Iron-Catalyzed C-C Bond Cleavage of Oximes for Direct Coupling of Benzothiazole in Water.

An Fe-catalyzed coupling reaction between oxime ester and benzothiazole is described, which involves C-C bond cleavage of oxime ester via a single-electron transfer process. This iron catalytic system performed in water under mild reaction conditions offers a streamlined strategy to the construction of alkyl nitrile substituted benzothiazole derivatives. Application of this strategy for the synthesis of some key important compounds including 4-heterocyclic-3-arylbutanoic acid is also reported.

Prediction of global potential suitable habitats of Nicotiana alata Link et Otto based on MaxEnt model.

Nicotiana alata Link et Otto, widely used in landscaping, is not only of great ornamental value but also of high commercial and medical value. The global potential habitat of N. alata and the environmental factors affecting its distribution are not that clear at present.

Clinical application of noninvasive prenatal testing in twin pregnancies: a single-center experience.

Objectives: To evaluate the clinical efficiency of noninvasive prenatal testing (NIPT) for fetal chromosomal aneuploidy screening in twin pregnancies.

Methods: A total of 1650 women with twin pregnancies were enrolled in the study, which underwent NIPT at the Southwest Hospital, Army Medical University, Chongqing, China from January 2013 to June 2022. Fetal karyotyping analysis was conducted in high-risk patients, with subsequent follow-up on pregnancy outcomes.

Rac1/PAK1 signaling contributes to bone cancer pain by Regulation dendritic spine remodeling in rats.

Bone cancer pain (BCP) is severe chronic pain caused by tumor metastasis to the bones, often resulting in significant skeletal remodeling and fractures. Currently, there is no curative treatment. Therefore, insight into the underlying mechanisms could guide the development of mechanism-based therapeutic strategies for BCP.

Protective effect of HDACIs in improves survival and organ injury after CLP-induced sepsis.

Introduction: The effects of isoform-specific histone deacetylase inhibitors (HDACIs) and the non-selective HDACI on sepsis have been profoundly reported. However, the best HDAC classes have not been fully evaluated. Therefore, this study aimed to determine which HDACIs are responsible for survival and beneficial for organ injury.

Knockdown of histone deacetylase 9 attenuates sepsis-induced myocardial injury and inflammatory response.

Myocardial cell damage is associated with apoptosis and excessive inflammatory response in sepsis. Histone deacetylases (HDACs) are implicated in the progression of heart diseases. This study aims to explore the role of histone deacetylase 9 (HDAC9) in sepsis-induced myocardial injury.

Oral administration of nanoformulated indoximod ameliorates ulcerative colitis by promoting mitochondrial function and mucosal healing.

Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease with serious mucosal inflammation mainly in the colon and rectum. Currently, there is no effective therapeutics for UC. Indoximod (IND) is a water-insoluble inhibitor for indolamine 2, 3-dioxygenase (IDO) and has been mainly reported in cancer therapy.

Development and validation of a nomogram to predict mortality risk in patients with ischemic heart disease.

Background: Ischemic Heart Disease (IHD) is the leading cause of death from cardiovascular disease. Currently, most studies have focused on factors influencing IDH or mortality risk, while few predictive models have been used for mortality risk in IHD patients. In this study, we constructed an effective nomogram prediction model to predict the risk of death in IHD patients by machine learning.

Multi-factor correlation analysis of the effect of root-promoting practices on tobacco rhizosphere microecology in growth stages.

Some agronomic practices not only promote the development of crop roots and increase overall plant performance but also affect colonisation by rhizosphere microorganisms. However, the composition and temporal dynamics of the tobacco rhizosphere microbiota under different root-promoting practices are poorly understood. Here, we characterised the tobacco rhizosphere microbiota at the knee-high, vigorous growing, and maturity stages under the application of potassium fulvic acid (PFA), γ-Polyglutamic acid (PGA), soymilk root irrigation (SRI), and conventional fertilization (CK) and its correlation with root characteristics and soil nutrients.

Non-monotonic changes in Asian Water Towers' streamflow at increasing warming levels.

Previous projections show consistent increases in river flows of Asian Water Towers under future climate change. Here we find non-monotonic changes in river flows for seven major rivers originating from the Tibetan Plateau at the warming levels of 1.5 °C, 2.

Association between dietary calcium and depression among American adults: National health and nutrition examination survey.

Background: There is only limited evidence for an association between calcium (Ca) and depression, and the relationship was inconsistent. Therefore, the aim of this study was to assess the relationship between dietary Ca and the risk of depressive symptoms in individuals over the age of 18 in the US.

Methods: We extracted 14,971 participants from the US National Health and Nutrition Examination Survey (NHANES) 2007-2016 to probe their associations.

Association of gut microbiota and SCFAs with finishing weight of Diannan small ear pigs.

Finishing weight is a key economic trait in the domestic pig industry. Evidence has linked the gut microbiota and SCFAs to health and production performance in pigs. Nevertheless, for Diannan small ear (DSE) pigs, a specific pig breed in China, the potential effect of gut microbiota and SCFAs on their finishing weight remains unclear.

A Pyridine Diketopyrrolopyrrole-Grafted Graphene Oxide Nanocomposite for the Sensitive Detection of Chloramphenicol by a Direct Electrochemical Method.

