A novel conditioning regimen with pre-transplantation immunosuppression reduces the complication rates in hematopoietic stem cell transplantation in transfusion-dependent β-thalassemia.

Background: Allo-HSCT is a curative therapy for patients with transfusion-dependent thalassemia (TDT). The high incidence of transplant-related complications is becoming an obstacle to safe and effective unrelated donor (URD) transplantation.

Methods: In this retrospective study, we reported the survival outcomes and complications of transplantation in thalassemia patients using a novel regimen consisting of pre-transplantation immunosuppression (PTIS) and modified myeloablative conditioning based on intravenous busulfan, cyclophosphamide, fludarabine, and rabbit anti-human thymocyte immunoglobulin.

Effects of amoxicillin dosage on cure rate, gut microbiota, and antibiotic resistome in vonoprazan and amoxicillin dual therapy for Helicobacter pylori: a multicentre, open-label, non-inferiority randomised controlled trial.

Background: Vonoprazan and amoxicillin (VA) dual therapy as a mainstream Helicobacter pylori regimen has gained momentum worldwide, but the optimum dosages remain unclear. We aimed to compare the efficacy and safety of VA dual therapy with 2 g amoxicillin or 3 g amoxicillin, and to assess the short-term effects of therapy on the gut microbiota and antibiotic resistome.

Methods: We conducted an open-label, non-inferiority randomised controlled trial at 12 centres in China.

Similarity-based context aware continual learning for spiking neural networks.

Biological brains have the capability to adaptively coordinate relevant neuronal populations based on the task context to learn continuously changing tasks in real-world environments. However, existing spiking neural network-based continual learning algorithms treat each task equally, ignoring the guiding role of different task similarity associations for network learning, which limits knowledge utilization efficiency. Inspired by the context-dependent plasticity mechanism of the brain, we propose a Similarity-based Context Aware Spiking Neural Network (SCA-SNN) continual learning algorithm to efficiently accomplish task incremental learning and class incremental learning.

Morphological, physiological, element absorption, and transcriptomic analysis reveals the mechanism of 2-(3,4-Dichlorophenoxy) trimethylamine alleviating copper stress in cucumber seedlings.

Copper (Cu) pollution resulting from human activities has emerged as a prominent issue stemming from industrial development. The entry of copper into the soil, either directly or through industrial wastewater, exerts adverse effects on plant growth, leading to its accumulation in significant quantities within the plant and subsequent endangerment of human health through the food chain. DCPTA [2-(3, 4-dichlorophenoxy) triethylamine] mitigates certain abiotic stresses, yet the precise mechanism by which it alleviates Cu-induced phytotoxicity remains unknown.

Automated classification of pathological differentiation in head and neck squamous cell carcinoma using combined radiomics models from CET1WI and T2WI.

Objectives: This study aims to develop an automated radiomics-based model to grade the pathological differentiation of head and neck squamous cell carcinoma (HNSCC) and to assess the influence of various magnetic resonance imaging (MRI) sequences on the model's performance.

Materials And Methods: We retrospectively analyzed MRI data from 256 patients across two medical centers, including both contrast-enhanced T1-weighted images (CET1WI) and T2-weighted images (T2WI). Regions of interest were delineated for radiomics feature extraction, followed by dimensionality reduction.

Integrated machine learning reveals the role of tryptophan metabolism in clear cell renal cell carcinoma and its association with patient prognosis.

Background: Precision oncology's implementation in clinical practice faces significant constraints due to the inadequacies in tools for detailed patient stratification and personalized treatment methodologies. Dysregulated tryptophan metabolism has emerged as a crucial factor in tumor progression, encompassing immune suppression, proliferation, metastasis, and metabolic reprogramming. However, its precise role in clear cell renal cell carcinoma (ccRCC) remains unclear, and predictive models or signatures based on tryptophan metabolism are conspicuously lacking.

Comparison of two different secondary rhinoplasties in patients with complete unilateral cleft lip and palate.

Background: The purpose of this study was to analysis the nostril symmetry and nasal stability following secondary rhinoplasty performed with either nasal septal cartilage implantation (G1) or simple alar cartilage suspension and internal fixation (G2) in patients with unilateral secondary cleft nasal deformity.

Methods: Nostril and alar symmetry were analyzed retrospectively in 13 consecutive patients in G1 and 17 in G2. Assessment of three indexes was first performed using photogrammetric measurements of photographs at pre-operation(T1), 7 days after repair (T2), and at least 6 months after repair (T3).

The asymptomatic tuberculosis proportion among the elderly population: a systematic review and meta-analysis.

