Cell Mol Life Sci
December 2024
Cell metabolism is crucial for orchestrating the differentiation and function of regulatory T cells (Tregs). However, the underlying mechanism that coordinates cell metabolism to regulate Treg activity is not completely understood. As a pivotal molecule in lipid metabolism, the role of SHIP-1 in Tregs remains unknown.
View Article and Find Full Text PDFIn recent years, targeting mitochondrial apoptosis has emerged as a promising therapeutic strategy for Acute Myeloid Leukemia (AML). The SLC25 family of mitochondrial carriers plays a critical role in maintaining mitochondrial function and regulating apoptosis. However, the role of SLC25A21, an oxodicarboxylate carrier, in AML progression and its potential as a prognostic biomarker remain underexplored.
View Article and Find Full Text PDFCarbon-encapsulated nanoscale zero-valent-iron (C@Fe) derived from plant-based extracts has been the subject of growing interest due to its environmental friendliness. However, the effects of various pyrolysis atmospheres on the structure-function connections of C@Fe are still unclear. In this study, three pyrolytic atmospheres, namely Air, N, and 5% H/Ar were selected to fabricate X-C@Fe (X represented as A, N, H) for removing 2,4,6-Trichlorophenol (TCP), and the relationships between their structures and functions were demonstrated.
View Article and Find Full Text PDFIntroduction: This study evaluated the efficacy of radiomic analysis with optimal volumes of interest (VOIs) on computed tomography images to preoperatively differentiate invasive mucinous adenocarcinoma (IMA) from non-mucinous adenocarcinoma (non-IMA) in patients with incidental pulmonary nodules (IPNs).
Methods: This multicenter, large-scale retrospective study included 1383 patients with IPNs, 110 (8%) of whom were pathologically diagnosed with IMA postoperatively. Radiomic features were extracted from multi-scale VOI subgroups (VOI, VOI, VOI , and VOI ).
Developing a mild and efficient pretreatment technique to fully utilize lignocellulosic biomass remains a challenge. In this work, a biphasic system with 2-phenoxyethanol (EPH) organic solvent and phosphotungstic acid (PTA) aqueous solution was employed to pretreat corn stover. The prominent synergistic effect between EPH and PTA was revealed to play a key role in the fractionation of corn stover.
View Article and Find Full Text PDFBackground: Alzheimer's Disease is a neurodegenerative condition leading to irreversible and progressive brain damage, with possible features such as structural atrophy. Effective precision diagnosis is crucial for slowing disease progression and reducing the incidence rate and morbidity. Traditional computer-aided diagnostic methods using structural MRI data often focus on capturing such features but face challenges, like overfitting with 3D image analysis and insufficient feature capture with 2D slices, potentially missing multi-planar information, and the complementary nature of features across different orientations.
View Article and Find Full Text PDFLong-term durable remission in patients with B cell malignancies following chimeric antigen receptor (CAR)-T cell immunotherapy remains unsatisfactory, often due to antigen escape. Malignant B cell transformation and oncogenic growth relies on efficient ATP synthesis, although the underlying mechanisms remain unclear. Here, we report that YTHDF2 facilitates energy supply and antigen escape in B cell malignancies, and its overexpression alone is sufficient to cause B cell transformation and tumorigenesis.
View Article and Find Full Text PDFBackground: A key factor underlying the failure of Chimeric Antigen Receptor-T Cell (CAR-T) therapy in ovarian cancer (OC) is the presence of an immunosuppressive tumor microenvironment, which is intricately linked to M2 polarization among tumor-infiltrating macrophages. P2X7 receptor has been previously documented as expressed within these macrophages and its correlation with M2 polarization is evident. This investigation scrutinizes whether silencing of P2X7 receptor within macrophages could lead to augmented anti-tumor potency of CAR-T.
View Article and Find Full Text PDFJAMA Netw Open
December 2024
Importance: It is unclear whether daily physical activity and sports participation relate to executive function (EF) in children.
Objective: To explore associations between early-life physical activity, sports participation, and executive function in primary school children.
Design, Setting, And Participants: Data for this cohort study were collected from April 2006 to December 2017 from the Groningen Expert Center for Kids with Obesity (GECKO) Drenthe birth cohort, which includes Northern Dutch children.
