Mental Health Literacy and Professional Psychological Help-Seeking Attitudes Among Primary Healthcare Workers: The Mediating Role of Social Support and Mental Illness Stigma.

Background: Research highlights poor mental health among healthcare workers, but limited attention has been given to the mental health literacy and professional psychological help-seeking attitudes of primary healthcare workers.This study investigates the relationship between primary healthcare workers' mental health literacy and their attitudes toward professional psychological help-seeking. It also explores the chain mediating roles of social support and mental illness stigma in this relationship.

Risk Factors Analysis and Predictive Model Construction for Autoimmune Gastritis: A Nationwide Multicenter Case-Control Study in China.

Objective: Here, we ascertained the clinical characteristics of Chinese patients with autoimmune gastritis (AIG) and determined the correlation of dietary and lifestyle factors with AIG occurrence and development to establish a noninvasive predictive model for AIG.

Methods: In this case-control study, we enrolled 479 patients from seven independent centers nationwide in China; of them, 279 had AIG, 112 had chronic atrophic gastritis mostly in the antrum, and 88 had chronic nonatrophic gastritis. Their clinical and lifestyle data were systematically collected and analyzed.

Assembling Ruthenium Complexes to Form Ruthenosome Unleashing Ferritinophagy-Mediated Tumor Suppression.

We introduce ruthenosomes, a fusion of liposomal and reactive oxygen species (ROS)-generating properties meticulously engineered as potent ferroptosis inducers (FINs), marking a significant advancement in metallodrug design for cancer therapy. Formed through the self-assembly of oleate-conjugated ruthenium complexes, these ruthenosomes exhibit exceptional cellular uptake, selectively accumulating in mitochondria and causing substantial disruption. This targeted mitochondrial damage significantly elevates ROS levels, triggering autophagy and selectively activating ferritinophagy.

Chemical Bonds Containing Hydrogen: Choices for Hydrogen Carriers and Catalysts.

Compounds containing B-H, C-H, N-H, or O-H bonds with high hydrogen content have been extensivley studied as potential hydrogen carriers. Their hydrogen storage performance is largely determined by the nature of these bonds, decomposition pathways and the properties of the dehydrogenation products. Among these compounds, methanol, cyclohexane, and ammonia stand out due to their low costs and established infrastructure, making them promising hydrogen carriers for large-scale storage and transport.

Mechanism of Chemically Induced Structural Evolution of Lead Azide under Hygrothermal Condition.

Aging behavior of pyrotechnic agents is a serious threat to the reliability of the practical application of pyrotechnic products, while multiple environmental factors make it challenging to characterize the aging mechanism of pyrotechnic agents. This paper explored the aging process of LA in four hygrothermal environments with morphology and structure analysis techniques. LA aging underwent three stages: rapid surface reaction with HO and CO, interior hydrolysis by HO, and CO reaction with lead oxides.

Predicting the Cell-level PD-L1 Expression Status from H&E-stained Histopathological Slide.

TPS (Tumor Proportion Score) serves as a crucial indicator to determine the eligibility of cancer patients for PD-L1 immunohistochemistry (IHC) treatment. In clinical practice, pathologists assess TPS primarily using IHC histopathological slides, which is time-consuming and incurs high treatment costs. In this paper, we introduce a novel approach for predicting PD-L1 positive cells using cost-effective and widely accessible Hematoxylin and Eosin (H&E) stained slides.

Cuff Electrode Impacts on Vagus Nerve Stimulation Threshold Under MR Gradient Coil Emission.

In this research, we investigate the impact of implantable cuff electrodes on the vagus nerve stimulation threshold due to the gradient fields during MR scans. We employ electromagnetic simulations in conjunction with the NEURON model for our study. Preliminary findings suggest that the cuff electrodes can substantially reduce the stimulation threshold for the specific configuration examined in this research.

Wearable Body Sensors Integrated into a Virtual Reality Environment - A Modality for Automating the Rehabilitation of the Motor Control System.

Amidst the rising incidences of stroke and spinal cord injuries, this study introduces a Virtual Reality (VR) system integrated with wearable sensor-based motion capture technology to enhance rehabilitation and assessment of upper limb impairments. The proposed motion capture system utilizes Inertial Measurement Units (IMUs) engineered in a modular and portable fashion to best fit different rehabilitation needs of the motor control system. The wearable sensor system consists of 15 modules capable of capturing the entire human body motion, along with a pair of hand gloves including 11 miniature sensors measuring hand motion.

Impact of mHealth-Enhanced Prenatal Education and Diet Recording on Gestational Diabetes Mellitus Prevention.

Gestational Diabetes Mellitus (GDM) is a common metabolic disorder during pregnancy, raising significant health risks to both mother and child. With the advent of mobile health (mHealth) technologies, there is a growing potential to enhance GDM prevention strategies. This study investigates the impact of mobile-based prenatal education and diet recording on GDM prevention, utilizing the self-management application of the Peking Union Medical College Hospital mHealth-Enhanced Prenatal Care Program in Beijing, China.

