F-box protein FBXO21 overexpression inhibits the proliferation and metastasis of clear cell renal cell carcinoma and is closely related to the CREB pathway and tumor immune cell infiltration.

Background: Many studies have shown that F-box proteins regulate epithelial-mesenchymal transition, which is closely related to tumor metastasis. However, there is still limited research on the role of F-box proteins in renal cell carcinoma (RCC).

Methods: Public databases were used to screen differentially expressed genes among 37 F-box proteins in clear cell RCC (ccRCC).

Efficient cleavage of CO bond of lignin by synergistic electrocatalysis using a polyoxometalate catalyst with bimetallic sites.

This study reported a low-cost and highly efficient Dexter-Silverton polyoxometalate (POM)/Ni foam composite (NiCo-POM/NF) with bimetallic sites for acetophenone production. With this novel composite as an electrocatalyst, β-O-4 in 2-phenoxy-1-phenylethanol (PPE), a typical β-O-4 model, can be selectively oxidized to aromatic chemicals with excellent yields (62 %-74 %) by controlled-potential electrolysis. A PPE conversion of 99.

The main active components of Prunella vulgaris L. alleviate myocardial ischemia-reperfusion injury by inhibiting oxidative stress and ferroptosis via the NRF2/GPX4 pathway.

Ethnopharmacological Relevance: Prunella vulgaris L. (PV) is a widely distributed medicinal and edible plant used in traditional Chinese medicine for its anti-tumor, anti-inflammatory, anti-oxidant, hypoglycemic, and anti-hypertensive effects. Despite the numerous studies reporting on its cardiovascular protective effects, it is still not known whether PV could relieve myocardial ischemia-reperfusion (MI/R) injury.

The rheumatoid arthritis drug Auranofin targets peroxiredoxin 1 and peroxiredoxin 2 to trigger ROS-endoplasmic reticulum stress axis-mediated cell death and cytoprotective autophagy.

Auranofin (AF) is a gold-based compound and it has been used in the treatment of rheumatoid arthritis for over four decades. Recently, it has been demonstrated to show significant antitumor activity across various cancer types and is being repurposed as an anticancer drug. However, the precise mechanisms underlying its antitumor effects, particularly its binding targets, remain poorly understood.

Effects of okadaic acid on Pyropia yezoensis: Evidence from growth, photosynthesis, oxidative stress and transcriptome analysis.

The frequent occurrences of harmful algal blooms potentially threaten marine organisms. The phycotoxin okadaic acid (OA) has been globally detected in seawater, however, the knowledge of effects of OA on macroalgae is limited. This study investigated the effects of OA (0.

Reactive bio-based flame retardant derived from chitosan, phytic acid, and epoxidized soybean oil for high-performance biodegradable foam.

Due to the shortage of global petrochemical resources, preparing biodegradable polyurethane foam (PUF) with excellent strength and resistance against fire is an important way for sustainable development. A reactive all bio-based flame retardant CPE was prepared using chitosan (CS), phytic acid (PA), and epoxidized soybean oil (ESO) as raw materials. Meanwhile, the bio-based PUF matrix, named ERP, was prepared with ESO, ricinoleic acid (RA) and 4,4-diphenylmethane diisocyanate (PMDI).

Exploring the mechanism of vitamin C on the co-expressed genes of papillary thyroid carcinoma and Epstein-Barr virus based on bioinformatics, network pharmacology and molecular docking analysis.

Objective: The study aims to evaluate the role and mechanism of action of vitamin C as an anti- Epstein-Barr virus (EBV) and papillary thyroid carcinoma (PTC) therapeutic agent.

Methods: The PTC/EBV-associated genes were obtained by intersection and further screen out hub genes to construct a prognostic model. The relationship between PTC/EBV-related genes and core genes and immune infiltration was analyzed, respectively.

Cost-effectiveness analysis of combination therapies involving novel agents for first/second-relapse patients with multiple myeloma: a Markov model approach with calibration techniques.

Background: As the number of randomized clinical trials (RCTs) demonstrating the survival benefits of combination therapies in previously treated multiple myeloma (MM) patients increases, it is essential to determine the most cost-effective treatment through robust economic evaluation. This study aims to assess the cost-effectiveness of combination therapies for first/second-relapse MM patients from the perspective of the Chinese healthcare system.

