Publications by authors named "Yang Linlin"

Based on whole genome data, the identification and expression pattern analysis of the Atropa belladonna WRKY transcription factor family were conducted to provide a theoretical foundation for studying the biological functions and mechanisms of these transcription factors. In this study, bioinformatics methods were employed to identify members of the A. belladonna WRKY gene family and to predict their physicochemical properties, conserved motifs, promoter cis-acting elements, and chromosomal localization.

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This study explored the growth-promoting effect and mechanism of the endophytic bacterium Kocuria rosea on Rehmannia glutinosa, aiming to provide a scientific basis for the development of green bacterial fertilizer. R. glutinosa 'Jinjiu' was treated with K.

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Root rot is a serious soil-borne disease in the field of Rehmannia glutinosa with continuous cropping obstacle, which se-riously affects the quality and yield of Rehmanniae Radix. In this study, a fungal strain causing root rot of R. glutinosa was isolated from the rhizosphere soil of R.

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Lithium-sulfur batteries (LSBs) are among the most promising next-generation energy storage technologies. However, a slow Li-S reaction kinetics at the LSB cathode limit their energy and power densities. To address these challenges, this study introduces an anionic-doped transition metal chalcogenide as an effective catalyst to accelerate the Li-S reaction.

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Background: The reduction in agricultural product quality and yield caused by fungal and bacterial plant diseases has led to considerable economic losses in global crop production and poses a threat to human health. The primary method of control remains the use of chemical agents. In an effort to develop novel and highly effective antimicrobial agents, a series of benzoylurea derivatives incorporating a difluoromethyl (trifluoromethyl) pyrimidine structure were designed and synthesized.

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Polycystic ovary syndrome (PCOS) is a prevalent yet complex reproductive endocrine disorder affecting 11-13% of women worldwide. Its main symptoms include elevated androgen levels, irregular menstrual cycles, and long-term metabolic and offspring health implications. Despite the disease's multifaceted nature involving genetic, epigenetic, and environmental factors, the role of alternative splicing in ovarian granulosa cells remains relatively unexplored.

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Background: Ischemia-reperfusion injury is a common cause of cardiovascular and cerebrovascular diseases. The reoxygenation during reperfusion leads to an overproduction of reactive oxygen species (ROS). As an antioxidant, HS can scavenge ROS to inhibit oxidative stress and inflammatory reaction, thus attenuating ischemia-reperfusion injury.

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Salicylic acid (SA) is widely used in food storage, preservatives, additives, healthcare, and the pharmaceutical industry. However, various poisoning symptoms are frequently reported upon ingestion of a large amount of SA. Therefore, discovering new tools for sensing SA with fast, simple, and portable performance is imperative.

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  • The study examines the relationship between the ratio of fasting C-peptide to diabetes duration (FCP/DD) and the occurrence of diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes (T2DM).
  • Conducted on 816 T2DM patients, it categorized them into DPN and non-DPN groups, revealing significant differences in age, diabetes duration, and other health indicators.
  • Results show that a higher FCP/DD ratio correlates with lower incidence of DPN and serves as a better predictor for its occurrence than just fasting C-peptide or diabetes duration alone.
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Designing ultrathin transition metal electrocatalysts with optimal surface chemistry state is crucial for oxygen evolution reaction (OER). However, the structure-dependent electrochemical performance and the underlying catalytic mechanisms are still not clearly distinguished. Herein, we synthesize ultrathin CoSe nanosheets (NSs) with subnanometer thickness by incorporating catalytically inactive selenium (Se) into ultrathin Co(OH), thereby switching the OER reaction pathway from adsorbate evolution mechanism (AEM) to oxide path mechanism (OPM).

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  • Multiple sclerosis (MS) is a common neurodegenerative disease that leads to damage in the central nervous system, and its mechanisms are still being investigated using the EAE mouse model.
  • In a recent study, researchers identified 744 proteins that change in the brain and 741 in the spinal cord of EAE mice, linking these proteins to processes like phagocytosis and inflammasome activation.
  • The study also revealed that targeting SUMOylation, a process modified by a selective inhibitor called TAK-981, can reduce MS symptoms and provide insights for potential new treatments.
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This study aimed to evaluate the efficacy of synthetic bacterial consortia transplantation (SBCT) and compare it with VMT (vaginal microbiota transplantation) in a mouse model of -induced Bacterial vaginosis (BV). A murine model of -induced BV was established, and mice were treated with SBCT, VMT, or saline. Histopathological changes, inflammatory cytokine levels, pro-inflammatory biomarker expression, helper T cell transcription factor expression, and vaginal microbiota composition were assessed.

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  • Nanoparticles (NPs) of high entropy materials (HEMs) are gaining popularity due to their versatility and various applications, with different synthesis methods available.
  • Key strategies for producing HEM NPs include thermodynamic methods that promote formation at higher temperatures and kinetic methods that involve rapid reactions or diluted precursors.
  • The review analyzes these synthesis strategies and emphasizes the importance of understanding the underlying mechanisms to optimize the production of HEM NPs for diverse scientific and technological uses.
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Acute myeloid leukemia (AML) is the most prevalent hematologic malignancy in adults. In 2022, the European LeukemiaNet (ELN) has updated its prognostic system that incorporates cytogenetics and molecular genetics based on data from patients undergoing intensive chemotherapy (IC). Recently, a risk stratification framework has been established for hypomethylating agents (HMA)-based low-intensity treatment (LIT) to fill the gaps in stratification for this treatment modality, but this needs further refinement.