Marine heatwave (MHW) can increase heat exchange between the land and the ocean, which may further develop into a consecutive marine and terrestrial heatwave (CMTHW). Despite their significance, the feedback mechanisms underlying these compound events remain inadequately understood. This study provides a comprehensive analysis of the interactions between terrestrial and marine heatwaves across China's coastal regions, leveraging multiple temperature datasets.
View Article and Find Full Text PDFPaspalum vaginatum, valued for its salt tolerance, is a vital species in the turfgrass and agricultural industries. Despite its significance, there are still gaps in its genetic composition, particularly in the mitochondrial (mtDNA) and chloroplast (cpDNA) genomes. Our study aimed to fill these knowledge gaps by investigating the evolutionary relationships within the paspalum family and examining the functions of organelle-encoded genes as well as the critical role of reactive oxygen species (ROS) in organelle-nucleus communication.
View Article and Find Full Text PDFIron reduction impacts the mobilization and thionation of diphenylarsinic acid (DPAA) in soil, but the contribution of crystalline and non-crystalline iron remains unknown. A paddy soil deficient in non-crystalline iron (P-Fe), crystalline and non-crystalline iron (P-Fe) were incubated with sulfate-plus-lactate, and the results were compared with paddy soil (P) in our previous study. For treatments without ferrous sulfide (FeS) precipitation, the solution-to-solid ratio (R) of DPAA increased slightly and dramatically with iron reduction, respectively, for P-Fe and P, suggesting that the reduction of non-crystalline iron contributes more to DPAA mobilization than crystalline iron.
View Article and Find Full Text PDFFront Immunol
December 2024
Rice bacterial blight is a devastating disease worldwide, causing significant yield losses. Understanding how plants defend against microbial infection is critical for sustainable crop production. We previously identified a pathogen-induced long noncoding RNA (ALEX1).
View Article and Find Full Text PDFHepatic ischemia-reperfusion injury (HIRI) is an important cause of liver injury following liver transplantation and major resections, and neutrophils are the key effector cells in HIRI. Double-negative T regulatory cells (DNT) are increasingly recognized as having critical regulatory functions in the immune system. Whether DNT expresses distinct immunoregulatory mechanisms to modulate neutrophils, as in HIRI, remains largely unknown.
View Article and Find Full Text PDFJ Colloid Interface Sci
December 2024
The redox reactions occurring at positive electrode of the lithium-sulfur (Li-S) batteries involve several key electrocatalytic processes that significantly impact the overall performance of the electrochemical energy storage system. This study presents a heterogeneous catalytic composite material composed of CoSe quantum dots (QDs) integrated with SnO nanosheets, which enhances the overall ionic conductivity and accessibility of active sites within the cathode. This controlled migration effectively traps polysulfides within the cathode, reducing their dissolution into the electrolyte and mitigating the shuttle effect.
View Article and Find Full Text PDFEthnopharmacological Relevance: The Reyanning Mixture (RYN) is a Chinese patent medicine widely used in the treatment of respiratory inflammatory diseases in China and has potential in the treatment of bacteria-infected pneumonia.
Aim Of The Study: The present study aimed to demonstrate the therapeutic potential of RYN in combination with linezolid for the treatment of MRSA-infected pneumonia and to explore the mechanisms of action and active components.
Materials And Methods: The pharmacodynamics of RYN alone and in combination with linezolid was investigated in a rat model of MRSA-induced pneumonia.
Objective: This study aimed to develop and validate a predictive model for assessing the efficacy of neoadjuvant chemotherapy (NACT) in nasopharyngeal carcinoma (NPC) by integrating radiomics and pathomics features using a particle swarm optimization-supported support vector machine (PSO-SVM).
Methods: A retrospective multi-center study was conducted, which included 389 NPC patients who received NACT from three institutions. Radiomics features were extracted from magnetic resonance imaging scans, while pathomics features were derived from histopathological images.
Bioresour Technol
December 2024
Background: Increased job stress and burnout are common among clinical nurses in China, reducing their work efficiency and nursing quality. Multiple studies have been conducted on brief interventions to reduce job stress and burnout among nurses. However, research has been hampered by a lack of psychological knowledge among nursing staff.
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