Effects of lithium carbonate combined with olanzapine on glucose and lipid metabolism in the treatment of bipolar disorder and gender differences.

To explore the effect of lithium carbonate combined with olanzapine on glucose and lipid metabolism, as well as gender differences in treating bipolar disorder (BD). 110 BD patients admitted to the Fifth People's Hospital of Luoyang from February 2022 to January 2024 were retrospectively included in the study. Patients were categorized into two groups based on treatment: The single group (lithium carbonate, n = 50) and the coalition group (lithium carbonate + olanzapine, n=60).

Dually Fluorinated Unimolecular Micelles for Stable Oxygen-Carrying and Enhanced Photosensitive Efficiency to Boost Photodynamic Therapy against Hypoxic Tumors.

Tumor hypoxia is one of key challenges in deep tumor photodynamic therapy (PDT), and how to fix this issue is attracting ongoing concerns worldwide. This work demonstrates dually fluorinated unimolecular micelles with desirable and stable oxygen-carrying capacity, high cellular penetration, and integrative type I & II PDT for deep hypoxic tumors. Dually fluorinated star copolymers with fluorinated phthalocyanines as the core are prepared through photoinitiated electron/energy transfer-reversible addition-fragmentation chain transfer (PET-RAFT) polymerization under irradiation with NIR LED light at room temperature, followed by assembly into unimolecular micelles.

Suppressing the progression of bladder cancer using cyclovirobuxine D based on network pharmacology and bioinformatics approaches.

Limited treatment options are available for bladder cancer (BCa) resulting in extremely high mortality rates. Cyclovirobuxine D (CVB-D), a naturally alkaloid, reportedly exhibits notable antitumor activity against diverse tumor types. However, its impact on CVB-D on BCa and its precise molecular targets remain unexplored.

Preharvest Treatment with Melatonin Improves Antioxidant and Phenylpropanoid Pathways During Postharvest Storage.

is known for its popularity and robust nutritional value. While fresh fruit is a perishable commodity, it has a short post-harvest life and is susceptible to fungal decay after harvest. Melatonin has been reported to delay the aging and quality decline of various fruits and vegetables after harvest.

Room temperature synthesis of one-dimensional hierarchical hollow BiOBr with tunable photocatalysis reaction pathway for RhB under visible light.

One-dimensional (1D) hierarchical photocatalyst has the advantages of 1D materials and hierarchical materials, which is a kind of potential high performance photocatalytic materials. However, how to efficiently synthesize 1D hierarchical BiOBr is still a huge challenge. Herein, 1D rod-like BiO(OH)(NO)·3HO, the hydrolysis product of Bi(NO)·5HO, was acted as both the template and Bi source to synthesize 1D hierarchical hollow BiOBr (1DHHBr) through a facile solution stirring method at room temperature, using KBr as Br source.

Elucidating the effect of chitosan microgel characteristics on the large amplitude oscillatory shear (LAOS) behavior of their stabilized high internal phase emulsions using the sequence of physical processes (SPP) approach and comparison with mayonnaise.

Chitosan microgels (h-CSMs) were prepared by cross-linking hydrophobically modified chitosan with sodium phytate (SP). Emulsions stabilized by h-CSMs with different inter-phase fraction, microgel concentration and cross-linking density were studied of their microstructural and rheological properties. In particular, the large amplitude oscillatory shear (LAOS) of the high internal phase emulsions (HIPEs) stabilized by h-CSMs were systematically analyzed using the Fourier transform with Chebyshev polynomials (FTC) and sequence of physical processes (SPP) methods, to explore their nonlinear rheological properties.

Near-infrared fluorogenic RNA for in vivo imaging and sensing.

Fluorogenic RNA aptamers have various applications, including use as fluorescent tags for imaging RNA trafficking and as indicators of RNA-based sensors that exhibit fluorescence upon binding small-molecule fluorophores in living cells. Current fluorogenic RNA:fluorophore complexes typically emit visible fluorescence. However, it is challenging to develop fluorogenic RNA with near-infrared (NIR) fluorescence for in vivo imaging and sensing studies.

Combination of plasma acoustic emission signal and laser-induced breakdown spectroscopy for accurate classification of steel.

Background: Fast and accurate classification of steel can effectively improve industrial production efficiency. In recent years, the use of laser-induced breakdown spectroscopy (LIBS) in conjunction with other techniques for material classification has been developing. Plasma Acoustic Emission Signal (PAES) is a type of modal information separate from spectra that is detected using LIBS, and it can reflect some of the sample's physicochemical information.

Improving flavor of Wuyi rock tea processed from rain-soaked leaves by optimizing withering conditions.