Methods: A Markov model was developed to evaluate three combination therapy groups based on primary drugs (bortezomib, lenalidomide, and carfilzomib).

Cajanus cajan (L.) Millsp. Leaves: A Comprehensive Review of Phytochemistry, Pharmacological Properties, Safety, and Clinical Applications.

Cajanus cajan (L.) Millsp. leaves (CCML), a well-known traditional Chinese medicine, is widely recognized for its protective effects against osteoporosis and osteonecrosis.

Proteomic signatures of type 2 diabetes predict the incidence of coronary heart disease.

Emerging evidence reveals a complex association between type 2 diabetes (T2D) and coronary heart disease (CHD), which share common risk factors and biological pathways. This study aims to identify the shared proteomic signatures of T2D and CHD, as well as whether the shared proteins predict incident CHD in T2D patients, and to develop predictive models. Utilizing data from 53,014 UK Biobank participants and 2923 plasma proteins, we identified 488 proteins associated with T2D, of which 125 proteins were also associated with CHD.

Development and validation of a risk score for predicting 30-day mortality in patients with ST elevation myocardial infarction.

The existing risk sores for ST-elevation myocardial infarction (STEMI) patients cannot balance timeliness, feasibility, and accuracy. This study aimed to develop and validate a two-stage scoring system capable of dynamic evaluation for 30-day mortality among STEMI patients. We recruited 3939 patients and randomly assigned (7:3) to derivation (N = 2757) and internal validation (N = 1182) datasets, an independent cohort of 1315 STEMI patients was used for external validation.

Nucleus pulposus cell-mimicking nanoparticles for cell-specific HIF1A editing to modulate SASP-mediated disc inflammation via autophagy activation.

Traditional methods of plasmid delivery, including viral vectors, lipofection, and electroporation, are widely used for gene editing but have limitations, such as cellular toxicity, limited transfection efficiency in primary cells, and nonspecific side effects. Here, we report the development of nucleus pulposus cell (NPC)-mimicking nanoparticles (HIF1A@NNP) with an NPC membrane as the shell and pcDNA3.1-rHIF1A encapsulated in the core via extrusion.

Dual-pathway EEG model with channel attention for virtual reality motion sickness detection.

Background: Motion sickness has been a key factor affecting user experience in Virtual Reality (VR) and limiting the development of the VR industry. Accurate detection of Virtual Reality Motion Sickness (VRMS) is a prerequisite for solving the problem.

New Method: In this paper, a dual-pathway model with channel attention for detecting VRMS is proposed.

Measurement of Very-High-Energy Diffuse Gamma-Ray Emissions from the Galactic Plane with LHAASO-WCDA.

The diffuse Galactic gamma-ray emission is a very important tool used to study the propagation and interaction of cosmic rays in the Milky Way. In this Letter, we report the measurements of the diffuse emission from the Galactic plane-covering Galactic longitudes from 15° to 235° and latitudes from -5° to +5°, in an energy range of 1 to 25 TeV-made with the Water Cherenkov Detector Array (WCDA) of the Large High Altitude Air Shower Observatory. After the sky regions of known sources are masked, the diffuse emission is detected with 24.

In Situ Secondary Growth Method for Dual-Chiral Blue Phase Liquid Crystal Films with Broadly Tunable Hyper-Reflective Photonic Bandgaps.

Blue-phase liquid crystals (BPLCs) have shown great potential in hyper-reflective display technology due to their narrow bandgap, high color saturation, and fast response characteristics. However, there remains a significant challenge for achieving open-patternable dual-chiral BPLC films (DH-BP) and precise tuning for efficient hyper-reflection due to the packaging limitations of liquid crystal cells and the complexities of the dynamic bandgap matching principle. In this study, an in situ secondary growth strategy was proposed to successfully fabricate structurally continuous and uniform DH-BP films.

N-acetyltransferase 10 catalyzes RNA N-acetylcytidine to regulate photosynthesis in rice.

N-acetylcytidine (acC) is a novel mRNA modification that enhances RNA stability and translation in mammals and plants. We previously identified acC in Arabidopsis, introduced by two homologs of human N-acetyltransferase 10 (NAT10). While acC influences leaf development in Arabidopsis, its role in rice is unclear.

