cystatin has protective effects against "two-hit" sepsis in mice by regulating the inflammatory microenvironment.

Objectives: To evaluate the protective effect of cystatin (r-Cystatin) in a mouse mode of "two-hit" sepsis.

Methods: Sixty male C57BL/6 mice randomized equally into sham-operated group, protein group, "two-hit" modeling group, and protein intervention group. In the former two groups, the mice received an intraperitoneal injection of 100 μL PBS followed by exposure of the cecum and then by intraperitoneal injection of 100 μL PBS or 25 μg r-Cystatin 30 min later; In the latter two groups, 100 μL PBS containing LPS (5 mg/kg) was injected intraperitoneally 24 h before cecal ligation and puncture (CLP), and 100 μL PBS or 25 μg r-Cystatin were injected 30 min after CLP.

A highly sensitive and selective SERS sensors based on Au@PATP@Ag@ZIF-8 for the detection of phosphate in water.

Rapid and sensitive detection of phosphate is of great significance for ensuring water safety and preventing eutrophication. In this study, we prepared Au@PATP@Ag NRs core-shell structures using 4-aminothiophenol (PATP) as an internal standard signal molecule to enhance the stability of the SERS signal. Based on the protective effect of ZIF-8 on the internal Au@PATP@Ag NRs and the phosphate-induced decomposition of ZIF-8, a phosphate SERS sensor (Au@PATP@Ag@ZIF-8) with high sensitivity, selectivity and stability was designed.

Development and validation of a novel vault prediction formula based on structural parameters of the anterior and posterior chambers.

Background: Accurate prediction of postoperative vault in implantable collamer lens (ICL) implantation is crucial; however, current formulas often fail to account for individual anatomical variations, leading to suboptimal visual outcomes and necessitating improved predictive models. We aimed to verify the prediction accuracy of our new predictive model for vaulting based on anterior and posterior chamber structural parameters.

Methods: This retrospective observational study included 137 patients (240 eyes) who previously underwent ICL surgery.

Cr-doping promoted surface reconstruction of NiN electrocatalysts toward efficient overall water splitting.

Understanding and utilizing the dynamic changes of electrocatalysts under working conditions are important for advancing the sustainable hydrogen production. Here, we for the first time report that Cr-doping can promote the in situ reconstruction of a self-supported NiN electrocatalyst (Cr-NiN/NF) during oxygen and hydrogen evolution reactions (OER and HER), and therefore improve the electrocatalytic water splitting performance. As identified by in situ measurements and theoretical calculations, Cr-doping enhances OH adsorption during OER at anode and thereby boosts the transformation of NiN pre-catalysts to defect-rich nickel oxyhydroxide (NiOOH) active species.

Leaf morphology related genes revealed by integrating Pan-transcriptome, GWAS and eQTL analyses in a Liriodendron population.

Leaf plays an indispensable role in plant development and growth. Although many known genes related to leaf morphology development have been identified, elucidating the complex genetic basis of leaf morphological traits remains a challenge. Liriodendron plants are common ornamental trees due to their unique leaf shapes, while the molecular mechanism underlying Liriodendron leaf morphogenesis has remained unknown.

Identifying depression's genetic role as a precursor to sepsis and increased mortality risk: Comprehensive insights from mendelian randomization analysis.

Background: Previous retrospective studies have shown a correlation between depression and increased risk of infections, including a moderate rise in sepsis likelihood associated with severe depression and anxiety. To investigate the potential causal links between depression, sepsis, and mortality risks, while considering confounding factors, we employed a Mendelian randomization (MR) approach.

Methods: In this two-sample Mendelian randomization study, we analyzed data from a large-scale genome-wide association study on depression, involving 807,553 European individuals (246,363 cases, 561,190 controls).

A Prospective Multicenter Study on the Additive Value of Contrast-Enhanced Ultrasound for Biopsy Decision of Ultrasound BI-RADS 4 Breast Lesions.

Objective: The main aim of this study was to determine whether the use of contrast-enhanced ultrasound (CEUS) could improve the categorization of suspicious breast lesions based on the Breast Imaging Reporting and Data System (BI-RADS), thereby reducing the number of benign breast lesions referred for biopsy.