Evolution of VO on TiO-ZSM-5 Composite Supports upon K Poisoning and Its Effects on Ultralow Temperature NH-SCR.

Compared with VO/TiO, vanadia catalysts supported on TiO-ZSM-5 composite support possess excellent resistance to potassium poisoning in the selective catalytic reduction of NO by NH (NH-SCR). Appropriate addition of ZSM-5 (10 wt %) enhances the low-temperature activity of NH-SCR with more than 80% NO conversion at 175-450 °C, as the combination of TiO and ZSM-5 is conducive to the formation of more low-valent (polymeric) VO preferentially deposited on TiO. Compared with VO/TiO, the composite support catalysts effectively shield VO as the main active species from K poisoning by preferential ion-exchange of K with Brønsted acid sites (Si-O(H)-Al) of ZSM-5.

Agomelatine as adjunctive therapy with SSRIs or SNRIs for major depressive disorder: a multicentre, double-blind, randomized, placebo-controlled trial.

Background: In general, traditional antidepressants often have limited efficacy in patients with major depressive disorder (MDD). Agomelatine, as an antidepressant with a different mechanism of action, might have adjunctive effects on traditional antidepressants. This study aimed to investigate the augmentation effect of agomelatine versus placebo in treating MDD patients who failed to respond to selective serotonin reuptake inhibitors (SSRIs) and serotonin-noradrenaline reuptake inhibitors (SNRIs).

Preparation of Cell-Cultured Fish Fat via Adipogenic Transdifferentiation of Muscle Satellite Cells.

Cell-cultured fish fat (CCF) has the potential to enhance the flavor and texture of cell-cultured fish meat (CCM). Herein, CCF was developed through the adipogenic transdifferentiation of muscle satellite cells (LCMSCs). A low-serum culture system and a large-scale culture system were established.

Preoperative optimization strategy management model applied in gallbladder surgery.

Purpose: To investigate the impact of implementing a pre-hospitalization optimization strategy on the length of stay and hospital costs for patients undergoing gallbladder surgery at a tertiary hospital, this study aims to analyze patient characteristics relevant to pre-hospitalization gallbladder surgery, focusing on age and underlying medical conditions.

Method: The data from patients who underwent the pre-hospitalization optimization strategy were analyzed and compared with that of patients receiving standard hospitalization to determine whether there were statistically significant differences in duration of stay and associated costs.

Results: Under the optimal management strategy for pre-hospitalization, we analyzed the hospitalization of patients with and without underlying diseases, specifically comparing those aged over 65 years to those under 65 years, against a cohort of general hospitalized patients.

In-depth profile of biosignatures for T2DM cohort utilizing an integrated targeted LC-MS platform.

The profiling of metabolites provides an immediate snapshot that depicts crucial physiological information, holding immense potential for the early diagnosis and prognosis of diseases, including diabetes. Herein, we proposed an optimized and in-depth target-based metabolome platform through an integration of six distinct conditions, including a normal phase, a pre-column chemical derivatization and four reversed phase separation methods for the quantification of a total of 1609 small molecules (32 sub-classes) in serum after normalization using isotope-labeled internal standards. After undergoing rigorous methodological validation and comprehensive comparison with untargeted strategies, we present a new dataset of metabolomic profile encompassing a cohort of 200 healthy individuals and 100 newly diagnosed Type 2 diabetes mellitus (T2DM) patients from the northern region of China.

Spatial-Temporal Information Fusion for Thyroid Nodule Segmentation in Dynamic Contrast-Enhanced MRI: A Novel Approach.

This study aims to develop a novel segmentation method that utilizes spatio-temporal information for segmenting two-dimensional thyroid nodules on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Leveraging medical morphology knowledge of the thyroid gland, we designed a semi-supervised segmentation model that first segments the thyroid gland, guiding the model to focus exclusively on the thyroid region. This approach reduces the complexity of nodule segmentation by filtering out irrelevant regions and artifacts.

Polysaccharides as submucosal injection materials (SIMs) in endoscopic resection: A comprehensive review.

Submucosal injection materials (SIMs) play a vital role in the endoscopic treatment of benign and early malignant gastrointestinal lesions by effectively elevating lesions while significantly reducing the risks of thermal injury and bleeding. However, the traditional use of normal saline (NS) presents challenges due to its rapid absorption, which necessitates frequent reapplications and complicates procedural efficiency. Therefore, there is a pressing need for ideal SIMs that are cost-effective, readily available, and suitable for personalized therapy, while also demonstrating excellent biocompatibility and physicochemical stability.

