tRNA-Ser-UGA efficiently promotes the rapid release of duck hepatitis A virus from infected enterocytes and its remote dissemination to hepatocytes.

Enterocytes are a necessary portal for fecal-oral transmission of viruses, including duck hepatitis A virus (DHAV), that act on the absorption of amino acids (AAs). We note that the rapid death of ducklings caused by DHAV is likely due to its rapid release from enterocytes. However, the underlying mechanism driving the release of DHAV remains poorly understood.

Association between prenatal exposure to phthalate esters and blood pressure in children aged 3-7 years: A prospective cohort study.

Background: An increasing number of animal studies have indicated that exposure to phthalate esters (PAEs) may cause high blood pressure. However, population-based evidence is limited, particularly for pregnant women and young children.

Objective: To examine the correlation between prenatal exposure to phthalate ester metabolites (mPAEs) and blood pressure in preschool children.

Exploring the Effect of Cheese Intake on Cholelithiasis Through Biomarkers: A Mendelian Randomization Study.

This study assesses the causal relationship between intake of cheese and cholelithiasis through the analysis of relevant biomarkers using Mendelian Randomization (MR). Genetic variants associated with cheese intake were employed as instrumental variables (IVs) to assess potential causal effects. Data from the Open GWAS project and FinnGen Biobank were used, including biomarkers related to blood cells, blood biochemistry, and blood pressure.

Mediation effects of metabolites and sex hormones on the relationship between body mass index and breast cancer: Mendelian randomization analysis and mediation analysis.

Background: Observational investigations have indicated a notable correlation between body mass index (BMI) and breast cancer (BC). Nevertheless, the precise biological pathways driving this correlation remain ambiguous. Consequently, we utilized Mendelian randomization (MR) techniques to explore the causative link between BMI and genetic predisposition to BC, as well as the potential intermediary influences.

Exploring Dietary Factors and Esophageal Adenocarcinoma: Insights From Mendelian Randomization Study.

Esophageal adenocarcinoma and diet are not well understood to be associated. We conducted Mendelian randomization analysis using 18 dietary factors as exposures (primarily including fruit consumption, vegetable consumption, alcohol consumption, meat consumption, tea intake, fish intake, etc.), with esophageal adenocarcinoma as the outcome.

Exosomal miR-155-5p Facilitates Lipopolysaccharide Transport and Foam Cell Formation: A Novel Link Between Periodontitis and Atherosclerosis.

Aim: To investigate the role of lipopolysaccharide (LPS) from Porphyromonas gingivalis and miR-155-5p-enriched exosomes in the formation of foam cells and the occurrence of carotid atherosclerosis (CAS).

Methods: The CAS tissue samples and plasma from the healthy control group or patients undergoing periodontitis without CAS and with CAS were collected at the Xuanwu Hospital, Capital Medical University. The expression level of miR-155-5p was evaluated by immunofluorescent analysis and qRT-PCR.

KangDuo surgical robot versus da Vinci robotic system in urologic surgery: a systematic review and meta-analysis.

It was a systematic review and meta-analysis that aimed to compare the efficiency and safety of robot-assisted urological surgery using both the KangDuo and da Vinci robotic systems. The PubMed, Embase, and Cochrane Library databases were searched for all papers published through September 1, 2024. The focus was on English-language papers comparing the KangDuo surgical robot and the da Vinci system in urological procedures.

A mendelian randomization study investigating the association between sleep apnea risk and cheese consumption through biomarker analysis.

Cheese consumption may play a role in mitigating sleep apnea risk, according to our Mendelian randomization (MR) study. Sleep apnea, a prevalent disorder associated with various health complications, affects millions worldwide, generating interest in dietary interventions. This study analyzed data from the UK Biobank and the FinnGen Biobank, focusing on cheese intake and its potential impact on sleep apnea through various biomarkers.

PID control algorithm based on multistrategy enhanced dung beetle optimizer and back propagation neural network for DC motor control.

Traditional Proportional-Integral-Derivative (PID) control systems often encounter challenges related to nonlinearity and time-variability. Original dung beetle optimizer (DBO) offers fast convergence and strong local exploitation capabilities. However, they are limited by poor exploration capabilities, imbalance between exploration and exploitation phases, and insufficient precision in global search.

Opioid-free strategies for patient-controlled intravenous postoperative analgesia: a review of recent studies.

Postoperative pain management has consistently been a critical topic in the medical field, with patient-controlled intravenous analgesia (PCIA) being one of the most commonly utilized methods for postoperative analgesia. Currently, opioids remain the primary choice for PCIA in clinical practice. However, in recent years, an increasing number of studies have explored analgesic strategies aimed at reducing or eliminating the use of opioids in PCIA to mitigate the associated side effects and dependence.

