Publications by authors named "Yang Liang"

Methylglyoxal is considered a key indicator in evaluating wine flavor and quality, as well as an important marker for diabetic pathological syndromes. Rapid and accurate quantitative detection of methylglyoxal is essential in scenarios of wine production standards and human health monitoring. Herein, we report a visual method for detecting methylglyoxal via an NIR-excitable reversible ratiometric fluorescent hydrogel sensor, where NIR-excited upconversion nanoparticles serve as energy donors and eosin B acts as the energy acceptor, together forming an integrated ratiometric nanophotonic probe that ensures the accuracy of detection without being affected by various background fluorescence interference in different scenarios.

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Purpose: This study aimed to examine the impact of high-risk cytogenetic abnormalities (HRA) on the survival outcomes of multiple myeloma patients with extramedullary disease (EMD) in the era of novel agents, utilizing the largest dataset of extramedullary multiple myeloma patients in China.

Methods: This study included a total of 371 patients with EMD, comprising 113 patients with de novo EME and 258 patients with EMB.

Results: Patients with one HRA and those with ≥ 2 HRA demonstrated significantly worse overall survival (OS) (P < 0.

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Garnet-type LiGaLaZrO(LGLZO) is believed to be a promising solid electrolyte for solid-state batteries due to its high ionic conductivity, safety, and good stability toward Li. However, one of the most challenges in practical application of LGLZO is the poor contact between Li and LGLZO. Herein, a ZnO layer is prepared on the surface of LGLZO pellet by ultrasonic spraying.

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Article Synopsis
  • Benign prostatic hyperplasia (BPH) is a common issue in older males, but how it develops is still not fully understood, prompting research into the role of sphingosine-1-phosphate (S1P) and its receptors (S1PRs) in the prostate.
  • The study found that S1P and its receptors are highly expressed in the prostate, and S1PR1, S1PR2, and S1PR3 are involved in promoting cell growth, muscle contraction, and reducing inflammation via various cellular pathways.
  • Treatment with S1P and specific receptor agonists led to prostate enlargement in rats, while antagonists of S1PR1 and S1PR3 reduced BPH symptoms
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Metagenomics, non-targeted metabolomics, and metaproteomics were employed to analyze the microecological succession of high-temperature Daqu during storage, elucidate the adaptation mechanism of the microbial community of Daqu to storage environments, and clarify the microecological characteristics of Daqu during different seasons. During storage, the relative abundances of Bacillus, Oceanobacillus, Staphylococcus, and Aspergillus in Daqu had significantly increased, while those of Kroppenstedtia, Saccharopolyspora, Thermoascus, and Thermomyces had significantly decreased. During the first 3 months of storage, compound metabolism of Daqu was primarily dominated by generation of small molecular substances and then shifted to metabolism of amino sugars.

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Glucosamine (GlcN) is a widely utilized amino monosaccharide. It is traditionally synthesized from N-acetylglucosamine (GlcNAc) via chemical processes that pose environmental threats. In pursuit of a greener alternative, our investigation explored biocatalysis with a Pantoea dispersa derived deacetylase (Pd-nagA), showcasing its efficacy as a catalyst in GlcN production.

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Three new 24-membered macrolactines, amylomacrolactines A-C (-), along with two known compounds and , were isolated from the Arctic bacteria SCSIO 41392. The configurations of - were assigned by a combination of coupling constants, NOESY, and analysis of MM2-optimized conformation, as well as by comparison with reports in the literature. Compounds and showed quorum sensing (QS) inhibitory activities against the PQS system and suppressed PQS-regulated virulence factor pyocyanin synthesis.

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Cancer stem cells (CSCs) represent a small yet pivotal subset of tumor cells endowed with self-renewal capabilities. These cells are intricately linked to tumor progression and are central to drug resistance, metastasis, and recurrence. The tumor microenvironment (TME) encompasses the cancer cells and their surrounding milieu, including immune and inflammatory cells, cancer-associated fibroblasts, adjacent stromal tissues, tumor vasculature, and a variety of cytokines and chemokines.

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The emergence of unisexual flower is an important event during plant evolution. The molecular mechanism underlying the formation of unisexual flowers remains unclear in dioecious spinach. In this study, we identified the spinach MALE STERILITY1 gene, SpMS1, which serves as a masculine factor to regulate male fertility and sex reversion.

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The low laser-induced damage threshold (LIDT) of HfO/SiO films is an important factor in limiting the further development of high repetition rate femtosecond (fs) laser systems. Conventional whole-layer annealing can effectively improve the properties of SiO films, but it is difficult to improve the properties of HfO films located in the intermediate layer and is also prone to introduce contaminants. In this study, an innovative magnetron sputtering-vacuum tube furnace combined system was presented to deposit and anneal the HfO/SiO films without contaminant.

