Publications by authors named "Yang Mi"
Despite intensive multimodal therapy, the prognosis for patients with digestive system cancers remains poor. Cancer cell heterogeneity and immunosuppressive microenvironments are the main barriers to the effective CAR-T cell therapy with solid malignancies. In parallel, tumor-associated macrophages (TAMs) are essential for tumor immunosuppressive microenvironment formation.
View Article and Find Full Text PDFThe direct effect of macroscopic loads on the microstructure of bone tissue in a vibration environment is not yet known. Therefore, this study aims to investigate the macro- and micro-biomechanical properties of the lumbar spine system under dynamic loading in such an environment. We analyzed the dynamic characteristics of osteon by establishing a macro- and micro-scale model of the lumbar spine, using a submodel-specific boundary displacement method based on St.
View Article and Find Full Text PDFBackground: Brain energy metabolism disorders, including glucose utilization disorders and abnormal insulin sensitivity, are linked to the pathogenesis of postoperative delirium. Intranasal insulin has shown significant benefits in improving glucose metabolism, insulin sensitivity and cognitive function. However, its impact on postoperative delirium and insulin sensitivity biomarkers remains unknown.
View Article and Find Full Text PDFLegumes form root nodules with symbiotic nitrogen-fixing rhizobacteria, which require ample iron to ensure symbiosis establishment and efficient nitrogen fixation. The functions and mechanisms of iron in nitrogen-fixing nodules are well established. However, the role of iron and the mechanisms by which legumes sense iron and incorporate this cue into nodulation signalling pathways remain unclear.
View Article and Find Full Text PDFDigital-based emergency prevention and control system: enhancing infection control in psychiatric hospitals.
BMC Med Inform Decis Mak
January 2025
Background: The practical application of infectious disease emergency plans in mental health institutions during the ongoing pandemic has revealed significant shortcomings. These manifest as chaotic management of mental health care, a lack of hospital infection prevention and control (IPC) knowledge among medical staff, and unskilled practical operation. These factors result in suboptimal decision-making and emergency response execution.
View Article and Find Full Text PDFNAD (Nicotinamide Adenine Dinucleotide) -related metabolic reprogramming in tumor cells involves multiple vital cellular processes. However, the role of NAD metabolism in immunity and the prognosis of gastric cancer (GC) remains not elucidated. Here we identified and clustered 33 NAD + metabolism-related genes (NMRGs) based on 808 GC samples from the Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) databases.
View Article and Find Full Text PDFArticle Synopsis
- Families involved with Child Protective Services (CPS) have diverse needs that often aren't fully addressed by existing services, which could affect child safety and permanence.
- * This study evaluates the outcomes of child welfare services, focusing on how well families' needs are met in terms of service referrals and receipt of those services.
- * Results indicate that specific services, especially for mental health and substance misuse, play a crucial role in reducing incidents of re-reporting and foster care placements for children.
The efficacy of Lactobacillus and Bifidobacterium in patients with schizophrenia: a meta-analysis.
Eur Arch Psychiatry Clin Neurosci
November 2024
The modulation of gut microbiota through probiotics holds promise as a novel avenue for schizophrenia treatment. This study aims to analyze probiotic complementary therapy on individuals with schizophrenia systematically, to investigate probiotic efficacy, potential mechanisms, and implications for clinical practice. Adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we searched in Medline, Web of Science, Embase, ClinicalTrials.
View Article and Find Full Text PDFWe present a dataset of six metagenomes and 323 metagenome assembled genomes (MAGs) describing the microbial community of anaerobic digesters at three Canadian pulp and paper mills. Our objective was to assess the coding potential of the microbial community and obtain draft genomes of key organisms in the digesters.
View Article and Find Full Text PDFObjective: This study examines biosafety management practices in a psychiatric hospital's laboratory in China, focusing on how outdated information technology impacts the hospital's ability to respond to public health emergencies. The goal is to enhance the hospital's emergency response capabilities by updating risk assessments, biosafety manuals, and implementing a comprehensive quality management system alongside a specialized infection control system for significant respiratory diseases.
Methods: We utilized an integrated research approach, expanding the scope of risk assessments, updating the biosafety manual according to the latest international standards, and implementing a quality management system.
Article Synopsis
- * A cross-sectional study in India analyzed data from adults aged 50 and over to examine the relationship, finding a positive correlation between sarcopenia and SUI in both men and women after adjusting for confounding factors.
- * The correlation was stronger in men who abstain from alcohol and women who haven't had a hysterectomy, suggesting that these factors might influence the association; further research is needed to confirm the findings.
The accumulation and systemic propagation of senescent cells contributes to physiological aging and age-related pathology. However, which cell types are most susceptible to the aged milieu and could be responsible for the propagation of senescence has remained unclear. Here we found that physiologically aged bone marrow monocytes/macrophages (BMMs) propagate senescence to multiple tissues, through extracellular vesicles (EVs), and drive age-associated dysfunction in mice.
View Article and Find Full Text PDFThe complexity of brain activity reflects its ability to process information, adapt to environmental changes, and transition between states. However, it remains unclear how schizophrenia (SZ) affects brain activity complexity, particularly its dynamic changes. This study aimed to investigate the abnormal patterns of brain activity complexity in SZ, their relationship with cognitive deficits, and the impact of antipsychotic medication.
View Article and Find Full Text PDFArticle Synopsis
- Sudden cardiac arrest is a critical global health issue, particularly concerning out-of-hospital cardiac arrests (OHCA), where bystander CPR and AEDs play a vital role in improving survival rates and neurological outcomes.
- A study analyzed data from South Korea from 2016 to 2021, focusing on adult OHCA cases to compare the effectiveness of bystander CPR with and without AED usage on patient survival and neurological recovery.