Gut commensal Parabacteroides distasonis exerts neuroprotective effects in acute ischemic stroke with hyperuricemia via regulating gut microbiota-gut-brain axis.

Background: Hyperuricemia is considered as an independent risk factor for acute ischemic stroke (AIS), and some AIS patients are accompanied by an increase in serum uric acid. Recent studies have highlighted the important role of gut microbiota in both hyperuricemia and AIS, but there is little available data on the relationship between gut microbiota and the pathogenesis of AIS with hyperuricemia (HAS).

Methods: Here we profiled the gut microbiota composition in 63 HAS patients and 269 non-HAS patients through 16s rRNA sequencing.

Gut commensal alleviates microglia-mediated neuroinflammation against pathogenesis of Alzheimer disease.

Gut microbiota plays a crucial role in the pathogenesis of Alzheimer disease (AD). Here, we found that AD patients had significantly lower abundance of , which were negatively correlated with cognitive impairment. Animal experiments showed that supplementation increased beneficial commensal bacteria, significantly improved pathological damage, and suppressed microglial activation in APP/PS1 mice.

Exosomal miR-155-5p promote the occurrence of carotid atherosclerosis.

Periodontitis is a significant independent risk factor for atherosclerosis. Yet, the exact mechanism of action is still not fully understood. In this study, we investigated the effect of exosomes-miR-155-5p derived from periodontal endothelial cells on atherosclerosis in vitro and in vivo.

Photobiomodulation therapy at 650 nm enhances osteogenic differentiation of osteoporotic bone marrow mesenchymal stem cells through modulating autophagy.

Background: Photobiomodulatiom therapy (PBMT) has biostimulatory effects on bone marrow mesenchymal stem cells (BMSCs), which takes a pivotal role in maintaining bone mass and avoiding osteoporosis (OP). Autophagy is an important regulator for cell survival and homeostasis. Previous researchers found that BMSCs derived from osteoporotic rats (OP-BMSCs) were with the feature of reduced osteogenic differentiation and autophagy dysfunction.

Exploring the Influence of Cheese Consumption on Blood Metabolites: Implications for Disease Pathogenesis, with a Focus on Essential Hypertension.

This study examines the causal effects of cheese consumption on blood metabolites and essential hypertension using Mendelian Randomization (MR). GWAS data from the Open GWAS project and FinnGen Biobank were analyzed, focusing on cheese intake, 249 metabolic traits, and hypertension. Instrumental variables were selected based on strict criteria, and causal relationships were assessed using IVW, weighted-median, and MR-Egger methods.

Delivery of liquid metal particles and tanshinone IIA into the pericardial cavity for myocardial infarction treatment.

Owing to their inherent flexibility and excellent biocompatibility, liquid metals (LMs) have been explored at the frontiers of clinical therapy. Herein, a LM and tanshinone IIA (TA) drugs were dispersed into sodium alginate (SA) solution by ultrasonication to prepare SA/LM/TA, which is an injectable biomaterial for stable drug release and intrapericardial injection for the treatment of myocardial infarction (MI). The SA/LM/TA has a low viscosity and can be injected smoothly using a syringe.

Rapid evaluation of vegetable oil varieties and geographical origins by ambient corona discharge ionization mass spectrometry.

The composition and ratio of unsaturated fatty acids in vegetable oils play a crucial role in determining their overall quality. In this study, we present a corona discharge ionization mass spectrometry (MS) method for the rapid differentiation of vegetable oil varieties and their geographical origins under environmental conditions. Abundant water dimer radical cations, (HO), were generated by the ionization setup, which effectively activated carbon‑carbon double bonds (C=C) to form epoxidized products.

Pupil Dynamics, Salivary Alpha-Amylase, and Prefrontal Haemodynamics in Response to Very Light Exercise.

This study aimed to investigate the effects of exercise on pupil dynamics, prefrontal haemodynamic, and salivary alpha-amylase (sAA) responses in 45 healthy graduate students. These participants were divided into two groups: a resting control group (CTL) and a very-light-intensity exercise group (EX). Participants in the EX-group engaged in a 10-min exercise at 30% O peak on a cycle ergometer.

Interaction of biochar with extracellular polymers of resistant bacteria restrains Pb(II) adsorption onto their composite: Macro and micro scale investigations.

Pb(II) sequestration in extracellular polymers-biochar composites (EPS-BC) was explored using macroscopic models and microscopic technology. The results showed that the actual adsorption capacity of EPS-BC was 52.2% lower than the calculated capacity based on adsorption onto pure components due to the interaction of polysaccharide and amide group in extracellular polymers with biochar, which masked the reactive sites related to Pb(II) in EPS-BC.