Observer-Based Control of Networked Periodic Piecewise Systems With Encoding-Decoding Mechanism.

This article deals with the observer-based control problem of networked periodic piecewise systems under encoding-decoding frameworks. An encoder with a uniform quantizer, which can compress and encrypt data, is provided to process the measurements from the sensors. The processed data is transmitted over the network to the decoder to recover the original data and then to the remote control station, thereby reducing the communication burden and ensuring data security.

Lyophilized monkeypox mRNA lipid nanoparticle vaccines with long-term stability and robust immune responses in mice.

The World Health Organization (WHO) has recently declared another global health emergency due to the rapidly spreading monkeypox (Mpox) outbreak in numerous African countries. To address the unmet need to contain the outbreak using the existing vaccines, this study developed a lyophilization process for an effective, scalable and affordable Mpox mRNA-LNP vaccine candidate to address the global health crisis. A comprehensive evaluation and optimization of the vaccine formulation (the type/concentration of cryoprotectants, the type/concentration of buffer system, as well as the mRNA concentration and reconstitution solvent) and the freeze-drying process parameters (freezing method, temperature, cooling rate and primary/secondary drying conditions) were conducted.

Adverse drug reactions to atezolizumab in combination with bevacizumab in hepatocellular carcinoma patients: an analysis of the food and drug administration adverse event reporting system database.

Purpose: The objective of the study is to systematically identify and evaluate the adverse drug reactions (ADRs) associated with the combination therapy of systematically and bevacizumab in patients with unresectable hepatocellular carcinoma (HCC).

Patients And Methods: Data were extracted from the Food and Drug Administration (FDA) Adverse Event Reporting System FDA Adverse Event Reporting System database. Disproportionality analysis was conducted using the reporting odds ratio (ROR), proportional reporting ratio (PRR) and Bayesian confidence propagation neural network (BCPNN) of information components (IC).

Spatial variations of PM-bound parent, nitrated, and oxygenated PAHs at urban and suburban sites in the Ili River Valley: Characteristics, sources, and health risks.

Polycyclic Aromatic Hydrocarbons (PAHs), along with their derivatives nitro-PAHs and oxy-PAHs, are globally recognized toxic pollutants. This research conducted daily PM sampling in winter 2021 at three urban (YNCE, SWP, and NG) and three suburban sites (HC, CTV, and YNE) in the Ili River Valley (IRV). For the first time in the IRV, a comprehensive study on 39 PAHs and derivatives was carried out.

SlKNUCKLES regulates floral meristem activity and controls fruit size in .

Timed termination of floral meristem (FM) is crucial for proper development of floral organs and fruits. In , ()- () feedback regulation maintains FM homeostasis in early stage of floral buds. It is known that the zinc finger protein SlKNUCKLES (SlKNU) functions to promote FM determinacy by directly repressing the stem cell identity gene .

"Relative symmetry with electronegativity of different key-groups" strategy for MRGPRX2 antagonist design and its effect on antigen-induced pulmonary inflammation.

MRGPRX2 antagonists possess the potential for the treatment of allergic rhinitis, atopic dermatitis, and chronic urticaria. Previously, we identified a class of diaryl urea (DPU) MRGPRX2 antagonists with sub-micromolar IC values . However, the structure-activity relationship remains unclear.

Do Current and Lifetime Mental Health Issues Influence Subjective Social Status?

Background: Mental health issues can impact overall health status, personal relationships, workplace productivity, and other outcomes.

Aims Of The Study: The primary objective of this study is to determine whether recent and lifetime mental health problems are significantly related to respondents' subjective social status (SSS).

Methods: Respondents to Waves IV (2008-2009) and V (2016-2018) of the National Longitudinal Survey of Adolescent to Adult Health (Add Health) provide the data for our research.

MrgX2-Targeting Ligand Screen for Antipseudoallergic Agents by Immobilized His-Tag-Fused Protein Technology.

Mas-related G protein-coupled receptor X2 (MrgX2) plays a key role in pseudoallergy reactions; thus, it is of great significance to screen compounds with antipseudoallergy activity via MrgX2. Cell membrane chromatography (CMC) demonstrates great potential in drug screening, but it requires further optimization to improve its specificity and stability. In this study, a new CMC system incorporating His-tag-oriented immobilized proteins was constructed to screen MrgX2 antagonists.

Repair of Isoaspartyl Residues by PCMT1 and Kidney Fibrosis.