- The findings revealed that while survival rates were higher for those treated with AEDs (46.6%) versus those without (23.0%), adjusting for other factors showed no significant difference in survival rates or neurological outcomes between the two groups, highlighting the importance of AED accessibility and preparedness among bystanders.
Article Synopsis
- This study explores how varying doses and administration frequencies of nicotine influence body weight, fat tissues, and liver health in male mice.
- Mice were given nicotine in different doses (0.5mg/kg, 1mg/kg, or 2mg/kg) either once, twice, or four times a day for four weeks, and their body and fat tissue weights were measured.
- Results showed that nicotine reduced body weight and fat tissue size more effectively with increased administration frequency, particularly finding that 2mg/kg given twice daily was the most effective for weight loss while revealing complex effects on different fat tissue types.
An Oxidative Stress Nano-Amplifier for Improved Tumor Elimination and Combined Immunotherapy.
Adv Healthc Mater
December 2024
Amplifying oxidative stress to disrupt intracellular redox homeostasis can accelerate tumor cell death. In this work, an oxidative stress amplifier (PP@T) is prepared for enhanced tumor oxidation therapy to reduce tumor growth and metastases. The nano-amplifier has been successfully constructed by embedding MTH1 inhibitor (TH588) in the PDA-coated porphyrin metal-organic framework PCN-224.
View Article and Find Full Text PDFArticle Synopsis
- TP53 plays a crucial role in regulating tumors and the study focuses on its related long non-coding RNAs (lncRNAs) in the context of gastric cancer (GC) and immune regulation.
- Eight lncRNAs were identified through multivariate COX regression analysis as key factors in predicting GC prognosis, which allowed categorizing patients into high-risk and low-risk groups based on lncRNA expression.
- High-risk GC patients exhibited greater infiltration of M2-macrophages and showed more sensitivity to chemotherapy, while low-risk patients demonstrated higher resistance to immunotherapy, suggesting that p53-associated lncRNAs could help in predicting immune status and survival outcomes in GC.
Article Synopsis
- This study is about gastric intestinal metaplasia (IM), a condition that can lead to stomach cancer, and how a medicine called metformin could help treat it.
- Researchers used different databases to find genes related to IM and metformin, discovering 99 common genes that could be important for treatment.
- The results showed that metformin changed how certain genes work, which helped slow down the effects of IM in mice, showing promise as a treatment option.
Article Synopsis
- Periodontitis is linked to the development of diabetes, with the bacteria Porphyromonas gingivalis potentially contributing to insulin resistance (IR) through periodontal inflammation.
- The study analyzed clinical samples and conducted experiments on cultured cells and mice, finding a correlation between P. gingivalis and IR, suggesting that the bacteria negatively impacts insulin receptor expression and glucose uptake.
- Results indicate that P. gingivalis can degrade insulin receptors via its protease (gingipain), leading to IR, and highlight the potential for targeting periodontal pathogens as a strategy to prevent diabetes.*
Article Synopsis
- Obesity leads to changes in the microRNA profile of extracellular vesicles released by bone marrow macrophages, which impact the differentiation of skeletal stem/progenitor cells (SSPCs) into either bone-building osteoblasts or fat-storing adipocytes, resulting in bone deterioration.
- Macrophage-derived extracellular vesicles from obese mice cause significant bone loss when introduced to lean mice, while those from lean mice can improve bone health in obese mice.
- Specific microRNAs, such as miR-140 and miR-378a, play opposing roles in regulating SSPC differentiation; targeting these microRNAs through an innovative delivery method restores bone health in obese mice, highlighting the role of bone marrow macrophages in obesity-related bone issues
Article Synopsis
- The study investigates the importance of anoikis resistance in colorectal cancer (CRC) for better diagnosis and treatment, identifying key genes associated with this resistance.
- Researchers used advanced data analysis techniques, including the LASSO machine learning algorithm, to develop a prognostic model that predicts CRC outcomes based on clinical factors.
- The model, which achieved high accuracy in predictions, is available through an interactive web tool to help clinicians and researchers assess individual patient risks and inform treatment decisions.
Article Synopsis
- - Autism Spectrum Disorder (ASD) is linked to gastrointestinal dysfunction and altered gut microbiota, affecting social skills and repetitive behaviors; this study explores how probiotics can interact with gut health in ASD mouse models.
- - Mice models showed compromised intestinal barriers, with increased permeability and inflammation markers; C. butyricum probiotic helped enhance intestinal barrier function and mitigate behavioral issues in these mice.
- - Results suggest that gut microbiota plays a significant role in ASD via the gut-brain axis, indicating that C. butyricum probiotics could be a potential therapeutic avenue for improving gut health and behavioral symptoms in ASD.
Article Synopsis
- Malignant cerebral edema (MCE) can occur after endovascular thrombectomy (EVT) for acute ischemic stroke (AIS), leading to serious health issues; this study aimed to create a prediction model for MCE using an imaging marker called hyperattenuated imaging marker (HIM).
- The study involved 151 patients with large-vessel occlusion, using machine learning techniques to analyze clinical and imaging data and create a nomogram for predicting MCE likelihood.
- Results showed that the nomogram had a high accuracy in predicting MCE, with an area under the curve (AUC) of 0.999 in the training group and 0.938 in the test group, suggesting it could be a valuable tool for
Baicalin Prevents Colon Cancer by Suppressing CDKN2A Protein Expression.
Chin J Integr Med
November 2024
Objective: To observe the therapeutic effects and underlying mechanism of baicalin against colon cancer.
Methods: The effects of baicalin on the proliferation and growth of colon cancer cells MC38 and CT26. WT were observed and predicted potential molecular targets of baicalin for colon cancer therapy were studied by network pharmacology.