Rainy weather restricts the formation of high-quality Wuyi rock tea (WRT). Herein, an optimized withering process for rain-soaked leaves was developed using response surface methodology. Results showed that increasing the withering temperature, relative humidity, and withering time from 25 °C to 40 °C, 80 % to 97 %, and 3 to 6 h, respectively, effectively improved the sensory qualities of the optimized primary WRT (WRTO) prepared from rain-soaked leaves compared with those before optimization.

Lattice Oxygen Redox Dynamics in Zeolite-Encapsulated CsPbBr Perovskite OER Electrocatalysts.

Understanding the oxygen evolution reaction (OER) mechanism is pivotal for improving the overall efficiency of water electrolysis. Despite methylammonium lead halide perovskites (MAPbX) have shown promising OER performance due to their soft-lattice nature that allows lattice-oxygen oxidation of active α-PbO layer surface, the role of A-site MA or X-site elements in the electrochemical reconstruction and OER mechanisms has yet to be explored. Here, it is demonstrated that the OER mechanism of perovskite@zeolite composites is intrinsically dominated by the A-site group of lead-halide perovskites, while the type of X-site halogen is crucial for the reconstruction kinetics of the composites.

Dimethylacridine based emitters for non-doped organic light-emitting diodes with improved efficiency.

Organic light-emitting diodes (OLEDs) has been attracting much extensive interest owing to their advantages of high-definition and flexible displays. Many advances have been focused on boosting the efficiency and stability. Two innovative dimethylacridine-based emitters,1,1,2,2-tetrakis(4- (2,7-di-tert-butyl-9,9-dimethylacridin-10(9H)-yl)phenyl ethene (AcTPE), and bis(4-(2,7-di-tert-butyl-9,9-dimethylacridin-10(9H)-yl)phenyl)methanone (Ac2BP) were designed and synthesized, in which TPE-baesed AcTPE presents AIE properties, and with the phenyl as spacer between the DMAC and carbony, aryl-ketone-based Ac2BP doesn't show AIE properties due to the absence of restriction of intramolecular rotations.

Asynchronous Embryo Transfer in Ewes.

The aim of the present study was to evaluate the effects of spatially and/or temporally asynchronous transfer of in vivo embryos at different stages in ewes during the breeding season. Four experiments were carried out. In Experiment 1, 207 blastocysts that had been frozen and thawed were transferred into the oviducts of 43 day two recipients, the oviducts of 23 day six recipients, and the uteri of 141 day six recipients, respectively.

GATA3-COMT1-Melatonin as Upstream Signaling of ABA Participated in Se-Enhanced Cold Tolerance by Regulate Iron Uptake and Distribution in Cucumis sativus L.

Selenium has the function of bio-stimulating hormone. However, the underlying physiological and molecular mechanisms of melatonin and abscisic acid as secondary messengers in improving cold tolerance by selenium are limited. This study investigated the effects of selenite on the cold stress of cucumber seedlings.

Manganese Galvanic Cells Intervene in Tumor Metabolism to Reinforce cGAS-STING Activation for Bidirectional Synergistic Hydrogen-Immunotherapy.

The cGAS-STING pathway is pivotal in initiating antitumor immunity. However, tumor metabolism, particularly glycolysis, negatively regulates the activation of the cGAS-STING pathway. Herein, Mn galvanic cells (MnG) are prepared via liquid-phase exfoliation and in situ galvanic replacement to modulate tumor metabolism, thereby enhancing cGAS-STING activation for bidirectional synergistic H-immunotherapy.

Computed tomography-guided microwave ablation therapy for pediatric adrenal neuroblastoma with lung nodule a case report.

Background: Solid lung lesions are common in clinical practice, and percutaneous thermal ablation has been shown to be an effective treatment for these lesions. While computed tomography (CT)-guided microwave ablation (MWA) therapy is frequently used for adult solid lesions, it is rarely considered for pediatric cases.

Case Presentation: A case of an 8-year-old child with adrenal neuroblastoma and a left upper lung mass.

Bullous pemphigoid and hypercoagulability: a review.

Introduction: Bullous pemphigoid (BP) is an autoimmune blistering disease characterized by autoantibodies against hemidesmosomal proteins on basal membrane zone. The presence of a high incidence of thrombotic events has led to the identification of a hypercoagulable state in BP patients.

Area Covers: This review highlights the interactions between coagulation and immune-inflammatory responses based on the current literature available, as well as individual changes of characteristic coagulation parameters in BP.