Background: Kidney fibrosis, the excessive accumulation and dysregulated remodeling of the extracellular matrix, is the principal pathophysiological process in chronic kidney disease (CKD). Protein L-isoaspartyl/D-aspartyl methyltransferase (PCMT1) is crucial in repairing post-translational modifications of L-isoaspartyl residues, which are important for extracellular matrix proteins because of their low turnover rate and susceptibility to accelerating factors. This study aimed to reveal a novel role of PCMT1 in kidney fibrosis.

Ultra-high dose rate radiotherapy overcomes radioresistance in head and neck squamous cell carcinoma.

Radiotherapy (RT) resistance in head and neck squamous cell carcinoma (HNSCC) significantly hampers local control and patient prognosis. This study investigated the efficacy and molecular mechanisms of high-energy X-ray-based ultra-high dose rate radiotherapy (UHDR-RT) in overcoming RT resistance. The established RT-resistant HNSCC cell lines and animal models were subjected to UHDR-RT or conventional RT (Conv-RT) via a high-power rhodotron accelerator.

CD146 regulates the stemness and chemoresistance of hepatocellular carcinoma via JAG2-NOTCH signaling.

CD146 plays a key role in cancer progression and metastasis. Cancer stem cells (CSCs) are responsible for tumor initiation, drug resistance, metastasis, and recurrence. In this study, we explored the role of CD146 in the regulation of liver CSCs.

MHFNet: A Multimodal Hybrid-embedding Fusion Network for Automatic Sleep Staging.

Scoring sleep stages is essential for evaluating the status of sleep continuity and comprehending its structure. Despite previous attempts, automating sleep scoring remains challenging. First, most existing works did not fuse local and global temporal information.

Learning Frame-Event Fusion for Motion Deblurring.

Motion deblurring is a highly ill-posed problem due to the significant loss of motion information in the blurring process. Complementary informative features from auxiliary sensors such as event cameras can be explored for guiding motion deblurring. The event camera can capture rich motion information asynchronously with microsecond accuracy.

Deep Learning Models for Predicting the Recurrence of Idiopathic Granulomatous Mastitis.

Background And Aim: Idiopathic granulomatous mastitis (IGM) is a rare chronic inflammatory breast disease that presents significant challenges in diagnosis and treatment. Predicting the recurrence of IGM is crucial for effective patient management and improved treatment outcomes. This study aims to evaluate and compare the performance of different machine learning models, including logistic regression, random forest, and neural networks, in predicting IGM recurrence using patient data.

Elucidating particle number concentrations and unveiling source mechanisms at a prominent national background site on the northeastern Qinghai-Tibetan Plateau.

Understanding the changes in particle physical and chemical characteristics is critical for investigating the formation mechanisms of particles. This study conducted an observation campaign at the National Background Station on the Qinghai-Tibetan Plateau. We employed a Scanning Mobility Particle Sizer (SMPS) for measuring particle number concentration (PNC), sized from 3.

A retrospective study of risk factors for thrombosis in patients with ITP.

Objectives: ITP is not only a bleeding disease but also a potential thrombotic disease.

Methods: This retrospective study analyzed the factors associated with the occurrence of thrombosis events in ITP patients.

Results: The overall incidence of thrombosis was 4.

Rhynchophylline alleviates cognitive deficits in multiple transgenic mouse models of Alzheimer's disease via modulating neuropathology and gut microbiota.

Amyloid-beta (Aβ) aggregation, phosphorylated tau accumulation and neuroinflammation are considered as three hallmarks of Alzheimer's disease (AD). Rhynchophylline (RN), the major alkaloid of a Chinese medicinal plant Uncaria rhynchophylla, has been shown to possess potent anti-AD effects. This study explored the effects of RN on Aβ pathology, tauopathy, and neuroinflammation using three AD mouse models, including TgCRND8, 3×Tg-AD, and 5×FAD, with RN treatment lasting for 4, 6, and 6 months, respectively, followed by behavioral tests and biological assays.

The TaCLE24b peptide signaling cascade modulates lateral root development and drought tolerance in wheat.

Plant peptide hormones play an important role in regulating root development and stress responses. Here, we identify a root-derived CLAVATA3/Endosperm surrounding region-related (CLE) peptide TaCLE24b and its leucine-rich repeat receptor-like kinase CLAVATA1 (CLV1) TaCLV1, which together regulate the formation of lateral root primordium and the outgrowth of lateral root in wheat. Additionally, a loss-of-function mutation of TaSG-D1, encoding a Ser/Thr protein kinase glycogen synthase kinase 3 (STKc_GSK3), also enhances the formation of lateral root primordium and the outgrowth of lateral roots in wheat.