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Article Synopsis
  • The study investigates how 35 nuclear receptors (NRs) influence the differentiation and maintenance of key immune cells using a method called "Rainbow-CRISPR."
  • It finds that receptors for retinoic acid have significant and specific roles in various immune cell types, particularly in macrophages.
  • Notably, it uncovers a unique function of the retinoic acid receptor gamma (RARγ) in regulating immune cell survival and inflammasome activity, revealing its dual role in promoting health or cell death in macrophages.
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Purpose: In recent years, ischemic preconditioning (IPC) has emerged as an effective strategy to increase tissue resistance against long-term ischemic damage and has been increasingly integrated into exercise regimens. However, further research is needed to explore the impact of IPC-mediated metabolic alterations from an exercise standpoint to conduct a comprehensive exploration of metabolic alterations and their exercise-related mechanisms during acute IPC.

Methods: Nontarget metabolomics was performed on blood samples obtained from 8 male athletes both before and after IPC.

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  • This study assesses the effectiveness and safety of different treatment regimens (RCHOP, R2-CHOP, and RCHOP plus BTKi) for double-expressor diffuse large B-cell lymphoma (DE-DLBCL), a type of cancer with a poor prognosis.
  • A total of 213 DE-DLBCL patients were analyzed, revealing high overall response rates across all treatment groups, with RCHOP plus BTKi showing a significant improvement in progression-free survival but no significant change in overall survival.
  • The findings suggest that while the addition of BTK inhibitors enhances progression-free survival, lenalidomide does not provide any extra benefits, highlighting the importance of treatment selection for improving outcomes in advanced-stage DE-DLBCL
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Fluoroquinolones (FQs) are widely used in hospitals, animal husbandry and aquaculture for the treatment of infectious diseases. However, overuse of FQs poses a potential threat to the environment and human. Detection of antibiotics is of great importance in various fields.

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The complexity of tumors and the challenges associated with treatment often stem from the limitations of existing models in accurately replicating authentic tumors. Recently, organoid technology has emerged as an innovative platform for tumor research. This bioengineering approach enables researchers to simulate, in vitro, the interactions between tumors and their microenvironment, thereby enhancing the intricate interplay between tumor cells and their surroundings.

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RNA modification has emerged as an important epigenetic mechanism that controls abnormal metabolism and growth in acute myeloid leukaemia (AML). However, the roles of RNA N-acetylcytidine (ac4C) modification in AML remain elusive. Here, we report that ac4C and its catalytic enzyme NAT10 drive leukaemogenesis and sustain self-renewal of leukaemic stem cells/leukaemia-initiating cells through reprogramming serine metabolism.

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Objective: Many studies have reported microbial signatures in thrombi at major vascular sites, such as the coronary artery and the middle cerebral artery, which are critical for maintaining proper blood flow and oxygenation. Chronic thromboembolic pulmonary hypertension (CTEPH) is a condition involving non-resolving thrombosis that has not been fully studied. This study explored the microbial taxonomy and functional profiles of both fresh and organized thrombi associated with CTEPH to investigate the role of microbiota in thrombus non-resolving.

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Studies on the prognosis of hepatitis B virus (HBV) reactivation following modern therapies for newly diagnosed MM (NDMM) are lacking. In this retrospective study, we aimed to assess the incidence, risk factors and prognosis of HBV reactivation in NDMM. A total of 33 of 355 patients with NDMM and HBV reactivation were included in this study.

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T cells occupy a pivotal position in the immune response against cancer by recognizing and eliminating cancer cells. However, the tumor microenvironment often suppresses the function of T cells, leading to immune evasion and cancer progression. Recent research has unveiled novel connections among T cells, ferroptosis, and cancer.

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Self-healing cellulose-based hydrogels (SHCHs) exhibit wide-ranging potential applications in the fields of biomedicine, environmental management, energy storage, and smart materials due to their unique physicochemical properties and biocompatibility. This review delves into the molecular design principles, performance characteristics, and diverse applications of SHCHs. Firstly, the molecular structure and physicochemical properties of cellulose are analyzed, along with strategies for achieving self-healing properties through molecular design, with particular emphasis on the importance of self-healing mechanisms.

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Objective: The purpose of the study is to develop a prognosis nomogram for esophageal squamous cell carcinoma (ESCC) patients with radical resection and to identify patients who may benefit from postoperative adjuvant radiotherapy/chemoradiotherapy through survival risk stratification.

Methods: We retrospectively enrolled patients who underwent esophagectomy in the First Affiliated Hospital of Nanjing Medical University from July 2015 to June 2017. Patients with stage I-III esophageal squamous cell carcinoma who received radical R0 resection with or without postoperative adjuvant radiotherapy/chemoradiotherapy were included.

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