Different Impacts of Long-Term Tillage and Manure on Yield and N Use Efficiency, Soil Fertility, and Fungal Community in Rainfed Wheat in Loess Plateau.

Conservation tillage and fertilization are widely adopted in agricultural systems to enhance soil fertility and influence fungal communities, thereby improving agroecosystems. However, the effects of no-tillage combined with manure on grain yield, nitrogen use efficiency (NUE), soil fertility, and rhizosphere fungal communities remain poorly understood, particularly in rainfed wheat fields on the Loess Plateau. A 15-year field experiment was conducted at the Niujiawa Experimental Farm of the Cotton Research Institute, Shanxi Agricultural University.

Echinacoside Alleviates Metabolic Dysfunction-Associated Steatotic Liver Disease by Inhibiting Ferroptosis via Nrf2/HMOX1 Pathway.

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a chronic liver disease characterized by hepatic lipid accumulation, and echinacoside (ECH) has demonstrated antioxidant and anti-inflammatory effects across multiple conditions, it has demonstrated hepatoprotective effects. Ferroptosis represents a novel mechanism of cell demise, differing from apoptosis and autophagy. Emerging research indicates that ferroptosis in hepatocytes plays a role in the development of alcoholic liver disease.

Comparative Analysis of Myofiber Characteristics, Shear Force, and Amino Acid Contents in Slow- and Fast-Growing Broilers.

Skeletal muscle fiber characteristics are pivotal in assessing meat quality. However, there is currently a lack of research precisely quantifying the total number of myofibers (TNM) of skeletal muscles. This study used Arbor Acres (AA) broilers and Wenchang (WC) chickens to determine the TNM of several skeletal muscles and the meat quality of the pectoralis major muscle (PM).

Fusion Partner Facilitates Expression of Cell-Penetrating Peptide L2 in .

Background: L2 is formed by combining the pheromone of () and a cell-penetrating peptide (CPP) with cell-penetrating selectivity. L2 has more significant penetration and better specificity for killing . However, the production of AMPs by chemical synthesis is always a challenge because of the production cost.

Evaluation of Cold Resistance in Alfalfa Varieties Based on Root Traits and Winter Survival in Horqin Sandy Land.

The Horqin Sandy Land in China is a key alfalfa production base, challenged by low winter temperatures and large diurnal temperature shifts, affecting alfalfa's winter survival. Alfalfa roots are the primary organs responsible for winter adaptability; consequently, by investigating the changes in the root physiology and nutritional components of alfalfa during the overwintering period, we can enhance our understanding of its mechanisms for cold resistance. Over the course of two years (2022-2023), field trials were conducted on 40 alfalfa varieties selected from both domestic and international sources for their potential cold resistance.

Intravenous iron therapy for treating patients with iron deficiency anaemia during the perioperative period of gynecological malignancy.

Anaemia is a common phenomenon in patients with malignant gynecological tumors. The occurrence of anaemia in the perioperative period leads to an increased probability of blood transfusion, increased surgical complications,poor wound healing, prolonged hospitalization, increased medical costs, and increased mortality. Intravenous iron, which is known for its rapid onset and lack of gastrointestinal side effects, has become increasingly prevalent in clinical practice.

Spontaneous Catalytic Reaction of a Surfactant in the Interfacial Microenvironment of Colloidal Gold Nanoparticles.

The performance of nanomaterials is significantly determined by the interfacial microenvironment, in which a surfactant plays an essential role as the adsorbent, but its involvement in the interfacial reaction is often overlooked. Here, it was discovered that citrate and ascorbic acid, the two primarily used surfactants for colloidal gold nanoparticles (Au NPs), can spontaneously undergo catalytic reaction with trace-level nitrogenous residue under ambient environment to form oxime, which is subsequently cleaved to generate CN or a compound containing the -CN group. Such a catalytic reaction shows wide universality in both reactants, including various carbonaceous and nitrogenous sources, and metal catalysts, including Au, Ag, Fe, Cu, Ni, Pt, and Pd NPs.

NGR-poly(2-ethyl-2-oxazoline)-cholesteryl methyl carbonate enhances the antitumor effect of quercetin liposomes in triple-negative breast cancer.

In this paper, the pH-sensitive targeting functional material NGR-poly(2-ethyl-2-oxazoline)-cholesteryl methyl carbonate (NGR-PEtOz-CHMC, NPC) modified quercetin (QUE) liposomes (NPC-QUE-L) was constructed. The structure of NPC was confirmed by infrared spectroscopy (IR) and nuclear magnetic resonance hydrogen spectrum (H-NMR). Pharmacokinetic results showed that the accumulation of QUE in plasma of the NPC-QUE-L group was 1.