the Sensitivity of Bladder Cancer to Olaparib via Causing G0 / G1 Arrest.

Bladder cancer (BC) is the 10 most common type of tumor worldwide, and recently approved immunotherapies and FGFR inhibitors have been shown to improve the prognosis of only a very limited subset of BC patients. Thus, the quest for more effective drugs remains an urgent priority for improving the quality of life of more BC patients. Previously, we demonstrated that a novel biguanide has potent antitumor activity.

IGF2BP3 promotes the proliferation and cisplatin resistance of bladder cancer by enhancing the mRNA stability of CDK6 in an m6A dependent manner.

Cisplatin-based chemotherapy is a primary treatment for bladder cancer, yet the development of chemoresistance poses a significant therapeutic challenge. Insulin-like growth factor II mRNA binding protein 3 (IGF2BP3) is an RNA-binding protein and a key m6A reader that regulates various cancers through m6A-dependent mechanisms. However, its role in chemotherapy resistance in bladder cancer remains unclear.