One Anastomosis Gastric Bypass Versus Roux‑en‑Y Gastric Bypass for Obesity: An Updated Meta‑analysis and Systematic Review of Randomized Controlled Trials.

Background: Roux-en-Y gastric bypass (RYGB) is widely regarded as a cornerstone intervention for individuals afflicted with metabolic syndromes and severe obesity. However, one anastomosis gastric bypass (OAGB) emerged after RYGB as a more straightforward and less technically demanding operation. This systematic review and meta-analysis aims to compare both procedures and update the currently existing evidence.

Copper-Catalyzed Dynamic Kinetic Asymmetric Arylation of Secondary Phosphine-Boranes for the Synthesis of P(III)-Stereogenic Centers.

Transition-metal-catalyzed asymmetric C-P(III) bond formation is a direct method for the construction of P(III)-stereogenic centers; however, achieving high enantioselectivity remains a challenge. Herein, an unprecedented Cu-catalyzed dynamic kinetic resolution of secondary phosphine-boranes was successfully developed. This asymmetric C-P(BH) coupling reaction provided the direct and highly enantioselective synthesis of P(III)-stereogenic centers, enabling the formation of chiral medium-sized benzophosphine-boranes (7-10-membered cycles).

Maximum a posteriori underwater acoustic source localization based on time differences of arrival accounting for refraction.

Traditional underwater acoustic source localization methods based on time differences of arrival (TDOA) in the presence of refraction first estimate the source depth and range to each hydrophone and then estimate the horizontal location of the source. The accuracy of these methods is compromised by errors in range estimation. To address this, we propose a three-dimensional source localization method that utilizes TDOA measurements between direct and surface-reflected arrivals at N(N ≥3) hydrophones, taking into account refraction effects.

Synergistic Modulation of Grain Boundary and Domain Boundary Enhances the Ionic Conductivity of LiLaTiO Solid Electrolyte.

The ABO perovskite oxide solid state electrolyte LiLaTiO (LLTO) has gained significant attention. Despite their potential, both the bulk and grain boundary conductivity values observed in practice fall short of theoretical expectations. In terms of structures, domain boundaries and grain boundaries play a crucial role in hindering ionic transport, and there has been no comprehensive study that enhances both the bulk and grain boundary conductivity by modification of these microstructures.

Spatially dependent Raman gain by vortex beam in a four-level N-typed atomic system.

An efficient scheme for controlling the spatial Raman gain is proposed in a cold atomic ensemble with a four-level N-typed configuration. The cold atoms are driven by the Laguerre-Gaussian (LG) vortex beams. Considering the control and driving fields are vortex beams and using experimentally achievable parameters, we identify the condition under which the topological charges (TCs) allows us to manipulate the radial distribution of the Raman gain spectra.

Multimodal Profiling of Iron Heterogeneity at the Nanoscale.

Life is inherently heterogeneous, and visualizing this heterogeneity in the spatial distribution of biometals offers valuable insights into various biological processes. While biometal mapping provides superior spatial resolution compared to other bioanalytical techniques, it alone cannot fully explain the functional roles of biometals in health and disease. In this study, we introduced a novel method using specially designed sample grids to facilitate beam-, X-ray-, and ion-beam-based imaging of biometals on the same tissue section.

Carcinoma arising in microglandular adenosis of the breast: clinicopathological and genetic analysis.

Aims: To study the clinicopathological, immunohistochemical and molecular features of carcinoma arising in microglandular adenosis (MGACA) of the breast.

Methods: Clinicopathological features of 13 cases of MGACA were analysed. All tumours were molecular subtype by immunohistochemistry (IHC) of AR, CD8, FOXC1 and DCLK1 expression.

Status of Cardiac Magnetic Resonance in Clinical Application and Scientific Research: A National Survey in China.

Background: Cardiovascular magnetic resonance (CMR) is rapidly expanding in China, yet comprehensive national data on its clinical application and research status are limited. This study aims to evaluate the current landscape of CMR across the country.

Methods: An electronic survey was conducted targeting two groups: physicians trained at the Fuwai Fellowship Program and members of the Chinese Society of Radiology.