Genetic Diversity and Population Structure of Phyllosphere-Associated Xanthomonas euvesicatoria Bacteria in Physalis pubescens Based on BOX-PCR and ERIC-PCR in China.

Xanthomonas euvesicatoria has become a serious problem in Physalis pubescens, leading to substantial crop losses. In our previous investigation, we used rapid molecular detection techniques to identify X. euvesicatoria; however, this pathogen's diversity and population structure remain poorly understood, despite their importance in disease management.

Biology, Pathogenicity, and Genetic Diversity of the Rice Pathogen in Heilongjiang Province, China.

Rice false smut (RFS) is pervasive and has emerged as the primary disease affecting rice productivity. Due to the lack of effective chemical control, disease-resistant varieties are the primary method of managing the disease. This study aimed to investigate the influence of biological characteristics such as hyphal growth rate, spore production and germination ability on the pathogenicity of .

Real-world setting comparison of bridging therapy versus direct mechanical thrombectomy for acute ischemic stroke: A meta-analysis.

Background And Purpose: Intravenous Thrombolysis (IVT) prior to Mechanical Thrombectomy (MT) for Acute Ischaemic Stroke (AIS) due to Large-Vessel Occlusion (LVO) remains controversial. Therefore, the authors performed a meta-analysis of the available real-world evidence focusing on the efficacy and safety of Bridging Therapy (BT) compared with direct MT in patients with AIS due to LVO.

Methods: Four databases were searched until 01 February 2023.

Single-cell and spatial transcriptomics reveal metastasis mechanism and microenvironment remodeling of lymph node in osteosarcoma.

Background: Osteosarcoma (OS) is the most common primary malignant bone tumor and is highly prone to metastasis. OS can metastasize to the lymph node (LN) through the lymphatics, and the metastasis of tumor cells reestablishes the immune landscape of the LN, which is conducive to the growth of tumor cells. However, the mechanism of LN metastasis of osteosarcoma and remodeling of the metastatic lymph node (MLN) microenvironment is not clear.

Comparative Genomic Analysis and Rapid Molecular Detection of Xanthomonas euvesicatoria Using Unique ATP-Dependent DNA Helicase recQ, hrpB1, and hrpB2 Genes Isolated from Physalis pubescens in China.

Ground cherry (Physalis pubescens) is the most prominent species in the Solanaceae family due to its nutritional content, and prospective health advantages. It is grown all over the world, but notably in northern China. In 2019 firstly bacterial leaf spot (BLS) disease was identified on P.

Case Report: Early-Onset Charcot-Marie-Tooth 2N With Reversible White Matter Lesions Repeatedly Mimicked Stroke or Encephalitis.

Introduction: Charcot-Marie-Tooth (CMT) disease is a rare group of peripheral neuropathies with high clinical and genetic heterogeneity. CMT type 2N (CMT 2N) is a rare subtype of CMT with few clinical reports. The clinical presentation mimics that of other diseases, frequently leading to misdiagnoses.

Case report: biotin-thiamine-responsive basal ganglia disease with severe subdural hematoma on magnetic resonance imaging.

: Biotin-thiamine-responsive basal ganglia disease (BTBGD) is a rare, treatable autosomal recessive neurometabolic disorder. This condition eventually leads to severe disability and death if not treated correctly. The clinical features of BTBGD, especially those with unusual complications, are not widely known by neurologists or pediatricians.

Endovascular treatment for wake-up stroke and daytime unwitnessed stroke: A meta-analysis.

Background: Evidence from sources outside the typical clinical research setting, such as a real-world setting, may complement evidence from randomised controlled trials (RCTs). The aim of the present study was to carry out a meta-analysis of available real-world evidence that focused on the efficacy and safety of endovascular treatment in patients with wake-up stroke (WUS) or daytime unwitnessed stroke (DUS) compared to that in patients treated ≤ 6 h after the onset of an ischemic stroke.

Methods: Data mining was conducted on 1 May 2021 from PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials Cochrane Library.

Characterization and Genetic Diversity of pv. Isolates Associated with Rice Bacterial Leaf Spot in Heilongjiang, China.

In China, rice is one of the most important cereal crops. Rice bacterial brown leaf spot caused by pv. is among the most damaging rice diseases in the Heilongjiang Province of China and results in substantial yield losses.

Cascades between miRNAs, lncRNAs and the NF-κB signaling pathway in gastric cancer (Review).

Gastric cancer is a common digestive tract malignancy that is mainly treated with surgery combined with perioperative adjuvant chemoradiotherapy and biological targeted therapy. However, the diagnosis rate of early gastric cancer is low and both postoperative recurrence and distant metastasis are thorny problems. Therefore, it is essential to study the pathogenesis of gastric cancer and search for more effective means of treatment.

14-3-3 σ: A potential biomolecule for cancer therapy.

As more studies have focused on the function of 14-3-3 proteins, their role in tumor progression has gradually improved. In the 14-3-3 protein family, 14-3-3σ is the protein that is most associated with tumor occurrence and development. In some malignancies, 14-3-3σ acts as a tumor suppressor via p53 and tumor suppressor genes.

Pre etched Ag nanocluster as SERS substrate for the rapid quantification of AFB1 in peanut oil via DFT coupled multivariate calibration.

The current study extends the use of surface-enhanced Raman spectroscopy (SERS) combined with density functional theory (DFT) and multivariate calibration towards the rapid quantification of aflatoxin B1 (AFB1) in peanut oil samples. It reports the design of pre etched Ag nanocluster as an active SERS substrate for quantifying AFB1, after being impregnated on its surface. The SERS spectra of AFB1@pre etched Ag nanocluster was recorded and its respective theoretical spectrum was calculated by density functional theory (DFT) to assign the characteristic peaks.