Quaternized chitosan-based photothermal antibacterial hydrogel with pro-vascularization and on-demand degradation properties for enhanced infected wound healing.

Compromised skin barrier fails to prevent pathogenic bacterial invasion, leading to wound infection and potentially severe tissue damage, for which conventional wound dressings provide inadequate therapeutic outcomes. Herein, we have developed a multifunctional injectable hydrogel (QCS-APA/P@D@C) based on quaternized chitosan (QCS) and aldehyde-modified aliphatic polycarbonate (APA), incorporating Prussian Blue (PB) @Polydopamine (PDA) @Cu (P@D@C) submicron particles (SPs). This novel hydrogel exhibits photothermal antibacterial properties, on-demand removal capability, and Cu-facilitated wound healing enhancement.

GB05, a safe and effective IFNα1b inhalation solution for treating respiratory syncytial virus infection.

Human respiratory syncytial virus (HRSV) infection is linked to significant morbidity and mortality in infants and young children worldwide, yet no effective treatment is available. Interferon α (IFNα), a major subtype among the IFN family, has demonstrated antiviral effects by activating the human immune system. Aerosol inhalation is a way of IFN administration that can enhance efficacy while decreasing serum IFNα concentrations and systemic exposure, thereby minimizing the risk of systemic toxicity.

Long circulating XTEN864-HGV-Apoptin fusion protein for selective cancer therapy.

The virus protein CAV-Apoptin and its homologue HGV-Apoptin selectively kill cancer cells but are not suitable for systemic treatment. The aim was to develop Apoptin-based fusion proteins for intravenous application in cancer therapy, which also contain the hydrophilic polypeptide XTEN, a cleavage site for MMP-2/9, and a TAT peptide for cell penetration. Expression of XTEN864-HGV-Apoptin in E.

Genome-wide identification of the ECERIFERUM (CER) gene family in cabbage and critical role of BoCER4.1 in wax biosynthesis.

The ECERIFERUM (CER) gene family is essential for the biosynthesis of plant cuticular wax. In this study, 32 BoCER genes were identified in cabbage through genome-wide analysis. We found that the BoCER genes are highly conserved with their homologous counterparts in Arabidopsis thaliana.

Discovery of a potent and in vivo anti-inflammatory Efficacious, P2YR antagonist with a novel benzisoxazoles scaffold by DNA-encoded chemical library technology.

P2YR is activated by UDP (uridine diphosphate) and UDP glucose and associated with the development of many inflammatory diseases. P2YR antagonists are expected to be a new choice for the treatment of inflammatory diseases. A DNA-encoded chemical library (DEL) of 4 billion molecules was screened, leading to the identification of compound A, a novel benzisoxazole scaffold-based P2Y antagonist with an IC value of 23.

Chicken anemia virus inhibits hematopoiesis and development of chicken embryo.

Chicken anemia virus (CAV), when primarily transmitted through the vertical route, could result in a significant global prevalence. Specifically, vertical CAV transmission, especially in newly-hatched chicks, may cause anemia and immunosuppression, leading to significant losses in the global poultry industry. Although CAV infection of chick embryos is critical in its vertical transmission, the pathogenicity of CAV in these embryos remains unclear.

Plasma IgG Glycosylation Profiling Reveals the Biological Features of Early Chronic Obstructive Pulmonary Disease.

Chronic inflammatory and immune dysregulation are critical drivers of the development and progression of chronic obstructive pulmonary disease (COPD). Posttranslational modifications, such as glycosylation of Immunoglobulin G (IgG), are crucial in modulating systemic inflammatory homeostasis. This study aims to profile plasma IgG glycopeptides (IgGPs) in COPD patients to uncover new insights into their pathogenesis and to identify novel biomarkers.

Comprehensive Experimental Insights into Ultra-Long Cycle Life of Zinc-Ion Batteries Inspired by Super Low Concentrations of a Derivative of Urea in the Zinc Sulfate Electrolyte.

In this study, a low-cost and friendly compound diazolidinylurea carrying a number of heteroatoms and inter/intra hydrogen bonding, a derivative of urea (), efficiently strengthened aqueous zinc ions batteries (AZIBs) in ZnSO electrolyte. The influence of on the zinc anode in the 2 M ZnSO electrolyte was fully studied by various surface chemistry and electrochemistry means. It is demonstrated that the super low concentration of (2 mM, 0.

Kisspeptin Administration Stimulates Reproductive Hormones But Does Not Affect Anxiety in Humans.

Background: Kisspeptin is a critical endogenous activator of the reproductive system, with escalating clinical interest as a novel therapeutic for common reproductive and psychosexual disorders. However, conflicting animal data suggest that kisspeptin can have anxiolytic, neutral, or anxiogenic effects. Given the rapid development of kisspeptin-based therapeutics, it is important to comprehensively investigate kisspeptin's effects on anxiety in humans.