Methods: This prospective study, conducted between January 2017 and December 2018, enrolled consenting patients from eight teaching hospitals in China, who had been diagnosed with solid breast lesions classified as BI-RADS 4 using conventional ultrasound. CEUS was performed within 1 wk of diagnosis for reclassification of breast lesions.

DunHuangStitch: Unsupervised Deep Image Stitching of Dunhuang Murals.

The digital construction of cultural heritage promotes communication and sharing of digital cultural resources across time and space. Digital storage serves as the foundation for the digital construction of cultural artifacts. In the digital storage of Dunhuang murals, image stitching plays a critical role in restoring the complete image of the cave murals.

Comprehensive deciphering the alternative splicing patterns involved in leaf morphogenesis of Liriodendron chinense.

Alternative splicing (AS), a pivotal post-transcriptional regulatory mechanism, profoundly amplifies diversity and complexity of transcriptome and proteome. Liriodendron chinense (Hemsl.) Sarg.

Image rectangling network based on reparameterized transformer and assisted learning.

Stitched images can offer a broader field of view, but their boundaries can be irregular and unpleasant. To address this issue, current methods for rectangling images start by distorting local grids multiple times to obtain rectangular images with regular boundaries. However, these methods can result in content distortion and missing boundary information.

Prevalence and Risk Factors of Hyperuricemia Among Young and Middle-Aged Tibetan Men Living at Ultrahigh Altitudes: A Cross-Sectional Study.

He, Ben, Jiayue Feng, Yan Shu, Lichun Yang, Zepin He, Kanxiu Liao, Hui Zhuo, and Hui Li. Prevalence and risk factors of hyperuricemia among young and middle-aged Tibetan men living at ultrahigh altitudes: a cross-sectional study. .

Analysis of Inter-Eye Vault Differences After Implantable Collamer Lens (V4c) Implantation.

Purpose: The safety and stability of implantable collamer lens (ICL) implantation are closely related to the vault. We aimed to assess clinical data from patients with similar anterior segment anatomy who received ICL of the same model placed in the same position and analyze common range and factors affecting the vault inter-eye difference.

Patients And Methods: A prospective study was performed, including 162 eyes of 81 patients with a bilateral ICL (V4c) implantation.

Genome-wide association study of multiyear dynamic growth traits in hybrid Liriodendron identifies robust genetic loci associated with growth trajectories.

The genetic factors underlying growth traits differ over time points or stages. However, most current studies of phenotypes at single time points do not capture all loci or explain the genetic differences underlying growth trajectories. Hybrid Liriodendron exhibits obvious heterosis and is widely cultivated, although its complex genetic mechanism underlying growth traits remains unknown.

Combining Structural Modification and Electrolyte Regulation to Enable Long-Term Cyclic Stability of MoO @TiO as Cathode for Aqueous Zn-Ion Batteries.

Orthorhombic MoO (α-MoO ) with multivalent redox couple of Mo /Mo and layered structure is a promising cathode for rechargeable aqueous Zn-ion batteries (AZIBs). However, pure α-MoO suffers rapid capacity decay due to the serious dissolution and structural collapse. Meanwhile, the growth of byproduct and dendrite on the anode also lead to the deterioration of cyclic stability.

Optimized Radiomics Nomogram Based on Automated Breast Ultrasound System: A Potential Tool for Preoperative Prediction of Metastatic Lymph Node Burden in Breast Cancer.

Background: Axillary lymph node dissection (ALND) can be safely avoided in women with T1 or T2 primary invasive breast cancer (BC) and one to two metastatic sentinel lymph nodes (SLNs). However, cancellation of ALND based solely on SLN biopsy (SLNB) may lead to adverse outcomes. Therefore, preoperative assessment of LN tumor burden becomes a new focus for ALN status.

Fine-grained multi-focus image fusion based on edge features.

Multi-focus image fusion is a process of fusing multiple images of different focus areas into a total focus image, which has important application value. In view of the defects of the current fusion method in the detail information retention effect of the original image, a fusion architecture based on two stages is designed. In the training phase, combined with the polarized self-attention module and the DenseNet network structure, an encoder-decoder structure network is designed for image reconstruction tasks to enhance the original information retention ability of the model.