Characterization, sources, and risk assessment of atmospheric PM-bound NPAHs and OPAHs in the core area of the Ili River Valley, China.

Statistical data indicate that Xinjiang is having the second-highest particulate matter emissions in China over the past two years, yet relevant research data are scarce. PM includes a variety of toxic organic substances, including nitro-PAHs (NPAHs) and oxy-PAHs (OPAHs). The objective of this study was to characterize and ascertain the sources of PM-bound NPAHs and OPAHs in the core area of the Ili River Valley.

Improved Selectivity of CeMnOx/Pt@SnO Laminated MOS Sensor for Hydrogen Cyanide Under Temperature Dynamic Modulation.

Poor selectivity is one of the main bottlenecks restricting the development of metal oxide semiconductor (MOS) sensors. In this paper, using hydrogen cyanide (HCN) as the target gas, CeMnOx as the catalytic layer material and Pt@SnO as the gas-sensitive layer material, we have proposed a scheme to improve the selectivity of a catalytic layer/gas-sensitive layer-laminated MOS sensor under dynamic temperature modulation. We tested HCN and 12 kinds of battlefield environment simulation gases, and the results showed that the CeMnOx/Pt@SnO sensor, under the condition of temperature dynamic modulation (a constant temperature of 400 °C for the gas-sensitive layer and a variable temperature of room temperature to 400 °C for the catalytic layer; the heating and cooling rates were 200 °C/s, the highest temperature was maintained for 2 s, and the lowest temperature was maintained for 2 s), distinct characteristic peaks appeared on the G-T curves of the resistance response to HCN only.

Defect Passivation and Stress Release Strategies for Inverted Perovskite Solar Cells Based on the Low-Pressure-Assisted Solution Process.

Perovskite solar cells (PSCs) have attracted much attention in the global photovoltaic field due to their excellent optoelectronic properties. However, the intrinsic crystalline properties and the preparation methods of perovskites result in numerous defects and residual stress in the perovskite film. To address this issue, the additive 3-methylthio-1-propylammonium bromide (3MeSPABr) was added to the perovskite precursor solution, and PSCs with an inverted structure via a low-pressure-assisted solution process were fabricated.

Traditional medicine Bazi Bushen potentiates immunosurveillance of senescent liver cancer cells via cGAS-STING signaling activation in macrophages.

Senescent cancer cells often evade immune clearance to exert profound effects on cancer progression and therapy resistance. Improving immunosurveillance to eliminate senescent cancer cells is a crucial measure to enhance anti-cancer therapy. Bazi Bushen (BZBS) is a traditional medicine with the function of relieving fatigue and delaying ageing, but its role in tumor treatment remains poorly understood.

Structural insights into dynamics of the BMV TLS aminoacylation.

Brome Mosaic Virus (BMV) utilizes a tRNA-like structure (TLS) within its 3' untranslated region to mimic host tRNA functions, aiding aminoacylation and viral replication. This study explores the structural dynamics of BMV TLS interacting with tyrosyl-tRNA synthetase (TyrRS) during aminoacylation. Using cryo-EM, we capture multiple states of the TLS-TyrRS complex, including unbound TLS, pre-1a, post-1a, and catalysis states, with resolutions of 4.

Corrigendum to "Sub-chronic toxicity of the active fraction of a modified Huang-Lian-Jie-Du Decoction" [Toxicol. Rep. 13 (2024) 101682].

[This corrects the article DOI: 10.1016/j.toxrep.

The mitochondrial DNAJC co-chaperone TCAIM reduces α-ketoglutarate dehydrogenase protein levels to regulate metabolism.

Mitochondrial heat shock proteins and co-chaperones play crucial roles in maintaining proteostasis by regulating unfolded proteins, usually without specific target preferences. In this study, we identify a DNAJC-type co-chaperone: T cell activation inhibitor, mitochondria (TCAIM), and demonstrate its specific binding to α-ketoglutarate dehydrogenase (OGDH), a key rate-limiting enzyme in mitochondrial metabolism. This interaction suppresses OGDH function and subsequently reduces carbohydrate catabolism in both cultured cells and murine models.