Background: The elderly population is a high-risk group for tuberculosis, and increasing evidence demonstrates a comparatively high proportion of asymptomatic tuberculosis in this group. This study aimed to determine the proportion of asymptomatic tuberculosis among patients with active tuberculosis through active case finding in the elderly population.

Materials And Methods: We searched for relevant articles published from the establishment of each database to December 31, 2023 in Web of Science, PubMed, VIP database, Chinese National Knowledge Infrastructure, and Wanfang database.

DMAP-Catalyzed [4 + 2] Annulation of Hex-5-en-2-ynoates with Electron-Poor Alkenes.

Herein, we report a DMAP-catalyzed [4 + 2] annulation reaction of hex-5-en-2-ynoates with electron-poor alkenes , which affords exocyclic olefinic cyclohexenes in good yields and excellent regio-, diastereo-, and / selectivities. Distinguished from previous allenoate- or alkynoate-based substrates, hex-5-en-2-ynoates use the β- and ε-carbons for the bond formation, presenting new and regiodivergent C synthons for Lewis base-catalyzed annulations.

Large Scale Synthesis of Red-Emitting Quantum Dots for Efficient and Stable Light-Emitting Diodes.

It is known that large-scale synthesis of emitters affords colloidal quantum dot (CQD) materials with a great opportunity toward the mass production of quantum dot light-emitting diodes (QLEDs) based commercial electronic products. Herein, an unprecedented example of scalable CQD (> 0.5 kilogram) is achieved by using a core/shell structure of CdZnSe/ZnSeS/CdZnS, in which CdZnSe, ZnSeS, and CdZnS alloys are used as the inner core, transition layer and outermost shell, respectively.

Plasmonic MOF for Highly Selective SERS Sensing of Trace Mercury (II) in Complex Matrices.

Developing Ag-based surface-enhanced Raman spectroscopy (SERS) sensors for detecting Hg(II) has garnered significant research interest due to their unparalleled selectivity, which is brought by the specific Ag-Hg amalgamation reaction. However, existing sensors perform unsatisfactorily in the trace detection of Hg(II) because the low concentration of Hg(II) does not have the redox potential sufficient to amalgamate with Ag. To address this challenge, a plasmonic MOF SERS sensor is developed, nanoetched Ag@UiO-68-SMe, by integrating the enormous Raman enhancement effects of nanoetched Ag with the selective enrichment function of UiO-68-SMe into single entity.

The accuracy of fluorine 18-labelled prostate-specific membrane antigen PET/CT and MRI for diagnosis of prostate cancer in PSA grey zone.

Background: The diagnostic utility of prostate biopsy is limited for prostate cancer (PCa) in the prostate-specific antigen (PSA) grey zone. This study aims to evaluate the diagnostic performance of multiparametric magnetic resonance imaging (mpMRI) and prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT) for PSA grey zone PCa and clinically significant PCa (csPCa).

Methods: A total of 82 patients with PSA levels ranging from 4 to 10 ng/mL who underwent F-PSMA-1007 PET/CT, mpMRI, and prostate biopsy were prospectively enrolled.

Comparative study of gravity effects in directional solidification of Al-3.5 wt.% Si and Al-10 wt.% Cu alloys.

Directional solidification experiments of Al-3.5 wt.% Si and Al-10 wt.

[HPLC-Q-TOF-MS/MS and network pharmacology reveal absorbed components of Bufei Pills, potential in treating respiratory disorders, and mechanism in recovery stage of COVID-19].

This study employed the methods of serum chemistry, in vivo drug distribution analysis, and network pharmacology to investigate the potential therapeutic effects of Bufei Pills on respiratory disorders and decipher the underlying mechanisms. For the in vivo distribution study, rats were administrated with Bufei Pills, and the absorbed components were analyzed by HPLC-Q-TOF-MS/MS. The results showed that 56 components were present in the rat serum, including neocyclomorusin, asterinin A, neoisostegane, goimisin R, and frehmaglutoside H.

Water-soluble polysaccharides from Torreya grandis nuts: Structural characterization and anti-inflammatory activity.

Torreya grandis (T. grandis) nuts are widely consumed as a functional food in China. In this study, we investigated the structural characteristics of T.

Hijacking endogenous iron to amplify lysosomal-mitochondrial cascade damage for boosting anti-tumor immunotherapy.

The cross-talk between lysosomes and mitochondria is crucial for keeping intracellular homeostasis and metabolic function, providing a promising approach for tumor therapy. Herein, we employed polyvinylpyrrolidone (PVP)-modified Cu-gallic acid (CuGA) complex nano-boosters for amplifying lysosomes-mitochondria cascaded damage, and thereby effectively inducing cuproptosis and pyroptosis of breast tumor cells to boost anti-tumor immunotherapy. The CuGA nano-boosters could hijack lysosomal iron to form a bimetallic catalyst Cu(Fe)GA in situ through ion-exchange reaction, and cause the release of Cu and metal ion dysregulation (i.