Circular RNAs in nasopharyngeal carcinoma.

Background: Nasopharyngeal carcinoma (NPC) is a geographical distributed epithelial tumor of head and neck, which is prevalent in east Africa and Asia, especially southern China. Moreover, NPC has an unfavorable clinical effect and is prone to metastasis at an advanced stage. Although the recovery rate of patients has been improved due to concurrent chemoradiotherapy, poor curative effects and low overall survival remain key issues.

Radio-Susceptibility of Nasopharyngeal Carcinoma: Focus on Epstein- Barr Virus, MicroRNAs, Long Non-Coding RNAs and Circular RNAs.

Nasopharyngeal carcinoma (NPC) is a type of head and neck cancer. As a neoplastic disorder, NPC is a highly malignant squamous cell carcinoma that is derived from the nasopharyngeal epithelium. NPC is radiosensitive; radiotherapy or radiotherapy combining with chemotherapy are the main treatment strategies.

Vortioxetine treatment for generalised anxiety disorder: a meta-analysis of anxiety, quality of life and safety outcomes.

Objectives: The aim of this study was to investigate the efficacy, tolerability, safety, and impact on quality of life (QoL) and functional status of vortioxetine treatment for patients with generalised anxiety disorder (GAD) by performing a meta-analysis of randomised controlled trials (RCTs).

Design: Systematic review and meta-analysis.

Data Sources: Data mining was conducted in January 2019 across PubMed, EMBASE, PsycINFO, Cochrane Central Register of Controlled Trials Cochrane Library, Web of science and ClinicalTrials.

rGO-NS SERS-based coupled chemometric prediction of acetamiprid residue in green tea.

Pesticide residue in food is of grave concern in recent years. In this paper, a rapid, sensitive, SERS (Surface-enhanced Raman scattering) active reduced-graphene-oxide-gold-nano-star (rGO-NS) nano-composite nanosensor was developed for the detection of acetamiprid (AC) residue in green tea. Different concentrations of AC combined with rGO-NS nano-composite electro-statically, yielded a strong SERS signal linearly with increasing concentration of AC ranging from 1.

Real-World Outcomes of Acute Ischemic Stroke Treatment with Intravenous Thrombolysis: A Systematic Review and Meta-Analysis.

Background: Evidence from outside the typical clinical research setting, such as the real-world setting, complements evidence coming from randomized controlled trials. The purpose of this study was to evaluate all available evidence from the real-world observational trials about long-term outcomes of treatment with intravenous (IV) recombinant tissue-type plasminogen activator (rt-PA) compared with not treated with IV rt-PA (non-rt-PA) in patients with acute ischemic stroke.

Methods: We searched PubMed and Embase until March 1, 2018 for observational studies reporting matched or adjusted results comparing IV rt-PA versus non-rt-PA in patients with acute ischemic stroke.

Effectiveness of high-frequency repetitive transcranial magnetic stimulation in patients with depression and Parkinson's disease: a meta-analysis of randomized, controlled clinical trials.

Aim: This meta-analysis aimed to assess the effect of high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) for the treatment of depression in patients with Parkinson's disease (PD).

Methods: The design was a meta-analysis of randomized controlled trials (RCTs). The participants were patients with PD who suffered from depression.

Near infrared system coupled chemometric algorithms for enumeration of total fungi count in cocoa beans neat solution.

Total fungi count (TFC) is a quality indicator of cocoa beans when unmonitored leads to quality and safety problems. Fourier transform near infrared spectroscopy (FT-NIRS) combined with chemometric algorithms like partial least square (PLS); synergy interval-PLS (Si-PLS); synergy interval-genetic algorithm-PLS (Si-GAPLS); Ant colony optimization - PLS (ACO-PLS) and competitive-adaptive reweighted sampling-PLS (CARS-PLS) was employed to predict TFC in cocoa beans neat solution. Model results were evaluated using the correlation coefficients of the prediction (Rp) and calibration (Rc); root mean square error of prediction (RMSEP), and the ratio of sample standard deviation to RMSEP (RPD).

A universal SERS aptasensor based on DTNB labeled GNTs/Ag core-shell nanotriangle and CS-FeO magnetic-bead trace detection of Aflatoxin B1.

A novel universal Surface-enhanced Raman Spectroscopy (SERS) based aptasensor platform for the trace detection of Aflatoxin B1 (AFB1), a common food contaminating mycotoxin, has been constructed, with the aid of the specific interaction between AFB1 and aptamers. The amino-terminal aptamer conjugated magnetic-bead (CS-FeO) and the gold nanotriangles (GNTs)-DTNB@Ag-DTNB nanotriangles (GDADNTs) were used as the capturer and the reporter of AFB1, respectively. Under the optimized assay condition, the platform shows a distinguished sensitivity with the LOD as low as 0.

A large Raman scattering cross-section molecular embedded SERS aptasensor for ultrasensitive Aflatoxin B1 detection using CS-FeO for signal enrichment.

With growing concern on oil safety problems, developing a simple and sensitive method to detect Aflatoxin B1 (AFB1), a common mycotoxin in peanut oil, is very necessary. In this study, Surface-enhanced Raman Scattering (SERS) aptasensor was developed for ultrasensitive AFB1 detection using the amino-terminal AFB1 aptamer (NH-DNA1); and thiol-terminal AFB1 complementary aptamer (SH-DNA2) conjugated magnetic-beads (CS-FeO) as enrichment nanoprobe and AuNR@DNTB@Ag nanorods (ADANRs) as reporter nanoprobe respectively. 5,5'-Dithiobis(2-nitrobenzoicacid) (DNTB) with large Raman scattering cross-section and no fluorescence interference was embedded in Au and Ag core/shell nanorods as Raman reporter molecules.