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  • Hepatic steatosis, or fatty liver disease, is linked to the development of coronary plaques, and this study investigates how precise liver measurements via spectral detector computed tomography (SDCT) influence these plaques.
  • The study involved 644 patients who underwent SDCT and coronary imaging; researchers analyzed liver fat metrics like effective atomic number (Zeff) and how they relate to plaque severity and extent, categorized by segmental involvement and stenosis scores.
  • Results showed that higher Zeff values correlated with increased risks of high segmental involvement and stenosis scores, indicating a relationship between liver fat levels and coronary plaque severity, especially in younger males with specific fat distributions.
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  • - The glucagon receptor (GCGR) is crucial for treating type 2 diabetes, but only one small molecule binding site has been identified so far.
  • - Researchers used molecular dynamics simulations to find and analyze allosteric pockets in the GCGR/glucagon complex, identifying 4 stable pockets and filtering 14 potential compounds for further study.
  • - The study revealed that one compound, gs6, exhibits antagonistic activity, and highlights new allosteric sites, paving the way for future GPCR research, though more simulation methods could enhance the findings.
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  • The study focuses on the trace amine-associated receptor 1 (TAAR1), which recognizes trace amines like β-phenylethylamine and methamphetamine in the brain and is linked to disorders such as schizophrenia and substance abuse.
  • Researchers determined the structure of the human TAAR1-G protein complex with methamphetamine and explored how TAAR1 selectively binds to different ligands through functional studies and molecular dynamics simulations.
  • The findings highlight a hydrophobic core in the receptor's transmembrane helices that activates TAAR1, providing insights for developing new treatments for substance abuse and various neurological disorders.
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Climate change is having important effects on the migration routes and seasonal-spatial distribution patterns of aquatic animals, including the cephalopods de Rochebrune (Hoyle, 1886) and (Hoyle, 1885) in the East China Sea region. We conducted bottom trawling surveys from 2018 to 2019 in the East China Sea region to identify the seasonal-spatial distribution patterns, including the locations of spawning and nursery grounds of both species, and to determine how they are related to environmental variables. We used random forests and boosted regression trees to identify the distribution patterns of both species from spring to winter to estimate the annual mean situations.

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  • Leukemia presents significant healthcare challenges in both China and the US, with research highlighting notable differences in incidence and mortality rates between the two countries.
  • Data from 1990 to 2021 indicates that while China has lower overall leukemia rates compared to the US, it sees significantly higher rates of acute lymphoblastic leukemia (ALL) and a stable incidence trend, contrasting with a decrease in the US.
  • The age-effect analysis reveals that while older individuals have higher risks of leukemia in both countries, children face a notably greater disease burden in China, and both countries are projected to see a decline in leukemia incidence and mortality over the next 15 years.
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The galvanic corrosion performance of AM60B coupled to DC01 was characterized in simulated environments with varying water salinity. The results showed that the coupled DC01 effectively accelerated the corrosion rate of AM60B, and the increased salt concentration had a significant effect on the deterioration process. The corrosion of AM60B mainly exhibits metal dissolution, and the formed Mg(OH) has weak a protective effect on the alloy substrate.

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The use of proton therapy (PT) in early-stage non-small cell lung cancer (ES-NSCLC) remains controversial, with insufficient evidence to determine its superiority over photon therapy (XRT). We conducted a systematic review of PT trials in ES-NSCLC, analyzing dosimetry, efficacy, and safety across to inform clinical decision-making. Our study showed that PT reduced lung and heart dosimetric parameters compared to XRT, with significant differences in lung V5, lung V10 and mean heart dose (MHD).

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Objectives: To evaluate the diagnostic accuracy of liver dual-layer spectral-detector CT (SDCT) derived parameters of liver parenchyma for grading steatosis with reference to magnetic resonance imaging-based proton density fat fraction (MRI-PDFF).

Methods: Altogether, 320 consecutive subjects who underwent MRI-PDFF and liver SDCT examinations were recruited and prospectively enrolled from four Chinese hospital centers. Participants were classified into normal (n = 152), mild steatosis (n = 110), and moderate/severe(mod/sev) steatosis (n = 58) groups based on MRI-PDFF.

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Glucagon receptor (GCGR) is a class B1 G-protein-coupled receptor that plays a crucial role in maintaining human blood glucose homeostasis and is a significant target for the treatment of type 2 diabetes mellitus (T2DM). Currently, six small molecules (Bay 27-9955, MK-0893, MK-3577, LY2409021, PF-06291874, and LGD-6972) have been tested or are undergoing clinical trials, but only the binding site of MK-0893 has been resolved. To predict binding sites for other small molecules, we utilized both the crystal structure of the GCGR and MK-0893 complex and dynamic conformations.

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Majority of macrozooplankton have a wider dietary niche breadth and utilize small invertebrates, microzooplankton and mesozooplankton, so effect on primary production might be through trophic cascading effect. To better understand the ecosystem structure of benthic oyster-macroalgae reefs, we analyzed zooplankton community structure before (July 2016) and after (from September 2016 to October 2017) the construction of benthic reefs in the 2 km2 sea ranch area in Xiangyun Cove, Tangshan, China. We identified 57 zooplankton species, including the 12 cnidarian (e.

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