Multimorbidity in elderly patients with or without T2DM: A real-world cross-sectional analysis based on primary care and hospitalisation data.

Background: Shanghai's high level of ageing has given rise to a considerable number of elderly patients with type 2 diabetes mellitus (T2DM) who are confronted with the challenge of managing multimorbidity. We aimed to determine the prevalence of multimorbidity in elderly T2DM patients in a representative Pudong New Area community and critically evaluate current guidelines' inclusiveness in addressing major comorbidities.

Methods: Through the Shanghai Health Cloud platform, we extracted medical records of residents in the Huamu community (Pudong New Area, Shanghai) to screen elderly patients with at least three outpatient visits or one hospitalisation per year between 2019 and 2022.

NPR1 promotes blue light-induced plant photomorphogenesis by ubiquitinating and degrading PIF4.

Light is a major determinant of plant growth and survival. NONEXPRESSER OF PATHOGENESIS-RELATED GENES 1 (NPR1) acts as a receptor for salicylic acid (SA) and serves as the key regulator of SA-mediated immune responses. However, the mechanisms by which plants integrate light and SA signals in response to environmental changes, as well as the role of NPR1 in regulating plant photomorphogenesis, remain poorly understood.

Bestrophin-4 relays HES4 and interacts with TWIST1 to suppress epithelial-to-mesenchymal transition in colorectal cancer cells.

Bestrophin isoform 4 () is a newly identified subtype of the calcium-activated chloride channel family. Analysis of colonic epithelial cell diversity by single-cell RNA-sequencing has revealed the existence of a cluster of + mature colonocytes in humans. However, if the role of is involved in regulating tumour progression remains largely unknown.

A flexible, water anchoring, and colorimetric ionogel for sweat monitoring.

As water-saturated polymer networks, the easy water loss of hydrogels directly affects their end-use applications. Minimizing the ratio of free water and increasing the ratio of bound water in the gel system has become key to extending the service life. In this work, an ionogel is prepared that effectively regulates the proportion of free water and bound water through the formation of wrinkle angles by the hydrophilic and hydrophobic chains in the gel system and the non-volatile nature of the ionic liquid.

Cross-Cultural Adaptation and Validation of the Central Sensitization Inventory Among Chinese Patients with Chronic Non-Specific Low Back Pain.

Purpose: This research aims to develop and validate the Chinese version of the Central Sensitization Inventory (CSI-CV) for patients suffering from chronic non-specific low back pain (CNSLBP). The study evaluates both the validity and reliability of the CSI-CV.

Patients And Methods: The cross-cultural adaptation of the scale strictly adhered to the principles of Bombardier and Beaton.

A rare case report of renal clear cell carcinoma with multiple skin metastases and a review of the literature.

Renal cell carcinoma is the most common type of primary renal cancer, and clear cell carcinoma is the most common subtype, accounting for approximately 70% of all adult renal cell carcinoma cases. At the time of diagnosis, many patients already have metastatic manifestations. Cutaneous metastasis of renal clear cell carcinoma is very rare and usually represents a poor prognosis, mostly affecting the head and neck.

Aberrant amplitude of low-frequency fluctuation and functional connectivity in children with different subtypes of ADHD: a resting-state fNIRS study.

Background: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with different subtypes of pathogenesis. Insufficient research on the subtypes of ADHD has limited the effectiveness of therapeutic methods.

Methods: This study used resting-state functional near-infrared spectroscopy (fNIRS) to record hemodynamic signals in 34 children with ADHD-combined subtype (ADHD-C), 52 children with ADHD-inattentive subtype (ADHD-I), and 24 healthy controls (HCs).

Research on the urban-rural differences and influencing factors of life satisfaction among elderly people in China.

Objective: To analyze the differences in life satisfaction and the factors that influence it among elderly people in urban and rural locations in China and to provide a reference for narrowing these differences.

Methods: Binary logistic regression was used to analyze 2018 data from the Chinese Longitudinal Healthy Longevity Survey (CLHLS) to understand the status of life satisfaction and urban-rural differences among the elderly.

Results: Among 4,910 elderly participants, the overall life satisfaction rate was 72.

A Novel Label-Free Method for Efficient Detection of Bisphosphonate Drug Dissolution Rates Using Surface-Enhanced Raman Spectroscopy.

We developed a novel method utilizing surface-enhanced Raman spectroscopy (SERS) with calcium ion-modified silver nanoparticles as the enhancing substrate. This approach enables label-free detection of the dissolution rate of bisphosphonates. This technique is fast, sensitive, and highly reproducible, significantly advancing drug quality control.