Genome-wide identification and characterization of reveals its potential role in lignin biosynthesis in .

Introduction: Wood formation is closely related to lignin biosynthesis. Cinnamoyl-CoA reductase (CCR) catalyzes the conversion of cinnamoyl-CoA to cinnamaldehydes, which is the initiation of the lignin biosynthesis pathway and a crucial point in the manipulation of associated traits. Liriodendron chinense is an economically significant timber tree.

The Impact of Posterior Corneal Astigmatism on Surgically Induced Astigmatism in Cataract Surgery.

Purpose: This study aimed to evaluate the changes in posterior corneal astigmatism after cataract surgery and provide a theoretical basis to accurately evaluate the total corneal astigmatism (TA) to be corrected before toric intraocular lens (IOL) implantation.

Patients And Methods: Sixty-two patients (89 eyes) who underwent phacoemulsification combined with toric IOL implantation (AcrySof IQ Toric SN6AT2-T9) at Shanxi Eye Hospital between January 2017 and September 2018 were enrolled. Surgically induced astigmatism of the posterior cornea (SIAPA) was analysed using vector analysis during pentacam examination.

Genome-wide identification of genes in and functional characterization of .

is a relic tree species of the family Magnoliaceae with multiple uses in timber production, landscape decoration, and afforestation. often experiences drought stress in arid areas. However, the molecular basis underlying the drought response of remains unclear.

Nickel sulfide-oxide heterostructured electrocatalysts: Bi-functionality for overall water splitting and in-situ reconstruction.

Bi-functional electrocatalysts are desired for both hydrogen and oxygen evolution reactions (HER and OER). Herein, facile O-plasma activation is introduced to improve the bi-functionality via constructing nickel sulfide-oxide heterostructures. NiS-NiO supported by nickel foam delivers obviously elevated HER and OER activity in comparison with pristine NiS and recently reported NiS-based electrocatalysts, featured by the low overpotentials for HER (104 mV) and OER (241 mV) at ±10 mA cm in 1.

The value of preoperative sentinel lymph node contrast-enhanced ultrasound for breast cancer: a large, multicenter trial.

Objective: The study conducted a multicenter study in China to explore the learning curve of contrast enhanced ultrasound (CEUS) for sentinel lymph nodes (SLNs), the feasibility of using this technique for the localization of SLNs and lymphatic channels (LCs) and its diagnostic performance for lymph node metastasis.

Method: Nine hundred two patients with early invasive breast cancer from six tertiary class hospitals in China were enrolled between December 2016 and December 2019. Each patient received general ultrasound scanning and SLN-CEUS before surgery.

The Roles of microRNA-Long Non-coding RNA-mRNA Networks in the Regulation of Leaf and Flower Development in .

The leaf and the flower are vital plant organs owing to their roles in photosynthesis and reproduction. Long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and transcription factors (TFs) are very important to the development of these organs. is a common ornamental tree species in southern China with an unusual leaf shape and tulip-like flowers.

mutation and litter size are associated with a 90-base pair deletion in in East Friesian and Hu crossbred sheep.

Litter size is a critical economic trait in livestock, but only a few studies have focused on associated indel mutations in , a key regulator of ovulation and litter size in sheep. We evaluated the effects of mutations on the reproductive performance of sheep. We used Hu, East Friesian, and East Friesian/Hu crossbred sheep as experimental subjects and identified a novel 90 bp deletion in , which coincides with the c.

Genetic divergence and local adaptation of Liriodendron driven by heterogeneous environments.

Ecological adaptive differentiation alters both the species diversity and intraspecific genetic diversity in forests, thus affecting the stability of forest ecosystems. Therefore, knowledge of the genetic underpinnings of the ecological adaptive differentiation of forest species is critical for effective species conservation. In this study, single-nucleotide polymorphisms (SNPs) from population transcriptomes were used to investigate the spatial distribution of genetic variation in Liriodendron to assess whether environmental variables can explain genetic divergence.