A novel direct electrochemical sensor, based on a pyridine diketopyrrolopyrrole/graphene oxide nanocomposite-modified glass carbon electrode (PDPP/GO/GCE), was developed herein for chloramphenicol (CAP) detection. In this research, PDPP was grafted onto GO by C-N bonds and π-π conjugation, which were synergistically confirmed by Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy. The morphology study shows that PDPP was uniformly dispersed on the GO in the form of particles.

Unsupervised Data-Driven Classification of Topological Gapped Systems with Symmetries.

A remarkable breakthrough in topological phase classification is the establishment of the topological periodic table, which is mainly based on the classifying space analysis or K theory, but not based on concrete Hamiltonians that possess finite bands or arise in a lattice. As a result, it is still difficult to identify the topological phase of an arbitrary Hamiltonian; the common practice is, instead, to check the incomplete and still growing list of topological invariants one by one, very often by trial and error. Here, we develop unsupervised classifications of topological gapped systems with symmetries, and demonstrate the data-driven construction of the topological periodic table without a priori knowledge of topological invariants.

High Glucose-Induced Kidney Injury via Activation of Necroptosis in Diabetic Kidney Disease.

Diabetic kidney disease (DKD) is a major microvascular complication of diabetes mellitus (DM) and is closely associated to programmed cell death. However, the complex mechanisms of necroptosis, an alternative cell death pathway, in DKD pathogenesis are yet to be elucidated. This study indicates that necroptosis is involved in DKD induced by high glucose (HG) both in vivo and in vitro.

Identification of nitrate sources of groundwater and rivers in complex urban environments based on isotopic and hydro-chemical evidence.

Groundwater and rivers in Chinese cities suffer from severe nitrate pollution. The accurate identification of nitrate sources throughout aquatic systems is key to the water nitrate pollution management. This study investigated nitrogen components of groundwater for twelve years and analyzed the sources of nitrate in the aquatic system based on dual isotopes (δN-NO and δO-NO) in the city of Nanjing, a core city of the Yangtze River Delta region, China.

Sensitive detection of 4-nitrophenol based on pyridine diketopyrrolopyrrole-functionalized graphene oxide direct electrochemical sensor.

For highly sensitive detection of 4-nitrophenol (4-NP) in the environment, a novel pyridine diketopyrrolopyrrole-functionalized graphene oxide (PDPP-GO) composite was constructed for the first time by an improved Hummers' method. Herein, PDPP was completely dissolved in sulfuric acid (6 mol L) and reacted with GO, promoting PDPP evenly adhering to the GO surface. Moreover, the specific surface area increased from 15.

Activated wood surface and functionalized cellulose co-building strong chemical wood bonding performance.

Herein, an activated wood surface rich in CHO groups was constructed by spraying a sodium periodate aqueous solution on a natural wood surface. Besides, microcrystalline cellulose was functionalized to obtain aminated cellulose, which was dissolved in an aqueous solution and used as a specific adhesive. Subsequently, an ultrastrong wood bonding interface was co-constructed with the activated wood surface and aminated cellulose, which was formed by a chemical covalent reaction between aldehyde groups at the activated wood interface and amino groups on aminated cellulose.

Effects of cadmium on transcription, physiology, and ultrastructure of two tobacco cultivars.

Cadmium (Cd) is one of the most toxic heavy metal pollutants worldwide. Tobacco is an important cash crop; however, the accumulation of Cd in its biomass is very high. Cadmium may enter the body of smokers with contaminated tobacco and the surrounding environment via smoke.

Pin1/YAP pathway mediates matrix stiffness-induced epithelial-mesenchymal transition driving cervical cancer metastasis via a non-Hippo mechanism.

Cervical cancer metastasis is an important cause of death in cervical cancer. Previous studies have shown that epithelial-mesenchymal transition (EMT) of tumors promotes its invasive and metastatic capacity. Alterations in the extracellular matrix (ECM) and mechanical signaling are closely associated with cancer cell metastasis.

Antifungal Activity and Biocontrol Potential of JC-1 against Multiple Fungal Pathogens of Oilseed Rape.

A fungal strain (JC-1) of was isolated from a pod of oilseed rape () infested with the blackleg pathogen . This study was done to clarify its taxonomic identity using morphological and molecular approaches, to characterize its antifungal activity through bioassays and genome-based identification of antifungal metabolites, and to determine its efficacy in inducing systemic resistance (ISR) in oilseed rape. The results showed that JC-1 belongs to It displayed a strong antagonistic relationship with , (gray mold) and (stem rot).

Chemical Compositions, Extraction Optimizations, and In Vitro Bioactivities of Flavonoids from Perilla Leaves () by Microwave-Assisted Natural Deep Eutectic Solvents.

Natural deep eutectic solvents (NADESs) have been gradually applied to green extraction of active ingredients. In this study, microwave-assisted NADESs were applied to the extraction of flavonoid compounds from perilla leaves. Through comparative experiments, NADES-3 (choline chloride and malic acid at a molar ratio of 1:1) was found to have the highest extraction efficiency of total flavonoids, including apigenin 7-O-caffeoylglucoside, scutellarein 7-O-diglucuronide, luteolin 7-O-diglucuronide, and scutellarein 7-O-glucuronide by HPLC-MS.